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This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediat... See more...
Aliases for DCN Gene
Aliases for DCN Gene
External Ids for DCN Gene
- HGNC: 2705
- NCBI Entrez Gene: 1634
- Ensembl: ENSG00000011465
- OMIM®: 125255
- UniProtKB/Swiss-Prot: P07585
Previous GeneCards Identifiers for DCN Gene
- GC12M090861
- GC12M091986
- GC12M091472
- GC12M090041
- GC12M088606
Summaries for DCN Gene
-
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
GeneCards Summary for DCN Gene
DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Corneal Dystrophy. Among its related pathways are Proteoglycans in cancer and Chondroitin sulfate/dermatan sulfate metabolism. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is BGN.
UniProtKB/Swiss-Prot Summary for DCN Gene
-
May affect the rate of fibrils formation.
Additional gene information for DCN Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCN Gene
Genomics for DCN Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for DCN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around DCN on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCN
- Top Transcription factor binding sites by QIAGEN in the DCN gene promoter:
-
- AP-1
Genomic Locations for DCN Gene
Latest Assembly
- chr12:91,140,484-91,183,217
- (GRCh38/hg38)
- Size:
- 42,734 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:91,534,261-91,576,594
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 42,334 bases
- Orientation:
- Minus strand
Genomic View for DCN Gene
Genes around DCN on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q21.33 by HGNC
- 12q21.33 by Entrez Gene
- 12q21.33 by Ensembl
DCN Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DCN Gene
Proteins for DCN Gene
-
Protein details for DCN Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P07585-PGS2_HUMAN
- Recommended name:
- Decorin
- Protein Accession:
- P07585
- Q9P0Z0
- Q9P0Z1
- Q9Y5N8
- Q9Y5N9
Protein attributes for DCN Gene
- Size:
- 359 amino acids
- Molecular mass:
- 39747 Da
- Quaternary structure:
-
- Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).
Protein Expression for DCN Gene
Post-translational modifications for DCN Gene
Other Protein References for DCN Gene
- ENSEMBL proteins:
-
- ENSP00000052754
- ENSP00000401021
- ENSP00000376862
- ENSP00000448853
- ENSP00000447654
- ENSP00000413723
- ENSP00000399815
- ENSP00000447674
- ENSP00000446530
- ENSP00000398514
- ENSP00000449408
- ENSP00000449782
- ENSP00000447886
- ENSP00000449014
- ENSP00000449438
- ENSP00000446527
- ENSP00000448857
- ENSP00000448057
- ENSP00000448274
- P07585.220
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences DCN / Decorin Antibody (LS-B33) and DCN / Decorin Antibody (LS-B8177)
- G Biosciences Immunotag™ DCN Antibody
- NSJ Bioreagents Decorin Antibody
-
Custom Antibody ServicesOriGene Antibodies for DCN
- Novus Biologicals Antibodies for DCN
-
Abcam antibodies for DCN
- Invitrogen Antibodies for DCN (AFLGC-DCN)
- antibodies-online: Show 54 available Decorin Antibodies ranked by validation data
- Compare Top Decorin Antibodies
-
Recommended
- 137 WB Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 33 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 42 WB Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
-
Custom Antibody ServicesProSci Antibodies for DCN
-
Santa Cruz Biotechnology (SCBT) Antibodies for DCN
- Sino Biological Antibodies for DCN
Protein products for research
- G Biosciences Human Decorin, Lyophilized (BAN1995) and Human Decorin, Lyophilized (BAN1992)
- Search Origene for MassSpec and Protein Over-expression Lysates for DCN
- Origene Custom Protein Services for DCN
- Sino Biological Recombinant Proteins for DCN
- Sino Biological Cell Lysates for DCN
- ProSpec Recombinant Proteins for DCN
-
ProSci Proteins for DCN
-
Abcam proteins for DCN
Assay products for research
- G Biosciences Immunotag™ Human DCN (Decorin) ELISA and Immunotag™ Decorin ELISA Kit
- RayBiotech Human Decorin ELISA
- antibodies-online: Show 97 available Decorin Elisa Kits ranked by validation data
- Compare Top Decorin Elisa Kits
-
Quality Products:
