The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for th... See more...

Aliases for DCP2 Gene

Aliases for DCP2 Gene

  • Decapping MRNA 2 2 3 5
  • NUDT20 2 3 4
  • Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 20 2 3
  • MRNA-Decapping Enzyme 2 3 4
  • M7GpppN-MRNA Hydrolase 3 4
  • HDpc 3 4
  • Nucleoside Diphosphate-Linked Moiety X Motif 20 4
  • DCP2 Decapping Enzyme Homolog (S. Cerevisiae) 2
  • DCP2 Decapping Enzyme Homolog 3
  • M(7)GpppN-MRNA Hydrolase 2
  • Nudix Motif 20 4
  • EC 3.6.1.62 4
  • DCP2 5

External Ids for DCP2 Gene

Previous GeneCards Identifiers for DCP2 Gene

  • GC05P112759
  • GC05P112343
  • GC05P112388
  • GC05P112340
  • GC05P107492
  • GC05P112313

Summaries for DCP2 Gene

Entrez Gene Summary for DCP2 Gene

  • The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

GeneCards Summary for DCP2 Gene

DCP2 (Decapping MRNA 2) is a Protein Coding gene. Diseases associated with DCP2 include Cholestasis, Intrahepatic, Of Pregnancy 3 and Non-Syndromic X-Linked Intellectual Disability. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and PERK regulates gene expression. Gene Ontology (GO) annotations related to this gene include RNA binding and manganese ion binding.

UniProtKB/Swiss-Prot Summary for DCP2 Gene

  • Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).

Gene Wiki entry for DCP2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCP2 Gene

Genomics for DCP2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DCP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J112973 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 619.9 +0.2 224 7.4 SP1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 ZNF512 LEF1 IKZF1 DCP2 HSALNG0044193 LOC105379126 lnc-MCC-2 YTHDC2 MCC XBP1P1 NONHSAG041263.2 TSSK1B
GH05J113018 Enhancer 1.1 Ensembl ENCODE dbSUPER 25 +44.3 44298 7.6 GATAD2A RCOR2 STAT3 RXRB IRF2 GABPA CEBPA SOX13 TCF7 JUND MCC DCP2 piR-48976 piR-30442 TSSK1B
GH05J113513 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 +538.0 537999 3.4 CREB1 GATAD2A CTCF ATF7 TEAD4 PRDM10 ZNF629 ZNF692 POLR2A BACH1 YTHDC2 lnc-MCC-1 DCP2 piR-39891-060 KCNN2
GH05J113037 Enhancer 0.9 Ensembl ENCODE dbSUPER 20.3 +62.7 62735 2.9 IKZF1 CTCF CTBP1 ZNF316 MAFF MAFK MAFG POLR2A JUN ZBTB33 DCP2 ENSG00000232633 MCC piR-30442 piR-46256-043 TSSK1B
GH05J113058 Enhancer 1.2 Ensembl ENCODE CraniofacialAtlas dbSUPER 15.2 +84.7 84698 8.8 PRDM10 ZIC2 POLR2A ZNF600 ZBTB20 RAD21 ZNF184 JUND EGR1 RUNX3 DCP2 MCC SRP19 REEP5 piR-46256-043 piR-30442 TSSK1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCP2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCP2

Top Transcription factor binding sites by QIAGEN in the DCP2 gene promoter:
  • c-Myb
  • CBF(2)
  • CBF-A
  • CBF-C
  • CUTL1
  • GATA-1
  • MRF-2
  • POU3F2
  • TGIF

Genomic Locations for DCP2 Gene

Genomic Locations for DCP2 Gene
chr5:112,976,702-113,022,195
(GRCh38/hg38)
Size:
45,494 bases
Orientation:
Plus strand
chr5:112,312,399-112,357,892
(GRCh37/hg19)
Size:
45,494 bases
Orientation:
Plus strand

Genomic View for DCP2 Gene

Genes around DCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP2 Gene

Proteins for DCP2 Gene

  • Protein details for DCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IU60-DCP2_HUMAN
    Recommended name:
    m7GpppN-mRNA hydrolase
    Protein Accession:
    Q8IU60
    Secondary Accessions:
    • C9J778
    • Q6P2D4
    • Q7Z5W5
    • Q8NBG5

