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Aliases for DCLK3 Gene

Aliases for DCLK3 Gene

  • Doublecortin Like Kinase 3 2 3 5
  • Doublecortin Domain-Containing Protein 3C 3 4
  • Doublecortin-Like And CAM Kinase-Like 3 3 4
  • Doublecortin And CaM Kinase-Like 3 2 3
  • Doublecortin-Like Kinase 3 2 4
  • DCAMKL3 3 4
  • DCDC3C 3 4
  • Serine/Threonine-Protein Kinase DCLK3 3
  • CLICK-I,II-Related 3
  • EC 4
  • KIAA1765 4
  • DCK3 3
  • CLR 3

External Ids for DCLK3 Gene

Previous HGNC Symbols for DCLK3 Gene


Summaries for DCLK3 Gene

GeneCards Summary for DCLK3 Gene

DCLK3 (Doublecortin Like Kinase 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK1.

Additional gene information for DCLK3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK3 Gene

Genomics for DCLK3 Gene

GeneHancer (GH) Regulatory Elements for DCLK3 Gene

Promoters and enhancers for DCLK3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J036890 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -129.3 -129328 5.4 HDAC1 PKNOX1 ATF1 RB1 BMI1 YBX1 ZBTB40 BATF CBX5 ZNF143 MLH1 EPM2AIP1 TRANK1 ENSG00000234073 DCLK3 GC03M036882
GH03J036677 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.3 +85.2 85211 4.1 GTF2E2 JUN TAL1 EBF1 CEBPG BATF RFX5 FOSL1 ZNF547 FOSL2 DCLK3 GC03P036685 NBPF21P
GH03J036874 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 -112.4 -112423 5.4 HDGF PKNOX1 BMI1 BATF IRF4 ATF7 BCLAF1 IKZF2 RUNX3 CREM TRANK1 RNU6ATAC4P DCLK3 ENSG00000234073 LRRFIP2 ENSG00000281100
GH03J036707 Enhancer 0.9 Ensembl ENCODE 11 +56.6 56609 0.3 CTCF PKNOX1 JUN BACH1 CEBPG EBF1 ZIC2 RAD21 RFX5 FOSL1 DCLK3 RN7SKP227 GC03M036732
GH03J036842 Enhancer 0.7 ENCODE 10.7 -79.2 -79198 1.1 CTCF BACH1 RAD21 CTBP1 ZNF316 CBX5 ZNF143 SMC3 ZNF444 NFE2 DCLK3 LRRFIP2 ENSG00000281100 ENSG00000234073 TRANK1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCLK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCLK3 gene promoter:
  • Elk-1
  • Pax-2b
  • Pax-2a
  • Pax-2
  • Ik-1
  • Evi-1
  • AML1a
  • GR
  • GR-alpha
  • GR-beta

Genomic Locations for DCLK3 Gene

Genomic Locations for DCLK3 Gene
51,928 bases
Minus strand
27,440 bases
Minus strand

Genomic View for DCLK3 Gene

Genes around DCLK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK3 Gene

Proteins for DCLK3 Gene

  • Protein details for DCLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase DCLK3
    Protein Accession:

    Protein attributes for DCLK3 Gene

    648 amino acids
    Molecular mass:
    73814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCLK3 Gene

Post-translational modifications for DCLK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCLK3 Gene

No data available for DME Specific Peptides for DCLK3 Gene

Domains & Families for DCLK3 Gene

Gene Families for DCLK3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for DCLK3 Gene

Suggested Antigen Peptide Sequences for DCLK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK3: view

Function for DCLK3 Gene

Molecular function for DCLK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for DCLK3 Gene

Gene Ontology (GO) - Molecular Function for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DCLK3: view
genes like me logo Genes that share phenotypes with DCLK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DCLK3

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCLK3

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCLK3 Gene

Localization for DCLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCLK3 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DCLK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCLK3 Gene

Pathways & Interactions for DCLK3 Gene

SuperPathways for DCLK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IEA,IBA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
GO:0035556 intracellular signal transduction IBA,IEA --
genes like me logo Genes that share ontologies with DCLK3: view

No data available for Pathways by source and SIGNOR curated interactions for DCLK3 Gene

Drugs & Compounds for DCLK3 Gene

(1) Drugs for DCLK3 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with DCLK3: view

Transcripts for DCLK3 Gene

mRNA/cDNA for DCLK3 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCLK3 Gene

Doublecortin-like kinase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCLK3

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK3 Gene

No ASD Table

Relevant External Links for DCLK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCLK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK3 Gene

This gene is overexpressed in Nerve - Tibial (x18.6), Brain - Nucleus accumbens (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCLK3 Gene

Protein tissue co-expression partners for DCLK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCLK3 Gene:


SOURCE GeneReport for Unigene cluster for DCLK3 Gene:


Evidence on tissue expression from TISSUES for DCLK3 Gene

  • Nervous system(4.1)
  • Urine(2.6)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with DCLK3: view

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCLK3 Gene

Orthologs for DCLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCLK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCLK3 34 33
  • 99.64 (n)
(Bos Taurus)
Mammalia DCLK3 34 33
  • 80.65 (n)
(Rattus norvegicus)
Mammalia Dclk3 33
  • 79.42 (n)
(Canis familiaris)
Mammalia DCLK3 34 33
  • 78.9 (n)
(Mus musculus)
Mammalia Dclk3 16 34 33
  • 78.1 (n)
(Monodelphis domestica)
Mammalia DCLK3 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia DCLK3 34
  • 47 (a)
(Gallus gallus)
Aves DCLK3 34 33
  • 62.11 (n)
(Anolis carolinensis)
Reptilia DCLK3 34
  • 50 (a)
(Danio rerio)
Actinopterygii dclk3 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F32D8.1 34 33
  • 49.68 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 34
  • 26 (a)
CMK2 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.6667 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6667 33
Species where no ortholog for DCLK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK3 Gene

Gene Tree for DCLK3 (if available)
Gene Tree for DCLK3 (if available)
Evolutionary constrained regions (ECRs) for DCLK3: view image

Paralogs for DCLK3 Gene

Variants for DCLK3 Gene

Sequence variations from dbSNP and Humsavar for DCLK3 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs373605259 A colorectal adenocarcinoma sample 36,737,396(-) C/T coding_sequence_variant, missense_variant
rs374711533 A lung squamous cell carcinoma sample 36,718,103(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant
VAR_040445 A breast infiltrating ductal carcinoma sample p.Pro108Leu
VAR_040447 A lung large cell carcinoma sample p.Ser472Asn
VAR_040449 A renal clear cell carcinoma sample p.Gly570Arg

Structural Variations from Database of Genomic Variants (DGV) for DCLK3 Gene

Variant ID Type Subtype PubMed ID
esv2665523 CNV deletion 23128226
esv3595873 CNV loss 21293372
nsv1007217 CNV gain 25217958
nsv834660 CNV loss 17160897

Variation tolerance for DCLK3 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCLK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK3 Gene

Disorders for DCLK3 Gene

Additional Disease Information for DCLK3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DCLK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK3 Gene

Publications for DCLK3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O … Bergmann S (BMC genomics 2006) 2 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58

Products for DCLK3 Gene

Sources for DCLK3 Gene

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