- ABIN6574301
- ABIN1114582
- ABIN625287
- ABIN415277
- ABIN856908
- ABIN1672790
- ABIN3032910
- ABIN1569359
- ABIN5520388
- ABIN2708192
- ABIN1114581
- ABIN1672791
- ABIN4993047
- ABIN625382
- ABIN5520389
- ABIN2708496
- ABIN6720190
- ABIN2684032
- ABIN5669771
- ABIN858169
- ABIN1114583
- ABIN5563450
- ABIN2748038
- ABIN5520390
- ABIN5670437
- ABIN626930
- ABIN6384462
- ABIN2946943
- ABIN6203708
- ABIN5072884
- ABIN858173
- ABIN5591958
- ABIN990903
- ABIN6384455
- ABIN6384463
- ABIN4881435
- ABIN1129286
-
Abcam assays for DCN
No data available for DME Specific Peptides for DCN Gene
Domains & Families for DCN Gene
Gene Families for DCN Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for DCN Gene
- InterPro:
- Blocks:
-
- Cysteine-rich flanking region, N-terminal
- Leucine-rich repeat signature
Suggested Antigen Peptide Sequences for DCN Gene
- GenScript: Design optimal peptide antigens:
-
- PG40 (PGS2_HUMAN)
- cDNA FLJ75936, highly similar to Homo sapiens decorin (DCN), transcript variant A1, mRNA (Q6FH10_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P07585UniProtKB/Swiss-Prot:
PGS2_HUMAN :- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
- Family:
-
- Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Function for DCN Gene
Molecular function for DCN Gene
- UniProtKB/Swiss-Prot Function:
- May affect the rate of fibrils formation.
- GENATLAS Biochemistry:
- decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells
Phenotypes From GWAS Catalog for DCN Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0005515 | protein binding | IEA,IPI | 1747115 |
| GO:0005518 | collagen binding | IEA | -- |
| GO:0005539 | glycosaminoglycan binding | IEA | -- |
| GO:0030021 | extracellular matrix structural constituent conferring compression resistance | IEA,RCA | 20551380 |
Phenotypes for DCN Gene
- MGI mutant phenotypes for DCN:
-
inferred from 3 alleles
- normal phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cellular phenotype
- behavior/neurological phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- integument phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for DCN:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DCN - Starting at $85 >
- * DCN CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DCN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCN
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCN
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCN
- Browse OriGene Inhibitory RNA Products For DCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCN
Clone products for research
- Applied Biological Materials (abm): Clones for DCN - Starting at $45 >
- * DCN as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223964
- MG224378
- MR223964
- MR223964L3
- MR223964L4
- MR224378
- MR224378L3
- MR224378L4
- RC202753
- RC202753L1
- RC202753L2
- RC202753L3
- RC202753L4
- RC212053
- RC212053L3
- RC212053L4
- RC212223
- RC212223L3
- RC212223L4
- RC218371
- RC218371L3
- RC218371L4
- RC218427
- RC218427L3
- RC218427L4
- RC218479
- RC218479L3
- RC218479L4
- RG202753
- RG212053
- RG212223
- RG218371
- RG218427
- RG218479
- RR208005
- RR208005L3
- RR208005L4
- MR223964L3V
- MR223964L4V
- MR224378L3V
- MR224378L4V
- RC202753L1V
- RC202753L2V
- RC202753L3V
- RC202753L4V
- RC212053L3V
- RC212053L4V
- RC212223L3V
- RC212223L4V
- RC218371L3V
- RC218371L4V
- RC218427L3V
- RC218427L4V
- RC218479L3V
- RC218479L4V
- RR208005L3V
- RR208005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DCN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCN
Cell Lines for research
-
Horizon Cell Lines for DCN
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DCN Gene
Localization for DCN Gene
Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene
- Secreted, extracellular space, extracellular matrix.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| lysosome | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA,TAS | -- |
| GO:0005589 | collagen type VI trimer | IEA | -- |
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005796 | Golgi lumen | TAS | -- |
| GO:0031012 | extracellular matrix | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCN Gene
