External Ids for DCTD Gene
Previous GeneCards Identifiers for DCTD Gene
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DCTD Gene
DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Aspartylglucosaminuria and Granulomatosis With Polyangiitis. Among its related pathways are Metabolism of nucleotides and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity and dCMP deaminase activity. An important paralog of this gene is CDADC1.
UniProtKB/Swiss-Prot Summary for DCTD Gene
Supplies the nucleotide substrate for thymidylate synthetase.