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Aliases for DCP1A Gene

Aliases for DCP1A Gene

  • Decapping MRNA 1A 2 3 5
  • Smad4-Interacting Transcriptional Co-Activator 3 4
  • Transcription Factor SMIF 3 4
  • SMIF 3 4
  • DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) 2
  • Putative Protein Product Of Nbla00360 3
  • DCP1 Decapping Enzyme-Like Protein A 3
  • DCP1 Decapping Enzyme Homolog A 3
  • MRNA-Decapping Enzyme 1A 3
  • Decapping Enzyme HDcp1a 3
  • EC 3.-.-.- 4
  • HSA275986 3
  • Nbla00360 3
  • SMAD4IP1 3

External Ids for DCP1A Gene

Previous GeneCards Identifiers for DCP1A Gene

  • GC03M053297
  • GC03M053319
  • GC03M053285
  • GC03M053288
  • GC03M053289
  • GC03M053290
  • GC03M053291
  • GC03M053294
  • GC03M053298

Summaries for DCP1A Gene

Entrez Gene Summary for DCP1A Gene

  • Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCP1A Gene

DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is DCP1B.

UniProtKB/Swiss-Prot for DCP1A Gene

  • Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Gene Wiki entry for DCP1A Gene

Additional gene information for DCP1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1A Gene

Genomics for DCP1A Gene

GeneHancer (GH) Regulatory Elements for DCP1A Gene

Promoters and enhancers for DCP1A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I053345 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 561.2 +0.3 302 2.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 DCP1A NISCH PBRM1 ENSG00000271976 RFT1 PHF7 ENSG00000212608 PRKCD NEK4 ACTR8
GH03I053233 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7 +108.2 108233 10.9 FOXA2 MLX ARID4B SIN3A GLI4 YY1 ZNF766 GLIS2 FOS RXRA PRKCD SNORD38C TKT DCP1A ITIH4 GNL3 STIMATE
GH03I053354 Enhancer 1.1 Ensembl ENCODE 10.1 -7.7 -7688 1.1 ATF1 ZNF133 TCF12 ZNF766 CAVIN1 ZNF592 MEF2D GMEB1 SMARCA4 NR2C1 PBRM1 SNORD38C ENSG00000212608 GLT8D1 GNL3 DCP1A RFT1 TKT LOC105377094 CACNA1D
GH03I053248 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.7 +94.9 94876 7.6 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TKT PRKCD DCP1A
GH03I053140 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +206.5 206526 1.4 HDGF ZSCAN26 ZSCAN4 ZNF133 MAX PAX8 SALL2 EBF1 ZFHX2 FOXK2 GLT8D1 RFT1 NISCH PRKCD ACTR8 NEK4 STIMATE ITIH4 DCP1A ITIH3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCP1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCP1A gene promoter:

Genomic Locations for DCP1A Gene

Genomic Locations for DCP1A Gene
chr3:53,283,423-53,347,627
(GRCh38/hg38)
Size:
64,205 bases
Orientation:
Minus strand
chr3:53,317,443-53,381,654
(GRCh37/hg19)

Genomic View for DCP1A Gene

Genes around DCP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1A Gene

Proteins for DCP1A Gene

  • Protein details for DCP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI6-DCP1A_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1A
    Protein Accession:
    Q9NPI6
    Secondary Accessions:
    • B4DHN9
    • U3KQM8

    Protein attributes for DCP1A Gene

    Size:
    582 amino acids
    Molecular mass:
    63309 Da
    Quaternary structure:
    • Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with NBDY (PubMed:27918561).

