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Aliases for DCTN4 Gene

Aliases for DCTN4 Gene

  • Dynactin Subunit 4 2 3 5
  • Dynactin Subunit P62 3 4
  • Dynactin 4 (P62) 2 3
  • DYN4 3 4
  • Dynactin P62 Subunit 3
  • P62 3

External Ids for DCTN4 Gene

Previous GeneCards Identifiers for DCTN4 Gene

  • GC05M150157
  • GC05M150685
  • GC05M150116
  • GC05M150068
  • GC05M145234

Summaries for DCTN4 Gene

GeneCards Summary for DCTN4 Gene

DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include Cystic Fibrosis. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot for DCTN4 Gene

  • Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Additional gene information for DCTN4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTN4 Gene

Genomics for DCTN4 Gene

GeneHancer (GH) Regulatory Elements for DCTN4 Gene

Promoters and enhancers for DCTN4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I150756 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 729 3.3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 DCTN4 TCOF1 SMIM3 HMGXB3 ZNF300P1 CCDC69 RPL7P1 RPS14 PIR34076
GH05I150699 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11 +58.5 58458 2.6 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 RBM22 ENSG00000250309 MYOZ3 DCTN4 SMIM3 HMGXB3 ENSG00000253852 SYNPO RPS14
GH05I150788 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -31.0 -30982 3.6 BCOR MEIS2 JUN ZMYM3 EBF1 BATF FOSL1 ZNF213 POLR2A EGR1 ZNF300P1 DCTN4 TNIP1 RBM22 SMIM3 CCDC69 CD74 IRGM
GH05I150846 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 11.5 -88.0 -87996 1.4 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF143 ATF7 RUNX3 JUNB REST IRGM ZNF300P1 SMIM3 DCTN4 GPX3 ZNF300
GH05I150800 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.8 -42.3 -42291 1.3 ATF1 FOXA2 ARNT ZFP64 ZNF143 ATF7 SP3 SMARCA4 ZNF184 NBN SMIM3 DCTN4 RPS20P4 IRGM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCTN4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCTN4 gene promoter:

Genomic Locations for DCTN4 Gene

Genomic Locations for DCTN4 Gene
50,670 bases
Minus strand

Genomic View for DCTN4 Gene

Genes around DCTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTN4 Gene

Proteins for DCTN4 Gene

  • Protein details for DCTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynactin subunit 4
    Protein Accession:
    Secondary Accessions:
    • B3KWW0
    • D3DQH0
    • E5RGT5
    • Q8TAN8

    Protein attributes for DCTN4 Gene

    460 amino acids
    Molecular mass:
    52337 Da
    Quaternary structure:
    • Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres (By similarity).

    Alternative splice isoforms for DCTN4 Gene


neXtProt entry for DCTN4 Gene

Post-translational modifications for DCTN4 Gene

  • Ubiquitination at posLast=146146 and posLast=181181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCTN4 Gene

Domains & Families for DCTN4 Gene

Gene Families for DCTN4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCTN4 Gene


Suggested Antigen Peptide Sequences for DCTN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynactin subunit 4 family.
  • Belongs to the dynactin subunit 4 family.
genes like me logo Genes that share domains with DCTN4: view

Function for DCTN4 Gene

Molecular function for DCTN4 Gene

UniProtKB/Swiss-Prot Function:
Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Phenotypes From GWAS Catalog for DCTN4 Gene

Gene Ontology (GO) - Molecular Function for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
GO:0047485 protein N-terminus binding IPI 16554302
genes like me logo Genes that share ontologies with DCTN4: view
genes like me logo Genes that share phenotypes with DCTN4: view

Human Phenotype Ontology for DCTN4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCTN4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTN4 Gene

Localization for DCTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCTN4 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=In skeletal muscles, demonstrates a punctate distribution along costameres (By similarity). Has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTN4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000922 spindle pole IEA --
GO:0001725 stress fiber IEA --
GO:0005634 nucleus TAS 10671518
GO:0005737 cytoplasm TAS 10671518
genes like me logo Genes that share ontologies with DCTN4: view

Pathways & Interactions for DCTN4 Gene

genes like me logo Genes that share pathways with DCTN4: view

Gene Ontology (GO) - Biological Process for DCTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0007097 nuclear migration IBA --
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS --
genes like me logo Genes that share ontologies with DCTN4: view

