Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DDA1 Gene

Aliases for DDA1 Gene

  • DET1 And DDB1 Associated 1 2 3 5
  • Placenta Cross-Immune Reaction Antigen 1 3 4
  • C19orf58 3 4
  • PCIA-1 3 4
  • PCIA1 3 4
  • Chromosome 19 Open Reading Frame 58 2
  • DET1- And DDB1-Associated Protein 1 3
  • Cross-Immune Reaction Antigen PCIA1 3

External Ids for DDA1 Gene

Previous HGNC Symbols for DDA1 Gene

  • C19orf58

Previous GeneCards Identifiers for DDA1 Gene

  • GC19P017284
  • GC19P017420
  • GC19P016986
  • GC19P017421
  • GC19P017684
  • GC19P017710
  • GC19P018280
  • GC19P018683
  • GC19P018987
  • GC19P019311

Summaries for DDA1 Gene

GeneCards Summary for DDA1 Gene

DDA1 (DET1 And DDB1 Associated 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DDA1 Gene

  • May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.

Additional gene information for DDA1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDA1 Gene

Genomics for DDA1 Gene

GeneHancer (GH) Regulatory Elements for DDA1 Gene

Promoters and enhancers for DDA1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I017307 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +1.2 1210 5.6 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 YY1 ABHD8 DDA1 CHERP MRPL34 C19orf44 ENSG00000268743 SIN3B ENSG00000269427 ENSG00000269044 ENSG00000267904
GH19I017333 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.7 +24.7 24743 2.4 FEZF1 IRF4 YY1 ZNF213 ZNF416 ZNF143 SP3 NFYC MEF2D ZNF610 GTPBP3 ANO8 CHERP IQCN C19orf44 ENSG00000267904 ENSG00000268743 ENSG00000268087 MRPL34 ENSG00000269578
GH19I017332 Enhancer 0.8 ENCODE 12.7 +23.3 23279 0.2 HDGF HDAC1 PKNOX1 ATF1 ARNT SIN3A ZNF143 KLF7 FOS ATF7 ABHD8 MRPL34 DDA1 MVB12A BST2 ANO8 PIR41076
GH19I017302 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.4 -5.0 -5011 5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 MRPL34 ABHD8 CHERP HAUS8 C19orf44 ENSG00000268743 IQCN MED26 ENSG00000269578 COLGALT1
GH19I017316 Enhancer 0.8 ENCODE 0.4 +8.0 8007 1.5 HDAC1 ATF1 NFIB KLF17 ZEB1 ZNF366 KLF7 FOS ATF7 CREM MRPL34 ENSG00000269578 C19orf44 ABHD8 ENSG00000268743 CHERP IQCN SIN3B ENSG00000268087 GTPBP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DDA1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DDA1 gene promoter:

Genomic Locations for DDA1 Gene

Genomic Locations for DDA1 Gene
chr19:17,309,518-17,323,301
(GRCh38/hg38)
Size:
13,784 bases
Orientation:
Plus strand
chr19:17,420,327-17,434,110
(GRCh37/hg19)

Genomic View for DDA1 Gene

Genes around DDA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDA1 Gene

Proteins for DDA1 Gene

  • Protein details for DDA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BW61-DDA1_HUMAN
    Recommended name:
    DET1- and DDB1-associated protein 1
    Protein Accession:
    Q9BW61

    Protein attributes for DDA1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11835 Da
    Quaternary structure:
    • Part of the DDD core complex containing DET1, DDA1 and DDB1. The DDD core complex recruits a specific UBE2E enzyme, such as UBE2E1, UBE2E2 UBE2E3, to form specific DDD-E2 complexes.

neXtProt entry for DDA1 Gene

Post-translational modifications for DDA1 Gene

  • Ubiquitination at posLast=7171
  • Modification sites at PhosphoSitePlus

Other Protein References for DDA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DDA1 Gene

Domains & Families for DDA1 Gene

Gene Families for DDA1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DDA1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DDA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BW61

UniProtKB/Swiss-Prot:

DDA1_HUMAN :
  • Belongs to the DDA1 family.
Family:
  • Belongs to the DDA1 family.
genes like me logo Genes that share domains with DDA1: view

Function for DDA1 Gene

Molecular function for DDA1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins.

