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Aliases for DCST1 Gene

Aliases for DCST1 Gene

  • DC-STAMP Domain Containing 1 2 3 5
  • DC-STAMP Domain-Containing Protein 1 3 4
  • RING-Type E3 Ubiquitin Transferase 3 4
  • E3 Ubiquitin-Protein Ligase DCST1 3
  • EC 2.3.2.27 4

External Ids for DCST1 Gene

Previous GeneCards Identifiers for DCST1 Gene

  • GC01P151820
  • GC01P153272
  • GC01P126368

Summaries for DCST1 Gene

Entrez Gene Summary for DCST1 Gene

  • This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for DCST1 Gene

DCST1 (DC-STAMP Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is DCST2.

UniProtKB/Swiss-Prot for DCST1 Gene

  • E3 ubiquitin-protein ligase which mediates Lys-48-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.

Additional gene information for DCST1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCST1 Gene

Genomics for DCST1 Gene

GeneHancer (GH) Regulatory Elements for DCST1 Gene

Promoters and enhancers for DCST1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J155015 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.4 -16.5 -16492 3.2 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 DCST1 KHDC4 GON4L ENSG00000271267 CLK2 UBAP2L MSTO2P LOC101928120 MSTO1 ASH1L-AS1
GH01J155033 Promoter 0.5 EPDnew 650.7 0.0 -1 0.1 DCST1 DCST2
GH01J154998 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.8 -29.4 -29355 11.3 CLOCK MLX YBX1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 ZBTB7B GON4L CLK2 UBAP2L KHDC4 ENSG00000271267 THBS3 RUSC1-AS1 SHC1 MSTO1
GH01J155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 36.3 +210.4 210436 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA GON4L KHDC4 CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01J154965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.7 -61.8 -61752 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 SHC1 CKS1B UBAP2L GON4L CLK2 KHDC4 THBS3 YY1AP1 KRTCAP2 ENSG00000271267
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCST1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCST1 gene promoter:

Genomic Locations for DCST1 Gene

Genomic Locations for DCST1 Gene
chr1:155,033,806-155,050,930
(GRCh38/hg38)
Size:
17,125 bases
Orientation:
Plus strand
chr1:155,006,282-155,023,406
(GRCh37/hg19)

Genomic View for DCST1 Gene

Genes around DCST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCST1 Gene

Proteins for DCST1 Gene

  • Protein details for DCST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T197-DCST1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase DCST1
    Protein Accession:
    Q5T197
    Secondary Accessions:
    • B4DXA0
    • E9PHV3
    • Q5T198
    • Q6P1W6
    • Q71S70
    • Q96M70

    Protein attributes for DCST1 Gene

    Size:
    706 amino acids
    Molecular mass:
    80712 Da
    Quaternary structure:
    • Interacts with STAT2; the interaction results in STAT2 Lys-48-linked ubiquitination leading to its proteasomal degradation.

    Alternative splice isoforms for DCST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCST1 Gene

Post-translational modifications for DCST1 Gene

  • Glycosylation at Asn525, Asn349, Asn321, Asn189, and Asn156
  • Modification sites at PhosphoSitePlus

Other Protein References for DCST1 Gene

No data available for DME Specific Peptides for DCST1 Gene

Domains & Families for DCST1 Gene

Gene Families for DCST1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for DCST1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCST1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5T197

UniProtKB/Swiss-Prot:

DCST1_HUMAN :
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity.
genes like me logo Genes that share domains with DCST1: view

Function for DCST1 Gene

Molecular function for DCST1 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which mediates Lys-48-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Induction:
Induced by IFNB1.