    Three dimensional structures from OCA and Proteopedia for DCP1A Gene

    Alternative splice isoforms for DCP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1A Gene

Post-translational modifications for DCP1A Gene

  • Ubiquitination at posLast=1717
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCP1A Gene

Domains & Families for DCP1A Gene

Gene Families for DCP1A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for DCP1A Gene

Suggested Antigen Peptide Sequences for DCP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPI6

UniProtKB/Swiss-Prot:

DCP1A_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1A: view

Function for DCP1A Gene

Molecular function for DCP1A Gene

UniProtKB/Swiss-Prot Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Enzyme Numbers (IUBMB) for DCP1A Gene

Phenotypes From GWAS Catalog for DCP1A Gene

Gene Ontology (GO) - Molecular Function for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 12417715
GO:0008047 enzyme activator activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with DCP1A: view
genes like me logo Genes that share phenotypes with DCP1A: view

Clone Products

  • Addgene plasmids for DCP1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCP1A Gene

Localization for DCP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1A Gene

Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250 UniProtKB:Q91YD3, ECO:0000269 PubMed:11836524, ECO:0000269 PubMed:16364915}.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IBA,ISS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 24965446
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with DCP1A: view

No data available for Subcellular locations from COMPARTMENTS for DCP1A Gene

Pathways & Interactions for DCP1A Gene

genes like me logo Genes that share pathways with DCP1A: view

Gene Ontology (GO) - Biological Process for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA,IBA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0043488 regulation of mRNA stability TAS --
genes like me logo Genes that share ontologies with DCP1A: view

No data available for SIGNOR curated interactions for DCP1A Gene

Drugs & Compounds for DCP1A Gene

No Compound Related Data Available

Transcripts for DCP1A Gene

Unigene Clusters for DCP1A Gene

DCP1 decapping enzyme homolog A (S. cerevisiae):
Representative Sequences:

Clone Products

  • Addgene plasmids for DCP1A

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A Gene

No ASD Table

Relevant External Links for DCP1A Gene

GeneLoc Exon Structure for
DCP1A
ECgene alternative splicing isoforms for
DCP1A

Expression for DCP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCP1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), CD8 Tcells (10.3), Lymph node (7.9), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCP1A Gene



Protein tissue co-expression partners for DCP1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCP1A Gene:

DCP1A

SOURCE GeneReport for Unigene cluster for DCP1A Gene:

Hs.476353

mRNA Expression by UniProt/SwissProt for DCP1A Gene:

Q9NPI6-DCP1A_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with DCP1A: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP1A Gene

Orthologs for DCP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1A 33
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia DCP1A 33
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia DCP1A 33
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Dcp1a 33 16
  • 88.41 (n)
rat
(Rattus norvegicus)
Mammalia Dcp1a 33
  • 87.64 (n)
chicken
(Gallus gallus)
Aves DCP1A 33
  • 68.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1a 33
  • 57.96 (n)
Str.19526 33
zebrafish
(Danio rerio)
Actinopterygii dcp1a 33
  • 61.44 (n)
mitc1 33
Species where no ortholog for DCP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCP1A Gene

ENSEMBL:
Gene Tree for DCP1A (if available)
TreeFam:
Gene Tree for DCP1A (if available)

Paralogs for DCP1A Gene

Paralogs for DCP1A Gene

(1) SIMAP similar genes for DCP1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCP1A: view

Variants for DCP1A Gene

Sequence variations from dbSNP and Humsavar for DCP1A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000001319 -- 53,296,170(-) C/T intron_variant
rs1000168137 -- 53,331,366(-) A/T intron_variant
rs1000266445 -- 53,317,139(-) A/G intron_variant
rs1000379307 -- 53,323,195(-) T/G intron_variant
rs1000385577 -- 53,322,997(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1A Gene

Variant ID Type Subtype PubMed ID
nsv3825 CNV insertion 18451855
nsv517233 CNV loss 19592680
nsv834699 CNV loss 17160897

Variation tolerance for DCP1A Gene

Gene Damage Index Score: 2.77; 47.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCP1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1A Gene

Disorders for DCP1A Gene

Additional Disease Information for DCP1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DCP1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCP1A Gene

Publications for DCP1A Gene

  1. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y … Gao G (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
  2. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PMID: 19150429) Cho H … Kim YK (Molecular cell 2009) 3 4 58
  3. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PMID: 18513389) Penco S … Grossi E (BMC bioinformatics 2008) 3 44 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. (PMID: 15687258) Lykke-Andersen J … Wagner E (Genes & development 2005) 3 4 58

Products for DCP1A Gene

  • Addgene plasmids for DCP1A

Sources for DCP1A Gene

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