Aliases for DDAH1 Gene
External Ids for DDAH1 Gene
Previous GeneCards Identifiers for DDAH1 Gene
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for DDAH1 Gene
DDAH1 (Dimethylarginine Dimethylaminohydrolase 1) is a Protein Coding gene. Diseases associated with DDAH1 include Cardiovascular System Disease and Hypertension, Essential. Among its related pathways are eNOS activation and regulation and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include amino acid binding and dimethylargininase activity. An important paralog of this gene is DDAH2.
UniProtKB/Swiss-Prot Summary for DDAH1 Gene
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.