Aliases for DCTD Gene
External Ids for DCTD Gene
- HGNC: 2710
- Entrez Gene: 1635
- Ensembl: ENSG00000129187
- OMIM: 607638
- UniProtKB: P32321
Previous GeneCards Identifiers for DCTD Gene
- GC04M184830
- GC04M184491
- GC04M184507
- GC04M184186
- GC04M184048
- GC04M183811
- GC04M179572
Summaries for DCTD Gene
-
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DCTD Gene
DCTD (DCMP Deaminase) is a Protein Coding gene. Diseases associated with DCTD include Glass Syndrome. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include hydrolase activity and dCMP deaminase activity.
UniProtKB/Swiss-Prot for DCTD Gene
-
Supplies the nucleotide substrate for thymidylate synthetase.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCTD Gene
Genomics for DCTD Gene
GeneHancer (GH) Regulatory Elements for DCTD Gene
Promoters and enhancers for DCTD Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J182915 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 665.4 | +0.0 | 16 | 3.9 | HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF207 | DCTD CDKN2AIP TRAPPC11 ENSG00000272646 | |
| GH04J182916 | Promoter | 0.5 | EPDnew | 650.7 | +2.3 | 2340 | 0.1 | DCTD ENSG00000272646 | ||
| GH04J182879 | Enhancer | 1.1 | Ensembl ENCODE | 16.7 | +36.8 | 36763 | 2.4 | ELF3 FOXA2 MLX ZFP64 ARID4B DMAP1 RAD21 THRB RARA ZNF614 | LOC105377576 GC04P182881 ENSG00000272646 DCTD | |
| GH04J182895 | Enhancer | 0.9 | ENCODE | 17.4 | +22.0 | 21996 | 0.9 | FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 NFKBIZ RXRA SP5 NFYC | DCTD ENSG00000272646 | |
| GH04J182897 | Enhancer | 1 | ENCODE | 10.8 | +19.4 | 19412 | 1.8 | FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 NFKBIZ RXRA SP5 | DCTD ENSG00000272646 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around DCTD on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for DCTD Gene
Genomic Locations for DCTD Gene
- chr4:182,890,060-182,917,936
- (GRCh38/hg38)
- Size:
- 27,877 bases
- Orientation:
- Minus strand
- chr4:183,811,213-183,839,089
- (GRCh37/hg19)
Genomic View for DCTD Gene
Genes around DCTD on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q35.1 by Entrez Gene
- 4q35.1 by HGNC
- 4q35.1 by Ensembl
DCTD Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DCTD Gene
Proteins for DCTD Gene
-
Protein details for DCTD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P32321-DCTD_HUMAN
- Recommended name:
- Deoxycytidylate deaminase
- Protein Accession:
- P32321
- B2R836
- D3DP49
- D3DP50
- Q5M7Z8
- Q9BVD8
Protein attributes for DCTD Gene
- Size:
- 178 amino acids
- Molecular mass:
- 20016 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Homohexamer.
Protein Expression for DCTD Gene
Post-translational modifications for DCTD Gene
Other Protein References for DCTD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006714179.1
- NP_001912.2
- XP_016863313.1
- NP_001338674.1
- XP_011529976.1
- NP_001338677.1
- XP_005262839.1
- XP_016863312.1
- XP_016863309.1
- NP_001338682.1
- NP_001338672.1
- XP_011529978.1
- XP_005262838.1
- XP_006714178.1
- XP_005262835.1
- XP_016863311.1
- NP_001338673.1
- NP_001012750.1
- NP_001338676.1
- NP_001338679.1
- XP_011529977.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DCTD
- Novus Biologicals Antibodies for DCTD
- Invitrogen Antibodies for DCTD
- antibodies-online: Search results for available DCTD related products ranked by validation data
- GeneTex DCTD Antibody for DCTD
-
Boster Bio Antibodies for DCTD
-
Santa Cruz Biotechnology (SCBT) Antibodies for DCTD
Protein Products
-
OriGene Purified Proteins for DCTD
- Search Origene for MassSpec and Protein Over-expression Lysates for DCTD
- Origene Custom Protein Services for DCTD
- ProSpec Recombinant Proteins for DCTD
- Search GeneTex for Proteins for DCTD
Assay Products
- antibodies-online: Search results for available DCTD related products ranked by validation data
No data available for DME Specific Peptides for DCTD Gene
Domains & Families for DCTD Gene
Gene Families for DCTD Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for DCTD Gene
Suggested Antigen Peptide Sequences for DCTD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P32321- Family:
-
- Belongs to the cytidine and deoxycytidylate deaminase family.
