Aliases for DCT Gene
Aliases for DCT Gene
External Ids for DCT Gene
- HGNC: 2709
- Entrez Gene: 1638
- Ensembl: ENSG00000080166
- OMIM: 191275
- UniProtKB: P40126
Previous HGNC Symbols for DCT Gene
- TYRP2
Previous GeneCards Identifiers for DCT Gene
- GC13M093451
- GC13M089476
- GC13M093926
- GC13M092789
- GC13M093889
- GC13M095091
- GC13M075688
Summaries for DCT Gene
GeneCards Summary for DCT Gene
DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include Microphthalmia and Hermansky-Pudlak Syndrome 3. Among its related pathways are Metabolism and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.
UniProtKB/Swiss-Prot for DCT Gene
-
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCT Gene
Genomics for DCT Gene
GeneHancer (GH) Regulatory Elements for DCT Gene
Promoters and enhancers for DCT Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13J094548 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE | 662.5 | +0.8 | 810 | 2.5 | HDGF SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 | DCT TRF-GAA1-5 GC13M094348 | |
| GH13J094479 | Promoter/Enhancer | 0.8 | EPDnew ENCODE | 650.2 | +70.6 | 70576 | 0.1 | EZH2 | DCT TRF-GAA1-5 GC13M094348 | |
| GH13J094500 | Promoter | 0.6 | EPDnew | 661.6 | +49.9 | 49914 | 0.1 | L3MBTL2 | DCT TRF-GAA1-5 GC13M094348 | |
| GH13J094545 | Enhancer | 0.4 | ENCODE | 17.2 | +4.0 | 4029 | 1.1 | SCRT2 MAFK | DCT TRF-GAA1-5 GC13M094348 | |
| GH13J094419 | Enhancer | 0.5 | ENCODE | 10.9 | +130.7 | 130663 | 0.1 | FOSL1 ATF4 EBF1 CEBPG PRDM10 ETV6 GABPA | DCT GC13M094348 TRF-GAA1-5 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around DCT on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the DCT gene promoter:
-
- SRY
- LCR-F1
- HSF1short
- HSF1 (long)
- FOXO4
- CUTL1
- PPAR-gamma2
- PPAR-gamma1
- Chx10
- ISGF-3
Regulatory Element Products
Genomic Locations for DCT Gene
Genomic Locations for DCT Gene
- chr13:94,436,808-94,550,265
- (GRCh38/hg38)
- Size:
- 113,458 bases
- Orientation:
- Minus strand
- chr13:95,089,558-95,131,936
- (GRCh37/hg19)
- Size:
- 42,379 bases
- Orientation:
- Minus strand
Genomic View for DCT Gene
Genes around DCT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q32.1 by Entrez Gene
- 13q32.1 by HGNC
- 13q32.1 by Ensembl
DCT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DCT Gene
Proteins for DCT Gene
-
Protein details for DCT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40126-TYRP2_HUMAN
- Recommended name:
- L-dopachrome tautomerase
- Protein Accession:
- P40126
- Q09GT4
Protein attributes for DCT Gene
- Size:
- 519 amino acids
- Molecular mass:
- 59145 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.
Protein Expression for DCT Gene
Post-translational modifications for DCT Gene
- Glycosylated.
- Glycosylation at Asn377, posLast=342342, Asn300, posLast=237237, Asn178, and posLast=170170
- Modification sites at PhosphoSitePlus
Other Protein References for DCT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for DCT
- Novus Biologicals Antibodies for DCT
- Invitrogen Antibodies for DCT (AFLGC-DCT)
- GeneTex DCT Antibody for DCT
-
Santa Cruz Biotechnology (SCBT) Antibodies for DCT
Protein Products
-
OriGene Purified Proteins for DCT
- Search Origene for MassSpec and Protein Over-expression Lysates for DCT
- Origene Custom Protein Services for DCT
- ProSpec Recombinant Proteins for DCT
- antibodies-online: Search results for 8 available DCT Proteins ranked by validation data
- Compare Top DCT Proteins
-
Quality Products:
- Search GeneTex for Proteins for DCT
-
Abcam proteins for DCT
Assay Products
No data available for DME Specific Peptides for DCT Gene
Domains & Families for DCT Gene
Gene Families for DCT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for DCT Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for DCT Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P40126- Family:
-
- Belongs to the tyrosinase family.
