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The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Glass Syndrome and Granulomatosis With Polyangiitis. Among its related pathways are Metabolism and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include hydrolase activity and dCMP deaminase activity. An important paralog of this gene is CDADC1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J182915 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE CraniofacialAtlas | 615.3 | +0.0 | 16 | 3.9 | SP1 HNRNPL GATAD2A CTCF ATF7 PRDM10 REST KDM1A POLR2A BACH1 | DCTD HSALNG0038896 | |
GH04J182916 | Promoter | 0.3 | EPDnew | 600.7 | +2.3 | 2340 | 0.1 | DCTD HSALNG0038896 RF00017-4467 | ||
GH04J182879 | Enhancer | 1.2 | Ensembl ENCODE CraniofacialAtlas | 16.8 | +36.7 | 36741 | 2.4 | GATAD2A RCOR2 RBFOX2 RXRB GABPA KMT2B MNT SOX13 TAF1 RNF2 | ENSG00000272646 LOC105377576 lnc-TENM3-1 DCTD lnc-DCTD-1 | |
GH04J182895 | Enhancer | 0.9 | ENCODE | 17.4 | +22.0 | 21996 | 0.9 | GATAD2A TFE3 SOX13 NFKBIZ RCOR2 GABPA RXRB IRF2 SP1 CEBPA | DCTD RF00017-4467 RF00017-4466 | |
GH04J182897 | Enhancer | 0.9 | ENCODE | 10.8 | +19.4 | 19412 | 1.8 | HNRNPL GATAD2A REST TFE3 SOX13 NFKBIZ RCOR2 ZNF7 RBFOX2 RXRB | RF00017-4467 DCTD RF00017-4466 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004132 | dCMP deaminase activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism of nucleotides | ||
2 | Metabolism |
.40
|
|
3 | Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics | ||
4 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006220 | pyrimidine nucleotide metabolic process | IEA,TAS | 7685356 |
GO:0006226 | dUMP biosynthetic process | IBA | 21873635 |
GO:0006231 | dTMP biosynthetic process | IBA | 21873635 |
GO:0008152 | metabolic process | IEA | -- |
GO:0009165 | nucleotide biosynthetic process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cytarabine | Approved, Experimental, Investigational | Pharma | Enzyme, substrate | 1335 | ||
Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2451 | ||
Ammonia | Approved | Pharma | 0 | |||
Water | Approved | Pharma | 0 | |||
dCMP | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: |
ExUns: | 11 | ^ | 12 |
---|---|---|---|
SP1: | |||
SP2: | |||
SP3: | |||
SP4: | |||
SP5: | |||
SP6: | |||
SP7: | |||
SP8: | |||
SP9: | |||
SP10: | |||
SP11: | |||
SP12: | |||
SP13: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DCTD 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | LOC607328 30 |
|
||
DCTD 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | DCTD 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Dctd 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dctd 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | DCTD 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DCTD 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DCTD 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DCTD 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dctd 30 |
|
||
Str.8923 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.8134 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dctd 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008158 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG6951 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | ZK643.2 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DCD1 31 33 |
|
OneToOne | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT3G48540 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os01g0765000 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
776032 | Benign: not provided | 182,894,595(-) | C/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv24217 | CNV | loss | 19812545 |
esv2763419 | CNV | loss | 21179565 |
nsv1016376 | CNV | gain | 25217958 |
nsv1122094 | CNV | deletion | 24896259 |
nsv949856 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
glass syndrome |
|
|
granulomatosis with polyangiitis |
|
|