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Aliases for DCP1B Gene

Aliases for DCP1B Gene

  • Decapping MRNA 1B 2 3 5
  • DCP1 Decapping Enzyme Homolog B (S. Cerevisiae) 2
  • DCP1 Decapping Enzyme Homolog B 3
  • MRNA-Decapping Enzyme 1B 3
  • Decapping Enzyme HDcp1b 3
  • EC 3.-.-.- 4
  • DCP1 3

External Ids for DCP1B Gene

Previous GeneCards Identifiers for DCP1B Gene

  • GC12M001940
  • GC12M001925
  • GC12M002055

Summaries for DCP1B Gene

Entrez Gene Summary for DCP1B Gene

  • This gene encodes a member of a family of proteins that function in removing the 5' cap from mRNAs, which is a step in regulated mRNA decay. This protein localizes to cytoplasmic foci which are the site of mRNA breakdown and turnover. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for DCP1B Gene

DCP1B (Decapping MRNA 1B) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include hydrolase activity and enzyme regulator activity. An important paralog of this gene is DCP1A.

UniProtKB/Swiss-Prot for DCP1B Gene

  • May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Gene Wiki entry for DCP1B Gene

Additional gene information for DCP1B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1B Gene

Genomics for DCP1B Gene

GeneHancer (GH) Regulatory Elements for DCP1B Gene

Promoters and enhancers for DCP1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I002003 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 565.2 +0.3 278 2.1 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B DCP1B ENSG00000203593 ITFG2 CBX3P4 IQSEC3P1 NRIP2 GC12M001963 CACNA1C
GH12I002256 Enhancer 1.1 ENCODE dbSUPER 84.7 -252.2 -252163 1.6 ZNF133 GLI4 TCF12 ZNF121 ZNF302 ZNF416 ZNF202 YY2 ZNF488 ZFP41 ITFG2 TULP3 DCP1B CBX3P4 IQSEC3P1 RPS27P3 ITFG2-AS1 CACNA1C-AS4 NRIP2 LINC00942
GH12I001604 Enhancer 1.5 Ensembl ENCODE dbSUPER 47.6 +398.7 398745 2.8 MLX FEZF1 IRF4 YY1 ZNF416 ZNF143 ZNF548 ZNF263 ZNF610 NBN RAD52 DCP1B ENSG00000250132 WNT5B LINC00942 ERC1 FBXL14 MIR3649
GH12I002811 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.8 -808.6 -808602 3 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ITFG2 ENSG00000256150 DCP1B TULP3 NRIP2 CBX3P4 IQSEC3P1
GH12I001924 Enhancer 1.2 ENCODE dbSUPER 49.3 +79.7 79725 0.8 ZNF133 FEZF1 GLI4 ZNF121 ZNF213 ZNF302 ZNF416 ZNF548 YY2 ZNF662 ITFG2 TULP3 RAD52 DCP1B CBX3P4 ENSG00000250132 ITFG2-AS1 LRTM2 IQSEC3P1 ERC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCP1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCP1B gene promoter:

Genomic Locations for DCP1B Gene

Genomic Locations for DCP1B Gene
chr12:1,946,048-2,004,535
(GRCh38/hg38)
Size:
58,488 bases
Orientation:
Minus strand
chr12:2,055,214-2,113,701
(GRCh37/hg19)

Genomic View for DCP1B Gene

Genes around DCP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1B Gene

Proteins for DCP1B Gene

  • Protein details for DCP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZD4-DCP1B_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1B
    Protein Accession:
    Q8IZD4
    Secondary Accessions:
    • B4DRD1
    • Q86XH9
    • Q96BP8
    • Q96MZ8

    Protein attributes for DCP1B Gene

    Size:
    617 amino acids
    Molecular mass:
    67723 Da
    Quaternary structure:
    • Binds DCP1A. Part of a complex containing enzymes involved in mRNA decay, including DCP2, LSM1, LSM3 and CNOT6.
    SequenceCaution:
    • Sequence=AAH15368.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCP1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1B Gene

Post-translational modifications for DCP1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCP1B Gene

No data available for DME Specific Peptides for DCP1B Gene

Domains & Families for DCP1B Gene

Gene Families for DCP1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DCP1B Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZD4

UniProtKB/Swiss-Prot:

DCP1B_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1B: view

Function for DCP1B Gene

Molecular function for DCP1B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP (By similarity).

