Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCDC5 Gene

Aliases for DCDC5 Gene

  • Doublecortin Domain Containing 5 2
  • KIAA1493 4

External Ids for DCDC5 Gene

Previous GeneCards Identifiers for DCDC5 Gene

  • GC11M030809

Summaries for DCDC5 Gene

GeneCards Summary for DCDC5 Gene

DCDC5 (Doublecortin Domain Containing 5) is a Protein Coding gene. Diseases associated with DCDC5 include Iris Disease and Aniridia 1.

UniProtKB/Swiss-Prot for DCDC5 Gene

  • Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).

Additional gene information for DCDC5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC5 Gene

Genomics for DCDC5 Gene

GeneHancer (GH) Regulatory Elements for DCDC5 Gene

Promoters and enhancers for DCDC5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J030991 Enhancer 0.7 ENCODE 650.7 +0.2 184 1.1 SOX13 FOXA2 SAP130 ARID4B BACH1 ZNF644 YY1 HNF4G NFE2 HOMEZ DCDC5 MPPED2 GC11P030983 DCDC1
GH11J030983 Enhancer 0.6 ENCODE 0.4 +7.7 7700 2.4 SOX13 USF2 SIN3A SP1 GATA3 POLR2A FOS FOSL2 MAFK GC11P030983 MPPED2 DCDC5 DCDC1
GH11J030984 Enhancer 0.5 UCNEbase 0.4 +9.9 9939 0.2 ATF2 GC11P030983 DCDC5 LOC105376611 DCDC1
GH11J030982 Enhancer 0.4 UCNEbase 0.4 +9.7 9710 0.2 GC11P030983 DCDC5 LOC105376611 DCDC1
GH11J030919 Enhancer 0.7 Ensembl ENCODE 0.2 +73.1 73074 1.2 PKNOX1 POLR2A IKZF1 IKZF2 SPI1 MPPED2 LOC105376611 GC11P030983 DCDC5 DCDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCDC5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCDC5 gene promoter:

Genomic Locations for DCDC5 Gene

Genomic Locations for DCDC5 Gene
129,084 bases
Minus strand

Genomic View for DCDC5 Gene

Genes around DCDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for DCDC5 Gene

Proteins for DCDC5 Gene

  • Protein details for DCDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B1AL47

    Protein attributes for DCDC5 Gene

    648 amino acids
    Molecular mass:
    72753 Da
    Quaternary structure:
    • Interacts with dynein intermediate chain, tubulin, RAB8A, RAB3IP, NUDC, PAFAH1B1 and DCTN1 (PubMed:22159412).
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAO03425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DCDC5 Gene

Post-translational modifications for DCDC5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DCDC5 Gene

Domains & Families for DCDC5 Gene

Gene Families for DCDC5 Gene

Protein Domains for DCDC5 Gene

Suggested Antigen Peptide Sequences for DCDC5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC5: view

No data available for UniProtKB/Swiss-Prot for DCDC5 Gene

Function for DCDC5 Gene

Molecular function for DCDC5 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).

Phenotypes From GWAS Catalog for DCDC5 Gene

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC5 Gene

Localization for DCDC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCDC5 Gene

Midbody, Midbody ring. Midbody. Cytoplasm, cytoskeleton, spindle. Note=Associated with microtubules, in particular, with stabilized microtubules of the mitotic spindle during metaphase and with midbody microtubules during cytokinesis. {ECO:0000269 PubMed:22159412}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC5 gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCDC5 Gene

Pathways & Interactions for DCDC5 Gene

SuperPathways for DCDC5 Gene

No Data Available

Interacting Proteins for DCDC5 Gene

Gene Ontology (GO) - Biological Process for DCDC5 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCDC5 Gene

Drugs & Compounds for DCDC5 Gene

No Compound Related Data Available

Transcripts for DCDC5 Gene

mRNA/cDNA for DCDC5 Gene

(0) Additional mRNA sequences :

Unigene Clusters for DCDC5 Gene

Doublecortin domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -

Relevant External Links for DCDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCDC5 Gene

This gene is overexpressed in Amniocyte (52.4) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC5 Gene

Protein tissue co-expression partners for DCDC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCDC5 Gene:


SOURCE GeneReport for Unigene cluster for DCDC5 Gene:


Evidence on tissue expression from TISSUES for DCDC5 Gene

  • Nervous system(4.1)
  • Kidney(3.5)
genes like me logo Genes that share expression patterns with DCDC5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC5 Gene

Orthologs for DCDC5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DCDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCDC5 33
  • 99.38 (n)
(Canis familiaris)
Mammalia LOC475957 33
  • 87.26 (n)
(Bos Taurus)
Mammalia DCDC5 33
  • 85.49 (n)
(Mus musculus)
Mammalia Dcdc5 16 33
  • 76.64 (n)
(Rattus norvegicus)
Mammalia Dcdc5 33
  • 74.3 (n)
Species where no ortholog for DCDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for DCDC5 Gene

Paralogs for DCDC5 Gene

(2) SIMAP similar genes for DCDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC5: view

No data available for Paralogs for DCDC5 Gene

Variants for DCDC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCDC5 Gene

Variant ID Type Subtype PubMed ID
dgv1088n100 CNV loss 25217958
esv1245858 CNV insertion 17803354
esv2540017 CNV loss 19546169
esv2759814 CNV loss 17122850
esv3411357 CNV insertion 20981092
esv3625821 CNV gain 21293372
nsv1035755 CNV gain 25217958
nsv1122602 CNV deletion 24896259
nsv1147322 CNV duplication 26484159
nsv473260 CNV novel sequence insertion 20440878
nsv480627 CNV novel sequence insertion 20440878
nsv507588 OTHER sequence alteration 20534489
nsv513309 CNV insertion 21212237
nsv516888 CNV loss 19592680
nsv529004 CNV loss 19592680
nsv553947 CNV gain 21841781
nsv553948 CNV loss 21841781

Additional Variant Information for DCDC5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for DCDC5 Gene

Disorders for DCDC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCDC5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
iris disease
  • iris diseases
aniridia 1
  • an1
- elite association - COSMIC cancer census association via MalaCards
Search DCDC5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCDC5

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC5 Gene

Publications for DCDC5 Gene

  1. Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. (PMID: 22159412) Kaplan A … Reiner O (Journal of cell science 2011) 4 58
  2. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 44 58
  3. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 44 58
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  5. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O … Bergmann S (BMC genomics 2006) 2 58

Products for DCDC5 Gene

Sources for DCDC5 Gene

Loading form....