    Protein attributes for DCP2 Gene

    Size:
    420 amino acids
    Molecular mass:
    48423 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, UPF1, UPF2 and UPF3B (PubMed:12417715, PubMed:12515382, PubMed:14527413). Forms a complex with DCP1A, EDC3, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC4/HEDLS (PubMed:15231747, PubMed:15067023, PubMed:16364915). Interacts with DPC1B (PubMed:15231747). Interacts (via N-terminus and C-terminus) with TRIM21 (via N-terminus and C-terminus) (PubMed:18361920). Associates with polysomes (PubMed:12218187). Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046). Interacts with DDX17 in an RNA-dependent manner (PubMed:21876179). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599). Interacts with ZFP36L1 (via N-terminus) (PubMed:15687258). Interacts with NBDY (PubMed:27918561).

    Three dimensional structures from OCA and Proteopedia for DCP2 Gene

    Alternative splice isoforms for DCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP2 Gene

Post-translational modifications for DCP2 Gene

  • Phosphorylated at ser-249 in a MTOR-dependent manner (PubMed:26098573).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCP2 Gene

No data available for DME Specific Peptides for DCP2 Gene

Domains & Families for DCP2 Gene

Gene Families for DCP2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for DCP2 Gene

Suggested Antigen Peptide Sequences for DCP2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ52185, highly similar to mRNA decapping enzyme 2 (EC 3.-.-.-) (B7Z3U5_HUMAN)
  • Nucleoside diphosphate-linked moiety X motif 20 (DCP2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IU60

UniProtKB/Swiss-Prot:

DCP2_HUMAN :
  • Belongs to the Nudix hydrolase family. DCP2 subfamily.
Family:
  • Belongs to the Nudix hydrolase family. DCP2 subfamily.
genes like me logo Genes that share domains with DCP2: view

Function for DCP2 Gene

Molecular function for DCP2 Gene

UniProtKB/Swiss-Prot Function:
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968, PubMed:28002401). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968, PubMed:28002401). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping (PubMed:28002401). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + H2O = a 5'-end phospho-adenosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate; Xref=Rhea:RHEA:60868, Rhea:RHEA-COMP:15682, Rhea:RHEA-COMP:15686, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:143974, ChEBI:CHEBI:143978; EC=3.6.1.62; Evidence={ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:28002401};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + H2O = a 5'-end phospho-guanosine in mRNA + 2 H(+) + N(7)-methylguanosine 5'-diphosphate; Xref=Rhea:RHEA:60872, Rhea:RHEA-COMP:15683, Rhea:RHEA-COMP:15687, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:63714, ChEBI:CHEBI:143975, ChEBI:CHEBI:143979; EC=3.6.1.62; Evidence={ECO:0000269|PubMed:12486012, ECO:0000269|PubMed:12923261, ECO:0000269|PubMed:21070968, ECO:0000269|PubMed:28002401};.

Enzyme Numbers (IUBMB) for DCP2 Gene

Phenotypes From GWAS Catalog for DCP2 Gene

Gene Ontology (GO) - Molecular Function for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0004534 5'-3' exoribonuclease activity IMP 26950371
GO:0005515 protein binding IPI 12417715
GO:0016787 hydrolase activity IEA --
GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters TAS --
genes like me logo Genes that share ontologies with DCP2: view
genes like me logo Genes that share phenotypes with DCP2: view

Animal Models for DCP2 Gene

MGI Knock Outs for DCP2:
  • Dcp2 Dcp2<tm1b(KOMP)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for DCP2

CRISPR Products

miRNA for DCP2 Gene

miRTarBase miRNAs that target DCP2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCP2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCP2 Gene

Localization for DCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP2 Gene

Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB) (PubMed:15273322). A minor amount is nuclear (PubMed:15273322). {ECO:0000269 PubMed:15273322, ECO:0000269 PubMed:16364915, ECO:0000269 PubMed:20616046}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytoplasmic bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20616046
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCP2: view

Pathways & Interactions for DCP2 Gene

genes like me logo Genes that share pathways with DCP2: view

Gene Ontology (GO) - Biological Process for DCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA 21873635
GO:0006402 mRNA catabolic process IEA,IDA 21070968
GO:0032211 negative regulation of telomere maintenance via telomerase IMP 26950371
GO:0043488 regulation of mRNA stability IDA,TAS --
genes like me logo Genes that share ontologies with DCP2: view

No data available for SIGNOR curated interactions for DCP2 Gene

Drugs & Compounds for DCP2 Gene

(3) Drugs for DCP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 56
genes like me logo Genes that share compounds with DCP2: view

Transcripts for DCP2 Gene

mRNA/cDNA for DCP2 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCP2

Alternative Splicing Database (ASD) splice patterns (SP) for DCP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4:
SP5: - -
SP6: - -
SP7: - -

Relevant External Links for DCP2 Gene

GeneLoc Exon Structure for
DCP2

Expression for DCP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCP2 Gene

mRNA differential expression in normal tissues according to GTEx for DCP2 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for DCP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.2), Placenta (16.4), and Monocytes (14.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCP2 Gene



Protein tissue co-expression partners for DCP2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCP2

SOURCE GeneReport for Unigene cluster for DCP2 Gene:

Hs.443875

mRNA Expression by UniProt/SwissProt for DCP2 Gene:

Q8IU60-DCP2_HUMAN
Tissue specificity: Expressed in brain and testis. Not detected in heart (at protein level).

Evidence on tissue expression from TISSUES for DCP2 Gene

  • Blood(4.4)
  • Liver(4.3)
  • Nervous system(3.2)
  • Kidney(2.3)
  • Skin(2.2)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with DCP2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP2 Gene

Orthologs for DCP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCP2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DCP2 30 31
  • 98.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DCP2 30 31
  • 96.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia DCP2 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Dcp2 30 17 31
  • 89.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dcp2 30
  • 89.18 (n)
Oppossum
(Monodelphis domestica)
Mammalia DCP2 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia DCP2 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DCP2 30 31
  • 82.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DCP2 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dcp2 30
  • 71.3 (n)
Str.18589 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.8706 30
Zebrafish
(Danio rerio)
Actinopterygii dcp2 31 31
  • 71 (a)
OneToMany
LOC100534849 30
  • 69.06 (n)
zgc55938 30
Fruit Fly
(Drosophila melanogaster)
Insecta Dcp2 31
  • 17 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea dcap-2 31
  • 16 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCP2 31
  • 10 (a)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.9654 31
  • 49 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11885 30
Species where no ortholog for DCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for DCP2 Gene

ENSEMBL:
Gene Tree for DCP2 (if available)
TreeFam:
Gene Tree for DCP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCP2: view image

Paralogs for DCP2 Gene

No data available for Paralogs for DCP2 Gene

Variants for DCP2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCP2 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs33555 - p.Leu16Phe

Additional dbSNP identifiers (rs#s) for DCP2 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCP2 Gene

Variant ID Type Subtype PubMed ID
esv3890710 CNV gain 25118596
nsv1028759 CNV gain 25217958
nsv478144 CNV novel sequence insertion 20440878
nsv599394 CNV gain 21841781

Variation tolerance for DCP2 Gene

Residual Variation Intolerance Score: 17.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP2 Gene

Disorders for DCP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cholestasis, intrahepatic, of pregnancy 3
  • icp3
non-syndromic x-linked intellectual disability
  • non-specific x-linked mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search DCP2 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with DCP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCP2 Gene

Publications for DCP2 Gene

  1. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. (PMID: 16699599) Wichroski MJ … Rana TM (PLoS pathogens 2006) 3 4 23
  2. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J (Molecular and cellular biology 2002) 2 3 4
  3. The hDcp2 protein is a mammalian mRNA decapping enzyme. (PMID: 12218187) Wang Z … Kiledjian M (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 4
  4. Reversible methylation of m6Am in the 5' cap controls mRNA stability. (PMID: 28002401) Mauer J … Jaffrey SR (Nature 2017) 3 4
  5. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. (PMID: 26098573) Hu G … Williamson PR (Nature cell biology 2015) 3 4

Products for DCP2 Gene

Sources for DCP2 Gene