Enzyme Numbers (IUBMB) for DCP1B Gene

Phenotypes From GWAS Catalog for DCP1B Gene

Gene Ontology (GO) - Molecular Function for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 15231747
GO:0008047 enzyme activator activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0030234 enzyme regulator activity IBA --
genes like me logo Genes that share ontologies with DCP1B: view
genes like me logo Genes that share phenotypes with DCP1B: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCP1B Gene

Localization for DCP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCP1B gene
Compartment Confidence
cytosol 5
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS,IDA --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with DCP1B: view

Pathways & Interactions for DCP1B Gene

genes like me logo Genes that share pathways with DCP1B: view

Pathways by source for DCP1B Gene

1 KEGG pathway for DCP1B Gene
1 Cell Signaling Technology pathway for DCP1B Gene

Gene Ontology (GO) - Biological Process for DCP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA,IEA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay TAS --
genes like me logo Genes that share ontologies with DCP1B: view

No data available for SIGNOR curated interactions for DCP1B Gene

Drugs & Compounds for DCP1B Gene

No Compound Related Data Available

Transcripts for DCP1B Gene

Unigene Clusters for DCP1B Gene

DCP1 decapping enzyme homolog B (S. cerevisiae):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: -
SP6:

Relevant External Links for DCP1B Gene

GeneLoc Exon Structure for
DCP1B
ECgene alternative splicing isoforms for
DCP1B

Expression for DCP1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCP1B Gene

Protein differential expression in normal tissues from HIPED for DCP1B Gene

This gene is overexpressed in Testis (22.6), CD8 Tcells (8.5), and Prostate (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCP1B Gene



Protein tissue co-expression partners for DCP1B Gene

NURSA nuclear receptor signaling pathways regulating expression of DCP1B Gene:

DCP1B

SOURCE GeneReport for Unigene cluster for DCP1B Gene:

Hs.130934

Evidence on tissue expression from TISSUES for DCP1B Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with DCP1B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP1B Gene

Orthologs for DCP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for DCP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1B 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia DCP1B 33 34
  • 87.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCP1B 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCP1B 34
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcp1b 33
  • 76.93 (n)
mouse
(Mus musculus)
Mammalia Dcp1b 33 16 34
  • 76.2 (n)
cow
(Bos Taurus)
Mammalia DCP1B 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCP1B 33 34
  • 74.02 (n)
lizard
(Anolis carolinensis)
Reptilia DCP1B 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1b 33
  • 63.59 (n)
zebrafish
(Danio rerio)
Actinopterygii dcp1b 33 34
  • 58.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dcp1 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dcap-1 34
  • 25 (a)
OneToMany
Species where no ortholog for DCP1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCP1B Gene

ENSEMBL:
Gene Tree for DCP1B (if available)
TreeFam:
Gene Tree for DCP1B (if available)

Paralogs for DCP1B Gene

Paralogs for DCP1B Gene

genes like me logo Genes that share paralogs with DCP1B: view

Variants for DCP1B Gene

Sequence variations from dbSNP and Humsavar for DCP1B Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000064599 -- 1,997,433(-) T/G intron_variant
rs1000246888 -- 1,990,736(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000270285 -- 1,941,925(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000324735 -- 1,978,172(-) C/G/T genic_downstream_transcript_variant, intron_variant
rs1000338283 -- 2,005,880(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1B Gene

Variant ID Type Subtype PubMed ID
esv2661228 CNV deletion 23128226
esv3309070 CNV mobile element insertion 20981092
esv3404287 CNV insertion 20981092
esv3628298 CNV loss 21293372
nsv1038533 CNV gain 25217958
nsv1040370 CNV gain 25217958
nsv1042378 CNV gain 25217958
nsv474435 CNV novel sequence insertion 20440878
nsv521838 CNV gain 19592680
nsv525455 CNV loss 19592680
nsv574 CNV insertion 18451855

Variation tolerance for DCP1B Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.76; 57.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCP1B Gene

Human Gene Mutation Database (HGMD)
DCP1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP1B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1B Gene

Disorders for DCP1B Gene

Additional Disease Information for DCP1B

No disorders were found for DCP1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCP1B Gene

Publications for DCP1B Gene

  1. Cytoplasmic foci are sites of mRNA decay in human cells. (PMID: 15067023) Cougot N … Séraphin B (The Journal of cell biology 2004) 2 3 4 58
  2. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J (Molecular and cellular biology 2002) 2 3 4 58
  3. A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303. (PMID: 22142827) Innocenti F … Ratain MJ (Clinical cancer research : an official journal of the American Association for Cancer Research 2012) 3 44 58
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J … Comb MJ (Nature biotechnology 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for DCP1B Gene

Sources for DCP1B Gene

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