Aliases for DCSTAMP Gene
External Ids for DCSTAMP Gene
Previous HGNC Symbols for DCSTAMP Gene
Previous GeneCards Identifiers for DCSTAMP Gene
This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
GeneCards Summary for DCSTAMP Gene
DCSTAMP (Dendrocyte Expressed Seven Transmembrane Protein) is a Protein Coding gene. Diseases associated with DCSTAMP include Paget's Disease Of Bone and Bone Resorption Disease. Gene Ontology (GO) annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances. An important paralog of this gene is DCST1.
UniProtKB/Swiss-Prot Summary for DCSTAMP Gene
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.