Pathways & Interactions for DCN Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
| 2 | Glycosaminoglycan metabolism | ||
| 3 | Degradation of the extracellular matrix | ||
| 4 | Proteoglycans in cancer | ||
| 5 | TGF-beta signaling pathway (KEGG) | ||
Pathways by source for DCN Gene
2 BioSystems pathways for DCN Gene
21 Reactome pathways for DCN Gene
2 KEGG pathways for DCN Gene
2 R&D Systems pathways for DCN Gene
1 GeneTex pathway for DCN Gene
Interacting Proteins for DCN Gene
Selected Interacting proteins:
P07585-PGS2_HUMAN
ENSP00000052754
for DCN Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for DCN
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001822 | kidney development | IEA | -- |
| GO:0001890 | placenta development | IEA | -- |
| GO:0007519 | skeletal muscle tissue development | IEA | -- |
| GO:0007568 | aging | IEA | -- |
| GO:0009612 | response to mechanical stimulus | IEA | -- |
Drugs & Compounds for DCN Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug products for research
- G Biosciences Human Decorin, Lyophilized (BAN1995) and Human Decorin, Lyophilized (BAN1992)
Transcripts for DCN Gene
mRNA/cDNA for DCN Gene
- 6 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000052754 6850 nts (view in UCSC)
- ENST00000393155 2344 nts (view in UCSC)
- ENST00000420120 753 nts (view in UCSC)
- ENST00000425043 1438 nts (view in UCSC)
- ENST00000441303 519 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for DCN - Starting at $85 >
- * DCN CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for DCN
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCN
-
Santa Cruz Biotechnology (SCBT) CRISPR for DCN
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCN
- Browse OriGene Inhibitory RNA Products For DCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCN
Clone products for research
- Applied Biological Materials (abm): Clones for DCN - Starting at $45 >
- * DCN as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG223964
- MG224378
- MR223964
- MR223964L3
- MR223964L4
- MR224378
- MR224378L3
- MR224378L4
- RC202753
- RC202753L1
- RC202753L2
- RC202753L3
- RC202753L4
- RC212053
- RC212053L3
- RC212053L4
- RC212223
- RC212223L3
- RC212223L4
- RC218371
- RC218371L3
- RC218371L4
- RC218427
- RC218427L3
- RC218427L4
- RC218479
- RC218479L3
- RC218479L4
- RG202753
- RG212053
- RG212223
- RG218371
- RG218427
- RG218479
- RR208005
- RR208005L3
- RR208005L4
- MR223964L3V
- MR223964L4V
- MR224378L3V
- MR224378L4V
- RC202753L1V
- RC202753L2V
- RC202753L3V
- RC202753L4V
- RC212053L3V
- RC212053L4V
- RC212223L3V
- RC212223L4V
- RC218371L3V
- RC218371L4V
- RC218427L3V
- RC218427L4V
- RC218479L3V
- RC218479L4V
- RR208005L3V
- RR208005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for DCN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCN
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - |
| ExUns: | 12d | · | 12e | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||
| SP10: | |||||||||||||||||||||||||||
| SP11: | |||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | - | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||
| SP17: |
Relevant External Links for DCN Gene
- GeneLoc Exon Structure for
- DCN
Expression for DCN Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Endochondral Osteoblasts Rostral Endochondral Facial Bones
- Endochondral Osteoblasts Caudal Facial Endochondral Bones
- Endochondral Osteoblasts Endochondral Facial Bones
- HyStem+TGFbeta3+GDF5-induced 4D20.8 cells(Sternberg H et. al. 2012)
- HyStem+BMP4-induced SM30 cells
-
Tendon & Ligament (Muscoskeletal System)
- Tenocytes Limb Tendons and Ligaments
- Early Tenocyte Cells Axial Tendon Primordia
- Tenocytes Axial Tendons and Ligamnets
- Early Tenocyte Cells Limb Tendon Primordia
- Cartilage (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
- Adipose (Muscoskeletal System)
This gene is overexpressed in Urinary Bladder (8.0) and Nasopharynx (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCN Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCN
SOURCE GeneReport for Unigene cluster for DCN Gene:
