Aliases for DCLRE1A Gene
External Ids for DCLRE1A Gene
Previous GeneCards Identifiers for DCLRE1A Gene
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for DCLRE1A Gene
DCLRE1A (DNA Cross-Link Repair 1A) is a Protein Coding gene. Diseases associated with DCLRE1A include Interstitial Nephritis, Karyomegalic and Fanconi Anemia, Complementation Group A. Among its related pathways are Chks in Checkpoint Regulation and Fanconi anemia pathway. Gene Ontology (GO) annotations related to this gene include 5'-3' exodeoxyribonuclease activity. An important paralog of this gene is DCLRE1B.
UniProtKB/Swiss-Prot Summary for DCLRE1A Gene
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.