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Aliases for DCSTAMP Gene

Aliases for DCSTAMP Gene

  • Dendrocyte Expressed Seven Transmembrane Protein 2 3 5
  • Transmembrane 7 Superfamily Member 4 2 3 4
  • Dendritic Cells (DC)-Specific Transmembrane Protein 2 3
  • IL-Four-Induced Protein 3 4
  • IL-Four INDuced 2 3
  • HDC-STAMP 3 4
  • TM7SF4 3 4
  • FIND 3 4
  • Dendrocyte-Expressed Seven Transmembrane Protein 4
  • Dendritic Cell-Specific Transmembrane Protein 3
  • DC-Specific Transmembrane Protein 3
  • IL-Four (IL-4) Induced 3
  • IL-4-Induced Protein 3
  • DC-STAMP 4

External Ids for DCSTAMP Gene

Previous HGNC Symbols for DCSTAMP Gene

  • TM7SF4

Previous GeneCards Identifiers for DCSTAMP Gene

  • GC08P105420
  • GC08P105020
  • GC08P105308

Summaries for DCSTAMP Gene

Entrez Gene Summary for DCSTAMP Gene

  • This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

GeneCards Summary for DCSTAMP Gene

DCSTAMP (Dendrocyte Expressed Seven Transmembrane Protein) is a Protein Coding gene. Diseases associated with DCSTAMP include Paget's Disease Of Bone. Gene Ontology (GO) annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot for DCSTAMP Gene

  • Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.

Additional gene information for DCSTAMP Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCSTAMP Gene

Genomics for DCSTAMP Gene

GeneHancer (GH) Regulatory Elements for DCSTAMP Gene

Promoters and enhancers for DCSTAMP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J104338 Enhancer 0.7 Ensembl ENCODE 680.1 -0.1 -86 1.2 ZFHX2 ATF4 EBF1 CEBPG EGR2 DCSTAMP PIR34879 DPYS
GH08J104339 Promoter/Enhancer 0.7 EPDnew ENCODE 680.1 +0.7 691 0.1 DCSTAMP GC08M104420 DPYS
GH08J104359 Enhancer 1.2 FANTOM5 Ensembl ENCODE 60 +22.2 22210 3 ATF1 JUN BACH1 ZNF384 CEBPG BATF ZBTB40 EED ATF7 NFE2 DCSTAMP LRP12 GC08M104420 DPYS
GH08J104336 Enhancer 1 FANTOM5 ENCODE 35.7 -2.0 -2039 0.9 HDAC1 ATF1 TCF12 ZNF366 FOS RCOR1 ATF7 CREM ZEB2 MTA1 DCSTAMP LRP12 PIR34879 DPYS
GH08J104664 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +326.6 326631 2.5 PKNOX1 ARNT IRF4 POLR2B ZNF766 E2F8 FOS JUNB ZNF592 MEF2D DCSTAMP LRP12 ENSG00000283157 GC08P104611 ZFPM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCSTAMP on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCSTAMP Gene

Genomic Locations for DCSTAMP Gene
chr8:104,339,087-104,356,689
(GRCh38/hg38)
Size:
17,603 bases
Orientation:
Plus strand
chr8:105,351,315-105,368,917
(GRCh37/hg19)
Size:
17,603 bases
Orientation:
Plus strand

Genomic View for DCSTAMP Gene

Genes around DCSTAMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCSTAMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCSTAMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCSTAMP Gene

Proteins for DCSTAMP Gene

  • Protein details for DCSTAMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H295-DCSTP_HUMAN
    Recommended name:
    Dendritic cell-specific transmembrane protein
    Protein Accession:
    Q9H295
    Secondary Accessions:
    • B7ZVW2
    • E7ESG0
    • Q2M2D5

    Protein attributes for DCSTAMP Gene

    Size:
    470 amino acids
    Molecular mass:
    53393 Da
    Quaternary structure:
    • Monomer. Homodimer. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 1 (via the C-terminus tail); the interaction induces DCSTAMP redistribution to the endoplasmic reticulum-Golgi intermediate compartment. Isoform 1 interacts (via the C-terminus cytoplasmic tail) with OS9 isoform 2 (via the C-terminus tail) (By similarity). Interacts with CREB3.

    Alternative splice isoforms for DCSTAMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCSTAMP Gene

Post-translational modifications for DCSTAMP Gene

No data available for DME Specific Peptides for DCSTAMP Gene

Domains & Families for DCSTAMP Gene

Gene Families for DCSTAMP Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for DCSTAMP Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCSTAMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H295

UniProtKB/Swiss-Prot:

DCSTP_HUMAN :
  • Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
Domain:
  • Several domains are necessary for interacting with OS9. The region in the cytoplasmic tail that is necessary for interaction with OS9, is also required for its transport (By similarity).
genes like me logo Genes that share domains with DCSTAMP: view

Function for DCSTAMP Gene

Molecular function for DCSTAMP Gene

UniProtKB/Swiss-Prot Function:
Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated by dexamethasone and up-regulated by IL4/interleukin-4 in macrophages. Down-regulated in CD40L-activated dendritic cells.