Hs.156316Evidence on tissue expression from TISSUES for DCN Gene
- Lung(4.9)
- Eye(4.8)
- Liver(4.8)
- Bone(4.8)
- Nervous system(4.8)
- Heart(4.7)
- Muscle(4.4)
- Intestine(4.4)
- Pancreas(4.3)
- Skin(4)
- Stomach(3.9)
- Kidney(3.6)
- Adrenal gland(3.1)
- Gall bladder(2.9)
- Lymph node(2.8)
- Thyroid gland(2.7)
- Blood(2.5)
- Spleen(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for DCN Gene
Germ Layers:
- ectoderm
Systems:
- nervous
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- head
General:
- peripheral nervous system
Primer products for research
-
OriGene qPCR primer pairs for DCN
-
OriGene qPCR primer pairs and template standards for DCN
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCN Gene
Orthologs for DCN Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | DCN 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | DCN 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | DCN 29 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | DCN 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | DCN 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Dcn 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Dcn 29 |
|
||
| Chicken (Gallus gallus) |
Aves | DCN 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | DCN 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | dcn 29 |
|
||
| Str.8982 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.24505 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | dcn 29 30 |
|
OneToOne | |
| -- 29 |
|
- Species where no ortholog for DCN was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for DCN Gene
- ENSEMBL:
- Gene Tree for DCN (if available)
- TreeFam:
- Gene Tree for DCN (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for DCN: view image
- Alliance of Genome Resources:
- Additional Orthologs for DCN
Paralogs for DCN Gene
Paralogs for DCN Gene
(22) SIMAP similar genes for DCN Gene using alignment to 12 proteins:
- PGS2_HUMAN
- F8VNV6_HUMAN
- F8VNW0_HUMAN
- F8VSI3_HUMAN
- F8VU58_HUMAN
- F8VUF6_HUMAN
- F8VWU0_HUMAN
- F8VX58_HUMAN
- F8VXZ8_HUMAN
- H0YI87_HUMAN
- H0YIH3_HUMAN
- Q6FH10_HUMAN
Variants for DCN Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCN Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 881297 | Benign: Congenital stromal corneal dystrophy | 91,153,171(-) |
G/A NM_001920.5(DCN):c.671C>T (p.Thr224Met) |
MISSENSE_VARIANT,INTRON | |
| 881298 | Uncertain Significance: Congenital stromal corneal dystrophy | 91,157,095(-) |
T/C NM_001920.5(DCN):c.632A>G (p.Asn211Ser) |
MISSENSE_VARIANT,INTRON | |
| 881299 | Uncertain Significance: Congenital stromal corneal dystrophy | 91,157,167(-) |
T/C NM_001920.5(DCN):c.560A>G (p.Lys187Arg) |
MISSENSE_VARIANT,INTRON | |
| 881300 | Likely Benign: Congenital stromal corneal dystrophy | 91,157,172(-) |
C/A NM_001920.5(DCN):c.555G>T (p.Pro185=) |
SYNONYMOUS_VARIANT,INTRON | |
| 881702 | Uncertain Significance: Congenital stromal corneal dystrophy | 91,145,492(-) |
A/T NM_001920.5(DCN):c.*566T>A |
THREE_PRIME_UTR |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.91;
48.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for DCN Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCN Gene
Disorders for DCN Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| corneal dystrophy, congenital stromal |
|
|
| stromal corneal dystrophy |
|
|
| stromal dystrophy |
|
|
| corneal dystrophy |
|
|
| localized scleroderma |
|
|
Search DCN in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PGS2_HUMAN- Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. {ECO:0000269 PubMed:15671264}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for DCN
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for DCN Gene
Publications for DCN Gene
- The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson KG … Iozzo RV (Genomics 1993) 2 3 4 22
- The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PMID: 16902402) Wang IJ … Lin LL (Molecular vision 2006) 3 22 40
- Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. (PMID: 15671264) Bredrup C … Boman H (Investigative ophthalmology & visual science 2005) 3 4 72
