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DCT (Dopachrome Tautomerase) is a Protein Coding gene. Diseases associated with DCT include Amelanotic Melanoma and Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1. Among its related pathways are Neural Crest Differentiation and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and dopachrome isomerase activity. An important paralog of this gene is TYRP1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH13J094548 | Promoter/Enhancer | 1.7 | EPDnew ENCODE CraniofacialAtlas | 612.4 | 0.0 | -49 | 2.5 | BRCA1 HNRNPL GATAD2A CTCF TEAD4 PRDM10 ZNF629 IKZF1 KDM1A ZNF692 | DCT TRF-GAA1-5 lnc-GPR180-11 lnc-TGDS-1 piR-43773-002 GPR180 TGDS | |
GH13J094479 | Promoter/Enhancer | 1.2 | EPDnew Ensembl ENCODE | 600.2 | +68.4 | 68405 | 3.2 | JUND BRCA1 MGA CEBPB EZH2 FOSL1 CEBPG POLR2A BHLHE40 SPI1 | DCT TGDS lnc-TGDS-2 lnc-DCT-1 | |
GH13J094500 | Promoter | 0.4 | EPDnew | 611.6 | +49.1 | 49055 | 0.1 | L3MBTL2 | DCT lnc-DCT-1 piR-55036-030 | |
GH13J094545 | Enhancer | 0.6 | Ensembl ENCODE | 17.5 | +3.1 | 3105 | 1.4 | TEAD4 SCRT2 MAFF MAFK | DCT lnc-TGDS-1 piR-55036-030 | |
GH13J094419 | Enhancer | 0.7 | Ensembl ENCODE | 10.9 | +129.8 | 129805 | 2 | JUND CEBPB FOS GABPA FOSL1 MAFK EBF1 ATF4 CEBPG ATF3 | DCT RF00998-039 lnc-DCT-11 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004167 | dopachrome isomerase activity | IBA,ISS | -- |
GO:0005507 | copper ion binding | TAS | 8206391 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0016853 | isomerase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IEA,ISS | -- |
GO:0005886 | plasma membrane | IDA | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Metabolism |
.40
|
|
2 | Aldosterone synthesis and secretion |
.41
|
|
3 | Tyrosine metabolism | ||
4 | Melanin biosynthesis | ||
5 | Viral mRNA Translation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002052 | positive regulation of neuroblast proliferation | IBA | 21873635 |
GO:0006583 | melanin biosynthetic process from tyrosine | IBA,ISS | -- |
GO:0008544 | epidermis development | TAS | 8206391 |
GO:0021847 | ventricular zone neuroblast division | IBA | 21873635 |
GO:0042438 | melanin biosynthetic process | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Bevacizumab | Approved, Investigational | Pharma | VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 2368 | ||
Ranibizumab | Approved | Pharma | 546 | |||
Angiogenesis Inhibitors | Pharma | 4526 | ||||
Antineoplastic Agents, Immunological | Pharma | 8762 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
5,6-Dihydroxyindole |
|
3131-52-0 | ||||
l-dopachrome |
|
89762-39-0 | ||||
5,6-Dihydroxyindole-2-carboxylic acid |
|
4790-08-3 |
|
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | |||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | DCT 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | DCT 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | DCT 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Dct 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Dct 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | DCT 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | DCT 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | DCT 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | DCT 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dct 30 |
|
||
Str.15440 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.12540 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | dct 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
CSA.6982 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.236 30 |
|
SNP ID | Clinical significance and condition | Chr 13 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709290 | Benign: not provided | 94,465,672(-) | C/T | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
717314 | Benign: not provided | 94,468,999(-) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT | |
730602 | Likely Benign: not provided | 94,468,832(-) | T/C | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
amelanotic melanoma |
|
|
vitiligo-associated multiple autoimmune disease susceptibility 1 |
|
|
tietz albinism-deafness syndrome |
|
|
chediak-higashi syndrome |
|
|
microphthalmia |
|