Aliases for DCTN2 Gene
External Ids for DCTN2 Gene
Previous GeneCards Identifiers for DCTN2 Gene
This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]
GeneCards Summary for DCTN2 Gene
DCTN2 (Dynactin Subunit 2) is a Protein Coding gene. Diseases associated with DCTN2 include Charcot-Marie-Tooth Disease and Neuronopathy, Distal Hereditary Motor, Type Viib. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include motor activity and spectrin binding.
UniProtKB/Swiss-Prot Summary for DCTN2 Gene
Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.