DCN Gene (Protein Coding)

Decorin

GC12M091140
GIFtS:
48
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediat... See more...

Aliases for DCN Gene

Aliases for DCN Gene

  • Decorin 2 3 4 5
  • Bone Proteoglycan II 3 4
  • SLRR1B 3 4
  • PG40 3 4
  • Dermatan Sulphate Proteoglycans II 3
  • Small Leucine-Rich Protein 1B 3
  • Proteoglycan Core Protein 3
  • Decorin Proteoglycan 2
  • DSPG2 3
  • PG-S2 4
  • CSCD 3
  • PGII 3
  • PGS2 3

External Ids for DCN Gene

Previous GeneCards Identifiers for DCN Gene

  • GC12M090861
  • GC12M091986
  • GC12M091472
  • GC12M090041
  • GC12M088606

Summaries for DCN Gene

Entrez Gene Summary for DCN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for DCN Gene

DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Corneal Dystrophy. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is BGN.

UniProtKB/Swiss-Prot Summary for DCN Gene

Gene Wiki entry for DCN Gene

Additional gene information for DCN Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCN Gene

Genomics for DCN Gene

GeneHancer (GH) Regulatory Elements for DCN Gene

Promoters and enhancers for DCN Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J091175 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +3.2 3170 9.7 CTCF RAD21 PRDM1 POLR2A ZNF512 ZSCAN4 CEBPB ZNF316 SMC3 NR2F2 DCN lnc-LUM-1 KERA LUM ENSG00000258100
GH12J091137 Enhancer 1.2 VISTA Ensembl ENCODE dbSUPER 11.3 +42.1 42128 6.6 ZNF384 POLR2A CEBPB JUN EP300 FOS STAT3 RCOR1 FEZF1 LUM DCN KERA ENSG00000258100 lnc-LUM-1
GH12J091357 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 10.2 -174.6 -174560 1.1 NFYC ELF3 SP1 PKNOX1 CTBP1 POLR2A ZNF217 GATA3 ELF1 JUND LUM DCN LOC105369898 LINC02823 ENSG00000258100
GH12J091272 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 10.3 -90.7 -90709 4.7 RFX1 RXRA POLR2A NR2F2 RAD21 DCN ENSG00000258100 HSALNG0093012 LINC02823 LOC105369898
GH12J091249 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 10.3 -67.1 -67064 2.2 MAFK ZNF316 CEBPG EMSY DCN HSALNG0093012 LINC02823 LOC105369898
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCN gene promoter:
  • AP-1

Genomic Locations for DCN Gene

Genomic Locations for DCN Gene
chr12:91,140,484-91,183,029
(GRCh38/hg38)
Size:
42,546 bases
Orientation:
Minus strand
chr12:91,539,025-91,576,900
(GRCh37/hg19)
Size:
37,876 bases
Orientation:
Minus strand

Genomic View for DCN Gene

Genes around DCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCN Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DCN Gene

Proteins for DCN Gene

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  • Protein details for DCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07585-PGS2_HUMAN
    Recommended name:
    Decorin
    Protein Accession:
    P07585
    Secondary Accessions:
    • Q9P0Z0
    • Q9P0Z1
    • Q9Y5N8
    • Q9Y5N9

    Protein attributes for DCN Gene

    Size:
    359 amino acids
    Molecular mass:
    39747 Da
    Quaternary structure:
    • Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

    Alternative splice isoforms for DCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCN Gene

Protein Expression for DCN Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DCN Gene

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
  • Glycosylation at Ser34, Asn211, Asn262, and Asn303
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for DCN Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DCN Gene

Domains & Families for DCN Gene

Gene Families for DCN Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for DCN Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCN Gene

GenScript: Design optimal peptide antigens:
  • PG40 (PGS2_HUMAN)
  • cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA (Q6FH10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P07585

UniProtKB/Swiss-Prot:

PGS2_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
genes like me logo Genes that share domains with DCN: view

Function for DCN Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  6. Cell Line

Molecular function for DCN Gene

UniProtKB/Swiss-Prot Function:
May affect the rate of fibrils formation.
GENATLAS Biochemistry:
decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells

Phenotypes From GWAS Catalog for DCN Gene

Gene Ontology (GO) - Molecular Function for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 1747115
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0030021 extracellular matrix structural constituent conferring compression resistance RCA 20551380
genes like me logo Genes that share ontologies with DCN: view
genes like me logo Genes that share phenotypes with DCN: view

Human Phenotype Ontology for DCN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DCN Gene

MGI Knock Outs for DCN:
  • Dcn Dcn<tm1Ioz>
  • Dcn Dcn<tm1.2Geno>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DCN Gene

Localization for DCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCN gene
Compartment Confidence
extracellular 4
lysosome 4
golgi apparatus 4
plasma membrane 1
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS,HDA --
GO:0005589 collagen type VI trimer IEA --
GO:0005615 extracellular space HDA 20551380
GO:0005796 Golgi lumen TAS --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with DCN: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCN Gene

Pathways & Interactions for DCN Gene

genes like me logo Genes that share pathways with DCN: view

SIGNOR curated interactions for DCN Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001890 placenta development IEA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007568 aging IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with DCN: view

