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This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
DDAH1 (Dimethylarginine Dimethylaminohydrolase 1) is a Protein Coding gene. Diseases associated with DDAH1 include Cardiovascular System Disease and Pulmonary Hypertension. Among its related pathways are Mesodermal Commitment Pathway and eNOS activation and regulation. Gene Ontology (GO) annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | TAS | 9874257 |
GO:0016403 | dimethylargininase activity | IEA,IDA | 19663506 |
GO:0016597 | amino acid binding | IBA | 21873635 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005829 | cytosol | TAS | -- |
GO:0070062 | extracellular exosome | HDA | 19056867 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | eNOS activation and regulation |
.01
|
|
2 | Mesodermal Commitment Pathway | ||
3 | Metabolism |
.40
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000052 | citrulline metabolic process | IEA,IDA | 19663506 |
GO:0003073 | regulation of systemic arterial blood pressure | ISS | -- |
GO:0006525 | arginine metabolic process | IBA | 21873635 |
GO:0006527 | arginine catabolic process | IEA,IDA | 24895913 |
GO:0007263 | nitric oxide mediated signal transduction | TAS | 9874257 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Dexlansoprazole | Approved, Investigational | Pharma | Target | 262 | ||
Esomeprazole | Approved, Investigational | Pharma | Target | Proton pump inhibitor | 427 | |
Pantoprazole | Approved | Pharma | Target, inhibitor | H+/K+-ATPase inhibitor | 210 | |
Water | Approved | Pharma | 0 | |||
N,N-dimethylarginine | Experimental | Pharma | 24 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DDAH1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DDAH1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DDAH1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ddah1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ddah1 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | DDAH1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DDAH1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DDAH1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DDAH1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ddah1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | ddah1-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | DDAH1 31 |
|
OneToOne | |
zgc:85829 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG1764 30 31 32 |
|
OneToMany | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001644 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv120n106 | CNV | duplication | 24896259 |
dgv31e214 | CNV | loss | 21293372 |
dgv32e214 | CNV | gain | 21293372 |
esv21828 | CNV | gain | 19812545 |
esv2440186 | CNV | deletion | 19546169 |
esv2647869 | CNV | gain | 19546169 |
esv2663134 | CNV | deletion | 23128226 |
esv2714296 | CNV | deletion | 23290073 |
esv2941567 | CNV | duplication | 24192839 |
esv34165 | CNV | loss | 18971310 |
esv3577995 | CNV | loss | 25503493 |
esv3577996 | CNV | loss | 25503493 |
esv3586681 | CNV | gain | 21293372 |
nsv1008877 | CNV | gain | 25217958 |
nsv1075778 | CNV | duplication | 25765185 |
nsv1128596 | CNV | duplication | 24896259 |
nsv1142063 | CNV | tandem duplication | 24896259 |
nsv1153631 | CNV | duplication | 26484159 |
nsv1766 | CNV | insertion | 18451855 |
nsv436030 | CNV | insertion | 17901297 |
nsv441699 | CNV | loss | 18776908 |
nsv821007 | CNV | duplication | 20802225 |
nsv823398 | CNV | loss | 20364138 |
nsv830459 | CNV | loss | 17160897 |
nsv830470 | CNV | loss | 17160897 |
nsv946038 | CNV | duplication | 23825009 |
nsv950202 | CNV | duplication | 24416366 |
nsv950203 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cardiovascular system disease |
|
|
pulmonary hypertension |
|
|
hypertension, essential |
|
|