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Aliases for DCTN4 Gene
Aliases for DCTN4 Gene
External Ids for DCTN4 Gene
- HGNC: 15518
- Entrez Gene: 51164
- Ensembl: ENSG00000132912
- OMIM: 614758
- UniProtKB: Q9UJW0
Previous GeneCards Identifiers for DCTN4 Gene
- GC05M150157
- GC05M150685
- GC05M150116
- GC05M150068
- GC05M145234
Summaries for DCTN4 Gene
GeneCards Summary for DCTN4 Gene
DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include Cystic Fibrosis and Discharging Ear. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.
UniProtKB/Swiss-Prot Summary for DCTN4 Gene
-
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Additional gene information for DCTN4 Gene
- HGNC(15518)
- Entrez Gene(51164)
- Ensembl(ENSG00000132912)
- OMIM(614758)
- UniProtKB(Q9UJW0)
- Open Targets Platform(ENSG00000132912)
- Monarch Initiative
- Search for DCTN4 at DataMed
- Search for DCTN4 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCTN4 Gene
Genomics for DCTN4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DCTN4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DCTN4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCTN4
- Top Transcription factor binding sites by QIAGEN in the DCTN4 gene promoter:
-
- AhR
- AREB6
- Arnt
- CREB
- Zic1
Genomic Locations for DCTN4 Gene
Genomic Locations for DCTN4 Gene
- chr5:150,708,440-150,759,109
- (GRCh38/hg38)
- Size:
- 50,670 bases
- Orientation:
- Minus strand
- chr5:150,088,002-150,138,671
- (GRCh37/hg19)
- Size:
- 50,670 bases
- Orientation:
- Minus strand
Genomic View for DCTN4 Gene
Genes around DCTN4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q33.1 by HGNC
- 5q33.1 by Entrez Gene
- 5q33.1 by Ensembl
DCTN4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DCTN4 Gene
Proteins for DCTN4 Gene
-
Protein details for DCTN4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJW0-DCTN4_HUMAN
- Recommended name:
- Dynactin subunit 4
- Protein Accession:
- Q9UJW0
- B3KWW0
- D3DQH0
- E5RGT5
- Q8TAN8
Protein attributes for DCTN4 Gene
- Size:
- 460 amino acids
- Molecular mass:
- 52337 Da
- Quaternary structure:
-
- Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).
Protein Expression for DCTN4 Gene
Post-translational modifications for DCTN4 Gene
Other Protein References for DCTN4 Gene
Antibody Products
- G Biosciences Immunotag™ DCTN4 Antibody
- HUABIO Anti-DCTN4 Antibody
- Novus Biologicals Antibodies for DCTN4
-
Abcam antibodies for DCTN4
- Invitrogen Antibodies for DCTN4 (AFLGC-DCTN4)
-
Boster Bio Antibodies for DCTN4
-
Santa Cruz Biotechnology (SCBT) Antibodies for DCTN4
Protein Products
-
OriGene Purified Proteins for DCTN4
- Search Origene for MassSpec and Protein Over-expression Lysates for DCTN4
- Origene Custom Protein Services for DCTN4
- antibodies-online: Show 4 available DCTN4 Proteins ranked by validation data
- Compare Top DCTN4 Proteins
-
Quality Products:
No data available for DME Specific Peptides for DCTN4 Gene
Domains & Families for DCTN4 Gene
Gene Families for DCTN4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for DCTN4 Gene
- GenScript: Design optimal peptide antigens:
-
- Dynactin subunit p62 (DCTN4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UJW0- Family:
-
- Belongs to the dynactin subunit 4 family.