Function for DCT Gene
Molecular function for DCT Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.
- GENATLAS Biochemistry:
- DOPAchrome tautomerase
Enzyme Numbers (IUBMB) for DCT Gene
Phenotypes From GWAS Catalog for DCT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004167 | dopachrome isomerase activity | ISS | -- |
| GO:0005507 | copper ion binding | TAS | 8206391 |
| GO:0016491 | oxidoreductase activity | TAS | -- |
| GO:0016853 | isomerase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for DCT Gene
- MGI mutant phenotypes for DCT:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for DCT:
-
- Dynamic nuclei (hole, folded or small irregular)
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased viability
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased viability after Maraba virus infection
Animal Models for DCT Gene
- MGI Knock Outs for DCT:
-
- Dct Dct<tm1b(KOMP)Mbp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DCT
-
CRISPR Products
-
OriGene CRISPR knockouts for DCT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
- genomics-online: gRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- Applied Biological Materials CRISPR for DCT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCT
- GenScript: Design CRISPR guide RNA sequences for DCT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCT
- Browse OriGene Inhibitory RNA Products For DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
- genomics-online: shRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
Clone Products
- Sino Biological Human cDNA Clone for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
- Applied Biological Materials Clones for DCT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for DCT
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DCT Gene
Localization for DCT Gene
Subcellular locations from UniProtKB/Swiss-Prot for DCT Gene
- Melanosome membrane; Single-pass type I membrane protein. Melanosome. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250 UniProtKB:P29812}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 2 |
| nucleus | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | -- |
| GO:0033162 | melanosome membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCT Gene
Pathways & Interactions for DCT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Aldosterone synthesis and secretion |
.41
|
|
| 3 | Phenylalanine metabolism | ||
| 4 | Melanin biosynthesis | ||
| 5 | Viral mRNA Translation | ||
Pathways by source for DCT Gene
1 BioSystems pathway for DCT Gene
3 Reactome pathways for DCT Gene
3 KEGG pathways for DCT Gene
UniProtKB/Swiss-Prot P40126-TYRP2_HUMAN
- Pathway: Pigment biosynthesis; melanin biosynthesis.
Interacting Proteins for DCT Gene
GPS-Prot Interaction Network for DCT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002052 | positive regulation of neuroblast proliferation | IEA | -- |
| GO:0006583 | melanin biosynthetic process from tyrosine | ISS,IEA | -- |
| GO:0008152 | metabolic process | IEA | -- |
| GO:0008544 | epidermis development | TAS | 8206391 |
| GO:0021847 | ventricular zone neuroblast division | IEA | -- |
No data available for SIGNOR curated interactions for DCT Gene
Drugs & Compounds for DCT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bevacizumab | Approved, Investigational | Pharma | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2087 | ||
| Ranibizumab | Approved | Pharma | 502 | |||
| Angiogenesis Inhibitors | Pharma | 4399 | ||||
| Angiogenesis Modulating Agents | Pharma | 4324 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5,6-Dihydroxyindole |
|
3131-52-0 | ||||
| l-dopachrome |
|
89762-39-0 | ||||
| 5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
Drug Products
Transcripts for DCT Gene
mRNA/cDNA for DCT Gene
- (10) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (166) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000377028 5064 bps (uc001vlv.6)
- ENST00000483392 1548 bps (uc058xtk.1)
- ENST00000490854 694 bps (uc058xtl.1)
- ENST00000472871 3540 bps (uc058xtn.1)
- ENST00000446125 2395 bps (uc010afh.5)
CRISPR Products
-
OriGene CRISPR knockouts for DCT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
- genomics-online: gRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- Applied Biological Materials CRISPR for DCT
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCT
- GenScript: Design CRISPR guide RNA sequences for DCT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCT
- Browse OriGene Inhibitory RNA Products For DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
- genomics-online: shRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
Clone Products
- Sino Biological Human cDNA Clone for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
- Applied Biological Materials Clones for DCT
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Expression for DCT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Melanocytes (Integumentary System)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
- Epidermis (Integumentary System)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Neural Tube (Nervous System)
- Skeletal Muscle (Muscoskeletal System)
- NULL (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for DCT Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.8) and Skin - Sun Exposed (Lower leg) (x14.8).
