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This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Corneal Dystrophy. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include collagen binding. An important paralog of this gene is BGN.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003723 | RNA binding | HDA | 22658674 |
GO:0005515 | protein binding | IPI | 1747115 |
GO:0005518 | collagen binding | IEA | -- |
GO:0005539 | glycosaminoglycan binding | IEA | -- |
GO:0030021 | extracellular matrix structural constituent conferring compression resistance | RCA | 20551380 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS,HDA | -- |
GO:0005589 | collagen type VI trimer | IEA | -- |
GO:0005615 | extracellular space | HDA | 20551380 |
GO:0005796 | Golgi lumen | TAS | -- |
GO:0031012 | extracellular matrix | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Chondroitin sulfate/dermatan sulfate metabolism | ||
2 | Glycosaminoglycan metabolism | ||
3 | Degradation of the extracellular matrix | ||
4 | Proteoglycans in cancer | ||
5 | TGF-beta signaling pathway (KEGG) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001822 | kidney development | IEA | -- |
GO:0001890 | placenta development | IEA | -- |
GO:0007519 | skeletal muscle tissue development | IEA | -- |
GO:0007568 | aging | IEA | -- |
GO:0009612 | response to mechanical stimulus | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Tromethamine | Approved | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP13: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - |
ExUns: | 12d | · | 12e | ^ | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · | 15d | ^ | 16a | · | 16b | · | 16c | · | 16d | · | 16e |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||
SP8: | |||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||
SP10: | |||||||||||||||||||||||||||
SP11: | |||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | |||||||||||||||||||||
SP13: | |||||||||||||||||||||||||||
SP14: | |||||||||||||||||||||||||||
SP15: | |||||||||||||||||||||||||||
SP16: | |||||||||||||||||||||||||||
SP17: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | DCN 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | DCN 33 32 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | DCN 33 32 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | DCN 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | DCN 33 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Dcn 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Dcn 32 |
|
||
chicken (Gallus gallus) |
Aves | DCN 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | DCN 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | dcn 32 |
|
||
Str.8982 32 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.24505 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | dcn 33 32 |
|
OneToOne | |
-- 32 |
|
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs141738168 | likely-benign, Congenital Stromal Corneal Dystrophy | 91,178,520(-) | T/C | coding_sequence_variant, synonymous_variant | |
rs142752401 | benign, Congenital Stromal Corneal Dystrophy | 91,158,410(-) | T/C | coding_sequence_variant, intron_variant, missense_variant | |
rs144307891 | likely-benign, Congenital Stromal Corneal Dystrophy | 91,151,660(-) | G/A | coding_sequence_variant, intron_variant, synonymous_variant | |
rs145597441 | likely-benign, Congenital Stromal Corneal Dystrophy | 91,178,499(-) | C/A/T | coding_sequence_variant, synonymous_variant | |
rs147956869 | likely-benign, Congenital Stromal Corneal Dystrophy | 91,182,946(-) | T/C | upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
corneal dystrophy, congenital stromal |
|
|
stromal corneal dystrophy |
|
|
stromal dystrophy |
|
|
interstitial keratitis |
|
|
localized scleroderma |
|