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Aliases for DCUN1D3 Gene

Aliases for DCUN1D3 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 3 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 3 3 4
  • Squamous Cell Carcinoma-Related Oncogene 3 3 4
  • DCUN1 Domain-Containing Protein 3 3 4
  • SCCRO3 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 3 3
  • DCN1-Like Protein 3 3
  • 44M2.4 3

External Ids for DCUN1D3 Gene

Previous GeneCards Identifiers for DCUN1D3 Gene

  • GC16M020776
  • GC16M019404

Summaries for DCUN1D3 Gene

GeneCards Summary for DCUN1D3 Gene

DCUN1D3 (Defective In Cullin Neddylation 1 Domain Containing 3) is a Protein Coding gene. An important paralog of this gene is DCUN1D2.

UniProtKB/Swiss-Prot for DCUN1D3 Gene

  • Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Additional gene information for DCUN1D3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D3 Gene

Genomics for DCUN1D3 Gene

GeneHancer (GH) Regulatory Elements for DCUN1D3 Gene

Promoters and enhancers for DCUN1D3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I020896 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 573.8 -2.3 -2272 11.5 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D GLIS1 DCUN1D3 LYRM1 THUMPD1 ACSM3 SMG1P3 ACSM1 CRYM ERI2 PIR35456 GC16P020829
GH16I020909 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 22.8 -12.0 -12038 5.4 HDGF PKNOX1 ZNF335 ZNF766 FOS ETV6 ATF7 EGR2 ZNF362 CEBPB DCUN1D3 ACSM3 DNAH3 TMEM159 CRYM ACSM1 THUMPD1 LYRM1 PIR35456 GC16P020829
GH16I021819 Promoter/Enhancer 1.5 Ensembl ENCODE 19.2 -919.9 -919917 1.8 HDGF SMAD1 ZFP64 SIN3A FEZF1 ZNF2 YY1 ZNF213 ZNF302 ZNF207 RRN3P1 NPIPB4 NPIPB5 NPIPB3 SMG1P3 ENSG00000260635 SMG1P4 SMG1P1 POLR3E ENSG00000260905
GH16I020849 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +49.2 49247 3.1 ARNT ARID4B ZNF2 YY1 SLC30A9 ARID2 ZNF143 DEK RXRA MXD4 PIR58963 THUMPD1 DCUN1D3 LYRM1 TMEM159 DNAH3 GC16P020829 REXO5 ERI2
GH16I020864 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +33.9 33884 3.6 PKNOX1 FEZF1 BATF IRF4 ZNF335 TCF12 ZNF23 ETV6 FOS ATF7 ACSM3 THUMPD1 LYRM1 DCUN1D3 TMEM159 DNAH3 PIR58963 ERI2 GC16P020829
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCUN1D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCUN1D3 gene promoter:

Genomic Locations for DCUN1D3 Gene

Genomic Locations for DCUN1D3 Gene
chr16:20,854,925-20,900,384
(GRCh38/hg38)
Size:
45,460 bases
Orientation:
Minus strand
chr16:20,866,247-20,911,706
(GRCh37/hg19)

Genomic View for DCUN1D3 Gene

Genes around DCUN1D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D3 Gene

Proteins for DCUN1D3 Gene

  • Protein details for DCUN1D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWE4-DCNL3_HUMAN
    Recommended name:
    DCN1-like protein 3
    Protein Accession:
    Q8IWE4
    Secondary Accessions:
    • B3KVY4

    Protein attributes for DCUN1D3 Gene

    Size:
    304 amino acids
    Molecular mass:
    34291 Da
    Quaternary structure:
    • Interacts with CAND1, CUL1, CUL3 and RBX1 through the DCUN1 domain. In vitro, the DCUN1/PONY domain binds UBE2F and, with lower affinity, UBE2M (PubMed:23201271). This interaction is not detected in vivo with full-length protein (PubMed:25349211).

    Three dimensional structures from OCA and Proteopedia for DCUN1D3 Gene

neXtProt entry for DCUN1D3 Gene

Post-translational modifications for DCUN1D3 Gene

No Post-translational modifications

Other Protein References for DCUN1D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCUN1D3 Gene

Domains & Families for DCUN1D3 Gene

Gene Families for DCUN1D3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCUN1D3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D3 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IWE4

UniProtKB/Swiss-Prot:

DCNL3_HUMAN :
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
Domain:
  • The DCUN1 domain, also known as PONY domain, mediates recognition of the N-terminally acetylated NEDD8-conjugating E2 enzyme. This domain is also involved in CAND1-, CUL1-, CUL3- and RBX1-binding.
genes like me logo Genes that share domains with DCUN1D3: view

Function for DCUN1D3 Gene

Molecular function for DCUN1D3 Gene

UniProtKB/Swiss-Prot Function:
Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Phenotypes From GWAS Catalog for DCUN1D3 Gene