Function for DCTN4 Gene
Molecular function for DCTN4 Gene
- UniProtKB/Swiss-Prot Function:
- Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Phenotypes From GWAS Catalog for DCTN4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0047485 | protein N-terminus binding | IPI | 16554302 |
Phenotypes for DCTN4 Gene
- MGI mutant phenotypes for DCTN4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for DCTN4:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with Ras
- Decreased viability in non-small-cell lung cancer (NSCLC) lineage
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Increased ionizing radiation sensitivity
- Increased S DNA content
- Decreased shRNA abundance (Z-score < -2)
- Increased number of mitotic cells
- Metaphase cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DCTN4 - Select products 50% OFF >
- * DCTN4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DCTN4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCTN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCTN4
miRNA for DCTN4 Gene
- miRTarBase miRNAs that target DCTN4
-
- mmu-miR-362-5p (MIRT008936)
- mmu-miR-181a-5p (MIRT014081)
- hsa-miR-142-3p (MIRT021605)
- hsa-miR-93-5p (MIRT028163)
- hsa-miR-484 (MIRT042076)
- hsa-miR-378a-3p (MIRT043893)
- hsa-miR-149-5p (MIRT045463)
- hsa-miR-548c-3p (MIRT165649)
- hsa-miR-4282 (MIRT165656)
- hsa-miR-6864-3p (MIRT486541)
- hsa-miR-3672 (MIRT486542)
- hsa-miR-3606-5p (MIRT486543)
- hsa-miR-6073 (MIRT486544)
- hsa-miR-873-3p (MIRT486545)
- hsa-miR-4522 (MIRT486546)
- hsa-miR-1251-5p (MIRT486547)
- hsa-miR-196b-5p (MIRT486548)
- hsa-miR-196a-5p (MIRT486549)
- hsa-miR-4690-5p (MIRT486550)
- hsa-miR-6510-5p (MIRT486551)
- hsa-miR-6165 (MIRT486552)
- hsa-miR-3664-5p (MIRT486553)
- hsa-miR-1264 (MIRT507596)
- hsa-miR-584-5p (MIRT507597)
- hsa-miR-4698 (MIRT507598)
- hsa-miR-8063 (MIRT507599)
- hsa-miR-758-5p (MIRT507600)
- hsa-miR-218-2-3p (MIRT507601)
- hsa-miR-522-3p (MIRT507602)
- hsa-miR-224-3p (MIRT507603)
- hsa-miR-299-5p (MIRT507604)
- hsa-miR-630 (MIRT712886)
- hsa-miR-4742-3p (MIRT712887)
- hsa-miR-6774-3p (MIRT712888)
- hsa-miR-486-5p (MIRT712889)
- hsa-miR-6082 (MIRT716254)
- hsa-miR-30e-5p (MIRT727897)
- hsa-miR-30d-5p (MIRT727898)
- hsa-miR-30c-5p (MIRT727899)
- hsa-miR-30b-5p (MIRT727900)
- hsa-miR-26b-5p (MIRT727901)
- hsa-miR-30a-5p (MIRT727902)
- hsa-miR-26a-5p (MIRT727903)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCTN4
- Browse OriGene Inhibitory RNA Products For DCTN4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN4
Clone Products
- Applied Biological Materials (abm): Clones for DCTN4 - Select products 50% OFF >
- * DCTN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207350
- MR207350
- MR207350L3
- MR207350L4
- RC205235
- RC205235L1
- RC205235L2
- RC205235L3
- RC205235L4
- RC226530
- RC226530L1
- RC226530L2
- RC226530L3
- RC226530L4
- RC226539
- RC226539L3
- RC226539L4
- RG205235
- RG226530
- RG226539
- RR214381
- RR214381L3
- RR214381L4
- MR207350L3V
- MR207350L4V
- RC205235L1V
- RC205235L2V
- RC205235L3V
- RC205235L4V
- RC226530L1V
- RC226530L2V
- RC226530L3V
- RC226530L4V
- RC226539L3V
- RC226539L4V
- RR214381L3V
- RR214381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DCTN4
- Addgene plasmids for DCTN4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCTN4
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN4 Gene
Localization for DCTN4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for DCTN4 Gene
- Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere. Note=Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin (PubMed:10671518). Overexpression in cultured mammalian cells revealed colocalization with cortical actin, stress fibers, and focal adhesion sites, sites of potential interaction between microtubules and the cell cortex (By similarity). In skeletal muscles, costamere localization requires the presence of ANK2 (By similarity). {ECO:0000250 UniProtKB:Q8CBY8, ECO:0000250 UniProtKB:Q9QUR2, ECO:0000269 PubMed:10671518}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Centrosome (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000776 | kinetochore | IEA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0001725 | stress fiber | IEA | -- |
| GO:0005634 | nucleus | TAS | 10671518 |
| GO:0005737 | cytoplasm | TAS | 10671518 |
Pathways & Interactions for DCTN4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport to the Golgi and subsequent modification | ||