No data available for SIGNOR curated interactions for DCTN4 Gene

Drugs & Compounds for DCTN4 Gene

No Compound Related Data Available

Transcripts for DCTN4 Gene

Unigene Clusters for DCTN4 Gene

Dynactin 4 (p62):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCTN4

Alternative Splicing Database (ASD) splice patterns (SP) for DCTN4 Gene

No ASD Table

Relevant External Links for DCTN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCTN4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCTN4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.6) and Islet of Langerhans (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCTN4 Gene

Protein tissue co-expression partners for DCTN4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCTN4 Gene:


SOURCE GeneReport for Unigene cluster for DCTN4 Gene:


Evidence on tissue expression from TISSUES for DCTN4 Gene

  • Nervous system(5)
  • Lung(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTN4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • urinary
Head and neck:
  • brain
  • ear
  • head
  • bronchus
  • heart
  • lung
  • biliary tract
  • duodenum
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • spleen
  • stomach
  • anus
  • rectum
  • testicle
  • blood
  • blood vessel
  • coagulation system
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with DCTN4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCTN4 Gene

Orthologs for DCTN4 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCTN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCTN4 33 34
  • 99.71 (n)
(Bos Taurus)
Mammalia DCTN4 33 34
  • 94.28 (n)
(Ornithorhynchus anatinus)
Mammalia DCTN4 34
  • 94 (a)
(Canis familiaris)
Mammalia DCTN4 33 34
  • 93.26 (n)
(Rattus norvegicus)
Mammalia Dctn4 33
  • 89.93 (n)
(Mus musculus)
Mammalia Dctn4 33 16 34
  • 89.64 (n)
(Gallus gallus)
Aves DCTN4 33 34
  • 80.22 (n)
(Anolis carolinensis)
Reptilia DCTN4 34
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dctn4 33
  • 76.09 (n)
(Danio rerio)
Actinopterygii dctn4 33 34
  • 75.25 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6759 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000908 33
  • 53.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12042 35 33 34
  • 50.81 (n)
(Caenorhabditis elegans)
Secernentea dnc-4 33 34
  • 45.5 (n)
C26B2.1 35
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
Species where no ortholog for DCTN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCTN4 Gene

Gene Tree for DCTN4 (if available)
Gene Tree for DCTN4 (if available)

Paralogs for DCTN4 Gene

(1) SIMAP similar genes for DCTN4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCTN4: view

No data available for Paralogs for DCTN4 Gene

Variants for DCTN4 Gene

Sequence variations from dbSNP and Humsavar for DCTN4 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000094028 -- 150,730,157(-) T/C intron_variant
rs1000094136 -- 150,719,344(-) G/C intron_variant
rs1000180638 -- 150,747,022(-) T/C/G intron_variant
rs1000287471 -- 150,758,307(-) T/C 5_prime_UTR_variant, intron_variant
rs1000293874 -- 150,753,421(-) GGG/GG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCTN4 Gene

Variant ID Type Subtype PubMed ID
esv2730916 CNV deletion 23290073
esv2759386 CNV loss 17122850
esv33898 CNV loss 17666407
nsv1128200 CNV deletion 24896259
nsv1137038 CNV deletion 24896259
nsv428129 CNV loss 18775914
nsv5066 CNV deletion 18451855

Variation tolerance for DCTN4 Gene

Residual Variation Intolerance Score: 16.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.48; 88.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTN4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTN4 Gene

Disorders for DCTN4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCTN4 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
cystic fibrosis
  • cf
- elite association - COSMIC cancer census association via MalaCards
Search DCTN4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCTN4

genes like me logo Genes that share disorders with DCTN4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTN4 Gene

Publications for DCTN4 Gene

  1. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. (PMID: 16554302) Lim CM … La Fontaine S (The Journal of biological chemistry 2006) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Transcription mapping of the 5q- syndrome critical region: cloning of two novel genes and sequencing, expression, and mapping of a further six novel cDNAs. (PMID: 10843801) Boultwood J … Wainscoat JS (Genomics 2000) 2 3 58
  5. A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1. (PMID: 10671518) Karki S … Holzbaur EL (The Journal of biological chemistry 2000) 3 4 58

Products for DCTN4 Gene

  • Addgene plasmids for DCTN4

Sources for DCTN4 Gene

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