Gene Ontology (GO) - Molecular Function for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 19617556
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D3: view

Phenotypes for DCUN1D3 Gene

genes like me logo Genes that share phenotypes with DCUN1D3: view

Animal Model Products

miRNA for DCUN1D3 Gene

miRTarBase miRNAs that target DCUN1D3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D3 Gene

Localization for DCUN1D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D3 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 3
extracellular 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IBA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 18823379
genes like me logo Genes that share ontologies with DCUN1D3: view

Pathways & Interactions for DCUN1D3 Gene

SuperPathways for DCUN1D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010225 response to UV-C IDA 18823379
GO:0010332 response to gamma radiation IDA 18823379
GO:0030308 negative regulation of cell growth IMP 18823379
GO:0043065 positive regulation of apoptotic process IMP 18823379
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCUN1D3: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D3 Gene

Drugs & Compounds for DCUN1D3 Gene

No Compound Related Data Available

Transcripts for DCUN1D3 Gene

mRNA/cDNA for DCUN1D3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCUN1D3 Gene

DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D3 Gene

No ASD Table

Relevant External Links for DCUN1D3 Gene

GeneLoc Exon Structure for
DCUN1D3
ECgene alternative splicing isoforms for
DCUN1D3

Expression for DCUN1D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCUN1D3 Gene

This gene is overexpressed in Breast (47.1) and Bone (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCUN1D3 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCUN1D3 Gene:

DCUN1D3

SOURCE GeneReport for Unigene cluster for DCUN1D3 Gene:

Hs.101007

mRNA Expression by UniProt/SwissProt for DCUN1D3 Gene:

Q8IWE4-DCNL3_HUMAN
Tissue specificity: Tends to be down-regulated in different type of cancers, including lung neuroendocrine carcinoma, thyroid Huerthle cell carcinoma and lung squamous cell carcinoma.

Evidence on tissue expression from TISSUES for DCUN1D3 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with DCUN1D3: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D3 Gene

Orthologs for DCUN1D3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCUN1D3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D3 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia DCUN1D3 33 34
  • 94.41 (n)
cow
(Bos Taurus)
Mammalia DCUN1D3 33 34
  • 94.3 (n)
mouse
(Mus musculus)
Mammalia Dcun1d3 33 16 34
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia Dcun1d3 33
  • 92.65 (n)
oppossum
(Monodelphis domestica)
Mammalia DCUN1D3 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D3 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D3 33 34
  • 77.56 (n)
lizard
(Anolis carolinensis)
Reptilia DCUN1D3 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d3 33
  • 75.39 (n)
Str.15235 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14461 33
zebrafish
(Danio rerio)
Actinopterygii zgc:154015 33
  • 67.63 (n)
DCUN1D3 34
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13322 33 34
  • 54.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9470 34
  • 23 (a)
OneToOne
Species where no ortholog for DCUN1D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCUN1D3 Gene

ENSEMBL:
Gene Tree for DCUN1D3 (if available)
TreeFam:
Gene Tree for DCUN1D3 (if available)

Paralogs for DCUN1D3 Gene

Paralogs for DCUN1D3 Gene

(3) SIMAP similar genes for DCUN1D3 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for DCUN1D3 Gene

genes like me logo Genes that share paralogs with DCUN1D3: view

Variants for DCUN1D3 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
VAR_072689 A cancer p.Gly2Ser
VAR_072690 A cancer p.Ser239Phe
rs1000143115 -- 20,875,681(-) G/A intron_variant
rs1000177459 -- 20,889,290(-) G/A intron_variant
rs1000183700 -- 20,896,657(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D3 Gene

Variant ID Type Subtype PubMed ID
nsv833165 CNV loss 17160897
nsv436835 CNV insertion 17901297
nsv1116119 CNV deletion 24896259
nsv1050009 CNV loss 25217958
esv3638159 CNV loss 21293372
esv2714065 CNV deletion 23290073

Variation tolerance for DCUN1D3 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCUN1D3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCUN1D3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D3 Gene

Disorders for DCUN1D3 Gene

Additional Disease Information for DCUN1D3

No disorders were found for DCUN1D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCUN1D3 Gene

Publications for DCUN1D3 Gene

  1. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). (PMID: 25349211) Huang G … Singh B (The Journal of biological chemistry 2014) 3 4 58
  2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda JK … Schulman BA (Structure (London, England : 1993) 2013) 3 4 58
  3. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. (PMID: 18823379) Ma T … Qiu X (Cancer science 2008) 3 22 58
  4. The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae. (PMID: 15988528) Kurz T … Peter M (Nature 2005) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DCUN1D3 Gene

Sources for DCUN1D3 Gene

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