Drugs & Compounds for DCN Gene

Products:

  1. Drug

(31) Drugs for DCN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tromethamine Approved Pharma Target 0

(40) Additional Compounds for DCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCN: view

Transcripts for DCN Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
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mRNA/cDNA for DCN Gene

(6) REFSEQ mRNAs :
(26) Additional mRNA sequences :
(2381) Selected AceView cDNA sequences:
(20) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: -
SP17: - -

ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCN Gene

GeneLoc Exon Structure for
DCN
ECgene alternative splicing isoforms for
DCN

Expression for DCN Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCN Gene

mRNA expression in normal human tissues for DCN Gene
mRNA expression by GTEx for DCN GenemRNA expression by BioGPS for DCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCN Gene

This gene is overexpressed in Urinary Bladder (8.0) and Nasopharynx (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCN Gene



Protein tissue co-expression partners for DCN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCN Gene:

DCN

SOURCE GeneReport for Unigene cluster for DCN Gene:

Hs.156316

Evidence on tissue expression from TISSUES for DCN Gene

  • Lung(4.9)
  • Bone(4.8)
  • Eye(4.8)
  • Liver(4.8)
  • Nervous system(4.7)
  • Heart(4.6)
  • Muscle(4.4)
  • Intestine(4.2)
  • Pancreas(4.1)
  • Skin(4)
  • Stomach(3.7)
  • Kidney(3.4)
  • Gall bladder(2.9)
  • Adrenal gland(2.8)
  • Lymph node(2.2)
  • Blood(2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DCN Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with DCN: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCN Gene

Orthologs for DCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DCN 33 32
  • 99.81 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia DCN 33 32
  • 90.41 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia DCN 33 32
  • 88.83 (n)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DCN 33
  • 86 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia DCN 33
  • 84 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Dcn 17 33 32
  • 80.7 (n)
rat
(Rattus norvegicus)
 Mammalia Dcn 32
  • 78.91 (n)
chicken
(Gallus gallus)
 Aves DCN 33 32
  • 75.35 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia DCN 33
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dcn 32
  • 70.76 (n)
Str.8982 32
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24505 32
zebrafish
(Danio rerio)
 Actinopterygii dcn 33 32
  • 66.85 (n)
 OneToOne
-- 32
Species where no ortholog for DCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCN Gene

ENSEMBL:
Gene Tree for DCN (if available)
TreeFam:
Gene Tree for DCN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCN: view image

Paralogs for DCN Gene

Paralogs for DCN Gene

(22) SIMAP similar genes for DCN Gene using alignment to 12 proteins:

  • PGS2_HUMAN
  • F8VNV6_HUMAN
  • F8VNW0_HUMAN
  • F8VSI3_HUMAN
  • F8VU58_HUMAN
  • F8VUF6_HUMAN
  • F8VWU0_HUMAN
  • F8VX58_HUMAN
  • F8VXZ8_HUMAN
  • H0YI87_HUMAN
  • H0YIH3_HUMAN
  • Q6FH10_HUMAN
genes like me logo Genes that share paralogs with DCN: view

Variants for DCN Gene

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Sequence variations from dbSNP and Humsavar for DCN Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs141738168 likely-benign, Congenital Stromal Corneal Dystrophy 91,178,520(-) T/C coding_sequence_variant, synonymous_variant
rs142752401 benign, Congenital Stromal Corneal Dystrophy 91,158,410(-) T/C coding_sequence_variant, intron_variant, missense_variant
rs144307891 likely-benign, Congenital Stromal Corneal Dystrophy 91,151,660(-) G/A coding_sequence_variant, intron_variant, synonymous_variant
rs145597441 likely-benign, Congenital Stromal Corneal Dystrophy 91,178,499(-) C/A/T coding_sequence_variant, synonymous_variant
rs147956869 likely-benign, Congenital Stromal Corneal Dystrophy 91,182,946(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCN Gene

Variant ID Type Subtype PubMed ID
dgv210n27 CNV loss 19166990
dgv2784n54 CNV loss 21841781
nsv559751 CNV loss 21841781
nsv559754 CNV loss 21841781
nsv832484 CNV gain+loss 17160897

Variation tolerance for DCN Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCN Gene

Human Gene Mutation Database (HGMD)
DCN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCN Gene

Disorders for DCN Gene

MalaCards: The human disease database

(26) MalaCards diseases for DCN Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, congenital stromal
  • cscd
stromal corneal dystrophy
  • stromal dystrophies corneal
stromal dystrophy
interstitial keratitis
localized scleroderma
  • circumscribed scleroderma
- elite association - COSMIC cancer census association via MalaCards
Search DCN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGS2_HUMAN
  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. {ECO:0000269 PubMed:15671264}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for DCN

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCN: view

No data available for Genatlas for DCN Gene

Publications for DCN Gene

  1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson KG … Iozzo RV (Genomics 1993) 2 3 4 23 56
  2. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PMID: 16902402) Wang IJ … Lin LL (Molecular vision 2006) 3 23 43 56
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 43 56
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 43 56

ExternalLinks

View latest publications for DCN gene in Mastermind

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