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Aliases for DCTN6 Gene

Aliases for DCTN6 Gene

  • Dynactin Subunit 6 2 3 4 5
  • Dynactin Subunit P27 3 4
  • Protein WS-3 3 4
  • Dynactin 6 2 3
  • WS3 3 4
  • Novel RGD-Containing Protein 3
  • WS-3 3
  • P27 3

External Ids for DCTN6 Gene

Previous GeneCards Identifiers for DCTN6 Gene

  • GC08P029929
  • GC08P030464
  • GC08P029870
  • GC08P030071
  • GC08P028558
  • GC08P030013

Summaries for DCTN6 Gene

Entrez Gene Summary for DCTN6 Gene

  • The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTN6 Gene

DCTN6 (Dynactin Subunit 6) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification.

Additional gene information for DCTN6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN6 Gene

Genomics for DCTN6 Gene

GeneHancer (GH) Regulatory Elements for DCTN6 Gene

Promoters and enhancers for DCTN6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J030088 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.2 -61.3 -61331 14.7 SP1 ZFX ELF3 ZKSCAN8 NKRF MLLT1 CEBPG POLR2A GTF2F1 ZNF687 LEPROTL1 GC08M030097 DCTN6 SARAF HSPA8P11 WRN GTF2E2 ENSG00000253708 MBOAT4
GH08J030155 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 600.7 +0.3 300 4 ZFX SP1 CC2D1A CTCF ELF3 SIX5 ZNF148 NKRF POLR2A MLLT1 DCTN6 ENSG00000271869 LEPROTL1 WRN SARAF RBPMS DUSP4 MBOAT4
GH08J029796 Enhancer 0.5 Ensembl 4.9 -359.0 -358996 1.8 ZNF148 NR2F2 RCOR1 FOS DUSP4 DCTN6 GC08P029814 LINC02099
GH08J030168 Enhancer 1.1 Ensembl ENCODE 0.4 +13.7 13725 3.2 CC2D1A CTCF CBFA2T2 ZNF121 ZNF384 TRIM24 PRDM1 ZNF639 RAD21 SMARCA4 RNU6-1218P LEPROTL1 SARAF HSPA8P11 ENSG00000271869 MBOAT4 ENSG00000253708 DCTN6
GH08J030174 Enhancer 1 Ensembl ENCODE 0.4 +17.9 17904 1.2 CBFA2T2 MLLT1 ZNF121 SMARCA4 DPF2 IKZF1 HDAC1 ZNF341 EP300 SOX6 LEPROTL1 RBPMS-AS1 RBPMS RNU6-1218P ENSG00000253708 DCTN6 MBOAT4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCTN6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCTN6 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • FosB
  • FOXC1
  • Fra-1
  • GATA-6
  • JunB
  • JunD
  • STAT3

Genomic Locations for DCTN6 Gene

Genomic Locations for DCTN6 Gene
27,343 bases
Plus strand
27,344 bases
Plus strand

Genomic View for DCTN6 Gene

Genes around DCTN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN6 Gene

Proteins for DCTN6 Gene

  • Protein details for DCTN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 6
    Protein Accession:
    Secondary Accessions:
    • B2RAC1

    Protein attributes for DCTN6 Gene

    190 amino acids
    Molecular mass:
    20747 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for DCTN6 Gene

neXtProt entry for DCTN6 Gene

Post-translational modifications for DCTN6 Gene

  • Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCTN6 Gene

No data available for DME Specific Peptides for DCTN6 Gene

Domains & Families for DCTN6 Gene

Gene Families for DCTN6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN6 Gene


Suggested Antigen Peptide Sequences for DCTN6 Gene

GenScript: Design optimal peptide antigens:
  • Protein WS-3 (DCTN6_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
genes like me logo Genes that share domains with DCTN6: view

Function for DCTN6 Gene

Phenotypes From GWAS Catalog for DCTN6 Gene

genes like me logo Genes that share phenotypes with DCTN6: view

Animal Model Products

CRISPR Products

miRNA for DCTN6 Gene

miRTarBase miRNAs that target DCTN6

Clone Products

  • Applied Biological Materials (abm): Clones for DCTN6 - Now 50% OFF >
  • * DCTN6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCTN6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN6 Gene

