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Aliases for DCT Gene
Aliases for DCT Gene
External Ids for DCT Gene
- HGNC: 2709
- Entrez Gene: 1638
- Ensembl: ENSG00000080166
- OMIM: 191275
- UniProtKB: P40126
Previous HGNC Symbols for DCT Gene
- TYRP2
Previous GeneCards Identifiers for DCT Gene
- GC13M093451
- GC13M089476
- GC13M093926
- GC13M092789
- GC13M093889
- GC13M095091
- GC13M075688
Summaries for DCT Gene
GeneCards Summary for DCT Gene
DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include Amelanotic Melanoma and Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1. Among its related pathways are Neural Crest Differentiation and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.
UniProtKB/Swiss-Prot Summary for DCT Gene
-
Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
Additional gene information for DCT Gene
- HGNC(2709)
- Entrez Gene(1638)
- Ensembl(ENSG00000080166)
- OMIM(191275)
- UniProtKB(P40126)
- Open Targets Platform(ENSG00000080166)
- Search for DCT at DataMed
- Search for DCT at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCT Gene
Genomics for DCT Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DCT Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH13J094548 | Promoter/Enhancer | 1.7 | EPDnew ENCODE CraniofacialAtlas | 612.4 | 0.0 | -49 | 2.5 | BRCA1 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 IKZF1 KDM1A ZNF692 | DCT TRF-GAA1-5 lnc-GPR180-11 lnc-TGDS-1 piR-43773-002 GPR180 TGDS | |
| GH13J094479 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 600.2 | +68.4 | 68405 | 3.2 | JUND BRCA1 MGA CEBPB EZH2 FOSL1 CEBPG POLR2A BHLHE40 SPI1 | DCT TGDS lnc-TGDS-2 lnc-DCT-1 | |
| GH13J094500 | Promoter | 0.4 | EPDnew | 611.6 | +49.1 | 49055 | 0.1 | L3MBTL2 | DCT lnc-DCT-1 piR-55036-030 | |
| GH13J094545 | Enhancer | 0.6 | Ensembl ENCODE | 17.5 | +3.1 | 3105 | 1.4 | TEAD4 SCRT2 MAFF MAFK | DCT lnc-TGDS-1 piR-55036-030 | |
| GH13J094419 | Enhancer | 0.7 | Ensembl ENCODE | 10.9 | +129.8 | 129805 | 2 | JUND CEBPB FOS GABPA FOSL1 MAFK EBF1 ATF4 CEBPG ATF3 | DCT RF00998-039 lnc-DCT-11 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DCT on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCT
- Top Transcription factor binding sites by QIAGEN in the DCT gene promoter:
-
- Chx10
- CUTL1
- FOXO4
- HSF1 (long)
- HSF1short
- ISGF-3
- LCR-F1
- PPAR-gamma1
- PPAR-gamma2
- SRY
Genomic Locations for DCT Gene
Genomic Locations for DCT Gene
- chr13:94,436,811-94,549,406
- (GRCh38/hg38)
- Size:
- 112,596 bases
- Orientation:
- Minus strand
- chr13:95,089,558-95,131,936
- (GRCh37/hg19)
- Size:
- 42,379 bases
- Orientation:
- Minus strand
Genomic View for DCT Gene
Genes around DCT on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 13q32.1 by HGNC
- 13q32.1 by Entrez Gene
- 13q32.1 by Ensembl
DCT Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DCT Gene
Proteins for DCT Gene
-
Protein details for DCT Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40126-TYRP2_HUMAN
- Recommended name:
- L-dopachrome tautomerase
- Protein Accession:
- P40126
- Q09GT4
Protein attributes for DCT Gene
- Size:
- 519 amino acids
- Molecular mass:
- 59145 Da
- Cofactor:
- Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Quaternary structure:
-
- Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.
Protein Expression for DCT Gene
Selected DME Specific Peptides for DCT Gene
- P40126:
-
- YNMVPFFPPVTN
- HSFLNGT
- HPDYVITTQHWLGLLGPNGT
- AIDFSHQGPAFVTWHRYHLL
- ELAPIGHNR
- SFRNALEGF
- FVWLHYYSVRDTLLGPGRP
- CTGNFAGYNCG
Post-translational modifications for DCT Gene
- Glycosylated.
