Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCTN5 Gene

Aliases for DCTN5 Gene

  • Dynactin Subunit 5 2 3 4 5
  • Dynactin Subunit P25 3 4
  • Dynactin 5 (P25) 2 3
  • Dynactin 4 3

External Ids for DCTN5 Gene

Previous GeneCards Identifiers for DCTN5 Gene

  • GC16P023561
  • GC16P021742

Summaries for DCTN5 Gene

Entrez Gene Summary for DCTN5 Gene

  • This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for DCTN5 Gene

DCTN5 (Dynactin Subunit 5) is a Protein Coding gene. Diseases associated with DCTN5 include Fanconi Anemia, Complementation Group N and Pancreatic Cancer 3. Among its related pathways are Vesicle-mediated transport and Transport to the Golgi and subsequent modification.

Gene Wiki entry for DCTN5 Gene

Additional gene information for DCTN5 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN5 Gene

Genomics for DCTN5 Gene

GeneHancer (GH) Regulatory Elements for DCTN5 Gene

Promoters and enhancers for DCTN5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J023639 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 676.5 +0.1 106 3.5 SP1 ZFX CC2D1A ELF3 MNT SIX5 CBFA2T2 NKRF POLR2A ZNF121 DCTN5 PALB2 PLK1 ENSG00000260751 RBBP6 UBFD1 PIR46977
GH16J023667 Enhancer 1.1 Ensembl ENCODE 91 +27.8 27782 4.1 SP1 CC2D1A CBFA2T2 JUND TRIM24 RELA CREM MLLT1 SMARCA4 ZBED1 ENSG00000260482 GC16P023669 PIR38573 PIR57634 PIR46977 DCTN5 PALB2
GH16J023536 Enhancer 1.4 Ensembl ENCODE dbSUPER 31.3 -102.1 -102082 4.8 ZNF652 ELF3 MNT CEBPG RERE NCOA3 BACH1 ZNF24 MAFK TFE3 DCTN5 COG7 NDUFAB1 PALB2 GGA2 SUB1P4 GC16M023544 EARS2
GH16J023509 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.9 -131.6 -131565 3.6 ZNF652 SP1 ZFX ELF3 MNT CBFA2T2 ZNF148 NKRF POLR2A CEBPG GGA2 PALB2 ENSG00000260905 DCTN5 ENSG00000260751 COG7 NDUFAB1 UBFD1 PIR42085 ENSG00000261528
GH16J023700 Enhancer 0.8 Ensembl ENCODE 46.4 +59.5 59487 0.7 ZFX ZNF121 ZIC2 REST SCRT2 CTBP1 SCRT1 ZFP69B SNIP1 BHLHE40 GC16M023700 DCTN5 RBBP6 PALB2 ENSG00000261723 ENSG00000260751 NDUFAB1 ENSG00000278912 ERN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCTN5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCTN5 gene promoter:
  • CUTL1
  • FOXJ2
  • FOXJ2 (long isoform)
  • HFH-1
  • HNF-3beta
  • LyF-1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx5-1

Genomic Locations for DCTN5 Gene

Genomic Locations for DCTN5 Gene
chr16:23,641,366-23,677,472
(GRCh38/hg38)
Size:
36,107 bases
Orientation:
Plus strand
chr16:23,652,687-23,685,068
(GRCh37/hg19)
Size:
32,382 bases
Orientation:
Plus strand

Genomic View for DCTN5 Gene

Genes around DCTN5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN5 Gene

Proteins for DCTN5 Gene

  • Protein details for DCTN5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTE1-DCTN5_HUMAN
    Recommended name:
    Dynactin subunit 5
    Protein Accession:
    Q9BTE1
    Secondary Accessions:
    • A8K9X8
    • H3BN51
    • H3BQA4

    Protein attributes for DCTN5 Gene

    Size:
    182 amino acids
    Molecular mass:
    20127 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10. Within the complex DCTN6 forms a heterodimer with DCTN5.

    Three dimensional structures from OCA and Proteopedia for DCTN5 Gene

    Alternative splice isoforms for DCTN5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTN5 Gene

Post-translational modifications for DCTN5 Gene

  • Ubiquitination at isoforms=175, posLast=1010, and isoforms=2, 321
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN5 Gene

Domains & Families for DCTN5 Gene

Gene Families for DCTN5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCTN5 Gene

GenScript: Design optimal peptide antigens:
  • Dynactin subunit p25 (DCTN5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BTE1

UniProtKB/Swiss-Prot:

DCTN5_HUMAN :
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
Family:
  • Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.
genes like me logo Genes that share domains with DCTN5: view

Function for DCTN5 Gene

Phenotypes From GWAS Catalog for DCTN5 Gene

Gene Ontology (GO) - Molecular Function for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCTN5: view
genes like me logo Genes that share phenotypes with DCTN5: view

Animal Models for DCTN5 Gene

MGI Knock Outs for DCTN5:
  • Dctn5 Dctn5<tm2a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for DCTN5 Gene

miRTarBase miRNAs that target DCTN5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN5

Clone Products

  • Applied Biological Materials (abm): Clones for DCTN5 - Now 50% OFF >
  • * DCTN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCTN5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCTN5 Gene

Localization for DCTN5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN5 Gene

Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN5 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 4
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005654 nucleoplasm IDA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCTN5: view

Pathways & Interactions for DCTN5 Gene

genes like me logo Genes that share pathways with DCTN5: view

Gene Ontology (GO) - Biological Process for DCTN5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
GO:0035904 aorta development IEA --
GO:0060976 coronary vasculature development IEA --
genes like me logo Genes that share ontologies with DCTN5: view

No data available for SIGNOR curated interactions for DCTN5 Gene

Drugs & Compounds for DCTN5 Gene

No Compound Related Data Available

Transcripts for DCTN5 Gene

Unigene Clusters for DCTN5 Gene

Dynactin 5 (p25):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN5

Clone Products

  • Applied Biological Materials (abm): Clones for DCTN5 - Now 50% OFF >
  • * DCTN5 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCTN5 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7:

Relevant External Links for DCTN5 Gene

GeneLoc Exon Structure for
DCTN5
ECgene alternative splicing isoforms for
DCTN5

Expression for DCTN5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN5 Gene

Protein differential expression in normal tissues from HIPED for DCTN5 Gene

This gene is overexpressed in Frontal cortex (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTN5 Gene



Protein tissue co-expression partners for DCTN5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN5 Gene:

DCTN5

SOURCE GeneReport for Unigene cluster for DCTN5 Gene:

Hs.435941

Evidence on tissue expression from TISSUES for DCTN5 Gene

  • Nervous system(4.4)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with DCTN5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN5 Gene

Orthologs for DCTN5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCTN5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCTN5 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia MGC3248 35
  • 95 (a)
OneToOne
DCTN5 34
  • 93.04 (n)
dog
(Canis familiaris)
Mammalia DCTN5 35 34
  • 93.04 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dctn5 34
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Dctn5 34 35 17
  • 92.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCTN5 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCTN5 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCTN5 34 35
  • 81.32 (n)
lizard
(Anolis carolinensis)
Reptilia DCTN5 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn5 34
  • 79.49 (n)
Str.13717 34
zebrafish
(Danio rerio)
Actinopterygii dctn5 35 34
  • 78.94 (n)
OneToOne
Dr.12983 34
fruit fly
(Drosophila melanogaster)
Insecta dyn-p25 35 34
  • 59.51 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dnc-5 35 34
  • 53.56 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 78 (a)
OneToOne
Cin.7368 34
bread mold
(Neurospora crassa)
Ascomycetes NCU07196 34
  • 54.33 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7368 34
Species where no ortholog for DCTN5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN5 Gene

ENSEMBL:
Gene Tree for DCTN5 (if available)
TreeFam:
Gene Tree for DCTN5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCTN5: view image

Paralogs for DCTN5 Gene

Pseudogenes.org Pseudogenes for DCTN5 Gene

genes like me logo Genes that share paralogs with DCTN5: view

No data available for Paralogs for DCTN5 Gene

Variants for DCTN5 Gene

Sequence variations from dbSNP and Humsavar for DCTN5 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1038099508 likely-benign, Hereditary cancer-predisposing syndrome 23,641,167(+) G/A upstream_transcript_variant
rs1057517585 likely-pathogenic, pathogenic, Familial cancer of breast, not provided, Hereditary cancer-predisposing syndrome 23,641,155(+) C/T upstream_transcript_variant
rs1057523580 likely-benign, not specified, Hereditary cancer-predisposing syndrome 23,641,091(+) C/G/T upstream_transcript_variant
rs1060499829 likely-pathogenic, Hereditary cancer-predisposing syndrome 23,641,109(+) CC/C upstream_transcript_variant
rs1060502744 uncertain-significance, Familial cancer of breast, Hereditary cancer-predisposing syndrome 23,641,133(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN5 Gene

Variant ID Type Subtype PubMed ID
esv2660866 CNV deletion 23128226
esv2714093 CNV deletion 23290073
esv3638233 CNV loss 21293372
nsv819151 CNV loss 19587683
nsv827603 CNV loss 20364138

Variation tolerance for DCTN5 Gene

Residual Variation Intolerance Score: 35.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTN5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTN5
Human Gene Mutation Database (HGMD)
DCTN5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN5 Gene

Disorders for DCTN5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for DCTN5 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group n
  • fancn
pancreatic cancer 3
  • pancreatic cancer, susceptibility to, 3
tracheoesophageal fistula
  • tracheoesophageal fistula with or without esophageal atresia
- elite association - COSMIC cancer census association via MalaCards
Search DCTN5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCTN5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCTN5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN5 Gene

Publications for DCTN5 Gene

  1. Dynactins p25 and p27 are predicted to adopt the LbetaH fold. (PMID: 15043994) Parisi G … Echave J (FEBS letters 2004) 2 3 23 58
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 58
  3. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. (PMID: 17554300) Wellcome Trust Case Control Consortium (Nature 2007) 3 45 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DCTN5 Gene

Sources for DCTN5 Gene

Content
Loading form....