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Aliases for DCUN1D1 Gene

Aliases for DCUN1D1 Gene

  • Defective In Cullin Neddylation 1 Domain Containing 1 2 3 5
  • Defective In Cullin Neddylation Protein 1-Like Protein 1 3 4
  • Squamous Cell Carcinoma-Related Oncogene 3 4
  • DCUN1 Domain-Containing Protein 1 3 4
  • DCUN1L1 3 4
  • SCCRO 3 4
  • RP42 3 4
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 1 (S. Cerevisiae) 2
  • DCN1, Defective In Cullin Neddylation 1, Domain Containing 1 3
  • Squamous Cell Carcinoma Related Oncogene 2
  • DCN1-Like Protein 1 3
  • RP42 Homolog 3
  • DCNL1 3
  • SCRO 3
  • Tes3 3
  • DCN1 4

External Ids for DCUN1D1 Gene

Previous GeneCards Identifiers for DCUN1D1 Gene

  • GC03M184144
  • GC03M182655
  • GC03M180065

Summaries for DCUN1D1 Gene

GeneCards Summary for DCUN1D1 Gene

DCUN1D1 (Defective In Cullin Neddylation 1 Domain Containing 1) is a Protein Coding gene. Diseases associated with DCUN1D1 include Squamous Cell Carcinoma Of The Oral Tongue and Squamous Cell Carcinoma. An important paralog of this gene is MCCC1.

UniProtKB/Swiss-Prot for DCUN1D1 Gene

  • Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene Wiki entry for DCUN1D1 Gene

Additional gene information for DCUN1D1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCUN1D1 Gene

Genomics for DCUN1D1 Gene

GeneHancer (GH) Regulatory Elements for DCUN1D1 Gene

Promoters and enhancers for DCUN1D1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J182978 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.4 +5.9 5927 3.4 HDAC1 FOXA2 RB1 SIN3A YY1 ZNF335 GLIS2 IKZF2 RUNX3 MIXL1 LOC105374246 DCUN1D1 MCCC1 LOC100505642
GH03J183883 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 -898.4 -898437 2.4 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PARL RPSAP31 ENSG00000283765 POLR2H HTR3D ENSG00000271682 YEATS2-AS1 RPS3P3 DVL3 DCUN1D1
GH03J182919 Enhancer 1.2 Ensembl ENCODE 11.7 +64.8 64830 2.3 PKNOX1 SMAD1 ATF1 ARNT FEZF1 TCF12 POLR2B ZNF766 GATA2 ZFP91 ENSG00000273261 DCUN1D1 ATP11B EIF3EP4
GH03J182212 Enhancer 1.2 Ensembl ENCODE 10.8 +773.2 773167 1.5 FOXA2 ARID4B SIN3A FEZF1 ZNF2 FOS REST ZNF662 MIER3 GLIS1 MCCC1-AS1 DCUN1D1 GC03P182239 LOC105374243
GH03J182925 Enhancer 0.9 Ensembl ENCODE 11.7 +60.3 60253 1 PKNOX1 BACH1 PAX8 IRF4 YY1 NFATC1 ATF7 BCLAF1 IKZF2 RUNX3 DCUN1D1 MCCC1 ENSG00000273261 LOC100505642
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCUN1D1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCUN1D1 gene promoter:
  • FOXL1
  • FOXJ2 (long isoform)
  • FOXJ2
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4
  • c-Jun
  • c-Fos

Genomic Locations for DCUN1D1 Gene

Genomic Locations for DCUN1D1 Gene
chr3:182,938,074-182,985,953
(GRCh38/hg38)
Size:
47,880 bases
Orientation:
Minus strand
chr3:182,655,862-182,703,741
(GRCh37/hg19)
Size:
47,880 bases
Orientation:
Minus strand

Genomic View for DCUN1D1 Gene

Genes around DCUN1D1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCUN1D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCUN1D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCUN1D1 Gene

Proteins for DCUN1D1 Gene

  • Protein details for DCUN1D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GG9-DCNL1_HUMAN
    Recommended name:
    DCN1-like protein 1
    Protein Accession:
    Q96GG9
    Secondary Accessions:
    • B2RB37
    • Q7L3G9
    • Q8TEX7
    • Q9H6M1
    • Q9HCT3

