This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010] See more...

Aliases for DCDC1 Gene

Aliases for DCDC1 Gene

  • Doublecortin Domain Containing 1 2 3 5
  • Doublecortin Domain-Containing 5 Protein 3 4
  • Doublecortin Domain-Containing Protein 1 3 4
  • DCDC5 3 4
  • Doublecortin Domain-Containing Protein 5 3
  • Doublecortin Domain Containing 5 2
  • KIAA1493 4

External Ids for DCDC1 Gene

Previous HGNC Symbols for DCDC1 Gene

  • DCDC5

Previous GeneCards Identifiers for DCDC1 Gene

  • GC00U900980
  • GC11M031248
  • GC11M031240
  • GC11M030964

Summaries for DCDC1 Gene

Entrez Gene Summary for DCDC1 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC1 Gene

DCDC1 (Doublecortin Domain Containing 1) is a Protein Coding gene. Diseases associated with DCDC1 include Brachyolmia Type 4 With Mild Epiphyseal And Metaphyseal Changes and Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome. An important paralog of this gene is KCTD9.

UniProtKB/Swiss-Prot Summary for DCDC1 Gene

  • Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).

Additional gene information for DCDC1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCDC1 Gene

Genomics for DCDC1 Gene

GeneHancer (GH) Regulatory Elements for DCDC1 Gene

Promoters and enhancers for DCDC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J031369 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 528.6 -0.5 -491 2.6 ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G SP1 PHF8 POLR2A ZBTB11 DCDC1 DNAJC24 piR-38352-073
GH11J031368 Promoter 0.3 Ensembl 500.7 +1.1 1109 0.2 DNAJC24 DCDC1 piR-57133-071
GH11J031139 Enhancer 0.6 Ensembl ENCODE 18.4 +229.2 229209 4 YY1 NANOG CHD7 EP300 SP1 DCDC1 piR-41594-008 piR-44451-002
GH11J031241 Enhancer 0.5 UCNEbase Ensembl 19.9 +127.0 127009 2.4 lnc-IMMP1L-8 DCDC1 DNAJC24 IMMP1L lnc-IMMP1L-3 CYCSP25
GH11J031663 Enhancer 1 VISTA UCNEbase Ensembl 9 -294.1 -294059 2.9 EP300 POLR2A DCDC1 IMMP1L lnc-DNAJC24-6 lnc-DNAJC24-3 ENSG00000228061 ELP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCDC1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCDC1

Top Transcription factor binding sites by QIAGEN in the DCDC1 gene promoter:
  • FOXL1
  • Pax-4a
  • POU2F1
  • POU2F1a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox5
  • TGIF

Genomic Locations for DCDC1 Gene

Genomic Locations for DCDC1 Gene
chr11:30,830,369-31,369,810
(GRCh38/hg38)
Size:
539,442 bases
Orientation:
Minus strand
chr11:30,851,916-31,391,357
(GRCh37/hg19)
Size:
539,442 bases
Orientation:
Minus strand

Genomic View for DCDC1 Gene

Genes around DCDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC1 Gene

Proteins for DCDC1 Gene

  • Protein details for DCDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    M0R2J8-DCDC1_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 1
    Protein Accession:
    M0R2J8
    Secondary Accessions:
    • A6PVL6
    • B1AL47
    • B7WNX6
    • P59894
    • Q6ZRR9
    • Q6ZU04

    Protein attributes for DCDC1 Gene

    Size:
    1783 amino acids
    Molecular mass:
    200591 Da
    Quaternary structure:
    • Interacts with dynein intermediate chain, tubulin, RAB8A, RAB3IP, NUDC, PAFAH1B1 and DCTN1 (PubMed:22159412).
    SequenceCaution:
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence and several conflicts. Sequence of unknown origin in the N-terminal part of the CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCDC1 Gene

Post-translational modifications for DCDC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DCDC1 Gene

Domains & Families for DCDC1 Gene

Gene Families for DCDC1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for DCDC1 Gene

Suggested Antigen Peptide Sequences for DCDC1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ44078 fis, clone TESTI4039038, highly similar to Doublecortin domain-containing protein 1 (B7WNX6_HUMAN)
  • Doublecortin domain-containing protein 1 (DCDC1_HUMAN)
  • Doublecortin domain-containing protein 5 (DCDC5_HUMAN)
  • KIAA1493 protein (Q9P235_HUMAN)
genes like me logo Genes that share domains with DCDC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DCDC1 Gene

Function for DCDC1 Gene

Molecular function for DCDC1 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-binding protein which plays an important role in mediating dynein-dependent transport of RAB8A-positive vesicles to the midbody during cytokinesis (PubMed:22159412).

Phenotypes From GWAS Catalog for DCDC1 Gene

Gene Ontology (GO) - Molecular Function for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22159412
GO:0008017 microtubule binding IDA 22159412
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with DCDC1: view
genes like me logo Genes that share phenotypes with DCDC1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC1 Gene

Localization for DCDC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCDC1 Gene

Midbody, Midbody ring. Midbody. Cytoplasm, cytoskeleton, spindle. Note=Associated with microtubules, in particular, with stabilized microtubules of the mitotic spindle during metaphase and with midbody microtubules during cytokinesis. {ECO:0000269 PubMed:22159412}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 1
mitochondrion 1
nucleus 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0030496 midbody IEA,IDA 22159412
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCDC1 Gene

Pathways & Interactions for DCDC1 Gene

PathCards logo

SuperPathways for DCDC1 Gene

No Data Available

Interacting Proteins for DCDC1 Gene

;

Gene Ontology (GO) - Biological Process for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0051301 cell division IEA --
GO:1902412 regulation of mitotic cytokinesis IMP 22159412
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC1 Gene

Drugs & Compounds for DCDC1 Gene

No Compound Related Data Available

Transcripts for DCDC1 Gene

mRNA/cDNA for DCDC1 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:

Relevant External Links for DCDC1 Gene

GeneLoc Exon Structure for
DCDC1

Expression for DCDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DCDC1 Gene

This gene is overexpressed in Pituitary (x8.3), Testis (x6.8), Brain - Hippocampus (x5.4), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for DCDC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC1 Gene



Protein tissue co-expression partners for DCDC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCDC1

SOURCE GeneReport for Unigene cluster for DCDC1 Gene:

Hs.592000

Evidence on tissue expression from TISSUES for DCDC1 Gene

  • Nervous system(4.1)
  • Kidney(3.5)
genes like me logo Genes that share expression patterns with DCDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC1 Gene

Orthologs for DCDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC1 31 30
  • 99.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC1 31 30
  • 90.75 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCDC1 31 30
  • 88.56 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC1 31
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC1 31
  • 58 (a)
OneToOne
Species where no ortholog for DCDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC1 Gene

ENSEMBL:
Gene Tree for DCDC1 (if available)
TreeFam:
Gene Tree for DCDC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCDC1: view image

Paralogs for DCDC1 Gene

Paralogs for DCDC1 Gene

(2) SIMAP similar genes for DCDC1 Gene using alignment to 6 proteins:

  • DCDC1_HUMAN
  • B6ZDN3_HUMAN
  • B7WNX6_HUMAN
  • H0Y2Q8_HUMAN
  • H7C298_HUMAN
  • M0R2J8_HUMAN
genes like me logo Genes that share paralogs with DCDC1: view

Variants for DCDC1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCDC1 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
718774 Benign: not provided 30,881,290(-) A/G MISSENSE_VARIANT
718775 Benign: not provided 30,903,511(-) T/C MISSENSE_VARIANT
718776 Benign: not provided 30,904,978(-) C/T MISSENSE_VARIANT
721756 Benign: not provided 30,899,605(-) C/G MISSENSE_VARIANT
rs11031357 - p.Glu7Gly

Additional dbSNP identifiers (rs#s) for DCDC1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCDC1 Gene

Variant ID Type Subtype PubMed ID
dgv1088n100 CNV loss 25217958
dgv1734n54 CNV loss 21841781
esv1245858 CNV insertion 17803354
esv2540017 CNV loss 19546169
esv2658686 CNV deletion 23128226
esv2751022 CNV loss 17911159
esv2759814 CNV loss 17122850
esv3411357 CNV insertion 20981092
esv3579461 CNV loss 25503493
esv3625821 CNV gain 21293372
esv3625826 CNV loss 21293372
nsv1035755 CNV gain 25217958
nsv1040432 CNV loss 25217958
nsv1042013 CNV loss 25217958
nsv1046329 CNV loss 25217958
nsv1122602 CNV deletion 24896259
nsv1139547 CNV duplication 24896259
nsv1147322 CNV duplication 26484159
nsv467784 CNV loss 19166990
nsv473260 CNV novel sequence insertion 20440878
nsv478430 CNV novel sequence insertion 20440878
nsv480627 CNV novel sequence insertion 20440878
nsv507588 OTHER sequence alteration 20534489
nsv508621 CNV deletion 20534489
nsv513309 CNV insertion 21212237
nsv516888 CNV loss 19592680
nsv529004 CNV loss 19592680
nsv529004 CNV loss 19592680
nsv553947 CNV gain 21841781
nsv553948 CNV loss 21841781
nsv553949 CNV loss 21841781
nsv553950 CNV loss 21841781
nsv7725 CNV deletion 18451855
nsv832106 CNV gain 17160897
nsv975898 CNV duplication 23825009

Variation tolerance for DCDC1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC1 Gene

Disorders for DCDC1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for DCDC1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search DCDC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCDC1

genes like me logo Genes that share disorders with DCDC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC1 Gene

Publications for DCDC1 Gene

  1. Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PMID: 12820024) Zeng L … Mao Y (Journal of human genetics 2003) 2 3 4 23 54
  2. Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. (PMID: 22159412) Kaplan A … Reiner O (Journal of cell science 2011) 3 4 54
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 54
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner BL … Wichterle H (PloS one 2015) 3 54

Products for DCDC1 Gene

Sources for DCDC1 Gene