Aliases for DCK Gene
External Ids for DCK Gene
Previous GeneCards Identifiers for DCK Gene
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
GeneCards Summary for DCK Gene
DCK (Deoxycytidine Kinase) is a Protein Coding gene. Diseases associated with DCK include Purine Nucleoside Phosphorylase Deficiency and Periampullary Adenocarcinoma. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Metabolism of nucleotides. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and nucleoside kinase activity. An important paralog of this gene is DGUOK.
UniProtKB/Swiss-Prot Summary for DCK Gene
Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine (PubMed:1996353, PubMed:12808445, PubMed:18377927, PubMed:19159229, PubMed:20614893). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents (PubMed:12808445).