Function for DCTD Gene
Molecular function for DCTD Gene
- UniProtKB/Swiss-Prot Function:
- Supplies the nucleotide substrate for thymidylate synthetase.
- UniProtKB/Swiss-Prot CatalyticActivity:
- dCMP + H(2)O = dUMP + NH(3).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP.
Enzyme Numbers (IUBMB) for DCTD Gene
Phenotypes From GWAS Catalog for DCTD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004132 | dCMP deaminase activity | IEA,IBA | -- |
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0042802 | identical protein binding | IPI | 16189514 |
Phenotypes for DCTD Gene
- GenomeRNAi human phenotypes for DCTD:
Animal Model Products
-
Taconic Biosciences Mouse Models for DCTD
- Cyagen custom Knockout/knockin (KOKI) mouse models for DCTD
-
CRISPR Products
-
OriGene CRISPR knockouts for DCTD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCTD
- genomics-online: gRNA clones - Search results for available DCTD gene related products
- Applied Biological Materials CRISPR for DCTD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCTD
- GenScript: Design CRISPR guide RNA sequences for DCTD
miRNA for DCTD Gene
- miRTarBase miRNAs that target DCTD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCTD
- Browse OriGene Inhibitory RNA Products For DCTD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTD
- genomics-online: shRNA clones - Search results for available DCTD gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for DCTD in any vector
- XM_005262781.4
- XM_006714115.3
- XM_005262779.3
- XM_005262780.3
- XM_006714116.3
- XM_005262782.3
- XM_005262778.3
- NM_001921.2
- XM_011531675.2
- XM_011531676.2
- XM_011531674.2
- XM_017007823.1
- XM_017007816.1
- XM_017007821.1
- NM_001351744.1
- NM_001351753.1
- NM_001351747.1
- NM_001351753.1
- NM_001351747.1
- XM_017007824.1
- NM_001012732.1
- XM_017007822.1
- XM_017007820.1
- XM_017007817.1
- NM_001351748.1
- NM_001351743.1
- NM_001351750.1
- NM_001351745.1
- XM_017007819.1
- XM_017007818.1
- Sino Biological Human cDNA Clone for DCTD
- VectorBuilder custom plasmid, inducible vectors for DCTD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DCTD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCTD
- genomics-online: cdna clones - Search results for available DCTD gene related products
- orf clones - Search results for available DCTD gene related products
- Applied Biological Materials Clones for DCTD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DCTD
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCTD Gene
Localization for DCTD Gene
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 3 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0070062 | extracellular exosome | HDA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCTD Gene
Pathways & Interactions for DCTD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Pyrimidine metabolism (REACTOME) | ||
| 3 | Pyrimidine metabolism (KEGG) | ||
| 4 | Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics | ||
| 5 | Purine metabolism | ||
Pathways by source for DCTD Gene
1 BioSystems pathway for DCTD Gene
4 Reactome pathways for DCTD Gene
1 PharmGKB pathway for DCTD Gene
2 KEGG pathways for DCTD Gene
Interacting Proteins for DCTD Gene
Selected Interacting proteins:
P32321-DCTD_HUMAN
ENSP00000349576
for DCTD Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for DCTD
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006220 | pyrimidine nucleotide metabolic process | IEA,TAS | 7685356 |
| GO:0006226 | dUMP biosynthetic process | IBA | -- |
| GO:0006231 | dTMP biosynthetic process | IBA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009165 | nucleotide biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for DCTD Gene
Drugs & Compounds for DCTD Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cytarabine | Approved, Investigational | Pharma | Enzyme, substrate | 1166 | ||
| Gemcitabine | Approved | Pharma | Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs | 2100 | ||
| Glycerol | Approved, Investigational | Pharma | Target | 175 | ||
| Ammonia | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| dUMP |
|
964-26-1 |
|
Transcripts for DCTD Gene
mRNA/cDNA for DCTD Gene
- (381) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (21) REFSEQ mRNAs :
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000357067 1931 bps (uc003ivg.4)
- ENST00000438320 1972 bps (uc003ivf.4)
- ENST00000500813 1829 bps (uc063bfg.1)
- ENST00000503182 578 bps (uc063bfk.1)
- ENST00000503820 896 bps (uc063bfq.1)
Unigene Clusters for DCTD Gene
- DCMP deaminase:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for DCTD
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCTD
- genomics-online: gRNA clones - Search results for available DCTD gene related products
- Applied Biological Materials CRISPR for DCTD
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCTD
- GenScript: Design CRISPR guide RNA sequences for DCTD
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCTD
- Browse OriGene Inhibitory RNA Products For DCTD
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCTD
- genomics-online: shRNA clones - Search results for available DCTD gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for DCTD in any vector
- XM_005262781.4
- XM_006714115.3
- XM_005262779.3
- XM_005262780.3
- XM_006714116.3
- XM_005262782.3
- XM_005262778.3
- NM_001921.2
- XM_011531675.2
- XM_011531676.2
- XM_011531674.2
- XM_017007823.1
- XM_017007816.1
- XM_017007821.1
- NM_001351744.1
- NM_001351753.1
- NM_001351747.1
- NM_001351753.1
- NM_001351747.1
- XM_017007824.1
- NM_001012732.1
- XM_017007822.1
- XM_017007820.1
- XM_017007817.1
- NM_001351748.1
- NM_001351743.1
- NM_001351750.1
- NM_001351745.1
- XM_017007819.1
- XM_017007818.1
- Sino Biological Human cDNA Clone for DCTD
- VectorBuilder custom plasmid, inducible vectors for DCTD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DCTD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCTD
- genomics-online: cdna clones - Search results for available DCTD gene related products
- orf clones - Search results for available DCTD gene related products
- Applied Biological Materials Clones for DCTD
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | · | 10e | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 11 | ^ | 12 |
|---|---|---|---|
| SP1: | |||
| SP2: | |||
| SP3: | |||
| SP4: | |||
| SP5: | |||
| SP6: | |||
| SP7: | |||
| SP8: | |||
| SP9: | |||
| SP10: | |||
| SP11: | |||
| SP12: | |||
| SP13: |
Expression for DCTD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Kidney (Urinary System)
-
Uterus (Reproductive System)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Fibroblasts (Uncategorized)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCTD Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of DCTD Gene:
DCTDSOURCE GeneReport for Unigene cluster for DCTD Gene:
Hs.183850Evidence on tissue expression from TISSUES for DCTD Gene
- Liver(4.3)
- Lung(4.3)
- Nervous system(3.9)
Primer Products
-
OriGene qPCR primer pairs and template standards for DCTD
-
OriGene qPCR primer pairs for DCTD
- genomics-online: primer clones - Search results for available DCTD gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCTD Gene
Orthologs for DCTD Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DCTD 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | LOC607328 33 |
|
||
| DCTD 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | DCTD 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Dctd 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dctd 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DCTD 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DCTD 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DCTD 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DCTD 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dctd 33 |
|
||
| Str.8923 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.8134 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dctd 34 33 |
|
OneToOne | |
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008158 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG6951 34 35 33 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | ZK643.2 34 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DCD1 36 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | AT3G48540 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os01g0765000 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for DCTD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for DCTD Gene
- ENSEMBL:
- Gene Tree for DCTD (if available)
- TreeFam:
- Gene Tree for DCTD (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DCTD: view image
Paralogs for DCTD Gene
No data available for Paralogs for DCTD Gene
Variants for DCTD Gene
| SNP ID | Clin | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000018152 | -- | 182,895,766(-) | C/T | intron_variant | |
| rs1000060262 | -- | 182,908,055(-) | A/C | intron_variant | |
| rs1000078661 | -- | 182,911,692(-) | C/T | intron_variant | |
| rs10001362 | -- | 182,893,669(-) | A/C | intron_variant | |
| rs1000205595 | -- | 182,896,155(-) | C/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv24217 | CNV | loss | 19812545 |
| esv2763419 | CNV | loss | 21179565 |
| nsv1016376 | CNV | gain | 25217958 |
| nsv1122094 | CNV | deletion | 24896259 |
| nsv949856 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.19;
4.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DCTD Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCTD Gene
Disorders for DCTD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| glass syndrome |
|
|
Search DCTD in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DCTD
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DCTD Gene
Publications for DCTD Gene
- Chromosomal location and structural organization of the human deoxycytidylate deaminase gene. (PMID: 7642519) Weiner KX … Maley GF (The Journal of biological chemistry 1995) 3 4 22 58
- Primary structure of human deoxycytidylate deaminase and overexpression of its functional protein in Escherichia coli. (PMID: 7685356) Weiner KX … Maley GF (The Journal of biological chemistry 1993) 3 4 22 58
- Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PMID: 20028759) Okazaki T … Li D (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 44 58
- Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. (PMID: 20665488) Tanaka M … Li D (Cancer 2010) 3 44 58
- Genetic factors influencing cytarabine therapy. (PMID: 19842938) Lamba JK (Pharmacogenomics 2009) 22 25 58
Products for DCTD Gene
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Sources for DCTD Gene
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