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Aliases for DCLK1 Gene

Aliases for DCLK1 Gene

  • Doublecortin Like Kinase 1 2 3 5
  • Doublecortin Domain-Containing Protein 3A 3 4
  • Doublecortin-Like And CAM Kinase-Like 1 3 4
  • Doublecortin-Like Kinase 1 2 4
  • DCAMKL1 3 4
  • DCDC3A 3 4
  • Serine/Threonine-Protein Kinase DCLK1 3
  • Doublecortin And CaM Kinase-Like 1 2
  • EC 2.7.11.1 4
  • KIAA0369 4
  • CLICK1 3
  • DCLK 3
  • CL1 3

External Ids for DCLK1 Gene

Previous HGNC Symbols for DCLK1 Gene

  • DCAMKL1

Previous GeneCards Identifiers for DCLK1 Gene

  • GC13M035244
  • GC13M036343
  • GC13M017156

Summaries for DCLK1 Gene

Entrez Gene Summary for DCLK1 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK1 Gene

DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Neuroscience. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK2.

UniProtKB/Swiss-Prot for DCLK1 Gene

  • Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Gene Wiki entry for DCLK1 Gene

Additional gene information for DCLK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK1 Gene

Genomics for DCLK1 Gene

GeneHancer (GH) Regulatory Elements for DCLK1 Gene

Promoters and enhancers for DCLK1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J036130 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.4 369 2.7 ZSCAN4 SIN3A KLF14 ZNF335 ZNF121 GLIS2 ZNF366 EGR2 SP3 ZNF398 DCLK1 SOHLH2 EXOSC8 CCDC169 RFXAP SUPT20H NMTRQ-TTG10-1
GH13J036163 Promoter/Enhancer 1.5 EPDnew ENCODE dbSUPER 662 -31.9 -31942 1.6 PKNOX1 MZF1 FEZF1 RFX5 ZNF213 ZNF366 OVOL3 CEBPB TSHZ1 ZEB2 DCLK1 RNU6-71P SOHLH2
GH13J035855 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 650.1 +275.0 275010 3.9 PKNOX1 KLF17 SIN3A ETS1 ZNF366 FOS TSHZ1 NR2F2 SP1 BCL6B LOC105370163 DCLK1 GC13P036065
GH13J036154 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -23.0 -22997 1.8 POLR2A SIN3A PRDM4 DCLK1 CCDC169 SOHLH2 SPART
GH13J035978 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.6 +152.2 152215 2.4 CTCF MXI1 RAD21 GATA3 ZNF143 SMC3 FOS ZNF362 ZNF654 TRIM22 RNU6-71P DCLK1 MAB21L1 GC13P036065 LOC105370163
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCLK1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCLK1 gene promoter:
  • SRF (504 AA)
  • SRF
  • STAT5B
  • Tal-1
  • E47
  • C/EBPalpha
  • CHOP-10
  • AREB6
  • Pax-5
  • c-Myb

Genomic Locations for DCLK1 Gene

Genomic Locations for DCLK1 Gene
chr13:35,768,652-36,132,020
(GRCh38/hg38)
Size:
363,369 bases
Orientation:
Minus strand
chr13:36,342,789-36,705,514
(GRCh37/hg19)
Size:
362,726 bases
Orientation:
Minus strand

Genomic View for DCLK1 Gene

Genes around DCLK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK1 Gene

Proteins for DCLK1 Gene

  • Protein details for DCLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15075-DCLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK1
    Protein Accession:
    O15075
    Secondary Accessions:
    • B7Z3E9
    • Q5VZY8
    • Q5VZZ0
    • Q5VZZ1

    Protein attributes for DCLK1 Gene

    Size:
    740 amino acids
    Molecular mass:
    82224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20824.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCLK1 Gene

    Alternative splice isoforms for DCLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK1 Gene

Post-translational modifications for DCLK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DCLK1

No data available for DME Specific Peptides for DCLK1 Gene

Domains & Families for DCLK1 Gene

Gene Families for DCLK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DCLK1 Gene

Graphical View of Domain Structure for InterPro Entry

O15075

UniProtKB/Swiss-Prot:

DCLK1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK1: view

Function for DCLK1 Gene

Molecular function for DCLK1 Gene

UniProtKB/Swiss-Prot Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for DCLK1 Gene

Phenotypes From GWAS Catalog for DCLK1 Gene

Gene Ontology (GO) - Molecular Function for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9747029
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005057 obsolete signal transducer activity, downstream of receptor TAS --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DCLK1: view
genes like me logo Genes that share phenotypes with DCLK1: view

Animal Models for DCLK1 Gene

MGI Knock Outs for DCLK1:

Animal Model Products

miRNA for DCLK1 Gene

miRTarBase miRNAs that target DCLK1

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCLK1 Gene

Localization for DCLK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCLK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005887 integral component of plasma membrane TAS 10036192
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with DCLK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCLK1 Gene

Pathways & Interactions for DCLK1 Gene

genes like me logo Genes that share pathways with DCLK1: view

Pathways by source for DCLK1 Gene

2 Sino Biological pathways for DCLK1 Gene
1 Cell Signaling Technology pathway for DCLK1 Gene

Gene Ontology (GO) - Biological Process for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006468 protein phosphorylation TAS 9747029
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development TAS 10036192
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with DCLK1: view