Phenotypes From GWAS Catalog for DDA1 Gene

Gene Ontology (GO) - Molecular Function for DDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
genes like me logo Genes that share ontologies with DDA1: view
genes like me logo Genes that share phenotypes with DDA1: view

Animal Model Products

CRISPR Products

miRNA for DDA1 Gene

miRTarBase miRNAs that target DDA1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDA1 Gene

Localization for DDA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDA1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DDA1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DDA1 Gene

Pathways & Interactions for DDA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DDA1: view

No data available for Pathways by source and SIGNOR curated interactions for DDA1 Gene

Drugs & Compounds for DDA1 Gene

No Compound Related Data Available

Transcripts for DDA1 Gene

Unigene Clusters for DDA1 Gene

DET1 and DDB1 associated 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DDA1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3:
SP4:

Relevant External Links for DDA1 Gene

GeneLoc Exon Structure for
DDA1
ECgene alternative splicing isoforms for
DDA1

Expression for DDA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDA1 Gene

Protein differential expression in normal tissues from HIPED for DDA1 Gene

This gene is overexpressed in Lung (22.0), Placenta (7.4), and CD8 Tcells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDA1 Gene



Protein tissue co-expression partners for DDA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DDA1 Gene:

DDA1

SOURCE GeneReport for Unigene cluster for DDA1 Gene:

Hs.466154

Evidence on tissue expression from TISSUES for DDA1 Gene

  • Liver(4.4)
  • Skin(4.3)
  • Muscle(2.5)
  • Nervous system(2.5)
  • Lung(2.4)
  • Intestine(2)
genes like me logo Genes that share expression patterns with DDA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDA1 Gene

Orthologs for DDA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DDA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDA1 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DDA1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DDA1 33 34
  • 91.83 (n)
MGC137055 34
  • 72 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DDA1 33 34
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Dda1 33
  • 87.58 (n)
mouse
(Mus musculus)
Mammalia Dda1 33 16 34
  • 86.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDA1 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDA1 33 34
  • 78.1 (n)
lizard
(Anolis carolinensis)
Reptilia DDA1 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dda1 33
  • 77.56 (n)
Str.6079 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24736 33
zebrafish
(Danio rerio)
Actinopterygii dda1 33 34
  • 78.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5435 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008078 33
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31855 34
  • 38 (a)
OneToOne
Species where no ortholog for DDA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DDA1 Gene

ENSEMBL:
Gene Tree for DDA1 (if available)
TreeFam:
Gene Tree for DDA1 (if available)

Paralogs for DDA1 Gene

Pseudogenes.org Pseudogenes for DDA1 Gene

genes like me logo Genes that share paralogs with DDA1: view

No data available for Paralogs for DDA1 Gene

Variants for DDA1 Gene

Sequence variations from dbSNP and Humsavar for DDA1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000018641 -- 17,312,285(+) G/T intron_variant
rs1000310237 -- 17,309,251(+) A/T upstream_transcript_variant
rs1000345753 -- 17,314,047(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000689099 -- 17,312,932(+) G/A intron_variant
rs1000760897 -- 17,313,259(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DDA1 Gene

Variant ID Type Subtype PubMed ID
esv1347676 CNV deletion 17803354
esv2657177 CNV deletion 23128226
esv2718275 CNV deletion 23290073
nsv1071514 CNV deletion 25765185
nsv1129618 CNV tandem duplication 24896259
nsv470129 CNV loss 18288195
nsv472615 CNV novel sequence insertion 20440878

Variation tolerance for DDA1 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DDA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDA1 Gene

Disorders for DDA1 Gene

Additional Disease Information for DDA1

No disorders were found for DDA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDA1 Gene

Publications for DDA1 Gene

  1. Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes. (PMID: 17452440) Pick E … Wei N (Molecular and cellular biology 2007) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase. (PMID: 28087699) Gao S … Cang Y (The Journal of biological chemistry 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. DDA1 promotes stage IIB-IIC colon cancer progression by activating NFκB/CSN2/GSK-3β signaling. (PMID: 26942699) Zhao S … Peng Z (Oncotarget 2016) 3 58

Products for DDA1 Gene

Sources for DDA1 Gene

Content
Loading form....