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCT Gene
NURSA nuclear receptor signaling pathways regulating expression of DCT Gene:
DCTSOURCE GeneReport for Unigene cluster for DCT Gene:
Hs.301865Evidence on tissue expression from TISSUES for DCT Gene
- Skin(4.7)
- Liver(4)
- Eye(2.8)
- Spleen(2.6)
- Lymph node(2.5)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for DCT
-
OriGene qPCR primer pairs and template standards for DCT
- genomics-online: primer clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCT Gene
Orthologs for DCT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DCT 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | DCT 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | DCT 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Dct 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Dct 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | DCT 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | DCT 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | DCT 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DCT 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | dct 33 |
|
||
| Str.15440 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12540 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | dct 34 33 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| CSA.6982 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| Cin.236 33 |
|
||||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.236 33 |
|
- Species where no ortholog for DCT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for DCT Gene
- ENSEMBL:
- Gene Tree for DCT (if available)
- TreeFam:
- Gene Tree for DCT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DCT: view image
Paralogs for DCT Gene
Variants for DCT Gene
| SNP ID | Clin | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000022877 | -- | 94,479,743(-) | G/A | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000060638 | -- | 94,450,597(-) | G/T | intron_variant | |
| rs1000082468 | -- | 94,528,080(-) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000112866 | -- | 94,517,316(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
| rs1000192577 | -- | 94,515,035(-) | A/G | genic_upstream_transcript_variant, intron_variant |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DCT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DCT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCT Gene
Disorders for DCT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microphthalmia |
|
|
| hermansky-pudlak syndrome 3 |
|
|
Search DCT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DCT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for DCT Gene
Publications for DCT Gene
- Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PMID: 8306979) Bouchard B … Dubertret L (European journal of biochemistry 1994) 2 3 4 22 58
- Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. (PMID: 11777994) Khong HT … Rosenberg SA (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 22 58
- Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. (PMID: 8530077) Sturm RA … Dunn IS (Genomics 1995) 3 4 22 58
- Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression. (PMID: 7929451) Yokoyama K … Shibahara S (The Journal of biological chemistry 1994) 3 4 22 58
- Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. (PMID: 8148378) Yokoyama K … Shibahara S (Biochimica et biophysica acta 1994) 3 4 22 58
Products for DCT Gene
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- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for DCT
- Invitrogen Antibodies for DCT (AFLGC-DCT)
- Cyagen custom Knockout/knockin (KOKI) mouse models for DCT
- antibodies-online: Search results for 101 available DCT Antibodies ranked by validation data
- Compare Top DCT Antibodies
- antibodies-online: Search results for 32 available DCT Elisa Kits ranked by validation data
- Compare Top DCT Elisa Kits
- antibodies-online: Search results for 8 available DCT Proteins ranked by validation data
- Compare Top DCT Proteins
- Quality Products:
- GeneTex DCT Antibody for DCT
- Search GeneTex for Proteins for DCT
- Santa Cruz Biotechnology (SCBT) Antibodies for DCT
- Search Santa Cruz Biotechnology (SCBT) for DCT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DCT
- Horizon Cell Lines for DCT
- genomics-online: cdna clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- orf clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- genomics-online: gRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- genomics-online: primer clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- genomics-online: shRNA clones - Search results for 82 available DCT gene related products
- Overview of 82 available DCT gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
- GeneCopoeia miRNA 3'UTR Target clone products for DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
Sources for DCT Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt