The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [prov... See more...

Aliases for DCTD Gene

Aliases for DCTD Gene

  • DCMP Deaminase 2 3 4 5
  • Deoxycytidylate Deaminase 3 4
  • EC 3.5.4.12 4 50
  • DCTD 5

External Ids for DCTD Gene

Previous GeneCards Identifiers for DCTD Gene

  • GC04M184830
  • GC04M184491
  • GC04M184507
  • GC04M184186
  • GC04M184048
  • GC04M183811
  • GC04M179572

Summaries for DCTD Gene

Entrez Gene Summary for DCTD Gene

  • The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCTD Gene

DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Aspartylglucosaminuria and Granulomatosis With Polyangiitis. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and dCMP deaminase activity. An important paralog of this gene is CDADC1.

UniProtKB/Swiss-Prot Summary for DCTD Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCTD Gene

Genomics for DCTD Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DCTD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J182915 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 265.3 +0.0 16 3.9 SP1 ZNF207 MYC ZNF592 ATF2 POLR2A ZNF10 NFIC ZIC2 ZBTB10 DCTD HSALNG0038896
GH04J182916 Promoter 0.3 EPDnew 250.7 +2.3 2340 0.1 DCTD HSALNG0038896 RF00017-4013
GH04J182879 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas 16.8 +36.8 36763 2.4 ZFP64 KMT2B FOXA2 KDM6A RXRA SMAD4 ZNF511 SAP130 RARA GABPB1 ENSG00000272646 LOC105377576 lnc-TENM3-1 DCTD lnc-DCTD-1
GH04J182895 Enhancer 0.9 ENCODE 17.4 +22.0 21996 0.9 CEBPA CHD4 YY1 MXD4 FOXA1 HOMEZ KMT2B THAP11 FOXA2 KDM6A DCTD RF00017-4013 RF00017-4012 HSALNG0038896
GH04J182970 Enhancer 1 Ensembl ENCODE 12.3 -51.8 -51834 1.5 NCOR1 IKZF1 ZNF592 NFIC BHLHE40 MNT TAL1 ELF1 MYNN STAT5A DCTD HSALNG0038899 MN298114-161 LOC107986327 WWC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCTD on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCTD

Top Transcription factor binding sites by QIAGEN in the DCTD gene promoter:
  • AML1a
  • FOXI1
  • HFH-3
  • HTF
  • NF-1/L
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for DCTD Gene

Latest Assembly
chr4:182,890,060-182,917,936
(GRCh38/hg38)
Size:
27,877 bases
Orientation:
Minus strand

Previous Assembly
chr4:183,811,244-183,838,764
(GRCh37/hg19 by Entrez Gene)
Size:
27,521 bases
Orientation:
Minus strand

chr4:183,811,213-183,839,089
(GRCh37/hg19 by Ensembl)
Size:
27,877 bases
Orientation:
Minus strand

Genomic View for DCTD Gene

Genes around DCTD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCTD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCTD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCTD Gene

Proteins for DCTD Gene

  • Protein details for DCTD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32321-DCTD_HUMAN
    Recommended name:
    Deoxycytidylate deaminase
    Protein Accession:
    P32321
    Secondary Accessions:
    • B2R836
    • D3DP49
    • D3DP50
    • Q5M7Z8
    • Q9BVD8

    Protein attributes for DCTD Gene

    Size:
    178 amino acids
    Molecular mass:
    20016 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    • Homohexamer.

    Three dimensional structures from OCA and Proteopedia for DCTD Gene

    Alternative splice isoforms for DCTD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCTD Gene

Selected DME Specific Peptides for DCTD Gene

P32321:
  • LFPCNECAKLIIQ
  • QVGACIV
  • LPWRRTA

Post-translational modifications for DCTD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibodies for research

  • Abcam antibodies for DCTD
  • Boster Bio Antibodies for DCTD
  • Santa Cruz Biotechnology (SCBT) Antibodies for DCTD

Domains & Families for DCTD Gene

Gene Families for DCTD Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DCTD Gene

Suggested Antigen Peptide Sequences for DCTD Gene

GenScript: Design optimal peptide antigens:
  • dCMP deaminase (DCTD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P32321

UniProtKB/Swiss-Prot:

DCTD_HUMAN :
  • Belongs to the cytidine and deoxycytidylate deaminase family.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family.
genes like me logo Genes that share domains with DCTD: view

Function for DCTD Gene

Molecular function for DCTD Gene

UniProtKB/Swiss-Prot Function:
Supplies the nucleotide substrate for thymidylate synthetase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=dCMP + H(+) + H2O = dUMP + NH4(+); Xref=Rhea:RHEA:22924, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57566, ChEBI:CHEBI:246422; EC=3.5.4.12;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.

