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Aliases for DCDC2C Gene

Aliases for DCDC2C Gene

  • Doublecortin Domain Containing 2C 2 3 5
  • Doublecortin Domain Containing 2C Pseudogene 2 3
  • Doublecortin Domain-Containing Protein 2C 3

External Ids for DCDC2C Gene

Previous GeneCards Identifiers for DCDC2C Gene

  • GC00U922108
  • GC02U901141

Summaries for DCDC2C Gene

GeneCards Summary for DCDC2C Gene

DCDC2C (Doublecortin Domain Containing 2C) is a Protein Coding gene. An important paralog of this gene is DCDC2.

Additional gene information for DCDC2C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2C Gene

Genomics for DCDC2C Gene

GeneHancer (GH) Regulatory Elements for DCDC2C Gene

Promoters and enhancers for DCDC2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J003702 Enhancer 0.3 Ensembl 655.2 +0.3 275 1.9 EZH2 DCDC2C LOC105373393 ALLC
GH02J003712 Enhancer 0.5 ENCODE 6.4 +9.3 9313 1.6 HLF CEBPA CEBPG REST ATF2 NR2F2 DCDC2C LOC105373393 GC02M003908
GH02J003758 Enhancer 0.2 ENCODE 11.4 +55.9 55944 1.2 LOC105373393 DCDC2C GC02M003908
GH02J003780 Enhancer 0.8 Ensembl 0.2 +77.2 77209 0.4 ELF3 ARID4B RAD21 ZNF143 CREM THAP11 ELF1 KAT8 KLF16 ETV4 LOC105373393 DCDC2C GC02M003908
GH02J003728 Enhancer 0.5 Ensembl 0.3 +24.5 24509 0.2 CTCF ZNF143 SMC3 REST RAD21 LOC105373393 DCDC2C GC02M003908
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCDC2C on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCDC2C Gene

Genomic Locations for DCDC2C Gene
chr2:3,703,592-3,847,411
(GRCh38/hg38)
Size:
143,820 bases
Orientation:
Plus strand
chr2:3,750,316-3,836,122
(GRCh37/hg19)

Genomic View for DCDC2C Gene

Genes around DCDC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2C Gene

Proteins for DCDC2C Gene

  • Protein details for DCDC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYV0-DCD2C_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2C
    Protein Accession:
    A8MYV0

    Protein attributes for DCDC2C Gene

    Size:
    355 amino acids
    Molecular mass:
    40425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2C Gene

Post-translational modifications for DCDC2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2C Gene

No data available for DME Specific Peptides for DCDC2C Gene

Domains & Families for DCDC2C Gene

Gene Families for DCDC2C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCDC2C Gene

Suggested Antigen Peptide Sequences for DCDC2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC2C: view

No data available for UniProtKB/Swiss-Prot for DCDC2C Gene

Function for DCDC2C Gene

Phenotypes From GWAS Catalog for DCDC2C Gene

Phenotypes for DCDC2C Gene

genes like me logo Genes that share phenotypes with DCDC2C: view

Animal Models for DCDC2C Gene

MGI Knock Outs for DCDC2C:
  • Dcdc2c Dcdc2c<tm1a(KOMP)Wtsi>

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2C Gene

Localization for DCDC2C Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCDC2C Gene

Cell projection, cilium, flagellum. Cytoplasm. Note=Detected along the length of the sperm flagellum and in the cytoplasm of the germ cells. {ECO:0000269 PubMed:28395323}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC2C gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DCDC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 28395323
GO:0005815 microtubule organizing center IBA --
GO:0005874 microtubule IBA --
GO:0030864 COLOCALIZES_WITH cortical actin cytoskeleton IBA --
GO:0036126 sperm flagellum IDA 28395323
genes like me logo Genes that share ontologies with DCDC2C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCDC2C Gene

Pathways & Interactions for DCDC2C Gene

SuperPathways for DCDC2C Gene

No Data Available

Interacting Proteins for DCDC2C Gene

Gene Ontology (GO) - Biological Process for DCDC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0032502 developmental process IBA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC2C: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC2C Gene

Drugs & Compounds for DCDC2C Gene

No Compound Related Data Available

Transcripts for DCDC2C Gene

mRNA/cDNA for DCDC2C Gene

(5) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2C Gene

No ASD Table

Relevant External Links for DCDC2C Gene

GeneLoc Exon Structure for
DCDC2C
ECgene alternative splicing isoforms for
DCDC2C

Expression for DCDC2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC2C Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2C Gene

This gene is overexpressed in Testis (x29.1) and Nerve - Tibial (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of DCDC2C Gene:

DCDC2C

mRNA Expression by UniProt/SwissProt for DCDC2C Gene:

A8MYV0-DCD2C_HUMAN
Tissue specificity: Expressed in testis and spermatozoa (at protein level).
genes like me logo Genes that share expression patterns with DCDC2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC2C Gene