-
Glycosylation at Asn170, Asn178, Asn237, Asn300, Asn342, and Asn377
- NX_P40126 (NX_P40126-1)
- Modification sites at PhosphoSitePlus
Other Protein References for DCT Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ DCT Antibody and Immunotag™ DCT(TRP2) Antibody
-
Custom Antibody ServicesOriGene Antibodies for DCT
- Novus Biologicals Antibodies for DCT
- Invitrogen Antibodies for DCT (AFLGC-DCT)
-
Santa Cruz Biotechnology (SCBT) Antibodies for DCT
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for DCT
- Origene Custom Protein Services for DCT
- ProSpec Recombinant Proteins for DCT
- antibodies-online: Show 9 available DCT Proteins ranked by validation data
- Compare Top DCT Proteins
-
Quality Products:
-
Abcam proteins for DCT
Assay Products
-
Signalway ELISA kits for DCT
Domains & Families for DCT Gene
Gene Families for DCT Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for DCT Gene
- InterPro:
- Blocks:
-
- Tyrosinase copper-binding domain signature
- ProtoNet:
Suggested Antigen Peptide Sequences for DCT Gene
- GenScript: Design optimal peptide antigens:
-
- Tyrosinase-related protein-2 (O75767_HUMAN)
- DCT (Q0PK43_HUMAN)
- Tyrosinase related protein-2 (Q9NQD7_HUMAN)
- Tyrosinase-related protein-2 (Q9NQD8_HUMAN)
- Tyrosinase-related protein 2 (TYRP2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40126- Family:
-
- Belongs to the tyrosinase family.
Function for DCT Gene
Molecular function for DCT Gene
- UniProtKB/Swiss-Prot Function:
- Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed:8306979). Involved in regulating eumelanin and phaeomelanin levels.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate; Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509; EC=5.3.3.12; Evidence={ECO:0000250|UniProtKB:P29812};.
- GENATLAS Biochemistry:
- DOPAchrome tautomerase
Enzyme Numbers (IUBMB) for DCT Gene
Phenotypes From GWAS Catalog for DCT Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004167 | dopachrome isomerase activity | IBA,ISS | -- |
| GO:0005507 | copper ion binding | TAS | 8206391 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0016853 | isomerase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for DCT Gene
- MGI mutant phenotypes for DCT:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for DCT:
-
- Large nuclei
- no effect
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased viability after Maraba virus infection
- Increased shRNA abundance (Z-score > 2)
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased nuclear migration speed
Animal Models for DCT Gene
- MGI Knock Outs for DCT:
-
- Dct Dct<tm1b(KOMP)Mbp>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DCT - Select products 50% OFF >
- * DCT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DCT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCT
- Browse OriGene Inhibitory RNA Products For DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
Clone Products
- Applied Biological Materials (abm): Clones for DCT - Select products 50% OFF >
- * DCT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
Cell Line Products
-
Horizon Cell Lines for DCT
No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DCT Gene
Localization for DCT Gene
Subcellular locations from UniProtKB/Swiss-Prot for DCT Gene
- Melanosome membrane. Single-pass type I membrane protein. Melanosome. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. {ECO:0000250 UniProtKB:P29812}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 5 |
| extracellular | 3 |
| nucleus | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
- Plasma membrane (3)
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IEA,ISS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS,IEA | -- |
Pathways & Interactions for DCT Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.40
|
|
| 2 | Aldosterone synthesis and secretion |
.41
|
|
| 3 | Tyrosine metabolism | ||
| 4 | Melanin biosynthesis | ||
| 5 | Viral mRNA Translation | ||
Pathways by source for DCT Gene
1 BioSystems pathway for DCT Gene
3 Reactome pathways for DCT Gene
3 KEGG pathways for DCT Gene
UniProtKB/Swiss-Prot P40126-TYRP2_HUMAN
- Pathway: Pigment biosynthesis; melanin biosynthesis.
Interacting Proteins for DCT Gene
Selected Interacting proteins:
P40126-TYRP2_HUMAN
ENSP00000392762
for DCT Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DCT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002052 | positive regulation of neuroblast proliferation | IBA | 21873635 |
| GO:0006583 | melanin biosynthetic process from tyrosine | IBA,ISS | -- |
| GO:0008544 | epidermis development | TAS | 8206391 |
| GO:0021847 | ventricular zone neuroblast division | IBA | 21873635 |
| GO:0042438 | melanin biosynthetic process | TAS | -- |
Drugs & Compounds for DCT Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Bevacizumab | Approved, Investigational | Pharma | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2368 | ||
| Ranibizumab | Approved | Pharma | 546 | |||
| Angiogenesis Inhibitors | Pharma | 4526 | ||||
| Antineoplastic Agents, Immunological | Pharma | 8762 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 5,6-Dihydroxyindole |
|
3131-52-0 | ||||
| l-dopachrome |
|
89762-39-0 | ||||
| 5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
Transcripts for DCT Gene
mRNA/cDNA for DCT Gene
- 7 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377028 5074 nts (view in UCSC)
- ENST00000483392 1548 nts (view in UCSC)
- ENST00000490854 694 nts (view in UCSC)
- ENST00000472871 3540 nts (view in UCSC)
- ENST00000446125 2395 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for DCT - Select products 50% OFF >
- * DCT CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for DCT
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCT
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCT
- Browse OriGene Inhibitory RNA Products For DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
Clone Products
- Applied Biological Materials (abm): Clones for DCT - Select products 50% OFF >
- * DCT as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for DCT Gene
- GeneLoc Exon Structure for
- DCT
Expression for DCT Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Melanocytes (Integumentary System)
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Retinal Pigmented Epithelium Progenitor Cells Retinal Pigmented Epithelium
- Conjunctival Epithelium
- Epidermis (Integumentary System)
-
Brain (Nervous System)
- Endothelial Cells Blood Brain Barrier
- Cerebellum
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Limb (Muscoskeletal System)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Ectoderm (Gastrulation Derivatives)
- Apical Ectodermal Ridge Cells Limb Ectoderm
-
Epithelial Cells
- Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Endothelium (Cardiovascular System)
- Endothelial Cells Blood Brain Barrier
- Neural Tube (Nervous System)
- Skeletal Muscle (Muscoskeletal System)
- NULL (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for DCT Gene
This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x14.8) and Skin - Sun Exposed (Lower leg) (x14.8).