No data available for SIGNOR curated interactions for DCLK1 Gene

Drugs & Compounds for DCLK1 Gene

(2) Drugs for DCLK1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
genes like me logo Genes that share compounds with DCLK1: view

Transcripts for DCLK1 Gene

Unigene Clusters for DCLK1 Gene

Doublecortin-like kinase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2:
SP3: -

Relevant External Links for DCLK1 Gene

GeneLoc Exon Structure for
DCLK1
ECgene alternative splicing isoforms for
DCLK1

Expression for DCLK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Hypothalamus (x4.1), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for DCLK1 Gene

This gene is overexpressed in Fetal Brain (31.4), Frontal cortex (13.1), and Brain (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCLK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCLK1 Gene:

DCLK1

SOURCE GeneReport for Unigene cluster for DCLK1 Gene:

Hs.507755

mRNA Expression by UniProt/SwissProt for DCLK1 Gene:

O15075-DCLK1_HUMAN
Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.

Evidence on tissue expression from TISSUES for DCLK1 Gene

  • Nervous system(5)
  • Intestine(2.6)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DCLK1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCLK1 Gene

Orthologs for DCLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK1 34 33
  • 99.73 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCLK1 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK1 34 33
  • 93.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dclk1 16 34 33
  • 89.89 (n)
cow
(Bos Taurus)
Mammalia DCLK1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK1 34 33
  • 86.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dckl1b 34
  • 77 (a)
OneToMany
dclk1a 34
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17528 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 34 33
  • 49.81 (n)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NNK1 36
rice
(Oryza sativa)
Liliopsida Os.4465 33
Species where no ortholog for DCLK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK1 Gene

ENSEMBL:
Gene Tree for DCLK1 (if available)
TreeFam:
Gene Tree for DCLK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCLK1: view image

Paralogs for DCLK1 Gene

Paralogs for DCLK1 Gene

(30) SIMAP similar genes for DCLK1 Gene using alignment to 2 proteins:

  • DCLK1_HUMAN
  • Q5VZY9_HUMAN
genes like me logo Genes that share paralogs with DCLK1: view

Variants for DCLK1 Gene

Sequence variations from dbSNP and Humsavar for DCLK1 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
VAR_045673 A gastric adenocarcinoma sample p.Gly29Cys
VAR_045674 A gastric adenocarcinoma sample p.Thr46Met
VAR_045675 A gastric adenocarcinoma sample p.Arg93Gln
VAR_045676 A gastric adenocarcinoma sample p.Ser291Phe
rs1000002557 -- 35,920,805(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK1 Gene

Variant ID Type Subtype PubMed ID
dgv3117n54 CNV loss 21841781
dgv3118n54 CNV loss 21841781
dgv948n106 CNV tandem duplication 24896259
esv22934 CNV loss 19812545
esv2429709 CNV insertion 19546169
esv2670454 CNV deletion 23128226
esv2671550 CNV deletion 23128226
esv2674324 CNV deletion 23128226
esv27255 CNV loss 19812545
esv2747262 CNV deletion 23290073
esv2772 CNV loss 18987735
esv3303266 CNV mobile element insertion 20981092
esv3327110 CNV insertion 20981092
esv3500 OTHER sequence alteration 18987735
esv3550313 CNV deletion 23714750
esv3631771 CNV loss 21293372
esv3631772 CNV loss 21293372
esv3631773 CNV loss 21293372
esv4059 OTHER complex 18987735
esv4657 CNV loss 18987735
nsv1070582 CNV deletion 25765185
nsv1132855 CNV insertion 24896259
nsv1138213 CNV deletion 24896259
nsv1138214 CNV deletion 24896259
nsv1147365 CNV deletion 26484159
nsv1152524 CNV insertion 26484159
nsv479188 CNV novel sequence insertion 20440878
nsv509501 CNV insertion 20534489
nsv510948 OTHER complex 20534489
nsv518674 CNV loss 19592680
nsv522911 CNV loss 19592680
nsv524786 CNV loss 19592680
nsv561489 CNV loss 21841781
nsv561492 CNV loss 21841781
nsv64246 CNV deletion 16902084
nsv832580 CNV loss 17160897
nsv952537 CNV duplication 24416366
nsv976103 CNV duplication 23825009
nsv977225 CNV duplication 23825009

Variation tolerance for DCLK1 Gene

Residual Variation Intolerance Score: 7.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCLK1 Gene

Human Gene Mutation Database (HGMD)
DCLK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCLK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK1 Gene

Disorders for DCLK1 Gene

Additional Disease Information for DCLK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DCLK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK1 Gene

Publications for DCLK1 Gene

  1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PMID: 9747029) Omori Y … Fujiwara T (Journal of human genetics 1998) 2 3 4 22 58
  2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PMID: 10036192) Sossey-Alaoui K … Srivastava AK (Genomics 1999) 2 3 4 58
  3. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells. (PMID: 20228126) Verissimo CS … Vreugdenhil E (Endocrine-related cancer 2010) 3 22 58

Products for DCLK1 Gene

Sources for DCLK1 Gene

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