Enzyme Numbers (IUBMB) for DCST1 Gene

Phenotypes From GWAS Catalog for DCST1 Gene

Gene Ontology (GO) - Molecular Function for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27782195
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 27782195
genes like me logo Genes that share ontologies with DCST1: view
genes like me logo Genes that share phenotypes with DCST1: view

Animal Model Products

miRNA for DCST1 Gene

miRTarBase miRNAs that target DCST1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCST1 Gene

Localization for DCST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCST1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCST1 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 27782195
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCST1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCST1 Gene

Pathways & Interactions for DCST1 Gene

SuperPathways for DCST1 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T197-DCST1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for DCST1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295542%0d%0a9606.ENSP00000451211%0d%0a
Selected Interacting proteins: Q5T197-DCST1_HUMAN ENSP00000295542 for DCST1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DCST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IMP 27782195
GO:0016567 protein ubiquitination IEA --
GO:0045087 innate immune response IEA --
GO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP 27782195
genes like me logo Genes that share ontologies with DCST1: view

No data available for Pathways by source and SIGNOR curated interactions for DCST1 Gene

Drugs & Compounds for DCST1 Gene

No Compound Related Data Available

Transcripts for DCST1 Gene

mRNA/cDNA for DCST1 Gene

Unigene Clusters for DCST1 Gene

DC-STAMP domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCST1 Gene

No ASD Table

Relevant External Links for DCST1 Gene

GeneLoc Exon Structure for
DCST1
ECgene alternative splicing isoforms for
DCST1

Expression for DCST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCST1 Gene

mRNA differential expression in normal tissues according to GTEx for DCST1 Gene

This gene is overexpressed in Testis (x15.5), Skin - Sun Exposed (Lower leg) (x5.4), and Skin - Not Sun Exposed (Suprapubic) (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of DCST1 Gene:

DCST1

SOURCE GeneReport for Unigene cluster for DCST1 Gene:

Hs.567717
genes like me logo Genes that share expression patterns with DCST1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCST1 Gene

Orthologs for DCST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCST1 34 33
  • 99.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCST1 34 33
  • 85.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCST1 34 33
  • 82.93 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcst1 33
  • 79.17 (n)
mouse
(Mus musculus)
Mammalia Dcst1 16 34 33
  • 78.06 (n)
oppossum
(Monodelphis domestica)
Mammalia DCST1 34
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCST1 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734054 33
  • 48.48 (n)
zebrafish
(Danio rerio)
Actinopterygii dcst1 34 33
  • 50.37 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005349 33
  • 41.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta snky 34 33
  • 40.48 (n)
OneToOne
Species where no ortholog for DCST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCST1 Gene

ENSEMBL:
Gene Tree for DCST1 (if available)
TreeFam:
Gene Tree for DCST1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCST1: view image

Paralogs for DCST1 Gene

Paralogs for DCST1 Gene

genes like me logo Genes that share paralogs with DCST1: view

Variants for DCST1 Gene

Sequence variations from dbSNP and Humsavar for DCST1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000109470 -- 155,042,975(+) G/A intron_variant
rs1000133826 -- 155,038,399(+) C/G intron_variant
rs1000343525 -- 155,041,453(+) C/A coding_sequence_variant, missense_variant
rs1000396168 -- 155,041,217(+) C/T intron_variant
rs1000459606 -- 155,035,635(+) AGAG/AG intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCST1 Gene

Variant ID Type Subtype PubMed ID
esv3587615 CNV gain 21293372
nsv1133910 CNV deletion 24896259
nsv509502 CNV insertion 20534489
nsv952212 CNV deletion 24416366

Variation tolerance for DCST1 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCST1 Gene

Human Gene Mutation Database (HGMD)
DCST1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCST1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCST1 Gene

Disorders for DCST1 Gene

Additional Disease Information for DCST1

No disorders were found for DCST1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCST1 Gene

Publications for DCST1 Gene

  1. Global functional profiling of human ubiquitome identifies E3 ubiquitin ligase DCST1 as a novel negative regulator of Type-I interferon signaling. (PMID: 27782195) Nair S … Krishnan MN (Scientific reports 2016) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. F-box only protein 9 is an E3 ubiquitin ligase of PPARγ. (PMID: 27197753) Lee KW … Park KS (Experimental & molecular medicine 2016) 3 58
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron ML … Lange BM (Nature communications 2013) 3 58
  5. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles RA … Easton DF (Nature genetics 2013) 3 58

Products for DCST1 Gene

Sources for DCST1 Gene

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