This gene is overexpressed in Urine (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCT Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCT
SOURCE GeneReport for Unigene cluster for DCT Gene:
Hs.301865Evidence on tissue expression from TISSUES for DCT Gene
- Skin(4.7)
- Liver(4.4)
- Eye(3.3)
- Blood(2.9)
- Spleen(2.9)
- Lymph node(2.8)
- Nervous system(2.7)
- Bone marrow(2.5)
- Heart(2.5)
- Kidney(2.3)
- Intestine(2.1)
- Muscle(2.1)
- Lung(2)
Primer Products
-
OriGene qPCR primer pairs for DCT
-
OriGene qPCR primer pairs and template standards for DCT
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCT Gene
Orthologs for DCT Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DCT 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DCT 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DCT 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dct 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Dct 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DCT 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DCT 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | DCT 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DCT 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dct 30 |
|
||
| Str.15440 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12540 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dct 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
| CSA.6982 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.236 30 |
|
- Species where no ortholog for DCT was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DCT Gene
- ENSEMBL:
- Gene Tree for DCT (if available)
- TreeFam:
- Gene Tree for DCT (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DCT: view image
Paralogs for DCT Gene
Variants for DCT Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCT Gene
| SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 709290 | Benign: not provided | 94,465,672(-) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 717314 | Benign: not provided | 94,468,999(-) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
| 730602 | Likely Benign: not provided | 94,468,832(-) | T/C | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Residual Variation Intolerance Score:
40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.79% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DCT Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DCT
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCT Gene
Disorders for DCT Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amelanotic melanoma |
|
|
| vitiligo-associated multiple autoimmune disease susceptibility 1 |
|
|
| tietz albinism-deafness syndrome |
|
|
| chediak-higashi syndrome |
|
|
| microphthalmia |
|
Search DCT in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for DCT
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for DCT Gene
Publications for DCT Gene
- Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells. (PMID: 8306979) Bouchard B … Dubertret L (European journal of biochemistry 1994) 2 3 4 23
- Pre-existing immunity to tyrosinase-related protein (TRP)-2, a new TRP-2 isoform, and the NY-ESO-1 melanoma antigen in a patient with a dramatic response to immunotherapy. (PMID: 11777994) Khong HT … Rosenberg SA (Journal of immunology (Baltimore, Md. : 1950) 2002) 3 4 23
- Chromosomal structure of the human TYRP1 and TYRP2 loci and comparison of the tyrosinase-related protein gene family. (PMID: 8530077) Sturm RA … Dunn IS (Genomics 1995) 3 4 23
- Molecular cloning and functional analysis of a cDNA coding for human DOPAchrome tautomerase/tyrosinase-related protein-2. (PMID: 8148378) Yokoyama K … Shibahara S (Biochimica et biophysica acta 1994) 3 4 23
- Sequence of the human dopachrome tautomerase-encoding TRP-2 cDNA. (PMID: 8206391) Cassady JL … Sturm RA (Gene 1994) 3 4 23
ExternalLinks
Products for DCT Gene
- Custom Antibody ServicesOriGene Antibodies for DCT
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DCT
- Origene Custom Protein Services for DCT
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCT
- Browse OriGene Inhibitory RNA Products For DCT
- OriGene qPCR primer pairs for DCT
- OriGene qPCR primer pairs and template standards for DCT
- OriGene CRISPR knockouts for DCT
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DCT
- Sino Biological Human cDNA Clone for DCT
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Novus Biologicals Antibodies for DCT
- Novus Biologicals proteins and lysates for DCT
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- Abcam proteins for DCT
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for DCT (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DCT (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DCT (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DCT CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DCT
- antibodies-online: Show 40 available DCT Antibodies ranked by validation data
- Compare Top DCT Antibodies
- antibodies-online: Show 37 available DCT Elisa Kits ranked by validation data
- Compare Top DCT Elisa Kits
- antibodies-online: Show 9 available DCT Proteins ranked by validation data
- Compare Top DCT Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for DCT
- Search Santa Cruz Biotechnology (SCBT) for DCT siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DCT
- Horizon Cell Lines for DCT
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCT
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCT
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DCT
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCT
Sources for DCT Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB