Aliases for DCHS1 Gene
External Ids for DCHS1 Gene
Previous HGNC Symbols for DCHS1 Gene
Previous GeneCards Identifiers for DCHS1 Gene
This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
GeneCards Summary for DCHS1 Gene
DCHS1 (Dachsous Cadherin-Related 1) is a Protein Coding gene. Diseases associated with DCHS1 include Van Maldergem Syndrome 1 and Mitral Valve Prolapse 2. Among its related pathways are ERK Signaling and Hippo signaling pathway - multiple species. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is DCHS2.
UniProtKB/Swiss-Prot Summary for DCHS1 Gene
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302).