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Aliases for DCDC2B Gene

Aliases for DCDC2B Gene

  • Doublecortin Domain Containing 2B 2 3 5

External Ids for DCDC2B Gene

Previous GeneCards Identifiers for DCDC2B Gene

  • GC01P032447
  • GC01P032675
  • GC01P030791

Summaries for DCDC2B Gene

Entrez Gene Summary for DCDC2B Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC2B Gene

DCDC2B (Doublecortin Domain Containing 2B) is a Protein Coding gene. Diseases associated with DCDC2B include Deafness, Autosomal Recessive 66. An important paralog of this gene is DCDC2.

Additional gene information for DCDC2B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2B Gene

Genomics for DCDC2B Gene

GeneHancer (GH) Regulatory Elements for DCDC2B Gene

Promoters and enhancers for DCDC2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I032208 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 83 1.4 PKNOX1 NFIB INSM2 BMI1 GATA3 POLR2A ZNF239 SCRT2 ZNF600 RFX1 DCDC2B IQCC TMEM234 GC01M032216
GH01I031924 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 -273.3 -273261 22.1 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 GC01P031934 PTP4A2 TXLNA SNRNP40 KHDRBS1 RBBP4 ENSG00000229447 TSSK3 ZBTB8A TMEM39B
GH01I032262 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34.4 +56.3 56294 4.8 ZNF493 ZNF529 ZFP64 RARA ZNF213 SCRT2 ZNF654 ZNF680 ZBTB11 CEBPB TXLNA RBBP4 SNRNP40 KHDRBS1 TSSK3 TMEM39B ZBTB8A ZNF362 DCDC2B S100PBP
GH01I032178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21 -28.7 -28749 4.1 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B TXLNA ENSG00000224066 IQCC DCDC2B SNRNP40 TSSK3 KPNA6 RBBP4 TMEM234 EIF3I
GH01I032813 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +608.1 608148 7.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 S100PBP YARS TXLNA TSSK3 RBBP4 ZBTB8A KHDRBS1 TMEM39B EIF3I FAM229A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCDC2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCDC2B gene promoter:

Genomic Locations for DCDC2B Gene

Genomic Locations for DCDC2B Gene
chr1:32,209,094-32,216,196
(GRCh38/hg38)
Size:
7,103 bases
Orientation:
Plus strand
chr1:32,674,695-32,681,797
(GRCh37/hg19)

Genomic View for DCDC2B Gene

Genes around DCDC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2B Gene

Proteins for DCDC2B Gene

  • Protein details for DCDC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VCK2-DCD2B_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2B
    Protein Accession:
    A2VCK2
    Secondary Accessions:
    • B7ZBC6

    Protein attributes for DCDC2B Gene

    Size:
    349 amino acids
    Molecular mass:
    37665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2B Gene

Post-translational modifications for DCDC2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCDC2B Gene

Domains & Families for DCDC2B Gene

Gene Families for DCDC2B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCDC2B Gene

Suggested Antigen Peptide Sequences for DCDC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC2B: view

No data available for UniProtKB/Swiss-Prot for DCDC2B Gene

Function for DCDC2B Gene

Gene Ontology (GO) - Molecular Function for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCDC2B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2B Gene

Localization for DCDC2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC2B gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DCDC2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DCDC2B Gene

Pathways & Interactions for DCDC2B Gene

SuperPathways for DCDC2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC2B: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC2B Gene

Drugs & Compounds for DCDC2B Gene

No Compound Related Data Available

Transcripts for DCDC2B Gene

mRNA/cDNA for DCDC2B Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC2B Gene

Doublecortin domain containing 2B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2B Gene

No ASD Table

Relevant External Links for DCDC2B Gene

GeneLoc Exon Structure for
DCDC2B
ECgene alternative splicing isoforms for
DCDC2B

Expression for DCDC2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC2B Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2B Gene

This gene is overexpressed in Fallopian Tube (x6.0), Cervix - Endocervix (x4.9), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for DCDC2B Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCDC2B Gene



Protein tissue co-expression partners for DCDC2B Gene

NURSA nuclear receptor signaling pathways regulating expression of DCDC2B Gene:

DCDC2B

SOURCE GeneReport for Unigene cluster for DCDC2B Gene:

Hs.424588
genes like me logo Genes that share expression patterns with DCDC2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC2B Gene

Orthologs for DCDC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC2B 33 34
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia DCDC2B 33 34
  • 86.41 (n)
dog
(Canis familiaris)
Mammalia DCDC2B 33 34
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Dcdc2b 33
  • 82 (n)
mouse
(Mus musculus)
Mammalia Dcdc2b 33 16 34
  • 79.14 (n)
oppossum
(Monodelphis domestica)
Mammalia DCDC2B 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2B 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCDC2B 34
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC2B 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcdc2b 33
  • 51.78 (n)
zebrafish
(Danio rerio)
Actinopterygii dcdc2b 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 34
  • 15 (a)
OneToMany
Species where no ortholog for DCDC2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCDC2B Gene

ENSEMBL:
Gene Tree for DCDC2B (if available)
TreeFam:
Gene Tree for DCDC2B (if available)

Paralogs for DCDC2B Gene

Paralogs for DCDC2B Gene

(1) SIMAP similar genes for DCDC2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC2B: view

Variants for DCDC2B Gene

Sequence variations from dbSNP and Humsavar for DCDC2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000506821 -- 32,208,946(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000713531 -- 32,216,362(+) T/C downstream_transcript_variant
rs1000992739 -- 32,209,678(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001072443 -- 32,213,878(+) A/G genic_downstream_transcript_variant, intron_variant
rs1001149018 -- 32,211,587(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC2B Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for DCDC2B Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCDC2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2B Gene

Disorders for DCDC2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCDC2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 66
  • dfnb66
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCDC2B

genes like me logo Genes that share disorders with DCDC2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC2B Gene

Publications for DCDC2B Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans TF … Vreugdenhil E (Central nervous system agents in medicinal chemistry 2010) 3 58
  4. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O … Bergmann S (BMC genomics 2006) 3 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58

Products for DCDC2B Gene

Sources for DCDC2B Gene

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