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DCTN4 (Dynactin Subunit 4) is a Protein Coding gene. Diseases associated with DCTN4 include Cystic Fibrosis and Discharging Ear. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include protein N-terminus binding.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 21516116 |
GO:0047485 | protein N-terminus binding | IPI | 16554302 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000776 | kinetochore | IEA | -- |
GO:0000922 | spindle pole | IEA | -- |
GO:0001725 | stress fiber | IEA | -- |
GO:0005634 | nucleus | TAS | 10671518 |
GO:0005737 | cytoplasm | TAS | 10671518 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Golgi-to-ER retrograde transport | ||
3 | Vesicle-mediated transport | ||
4 | Metabolism of proteins | ||
5 | Parkinson disease |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006888 | ER to Golgi vesicle-mediated transport | TAS | -- |
GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DCTN4 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DCTN4 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dctn4 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dctn4 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DCTN4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DCTN4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dctn4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dctn4 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6759 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000908 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG12042 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | dnc-4 30 31 |
|
OneToOne | |
C26B2.1 32 |
|
|
|||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
712579 | Benign: not provided | 150,715,603(-) | A/G | SYNONYMOUS_VARIANT | |
776079 | Benign: not provided | 150,711,239(-) | G/T | SYNONYMOUS_VARIANT | |
792017 | Benign: not provided | 150,719,764(-) | A/G | SYNONYMOUS_VARIANT | |
rs11550931 | - | p.Pro95Thr | |||
rs11954652 | - | p.Phe342Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2730916 | CNV | deletion | 23290073 |
esv2759386 | CNV | loss | 17122850 |
esv33898 | CNV | loss | 17666407 |
nsv1128200 | CNV | deletion | 24896259 |
nsv1137038 | CNV | deletion | 24896259 |
nsv428129 | CNV | loss | 18775914 |
nsv5066 | CNV | deletion | 18451855 |
Disorder | Aliases | PubMed IDs |
---|---|---|
cystic fibrosis |
|
|
discharging ear |
|
|
alzheimer's disease 1 |
|
|