- The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes. (PMID: 12187087) De Cosmo S … Viberti GC (Nephron 2002) 3 22 40
- GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat BE … Tseng ZH (BMC cardiovascular disorders 2011) 3 40
ExternalLinks
Products for DCN Gene
- View all 11 R&D Systems DCN (Decorin) Products
- View all R&D Systems DCN (Decorin) Proteins and Enzymes
- View all 8 R&D Systems DCN (Decorin) Primary Antibodies
- View all R&D Systems DCN (Decorin) ELISAs
- View all R&D Systems DCN (Decorin) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom DCN antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for DCN
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for DCN
- Origene Custom Protein Services for DCN
- Origene shrna, sirna, and RNAi products in human, mouse, rat for DCN
- Browse OriGene Inhibitory RNA Products For DCN
- OriGene qPCR primer pairs for DCN
- OriGene qPCR primer pairs and template standards for DCN
- OriGene CRISPR knockouts for DCN
- MG223964
- MG224378
- MR223964
- MR223964L3
- MR223964L4
- MR224378
- MR224378L3
- MR224378L4
- RC202753
- RC202753L1
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- RC202753L3
- RC202753L4
- RC212053
- RC212053L3
- RC212053L4
- RC212223
- RC212223L3
- RC212223L4
- RC218371
- RC218371L3
- RC218371L4
- RC218427
- RC218427L3
- RC218427L4
- RC218479
- RC218479L3
- RC218479L4
- RG202753
- RG212053
- RG212223
- RG218371
- RG218427
- RG218479
- RR208005
- RR208005L3
- RR208005L4
- MR223964L3V
- MR223964L4V
- MR224378L3V
- MR224378L4V
- RC202753L1V
- RC202753L2V
- RC202753L3V
- RC202753L4V
- RC212053L3V
- RC212053L4V
- RC212223L3V
- RC212223L4V
- RC218371L3V
- RC218371L4V
- RC218427L3V
- RC218427L4V
- RC218479L3V
- RC218479L4V
- RR208005L3V
- RR208005L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For DCN
- Sino Biological Human cDNA Clone for DCN
- Sino Biological Recombinant Proteins for DCN
- Sino Biological Cell Lysates for DCN
- Sino Biological Antibodies for DCN
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for DCN
- Novus Biologicals proteins and lysates for DCN
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for DCN
- Abcam proteins for DCN
- Abcam assays for DCN
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for DCN (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for DCN (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for DCN (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for DCN CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for DCN
- antibodies-online: Show 54 available Decorin Antibodies ranked by validation data
- Compare Top Decorin Antibodies
- Recommended
- 137 WB Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 FACS Antibody (anti-human)
- 33 WB Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 42 WB Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- antibodies-online: Show 97 available Decorin Elisa Kits ranked by validation data
- Compare Top Decorin Elisa Kits
- Quality Products:
- ABIN6574301
- ABIN1114582
- ABIN625287
- ABIN415277
- ABIN856908
- ABIN1672790
- ABIN3032910
- ABIN1569359
- ABIN5520388
- ABIN2708192
- ABIN1114581
- ABIN1672791
- ABIN4993047
- ABIN625382
- ABIN5520389
- ABIN2708496
- ABIN6720190
- ABIN2684032
- ABIN5669771
- ABIN858169
- ABIN1114583
- ABIN5563450
- ABIN2748038
- ABIN5520390
- ABIN5670437
- ABIN626930
- ABIN6384462
- ABIN2946943
- ABIN6203708
- ABIN5072884
- ABIN858173
- ABIN5591958
- ABIN990903
- ABIN6384455
- ABIN6384463
- ABIN4881435
- ABIN1129286
- antibodies-online: Show 35 available Decorin Proteins ranked by validation data
- Compare Top Decorin Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for DCN
- Search Santa Cruz Biotechnology (SCBT) for DCN siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DCN
- Custom Antibody ServicesProSci Antibodies for DCN
- ProSci Proteins for DCN
- Horizon Cell Lines for DCN
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for DCN
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for DCN
- Search GeneCopoeia for miRNA 3'UTR Target clone products for DCN
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCN
Sources for DCN Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources