This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] See more...

Aliases for DCP1B Gene

Aliases for DCP1B Gene

  • Decapping MRNA 1B 2 3 5
  • MRNA-Decapping Enzyme 1B 3 4
  • DCP1 Decapping Enzyme Homolog B (S. Cerevisiae) 2
  • DCP1 Decapping Enzyme Homolog B 3
  • Decapping Enzyme HDcp1b 3
  • EC 3.-.-.- 4
  • DCP1 3

External Ids for DCP1B Gene

Previous GeneCards Identifiers for DCP1B Gene

  • GC12M001940
  • GC12M001925
  • GC12M002055

Summaries for DCP1B Gene

Entrez Gene Summary for DCP1B Gene

  • This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DCP1B Gene

DCP1B (Decapping MRNA 1B) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. Gene Ontology (GO) annotations related to this gene include hydrolase activity and enzyme regulator activity. An important paralog of this gene is DCP1A.

UniProtKB/Swiss-Prot Summary for DCP1B Gene

  • May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Gene Wiki entry for DCP1B Gene

Additional gene information for DCP1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCP1B Gene

Genomics for DCP1B Gene

GeneHancer (GH) Regulatory Elements for DCP1B Gene

Promoters and enhancers for DCP1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCP1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCP1B gene promoter:
  • C/EBPalpha
  • ITF-2
  • NF-1
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)
  • Tal-1beta
  • USF-1
  • USF1

Genomic Locations for DCP1B Gene

Genomic Locations for DCP1B Gene
chr12:1,946,048-2,004,535
(GRCh38/hg38)
Size:
58,488 bases
Orientation:
Minus strand
chr12:2,055,214-2,113,701
(GRCh37/hg19)
Size:
58,488 bases
Orientation:
Minus strand

Genomic View for DCP1B Gene

Genes around DCP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1B Gene

Proteins for DCP1B Gene

  • Protein details for DCP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD4-DCP1B_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1B
    Protein Accession:
    Q8IZD4
    Secondary Accessions:
    • B4DRD1
    • Q86XH9
    • Q96BP8
    • Q96MZ8

    Protein attributes for DCP1B Gene

    Size:
    617 amino acids
    Molecular mass:
    67723 Da
    Quaternary structure:
    • Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.
    SequenceCaution:
    • Sequence=AAH15368.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1B Gene

Post-translational modifications for DCP1B Gene

  • Ubiquitination at Lys12
  • Modification sites at PhosphoSitePlus

Other Protein References for DCP1B Gene

No data available for DME Specific Peptides for DCP1B Gene

Domains & Families for DCP1B Gene

Gene Families for DCP1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DCP1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCP1B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59742, highly similar to mRNA decapping enzyme 1B (EC 3.-.-.-) (B4DRD1_HUMAN)
  • cDNA FLJ57612, highly similar to mRNA decapping enzyme 1B (EC 3.-.-.-) (B4DVJ6_HUMAN)
  • mRNA-decapping enzyme 1B (DCP1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZD4

UniProtKB/Swiss-Prot:

DCP1B_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1B: view

Function for DCP1B Gene

Molecular function for DCP1B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Enzyme Numbers (IUBMB) for DCP1B Gene

Phenotypes From GWAS Catalog for DCP1B Gene

Gene Ontology (GO) - Molecular Function for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15231747
GO:0008047 enzyme activator activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with DCP1B: view
genes like me logo Genes that share phenotypes with DCP1B: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCP1B Gene

Localization for DCP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCP1B gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA 21873635
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DCP1B: view

Pathways & Interactions for DCP1B Gene

genes like me logo Genes that share pathways with DCP1B: view

Pathways by source for DCP1B Gene

1 KEGG pathway for DCP1B Gene
1 Cell Signaling Technology pathway for DCP1B Gene

Gene Ontology (GO) - Biological Process for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA,IEA 21873635
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA 21873635
GO:0043085 positive regulation of catalytic activity IEA --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
genes like me logo Genes that share ontologies with DCP1B: view

No data available for SIGNOR curated interactions for DCP1B Gene

Drugs & Compounds for DCP1B Gene

No Compound Related Data Available

Transcripts for DCP1B Gene

mRNA/cDNA for DCP1B Gene

2 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for DCP1B Gene

GeneLoc Exon Structure for
DCP1B

Expression for DCP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCP1B Gene

Protein differential expression in normal tissues from HIPED for DCP1B Gene

This gene is overexpressed in Testis (22.6), CD8 Tcells (8.5), and Prostate (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCP1B Gene



Protein tissue co-expression partners for DCP1B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCP1B

SOURCE GeneReport for Unigene cluster for DCP1B Gene:

Hs.130934

Evidence on tissue expression from TISSUES for DCP1B Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with DCP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP1B Gene

Orthologs for DCP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for DCP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1B 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCP1B 31 30
  • 87.67 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCP1B 31
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCP1B 31
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp1b 30
  • 76.93 (n)
mouse
(Mus musculus)
Mammalia Dcp1b 17 31 30
  • 76.2 (n)
cow
(Bos Taurus)
Mammalia DCP1B 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCP1B 31 30
  • 74.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCP1B 31
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1b 30
  • 63.59 (n)
zebrafish
(Danio rerio)
Actinopterygii dcp1b 31 30
  • 58.27 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dcp1 31
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcap-1 31
  • 25 (a)
OneToMany
Species where no ortholog for DCP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP1B Gene

ENSEMBL:
Gene Tree for DCP1B (if available)
TreeFam:
Gene Tree for DCP1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCP1B: view image

Paralogs for DCP1B Gene

Paralogs for DCP1B Gene

genes like me logo Genes that share paralogs with DCP1B: view

Variants for DCP1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCP1B Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
712109 Likely Benign: not provided 1,949,230(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
773020 Benign: not provided 1,953,038(-) C/G MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
776685 Benign: not provided 1,949,158(-) C/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
781059 Benign: not provided 1,952,789(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs12423058 - p.Asn195Asp

Additional dbSNP identifiers (rs#s) for DCP1B Gene

Structural Variations from Database of Genomic Variants (DGV) for DCP1B Gene

Variant ID Type Subtype PubMed ID
esv2661228 CNV deletion 23128226
esv3309070 CNV mobile element insertion 20981092
esv3404287 CNV insertion 20981092
esv3628298 CNV loss 21293372
nsv1038533 CNV gain 25217958
nsv1040370 CNV gain 25217958
nsv1042378 CNV gain 25217958
nsv474435 CNV novel sequence insertion 20440878
nsv521838 CNV gain 19592680
nsv525455 CNV loss 19592680
nsv574 CNV insertion 18451855

Variation tolerance for DCP1B Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCP1B Gene

Human Gene Mutation Database (HGMD)
DCP1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1B Gene

Disorders for DCP1B Gene

Additional Disease Information for DCP1B

No disorders were found for DCP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCP1B Gene

Publications for DCP1B Gene

  1. Cytoplasmic foci are sites of mRNA decay in human cells. (PMID: 15067023) Cougot N … Séraphin B (The Journal of cell biology 2004) 2 3 4 54
  2. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J (Molecular and cellular biology 2002) 2 3 4 54
  3. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PMID: 22142827) Innocenti F … Ratain MJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2012) 3 41 54
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for DCP1B Gene

Sources for DCP1B Gene