| 2 | Golgi-to-ER retrograde transport | ||
| 3 | Vesicle-mediated transport | ||
| 4 | Metabolism of proteins | ||
| 5 | Parkinson disease | ||
Pathways by source for DCTN4 Gene
14 Reactome pathways for DCTN4 Gene
2 KEGG pathways for DCTN4 Gene
2 GeneGo (Thomson Reuters) pathways for DCTN4 Gene
- Cell cycle_Spindle assembly and chromosome separation
- Cytoskeleton remodeling Neurofilaments
Interacting Proteins for DCTN4 Gene
Selected Interacting proteins:
Q9UJW0-DCTN4_HUMAN
ENSP00000414906
for DCTN4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for DCTN4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
| GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
No data available for SIGNOR curated interactions for DCTN4 Gene
Transcripts for DCTN4 Gene
mRNA/cDNA for DCTN4 Gene
- 3 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000447998 4208 nts (view in UCSC)
- ENST00000424236 4054 nts (view in UCSC)
- ENST00000446090 1737 nts (view in UCSC)
- ENST00000518909 614 nts (view in UCSC)
- ENST00000522625 598 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DCTN4 - Select products 50% OFF >
- * DCTN4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DCTN4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCTN4
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCTN4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCTN4
- Browse OriGene Inhibitory RNA Products For DCTN4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN4
Clone Products
- Applied Biological Materials (abm): Clones for DCTN4 - Select products 50% OFF >
- * DCTN4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG207350
- MR207350
- MR207350L3
- MR207350L4
- RC205235
- RC205235L1
- RC205235L2
- RC205235L3
- RC205235L4
- RC226530
- RC226530L1
- RC226530L2
- RC226530L3
- RC226530L4
- RC226539
- RC226539L3
- RC226539L4
- RG205235
- RG226530
- RG226539
- RR214381
- RR214381L3
- RR214381L4
- MR207350L3V
- MR207350L4V
- RC205235L1V
- RC205235L2V
- RC205235L3V
- RC205235L4V
- RC226530L1V
- RC226530L2V
- RC226530L3V
- RC226530L4V
- RC226539L3V
- RC226539L4V
- RR214381L3V
- RR214381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DCTN4
- Addgene plasmids for DCTN4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCTN4
Relevant External Links for DCTN4 Gene
- GeneLoc Exon Structure for
- DCTN4
Expression for DCTN4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Islet of Langerhans (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTN4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCTN4
SOURCE GeneReport for Unigene cluster for DCTN4 Gene:
Hs.675564Evidence on tissue expression from TISSUES for DCTN4 Gene
- Nervous system(5)
- Lung(2.7)
- Muscle(2.1)
- Skin(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN4 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- endocrine
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- respiratory
- skeletal muscle
- urinary
Regions:
Head and neck:
- brain
- ear
- head
Thorax:
- bronchus
- heart
- lung
Abdomen:
- biliary tract
- duodenum
- intestine
- kidney
- large intestine
- liver
- pancreas
- small intestine
- spleen
- stomach
Pelvis:
- anus
- rectum
- testicle
General:
- blood
- blood vessel
- coagulation system
- skin
- sweat gland
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for DCTN4
-
OriGene qPCR primer pairs and template standards for DCTN4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN4 Gene
Orthologs for DCTN4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DCTN4 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dctn4 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dctn4 30 17 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DCTN4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DCTN4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dctn4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dctn4 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6759 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000908 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG12042 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | dnc-4 30 31 |
|
OneToOne | |
| C26B2.1 32 |
|
|
|||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for DCTN4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for DCTN4 Gene
- ENSEMBL:
- Gene Tree for DCTN4 (if available)
- TreeFam:
- Gene Tree for DCTN4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DCTN4: view image
