Aliases for DCLRE1A Gene
External Ids for DCLRE1A Gene
Previous GeneCards Identifiers for DCLRE1A Gene
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for DCLRE1A Gene
DCLRE1A (DNA Cross-Link Repair 1A) is a Protein Coding gene. Diseases associated with DCLRE1A include Interstitial Nephritis, Karyomegalic and Fanconi Anemia, Complementation Group A. Among its related pathways are DNA Double-Strand Break Repair and Chks in Checkpoint Regulation. Gene Ontology (GO) annotations related to this gene include 5'-3' exodeoxyribonuclease activity. An important paralog of this gene is DCLRE1B.
UniProtKB/Swiss-Prot Summary for DCLRE1A Gene
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.