Localization for DCTN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN6 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 2
nucleus 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DCTN6: view

Pathways & Interactions for DCTN6 Gene

genes like me logo Genes that share pathways with DCTN6: view

Gene Ontology (GO) - Biological Process for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN6: view

No data available for SIGNOR curated interactions for DCTN6 Gene

Drugs & Compounds for DCTN6 Gene

No Compound Related Data Available

Transcripts for DCTN6 Gene

mRNA/cDNA for DCTN6 Gene

Unigene Clusters for DCTN6 Gene

Dynactin 6:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for DCTN6 - Now 50% OFF >
  • * DCTN6 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCTN6 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4: - -

Relevant External Links for DCTN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTN6 Gene

Protein tissue co-expression partners for DCTN6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN6 Gene:


SOURCE GeneReport for Unigene cluster for DCTN6 Gene:


mRNA Expression by UniProt/SwissProt for DCTN6 Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DCTN6 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DCTN6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN6 Gene

Orthologs for DCTN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCTN6 35 34
  • 99.82 (n)
(Canis familiaris)
Mammalia DCTN6 35 34
  • 92.11 (n)
(Ornithorhynchus anatinus)
Mammalia DCTN6 35
  • 90 (a)
(Bos Taurus)
Mammalia DCTN6 35 34
  • 89.65 (n)
(Monodelphis domestica)
Mammalia DCTN6 35
  • 88 (a)
(Mus musculus)
Mammalia Dctn6 17 35 34
  • 86.49 (n)
(Rattus norvegicus)
Mammalia Dctn6 34
  • 86.32 (n)
(Gallus gallus)
Aves DCTN6 34 35
  • 78.42 (n)
(Anolis carolinensis)
Reptilia DCTN6 35
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn6 34
  • 77.47 (n)
Str.15736 34
(Danio rerio)
Actinopterygii zgc:112102 34
  • 70.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12481 34
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Ce 35 34
  • 52.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006924 34
  • 51.36 (n)
(Caenorhabditis elegans)
Secernentea dnc-6 35 34
  • 46.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
Species where no ortholog for DCTN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN6 Gene

Gene Tree for DCTN6 (if available)
Gene Tree for DCTN6 (if available)
Evolutionary constrained regions (ECRs) for DCTN6: view image

Paralogs for DCTN6 Gene Pseudogenes for DCTN6 Gene

genes like me logo Genes that share paralogs with DCTN6: view

No data available for Paralogs for DCTN6 Gene

Variants for DCTN6 Gene

Sequence variations from dbSNP and Humsavar for DCTN6 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000093106 -- 30,176,369(+) A/C intron_variant
rs1000156469 -- 30,157,293(+) A/G intron_variant
rs1000165544 -- 30,179,168(+) A/G intron_variant
rs1000193317 -- 30,177,008(+) C/T intron_variant
rs1000388650 -- 30,172,819(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN6 Gene

Variant ID Type Subtype PubMed ID
nsv1019816 CNV gain 25217958
nsv6139 CNV deletion 18451855
nsv831277 CNV gain 17160897

Variation tolerance for DCTN6 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTN6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN6 Gene

Disorders for DCTN6 Gene

Additional Disease Information for DCTN6

No disorders were found for DCTN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN6 Gene

Publications for DCTN6 Gene

  1. Cloning and characterization of a novel gene, WS-3, in human chromosome 8p11-p12. (PMID: 9168138) Ichikawa K … Furuichi Y (Gene 1997) 2 3 4 23 58
  2. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. (PMID: 23455152) Yeh TY … Schroer TA (The EMBO journal 2013) 3 4 58
  3. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G … Echave J (FEBS letters 2004) 3 23 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. (PMID: 28218281) Luo S … Diao A (Scientific reports 2017) 3 58

Products for DCTN6 Gene

Sources for DCTN6 Gene

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