Paralogs for DCTN4 Gene
(1) SIMAP similar genes for DCTN4 Gene using alignment to 5 proteins:
- DCTN4_HUMAN
- E5RGG1_HUMAN
- E5RI97_HUMAN
- E5RK21_HUMAN
- H9KVE0_HUMAN
No data available for Paralogs for DCTN4 Gene
Variants for DCTN4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCTN4 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 712579 | Benign: not provided | 150,715,603(-) | A/G | SYNONYMOUS_VARIANT | |
| 776079 | Benign: not provided | 150,711,239(-) | G/T | SYNONYMOUS_VARIANT | |
| 792017 | Benign: not provided | 150,719,764(-) | A/G | SYNONYMOUS_VARIANT | |
| rs11550931 | - | p.Pro95Thr | |||
| rs11954652 | - | p.Phe342Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2730916 | CNV | deletion | 23290073 |
| esv2759386 | CNV | loss | 17122850 |
| esv33898 | CNV | loss | 17666407 |
| nsv1128200 | CNV | deletion | 24896259 |
| nsv1137038 | CNV | deletion | 24896259 |
| nsv428129 | CNV | loss | 18775914 |
| nsv5066 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.48;
88.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DCTN4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN4 Gene
Disorders for DCTN4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cystic fibrosis |
|
|
| discharging ear |
|
|
| alzheimer's disease 1 |
|
|
Search DCTN4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DCTN4
No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN4 Gene
Publications for DCTN4 Gene
- Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PMID: 16554302) Lim CM … La Fontaine S (The Journal of biological chemistry 2006) 2 3 4 23
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PMID: 10671518) Karki S … Holzbaur EL (The Journal of biological chemistry 2000) 3 4
- Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J … Wainscoat JS (Genomics 2000) 2 3
ExternalLinks
Products for DCTN4 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DCTN4
- Search Origene for MassSpec and Protein Over-expression Lysates for DCTN4
- Origene Custom Protein Services for DCTN4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCTN4
- Browse OriGene Inhibitory RNA Products For DCTN4
- OriGene qPCR primer pairs for DCTN4
- OriGene qPCR primer pairs and template standards for DCTN4
- OriGene CRISPR knockouts for DCTN4
- MG207350
- MR207350
- MR207350L3
- MR207350L4
- RC205235
- RC205235L1
- RC205235L2
- RC205235L3
- RC205235L4
- RC226530
- RC226530L1
- RC226530L2
- RC226530L3
- RC226530L4
- RC226539
- RC226539L3
- RC226539L4
- RG205235
- RG226530
- RG226539
- RR214381
- RR214381L3
- RR214381L4
- MR207350L3V
- MR207350L4V
- RC205235L1V
- RC205235L2V
- RC205235L3V
- RC205235L4V
- RC226530L1V
- RC226530L2V
- RC226530L3V
- RC226530L4V
- RC226539L3V
- RC226539L4V
- RR214381L3V
- RR214381L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DCTN4
- Sino Biological Human cDNA Clone for DCTN4
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for DCTN4
- Novus Biologicals proteins and lysates for DCTN4
- Browse Antibodies
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- Abcam antibodies for DCTN4
- Find your target
- Browse Primary Antibodies
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- Invitrogen Antibodies for DCTN4 (AFLGC-DCTN4)
- VectorBuilder Custom and pre-made DNA vectors for DCTN4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DCTN4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DCTN4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DCTN4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DCTN4
- Addgene plasmids for DCTN4
- antibodies-online: Show 21 available DCTN4 Antibodies ranked by validation data
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- antibodies-online: Search results for available DCTN4 related products ranked by validation data
- antibodies-online: Show 4 available DCTN4 Proteins ranked by validation data
- Compare Top DCTN4 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for DCTN4
- Search Santa Cruz Biotechnology (SCBT) for DCTN4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DCTN4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCTN4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCTN4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DCTN4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTN4
- Boster Bio Antibodies for DCTN4
- Browse Boster Bio ELISA Kits
Sources for DCTN4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB