Aliases for DCP1A Gene
External Ids for DCP1A Gene
Previous GeneCards Identifiers for DCP1A Gene
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for DCP1A Gene
DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Diseases associated with DCP1A include Metaphyseal Chondrodysplasia, Schmid Type and Noonan Syndrome 3. Among its related pathways are Deadenylation-dependent mRNA decay and Viral mRNA Translation. Gene Ontology (GO) annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is DCP1B.
UniProtKB/Swiss-Prot Summary for DCP1A Gene
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.