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Aliases for DCTN6 Gene

Aliases for DCTN6 Gene

  • Dynactin Subunit 6 2 3 5
  • Dynactin Subunit P27 3 4
  • Protein WS-3 3 4
  • Dynactin 6 2 3
  • WS3 3 4
  • Novel RGD-Containing Protein 3
  • WS-3 3
  • P27 3

External Ids for DCTN6 Gene

Previous GeneCards Identifiers for DCTN6 Gene

  • GC08P029929
  • GC08P030464
  • GC08P029870
  • GC08P030071
  • GC08P028558
  • GC08P030013

Summaries for DCTN6 Gene

Entrez Gene Summary for DCTN6 Gene

  • The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTN6 Gene

DCTN6 (Dynactin Subunit 6) is a Protein Coding gene. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification.

Additional gene information for DCTN6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN6 Gene

Genomics for DCTN6 Gene

GeneHancer (GH) Regulatory Elements for DCTN6 Gene

Promoters and enhancers for DCTN6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I030155 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.6 568 3.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 DCTN6 MBOAT4 ENSG00000271869 WRN LEPROTL1 SARAF DUSP4 HSPA8P11
GH08I030168 Enhancer 1 Ensembl ENCODE 0.4 +13.3 13299 1.8 PKNOX1 FEZF1 RAD21 ZNF121 ZSCAN5C SCRT2 ZNF143 ZNF362 ZNF654 CEBPB RNU6-1218P HSPA8P11 LEPROTL1 ENSG00000271869 DCTN6 MBOAT4 ENSG00000253708
GH08I030174 Enhancer 0.8 ENCODE 0.4 +17.8 17844 0.6 HDAC1 TCF12 GATA2 EGR1 CREM EGR2 KLF16 SMARCA4 IKZF1 ZNF341 RBPMS RBPMS-AS1 RNU6-1218P ENSG00000253708 MBOAT4 DCTN6 LEPROTL1
GH08I030173 Enhancer 0.7 ENCODE 0.4 +16.9 16882 0.1 SMARCE1 MTA2 SOX6 TEAD4 TAL1 CBFA2T3 DPF2 EP300 TCF12 NCOR1 RBPMS RBPMS-AS1 RNU6-1218P ENSG00000253708 MBOAT4 DCTN6 LEPROTL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCTN6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCTN6 gene promoter:

Genomic Locations for DCTN6 Gene

Genomic Locations for DCTN6 Gene
chr8:30,156,297-30,183,640
(GRCh38/hg38)
Size:
27,344 bases
Orientation:
Plus strand
chr8:30,013,813-30,041,156
(GRCh37/hg19)

Genomic View for DCTN6 Gene

Genes around DCTN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN6 Gene

Proteins for DCTN6 Gene

  • Protein details for DCTN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00399-DCTN6_HUMAN
    Recommended name:
    Dynactin subunit 6
    Protein Accession:
    O00399
    Secondary Accessions:
    • B2RAC1

    Protein attributes for DCTN6 Gene

    Size:
    190 amino acids
    Molecular mass:
    20747 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5. Interacts with PLK1.

    Three dimensional structures from OCA and Proteopedia for DCTN6 Gene

neXtProt entry for DCTN6 Gene

Post-translational modifications for DCTN6 Gene

  • Phosphorylation at Thr-186 by CDK1 during mitotic prometaphase creates a binding site for PLK1 that facilitates its recruitment to kinetochores.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCTN6 Gene

No data available for DME Specific Peptides for DCTN6 Gene

Domains & Families for DCTN6 Gene

Gene Families for DCTN6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN6 Gene

Suggested Antigen Peptide Sequences for DCTN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00399

UniProtKB/Swiss-Prot:

DCTN6_HUMAN :
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
Family:
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.
genes like me logo Genes that share domains with DCTN6: view