    Protein attributes for DCUN1D1 Gene

    Size:
    259 amino acids
    Molecular mass:
    30124 Da
    Quaternary structure:
    • Part of an E3 complex for neddylation composed of cullins, RBX1, UBE2M and CAND1. Interacts (via the C-terminus 50 AA) with CUL1, CUL2, CUL3, CUL4 and CUL5. Binds neddylated CUL1. Interacts (via the C-terminus 50 AA) directly with RBX1 (PubMed:18826954). Interacts (via DCUN1 domain) with UBE2M (acetylated at N-terminal methionine) (PubMed:28581483). Interacts preferentially with UBE2M-NEDD8 thioester (via N-terminus 1-26 AA) than with free UBE2M (PubMed:18826954, PubMed:25349211). UBE2M N-terminal acetylation increases the affinity of this interaction by about 2 orders of magnitude (PubMed:21940857). Interacts with CAND1 when in complex with CUL1-RBX1 (PubMed:18826954).
    SequenceCaution:
    • Sequence=BAB15235.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCUN1D1 Gene

neXtProt entry for DCUN1D1 Gene

Post-translational modifications for DCUN1D1 Gene

  • Ubiquitination at posLast=191191, posLast=143143, posLast=6464, posLast=6363, and Lys36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCUN1D1 Gene

Domains & Families for DCUN1D1 Gene

Gene Families for DCUN1D1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCUN1D1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCUN1D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GG9

UniProtKB/Swiss-Prot:

DCNL1_HUMAN :
  • The DCUN1 domain, also known as PONY domain mediates its interaction with N-terminally acetylated UBE2M.
Domain:
  • The DCUN1 domain, also known as PONY domain mediates its interaction with N-terminally acetylated UBE2M.
genes like me logo Genes that share domains with DCUN1D1: view

Function for DCUN1D1 Gene

Molecular function for DCUN1D1 Gene

UniProtKB/Swiss-Prot Function:
Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (PubMed:25349211, PubMed:28581483). Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity).

Gene Ontology (GO) - Molecular Function for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI,IEA 16189514
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0032182 ubiquitin-like protein binding IBA --
GO:0097602 cullin family protein binding IBA --
genes like me logo Genes that share ontologies with DCUN1D1: view

Phenotypes for DCUN1D1 Gene

genes like me logo Genes that share phenotypes with DCUN1D1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCUN1D1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCUN1D1 Gene

Localization for DCUN1D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCUN1D1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCUN1D1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 18826954
GO:0005634 nucleus IDA --
GO:0005829 cytosol IDA,TAS --
genes like me logo Genes that share ontologies with DCUN1D1: view

Pathways & Interactions for DCUN1D1 Gene

SuperPathways for DCUN1D1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCUN1D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0043687 post-translational protein modification TAS --
GO:0045116 protein neddylation IBA --
GO:0051443 positive regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with DCUN1D1: view

No data available for Pathways by source and SIGNOR curated interactions for DCUN1D1 Gene

Drugs & Compounds for DCUN1D1 Gene

No Compound Related Data Available

Transcripts for DCUN1D1 Gene

Unigene Clusters for DCUN1D1 Gene

DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCUN1D1

Alternative Splicing Database (ASD) splice patterns (SP) for DCUN1D1 Gene

No ASD Table

Relevant External Links for DCUN1D1 Gene

GeneLoc Exon Structure for
DCUN1D1
ECgene alternative splicing isoforms for
DCUN1D1

Expression for DCUN1D1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCUN1D1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCUN1D1 Gene

This gene is overexpressed in Testis (x4.7).

Protein differential expression in normal tissues from HIPED for DCUN1D1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCUN1D1 Gene



Protein tissue co-expression partners for DCUN1D1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCUN1D1 Gene:

DCUN1D1

SOURCE GeneReport for Unigene cluster for DCUN1D1 Gene:

Hs.744153

mRNA Expression by UniProt/SwissProt for DCUN1D1 Gene:

Q96GG9-DCNL1_HUMAN
Tissue specificity: Expressed in pancreas, kidney, placenta, brain and heart. Weakly or not expressed in liver, skeletal muscle and lung. Strongly overexpressed in thyroid tumors, bronchioloalveolar carcinomas, and malignant tissues of squamous cell carcinoma of the oral tongue. Not overexpressed in aggressive adrenocortical carcinomas.