Enzyme Numbers (IUBMB) for DCTD Gene

Phenotypes From GWAS Catalog for DCTD Gene

Gene Ontology (GO) - Molecular Function for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0004132 dCMP deaminase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCTD: view
genes like me logo Genes that share phenotypes with DCTD: view

Animal Models for research

  • Taconic Biosciences Mouse Models for DCTD

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTD

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTD Gene

Localization for DCTD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCTD gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCTD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCTD Gene

Pathways & Interactions for DCTD Gene

genes like me logo Genes that share pathways with DCTD: view

Pathways by source for DCTD Gene

Gene Ontology (GO) - Biological Process for DCTD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006220 pyrimidine nucleotide metabolic process IEA,TAS 7685356
GO:0006226 dUMP biosynthetic process IBA 21873635
GO:0006231 dTMP biosynthetic process IBA 21873635
GO:0008152 metabolic process IEA --
GO:0009165 nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with DCTD: view

No data available for SIGNOR curated interactions for DCTD Gene

Drugs & Compounds for DCTD Gene

(13) Drugs for DCTD Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1376
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 2590
Ammonia Approved Pharma 0
Water Approved Pharma 0
dCMP Experimental Pharma 0

(9) Additional Compounds for DCTD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCTD: view

Transcripts for DCTD Gene

mRNA/cDNA for DCTD Gene

9 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTD

Alternative Splicing Database (ASD) splice patterns (SP) for DCTD Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - - - -
SP9: - - -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 11 ^ 12
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for DCTD Gene

GeneLoc Exon Structure for
DCTD

Expression for DCTD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCTD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTD Gene



Protein tissue co-expression partners for DCTD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCTD

SOURCE GeneReport for Unigene cluster for DCTD Gene:

Hs.183850

Evidence on tissue expression from TISSUES for DCTD Gene

  • Liver(4.4)
  • Lung(4.3)
  • Nervous system(4.1)
  • Intestine(2.2)
  • Skin(2.1)
  • Pancreas(2.1)
genes like me logo Genes that share expression patterns with DCTD: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTD Gene

Orthologs for DCTD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCTD Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DCTD 29 30
  • 97 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia LOC607328 29
  • 88.26 (n)
DCTD 30
  • 61 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia DCTD 29 30
  • 87.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Dctd 29 16 30
  • 86.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dctd 29
  • 86.11 (n)
Oppossum
(Monodelphis domestica)
Mammalia DCTD 30
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DCTD 30
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DCTD 29 30
  • 78.41 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DCTD 30
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dctd 29
  • 76.86 (n)
Str.8923 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.8134 29
Zebrafish
(Danio rerio)
Actinopterygii dctd 29 30
  • 74.07 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008158 29
  • 63.73 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG6951 29 30 31
  • 58.23 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea ZK643.2 30
  • 31 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCD1 30 32
  • 14 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT3G48540 29
  • 54.83 (n)
Rice
(Oryza sativa)
Liliopsida Os01g0765000 29
  • 53.41 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 65 (a)
OneToOne
Species where no ortholog for DCTD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DCTD Gene

ENSEMBL:
Gene Tree for DCTD (if available)
TreeFam:
Gene Tree for DCTD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCTD: view image
Alliance of Genome Resources:
Additional Orthologs for DCTD

Paralogs for DCTD Gene

Paralogs for DCTD Gene

genes like me logo Genes that share paralogs with DCTD: view

Variants for DCTD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCTD Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
rs6552619 Benign: not provided 182,894,595(-) C/G
NM_001921.2(DCTD):c.255G>C (p.Ala85=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DCTD Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DCTD Gene

Variant ID Type Subtype PubMed ID
esv24217 CNV loss 19812545
esv2763419 CNV loss 21179565
nsv1016376 CNV gain 25217958
nsv1122094 CNV deletion 24896259
nsv949856 CNV deletion 24416366

Variation tolerance for DCTD Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCTD Gene

Human Gene Mutation Database (HGMD)
DCTD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCTD
Leiden Open Variation Database (LOVD)
DCTD

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTD Gene

Disorders for DCTD Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCTD Gene - From: COP and GCD

Disorder Aliases PubMed IDs
aspartylglucosaminuria
  • agu
granulomatosis with polyangiitis
  • gpa
- elite association - COSMIC cancer census association via MalaCards
Search DCTD in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCTD

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with DCTD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCTD Gene

Publications for DCTD Gene

  1. Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PMID: 7642519) Weiner KX … Maley GF (The Journal of biological chemistry 1995) 3 4 22
  2. Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PMID: 7685356) Weiner KX … Maley GF (The Journal of biological chemistry 1993) 3 4 22
  3. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T … Li D (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 40
  4. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. (PMID: 20665488) Tanaka M … Li D (Cancer 2010) 3 40
  5. Genetic factors influencing cytarabine therapy. (PMID: 19842938) Lamba JK (Pharmacogenomics 2009) 22 25

Products for DCTD Gene

Sources for DCTD Gene