Phenotypes From GWAS Catalog for DCSTAMP Gene

Gene Ontology (GO) - Molecular Function for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20546900
genes like me logo Genes that share ontologies with DCSTAMP: view
genes like me logo Genes that share phenotypes with DCSTAMP: view

Animal Models for DCSTAMP Gene

MGI Knock Outs for DCSTAMP:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCSTAMP

CRISPR Products

miRNA for DCSTAMP Gene

miRTarBase miRNAs that target DCSTAMP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCSTAMP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCSTAMP Gene

Localization for DCSTAMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCSTAMP Gene

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localizes to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCSTAMP gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
endosome 4
extracellular 1
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IDA,IEA 15601667
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IDA 11169400
genes like me logo Genes that share ontologies with DCSTAMP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCSTAMP Gene

Pathways & Interactions for DCSTAMP Gene

SuperPathways for DCSTAMP Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCSTAMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA,IBA --
GO:0030308 negative regulation of cell growth ISS --
GO:0030316 osteoclast differentiation ISS --
GO:0034241 positive regulation of macrophage fusion ISS --
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus ISS --
genes like me logo Genes that share ontologies with DCSTAMP: view

No data available for Pathways by source and SIGNOR curated interactions for DCSTAMP Gene

Drugs & Compounds for DCSTAMP Gene

No Compound Related Data Available

Transcripts for DCSTAMP Gene

mRNA/cDNA for DCSTAMP Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCSTAMP Gene

Dendrocyte expressed seven transmembrane protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCSTAMP

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCSTAMP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - -
SP2:
SP3:
SP4: -

Relevant External Links for DCSTAMP Gene

GeneLoc Exon Structure for
DCSTAMP
ECgene alternative splicing isoforms for
DCSTAMP

Expression for DCSTAMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCSTAMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCSTAMP Gene

This gene is overexpressed in Brain - Amygdala (x17.9), Lung (x9.4), and Adipose - Subcutaneous (x4.2).

Protein differential expression in normal tissues from HIPED for DCSTAMP Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCSTAMP Gene



Protein tissue co-expression partners for DCSTAMP Gene

NURSA nuclear receptor signaling pathways regulating expression of DCSTAMP Gene:

DCSTAMP

SOURCE GeneReport for Unigene cluster for DCSTAMP Gene:

Hs.652230

mRNA Expression by UniProt/SwissProt for DCSTAMP Gene:

Q9H295-DCSTP_HUMAN
Tissue specificity: Preferentially expressed by dendritic cells (DCs). Detected in both immature and mature DCs. Highly expressed in lymph nodes, lung, kidney and liver. Expressed at lower levels in pancreas, bone marrow, spleen, leukocytes, in freshly isolated peripheral blood mononuclear cells (PBMC) and B-cells. Not expressed in freshly isolated monocytes.

Evidence on tissue expression from TISSUES for DCSTAMP Gene

  • Blood(4.3)
  • Bone(2.7)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with DCSTAMP: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DCSTAMP Gene

Orthologs for DCSTAMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCSTAMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TM7SF4 33
  • 99.72 (n)
DCSTAMP 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TM7SF4 33
  • 84.54 (n)
DCSTAMP 34
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCSTAMP 34 33
  • 83.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dcstamp 16 34 33
  • 79.42 (n)
rat
(Rattus norvegicus)
Mammalia Dcstamp 33
  • 78.07 (n)
oppossum
(Monodelphis domestica)
Mammalia DCSTAMP 34
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCSTAMP 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCSTAMP 34 33
  • 56.92 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCSTAMP 34
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcstamp 33
  • 50.74 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101883335 33
  • 45.71 (n)
DCSTAMP 34
  • 32 (a)
OneToOne
Species where no ortholog for DCSTAMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCSTAMP Gene

ENSEMBL:
Gene Tree for DCSTAMP (if available)
TreeFam:
Gene Tree for DCSTAMP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCSTAMP: view image

Paralogs for DCSTAMP Gene

No data available for Paralogs for DCSTAMP Gene

Variants for DCSTAMP Gene

Sequence variations from dbSNP and Humsavar for DCSTAMP Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000220101 -- 104,352,319(+) A/G intron_variant
rs1000255059 -- 104,342,702(+) C/A/G/T intron_variant
rs1000522155 -- 104,353,696(+) G/C/T intron_variant
rs1000593572 -- 104,352,580(+) C/A/T intron_variant
rs1000995391 -- 104,347,577(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCSTAMP Gene

Variant ID Type Subtype PubMed ID
esv3618273 CNV loss 21293372
nsv1032775 CNV gain 25217958

Variation tolerance for DCSTAMP Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.18; 80.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCSTAMP Gene

Human Gene Mutation Database (HGMD)
DCSTAMP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCSTAMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCSTAMP Gene

Disorders for DCSTAMP Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCSTAMP Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
paget's disease of bone
  • familial paget's disease of bone
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCSTAMP

genes like me logo Genes that share disorders with DCSTAMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCSTAMP Gene

Publications for DCSTAMP Gene

  1. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. (PMID: 11169400) Hartgers FC … Adema GJ (European journal of immunology 2000) 2 3 4 22 58
  2. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. (PMID: 15601667) Eleveld-Trancikova D … Adema GJ (Journal of leukocyte biology 2005) 3 4 22 58
  3. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. (PMID: 20546900) Eleveld-Trancikova D … Adema GJ (Molecular immunology 2010) 3 4 58
  4. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. (PMID: 18952287) Jansen BJ … Adema GJ (Molecular immunology 2009) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DCSTAMP Gene

Sources for DCSTAMP Gene

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