Evidence on tissue expression from TISSUES for DCUN1D1 Gene

  • Lung(4.4)
  • Nervous system(4.4)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DCUN1D1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DCUN1D1 Gene

Orthologs for DCUN1D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCUN1D1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCUN1D1 34 33
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCUN1D1 34 33
  • 97.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCUN1D1 34 33
  • 96.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dcun1d1 16 34 33
  • 96.14 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912352 33
  • 95.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCUN1D1 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCUN1D1 34 33
  • 88.03 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCUN1D1 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcun1d1 33
  • 85.2 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13196 33
zebrafish
(Danio rerio)
Actinopterygii dcun1d1 34 33
  • 79.25 (n)
OneToOne
wufd19a01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8737 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004420 33
  • 63.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7427 34 33
  • 61.45 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcn-1 34
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCN1 36 34
  • 23 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7349 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7926 34
  • 44 (a)
OneToMany
Species where no ortholog for DCUN1D1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCUN1D1 Gene

ENSEMBL:
Gene Tree for DCUN1D1 (if available)
TreeFam:
Gene Tree for DCUN1D1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCUN1D1: view image

Paralogs for DCUN1D1 Gene

Paralogs for DCUN1D1 Gene

(4) SIMAP similar genes for DCUN1D1 Gene using alignment to 7 proteins:

  • DCNL1_HUMAN
  • C9J0B2_HUMAN
  • C9J8R4_HUMAN
  • C9JRU6_HUMAN
  • C9JUW4_HUMAN
  • C9JVE2_HUMAN
  • F8WC32_HUMAN

Pseudogenes.org Pseudogenes for DCUN1D1 Gene

genes like me logo Genes that share paralogs with DCUN1D1: view

Variants for DCUN1D1 Gene

Sequence variations from dbSNP and Humsavar for DCUN1D1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000117400 -- 182,983,600(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000153757 -- 182,979,974(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000207386 -- 182,947,013(-) G/A intron_variant
rs1000213410 -- 182,955,849(-) G/C intron_variant
rs1000224837 -- 182,979,705(-) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCUN1D1 Gene

Variant ID Type Subtype PubMed ID
nsv1073269 CNV deletion 25765185
nsv1126660 CNV deletion 24896259
nsv461031 CNV loss 19166990
nsv477590 CNV novel sequence insertion 20440878
nsv482968 CNV gain 15286789
nsv508968 CNV insertion 20534489
nsv592654 CNV loss 21841781
nsv967097 CNV duplication 23825009

Variation tolerance for DCUN1D1 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCUN1D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCUN1D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCUN1D1 Gene

Disorders for DCUN1D1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCUN1D1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
squamous cell carcinoma of the oral tongue
  • otscc
squamous cell carcinoma
  • epidermoid carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCUN1D1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCUN1D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCUN1D1 Gene

Publications for DCUN1D1 Gene

  1. Squamous cell carcinoma related oncogene/DCUN1D1 is highly conserved and activated by amplification in squamous cell carcinomas. (PMID: 17018598) Sarkaria I … Singh B (Cancer research 2006) 3 4 22 58
  2. Squamous cell carcinoma-related oncogene is highly expressed in developing, normal, and adenomatous adrenal tissue but not in aggressive adrenocortical carcinomas. (PMID: 15657565) Sarkaria IS … Singh B (Surgery 2004) 3 4 22 58
  3. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. (PMID: 12796399) Estilo CL … Singh B (Clinical cancer research : an official journal of the American Association for Cancer Research 2003) 3 4 22 58
  4. Cloning and expression analysis of a novel gene, RP42, mapping to an autism susceptibility locus on 6q16. (PMID: 10777668) Mas C … Simonneau M (Genomics 2000) 2 3 4 58
  5. Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase. (PMID: 28581483) Scott DC … Guy RK (Nature chemical biology 2017) 3 4 58

Products for DCUN1D1 Gene

Sources for DCUN1D1 Gene

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