Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathw... See more...

Aliases for DCP1A Gene

Aliases for DCP1A Gene

  • Decapping MRNA 1A 2 3 5
  • SMIF 2 3 4
  • Smad4-Interacting Transcriptional Co-Activator 3 4
  • Transcription Factor SMIF 3 4
  • MRNA-Decapping Enzyme 1A 3 4
  • HSA275986 2 3
  • SMAD4IP1 2 3
  • DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) 2
  • Putative Protein Product Of Nbla00360 3
  • DCP1 Decapping Enzyme-Like Protein A 3
  • DCP1 Decapping Enzyme Homolog A 3
  • Decapping Enzyme HDcp1a 3
  • EC 3.-.-.- 4
  • Nbla00360 3
  • DCP1A 5

External Ids for DCP1A Gene

Previous GeneCards Identifiers for DCP1A Gene

  • GC03M053297
  • GC03M053319
  • GC03M053285
  • GC03M053288
  • GC03M053302
  • GC03M053303
  • GC03M053304
  • GC03M053307
  • GC03M053289
  • GC03M053290
  • GC03M053291
  • GC03M053294
  • GC03M053298
  • GC03M053299
  • GC03M053300

Summaries for DCP1A Gene

Entrez Gene Summary for DCP1A Gene

  • Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCP1A Gene

DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Diseases associated with DCP1A include Noonan Syndrome 3. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Gene Expression. Gene Ontology (GO) annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is DCP1B.

UniProtKB/Swiss-Prot Summary for DCP1A Gene

  • Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Gene Wiki entry for DCP1A Gene

Additional gene information for DCP1A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCP1A Gene

Genomics for DCP1A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DCP1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCP1A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCP1A

Top Transcription factor binding sites by QIAGEN in the DCP1A gene promoter:
  • FOXD3
  • FOXO1
  • FOXO1a
  • GR
  • GR-alpha
  • p53
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c

Genomic Locations for DCP1A Gene

Genomic Locations for DCP1A Gene
chr3:53,283,429-53,347,586
(GRCh38/hg38)
Size:
64,158 bases
Orientation:
Minus strand
chr3:53,317,443-53,381,654
(GRCh37/hg19)
Size:
64,212 bases
Orientation:
Minus strand

Genomic View for DCP1A Gene

Genes around DCP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1A Gene

Proteins for DCP1A Gene

  • Protein details for DCP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI6-DCP1A_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1A
    Protein Accession:
    Q9NPI6
    Secondary Accessions:
    • B4DHN9
    • U3KQM8

    Protein attributes for DCP1A Gene

    Size:
    582 amino acids
    Molecular mass:
    63278 Da
    Quaternary structure:
    • Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with NBDY (PubMed:27918561).

    Three dimensional structures from OCA and Proteopedia for DCP1A Gene

    Alternative splice isoforms for DCP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1A Gene

Post-translational modifications for DCP1A Gene

  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCP1A Gene

Domains & Families for DCP1A Gene

Gene Families for DCP1A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Protein Domains for DCP1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCP1A Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor SMIF (DCP1A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPI6

UniProtKB/Swiss-Prot:

DCP1A_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1A: view

Function for DCP1A Gene

Molecular function for DCP1A Gene

UniProtKB/Swiss-Prot Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Enzyme Numbers (IUBMB) for DCP1A Gene

Phenotypes From GWAS Catalog for DCP1A Gene

Gene Ontology (GO) - Molecular Function for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA 21873635
GO:0005515 protein binding IPI 12417715
GO:0008047 enzyme activator activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with DCP1A: view
genes like me logo Genes that share phenotypes with DCP1A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCP1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCP1A Gene

Localization for DCP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1A Gene

Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250 UniProtKB:Q91YD3, ECO:0000269 PubMed:11836524, ECO:0000269 PubMed:16364915}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCP1A gene
Compartment Confidence
nucleus 4
cytosol 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 24965446
GO:0005829 cytosol TAS --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DCP1A: view

Pathways & Interactions for DCP1A Gene

genes like me logo Genes that share pathways with DCP1A: view

Gene Ontology (GO) - Biological Process for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IEA,IBA 21873635
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA 21873635
GO:0043085 positive regulation of catalytic activity IEA --
GO:0043488 regulation of mRNA stability TAS --
genes like me logo Genes that share ontologies with DCP1A: view

No data available for SIGNOR curated interactions for DCP1A Gene

Drugs & Compounds for DCP1A Gene

No Compound Related Data Available

Transcripts for DCP1A Gene

mRNA/cDNA for DCP1A Gene

5 REFSEQ mRNAs :
23 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCP1A

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A Gene

No ASD Table

Relevant External Links for DCP1A Gene

GeneLoc Exon Structure for
DCP1A

Expression for DCP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCP1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), CD8 Tcells (10.3), Lymph node (7.9), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCP1A Gene



Protein tissue co-expression partners for DCP1A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCP1A

SOURCE GeneReport for Unigene cluster for DCP1A Gene:

Hs.476353

mRNA Expression by UniProt/SwissProt for DCP1A Gene:

Q9NPI6-DCP1A_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.

Evidence on tissue expression from TISSUES for DCP1A Gene

  • Nervous system(4.3)
  • Muscle(4.2)
  • Liver(4.2)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with DCP1A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP1A Gene

Orthologs for DCP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCP1A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DCP1A 30
  • 99.66 (n)
Dog
(Canis familiaris)
Mammalia DCP1A 30
  • 90.17 (n)
Cow
(Bos Taurus)
Mammalia DCP1A 30
  • 90.16 (n)
Mouse
(Mus musculus)
Mammalia Dcp1a 30 17
  • 88.41 (n)
Rat
(Rattus norvegicus)
Mammalia Dcp1a 30
  • 87.64 (n)
Chicken
(Gallus gallus)
Aves DCP1A 30
  • 68.07 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dcp1a 30
  • 57.96 (n)
Str.19526 30
Zebrafish
(Danio rerio)
Actinopterygii dcp1a 30
  • 61.44 (n)
mitc1 30
Species where no ortholog for DCP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DCP1A Gene

ENSEMBL:
Gene Tree for DCP1A (if available)
TreeFam:
Gene Tree for DCP1A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCP1A: view image

Paralogs for DCP1A Gene

Paralogs for DCP1A Gene

(1) SIMAP similar genes for DCP1A Gene using alignment to 4 proteins:

  • DCP1A_HUMAN
  • U3KQI9_HUMAN
  • U3KQM8_HUMAN
  • U3KQU1_HUMAN
genes like me logo Genes that share paralogs with DCP1A: view

Variants for DCP1A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCP1A Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
770142 Benign: not provided 53,292,112(-) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for DCP1A Gene

Structural Variations from Database of Genomic Variants (DGV) for DCP1A Gene

Variant ID Type Subtype PubMed ID
nsv3825 CNV insertion 18451855
nsv517233 CNV loss 19592680
nsv834699 CNV loss 17160897

Variation tolerance for DCP1A Gene

Gene Damage Index Score: 2.77; 47.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCP1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP1A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1A Gene

Disorders for DCP1A Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCP1A Gene - From: DISEASES

Disorder Aliases PubMed IDs
noonan syndrome 3
  • ns3
- elite association - COSMIC cancer census association via MalaCards
Search DCP1A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCP1A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with DCP1A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCP1A Gene

Publications for DCP1A Gene

  1. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y … Gao G (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4
  2. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PMID: 19150429) Cho H … Kim YK (Molecular cell 2009) 3 4
  3. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PMID: 18513389) Penco S … Grossi E (BMC bioinformatics 2008) 3 41
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PMID: 16364915) Fenger-Grøn M … Lykke-Andersen J (Molecular cell 2005) 3 4

Products for DCP1A Gene

Sources for DCP1A Gene