Function for DCTN6 Gene

genes like me logo Genes that share phenotypes with DCTN6: view

miRNA for DCTN6 Gene

miRTarBase miRNAs that target DCTN6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN6 Gene

Localization for DCTN6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN6 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN6 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
plasma membrane 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
genes like me logo Genes that share ontologies with DCTN6: view

Pathways & Interactions for DCTN6 Gene

genes like me logo Genes that share pathways with DCTN6: view

Gene Ontology (GO) - Biological Process for DCTN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN6: view

No data available for SIGNOR curated interactions for DCTN6 Gene

Drugs & Compounds for DCTN6 Gene

No Compound Related Data Available

Transcripts for DCTN6 Gene

Unigene Clusters for DCTN6 Gene

Dynactin 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for DCTN6 Gene

GeneLoc Exon Structure for
DCTN6
ECgene alternative splicing isoforms for
DCTN6

Expression for DCTN6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.4) and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN6 Gene



Protein tissue co-expression partners for DCTN6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN6 Gene:

DCTN6

SOURCE GeneReport for Unigene cluster for DCTN6 Gene:

Hs.158427

mRNA Expression by UniProt/SwissProt for DCTN6 Gene:

O00399-DCTN6_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DCTN6 Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with DCTN6: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN6 Gene

Orthologs for DCTN6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN6 33 34
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia DCTN6 33 34
  • 92.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN6 34
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCTN6 33 34
  • 89.65 (n)
oppossum
(Monodelphis domestica)
Mammalia DCTN6 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dctn6 33 16 34
  • 86.49 (n)
rat
(Rattus norvegicus)
Mammalia Dctn6 33
  • 86.32 (n)
chicken
(Gallus gallus)
Aves DCTN6 33 34
  • 78.42 (n)
lizard
(Anolis carolinensis)
Reptilia DCTN6 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn6 33
  • 77.47 (n)
Str.15736 33
zebrafish
(Danio rerio)
Actinopterygii zgc:112102 33
  • 70.09 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12481 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)37Ce 33 34
  • 52.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006924 33
  • 51.36 (n)
worm
(Caenorhabditis elegans)
Secernentea dnc-6 33 34
  • 46.23 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
Species where no ortholog for DCTN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN6 Gene

ENSEMBL:
Gene Tree for DCTN6 (if available)
TreeFam:
Gene Tree for DCTN6 (if available)

Paralogs for DCTN6 Gene

Pseudogenes.org Pseudogenes for DCTN6 Gene

genes like me logo Genes that share paralogs with DCTN6: view

No data available for Paralogs for DCTN6 Gene

Variants for DCTN6 Gene

Sequence variations from dbSNP and Humsavar for DCTN6 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000093106 -- 30,176,369(+) A/C intron_variant
rs1000156469 -- 30,157,293(+) A/G intron_variant
rs1000165544 -- 30,179,168(+) A/G intron_variant
rs1000193317 -- 30,177,008(+) C/T intron_variant
rs1000388650 -- 30,172,819(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN6 Gene

Variant ID Type Subtype PubMed ID
nsv1019816 CNV gain 25217958
nsv6139 CNV deletion 18451855
nsv831277 CNV gain 17160897

Variation tolerance for DCTN6 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTN6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTN6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN6 Gene

Disorders for DCTN6 Gene

Additional Disease Information for DCTN6

No disorders were found for DCTN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCTN6 Gene

Publications for DCTN6 Gene

  1. Cloning and characterization of a novel gene, WS-3, in human chromosome 8p11-p12. (PMID: 9168138) Ichikawa K … Furuichi Y (Gene 1997) 2 3 4 22 58
  2. Dynactin helps target Polo-like kinase 1 to kinetochores via its left-handed beta-helical p27 subunit. (PMID: 23455152) Yeh TY … Schroer TA (The EMBO journal 2013) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G … Echave J (FEBS letters 2004) 3 22 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DCTN6 Gene

Sources for DCTN6 Gene

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