Orthologs for DCDC2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC2C 34 33
  • 99.07 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC2C 34 33
  • 84.93 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCDC2C 34 33
  • 82.2 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcdc2c 33
  • 80.04 (n)
mouse
(Mus musculus)
Mammalia Dcdc2c 16 34 33
  • 78.18 (n)
oppossum
(Monodelphis domestica)
Mammalia DCDC2C 34
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2C 34
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 34
  • 11 (a)
OneToMany
Species where no ortholog for DCDC2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC2C Gene

ENSEMBL:
Gene Tree for DCDC2C (if available)
TreeFam:
Gene Tree for DCDC2C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCDC2C: view image

Paralogs for DCDC2C Gene

Paralogs for DCDC2C Gene

(1) SIMAP similar genes for DCDC2C Gene using alignment to 2 proteins:

  • DCD2C_HUMAN
  • H7C242_HUMAN
genes like me logo Genes that share paralogs with DCDC2C: view

Variants for DCDC2C Gene

Sequence variations from dbSNP and Humsavar for DCDC2C Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000012832 -- 3,747,170(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000025294 -- 3,810,153(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000034565 -- 3,755,492(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000048449 -- 3,726,793(+) C/A intron_variant
rs1000102758 -- 3,791,191(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC2C Gene

Variant ID Type Subtype PubMed ID
dgv1850n106 CNV deletion 24896259
dgv2047e59 CNV duplication 20981092
dgv3702n100 CNV gain 25217958
dgv3703n100 CNV loss 25217958
dgv583e201 CNV deletion 23290073
esv1004556 CNV deletion 20482838
esv1008461 CNV deletion 20482838
esv1340410 CNV deletion 17803354
esv1348299 CNV deletion 17803354
esv1568450 CNV deletion 17803354
esv1607144 CNV deletion 17803354
esv1753884 CNV deletion 17803354
esv1775252 CNV deletion 17803354
esv2055557 CNV deletion 18987734
esv2163054 CNV deletion 18987734
esv2185351 CNV deletion 18987734
esv2482665 CNV deletion 19546169
esv2607811 CNV deletion 19546169
esv2660453 CNV deletion 23128226
esv2668654 CNV deletion 23128226
esv2670253 CNV deletion 23128226
esv2719528 CNV deletion 23290073
esv2719530 CNV deletion 23290073
esv2719532 CNV deletion 23290073
esv2719534 CNV deletion 23290073
esv2719535 CNV deletion 23290073
esv2719536 CNV deletion 23290073
esv2719537 CNV deletion 23290073
esv2719538 CNV deletion 23290073
esv2743354 CNV deletion 23290073
esv275260 CNV gain+loss 21479260
esv2759019 CNV gain 17122850
esv2762239 CNV gain 21179565
esv2763276 CNV gain+loss 21179565
esv2777 CNV loss 18987735
esv2845791 CNV deletion 24192839
esv3008670 CNV deletion 24192839
esv3343878 CNV duplication 20981092
esv3551733 CNV deletion 23714750
esv3589668 CNV loss 21293372
esv4287 CNV loss 18987735
esv4379 CNV loss 18987735
esv4544 CNV loss 18987735
esv5118 CNV loss 18987735
nsv1004469 CNV gain 25217958
nsv1007039 CNV gain 25217958
nsv1008961 CNV loss 25217958
nsv1013223 CNV gain 25217958
nsv1069847 CNV deletion 25765185
nsv1115554 CNV duplication 24896259
nsv1115555 CNV duplication 24896259
nsv1121561 CNV deletion 24896259
nsv1125624 CNV deletion 24896259
nsv1129979 CNV deletion 24896259
nsv1135534 CNV deletion 24896259
nsv1146744 CNV duplication 26484159
nsv214960 CNV deletion 16902084
nsv468961 CNV gain 19166990
nsv506993 OTHER sequence alteration 20534489
nsv511763 CNV loss 21212237
nsv580822 CNV gain 21841781
nsv580825 CNV gain 21841781
nsv821189 CNV duplication 20802225
nsv828175 CNV gain 20364138
nsv954753 CNV deletion 24416366
nsv999394 CNV gain 25217958

Variation tolerance for DCDC2C Gene

Gene Damage Index Score: 6.90; 79.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCDC2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2C Gene

Disorders for DCDC2C Gene

Additional Disease Information for DCDC2C

No disorders were found for DCDC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC2C Gene

Publications for DCDC2C Gene

  1. Defining the human sperm microtubulome: an integrated genomics approach. (PMID: 28395323) Jumeau F … Mitchell V (Biology of reproduction 2017) 3 4 58
  2. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X … Tai ES (PLoS genetics 2011) 3 44 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 44 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for DCDC2C Gene

Sources for DCDC2C Gene

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