Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCDC1 Gene

Aliases for DCDC1 Gene

  • Doublecortin Domain Containing 1 2 3 5
  • Doublecortin Domain-Containing Protein 1 3
  • Doublecortin Domain-Containing Protein 5 3
  • Doublecortin Domain Containing 5 3

External Ids for DCDC1 Gene

Previous GeneCards Identifiers for DCDC1 Gene

  • GC00U900980
  • GC11M031248
  • GC11M031240
  • GC11M030964

Summaries for DCDC1 Gene

Entrez Gene Summary for DCDC1 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC1 Gene

DCDC1 (Doublecortin Domain Containing 1) is a Protein Coding gene.

Additional gene information for DCDC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC1 Gene

Genomics for DCDC1 Gene

GeneHancer (GH) Regulatory Elements for DCDC1 Gene

Promoters and enhancers for DCDC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J031369 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 678 -0.1 -91 1.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 DCDC1 DNAJC24 GC11M031425
GH11J031026 Enhancer 0.5 UCNEbase 15 +343.3 343273 0.3 POLR2A GC11P031026 DCDC1 GC11P031127
GH11J031794 Enhancer 1.1 VISTA UCNEbase dbSUPER 6.7 -426.1 -426079 2 USF1 PAX6 RCN1 DCDC1 GC11P031784 PAUPAR PAX6-AS1
GH11J031139 Enhancer 0.4 ENCODE 18.4 +230.0 230044 0.8 SP1 NANOG DCDC1 GC11P031127 GC11M031165
GH11J032259 Enhancer 0.6 ENCODE 4.8 -890.1 -890121 0.6 GATA3 NFIC SMAD1 IKZF1 JUNB FOS CUX1 BATF DCDC1 PIR50067 THEM7P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCDC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCDC1 gene promoter:
  • POU2F1a
  • POU2F1
  • POU3F2 (N-Oct-5b)
  • POU3F2 (N-Oct-5a)
  • POU3F2
  • Pax-4a
  • FOXL1
  • Sox5
  • TGIF

Genomic Locations for DCDC1 Gene

Genomic Locations for DCDC1 Gene
539,442 bases
Minus strand
539,442 bases
Minus strand

Genomic View for DCDC1 Gene

Genes around DCDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC1 Gene

Proteins for DCDC1 Gene

  • Protein details for DCDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6PVL6
    • B7WNX6
    • Q6ZU04

    Protein attributes for DCDC1 Gene

    354 amino acids
    Molecular mass:
    39859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCDC1 Gene


neXtProt entry for DCDC1 Gene

Post-translational modifications for DCDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCDC1 Gene

Domains & Families for DCDC1 Gene

Gene Families for DCDC1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for DCDC1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC1: view

No data available for UniProtKB/Swiss-Prot for DCDC1 Gene

Function for DCDC1 Gene

Phenotypes From GWAS Catalog for DCDC1 Gene

Gene Ontology (GO) - Molecular Function for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22159412
GO:0008017 microtubule binding IDA 22159412
genes like me logo Genes that share ontologies with DCDC1: view
genes like me logo Genes that share phenotypes with DCDC1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC1 Gene

Localization for DCDC1 Gene

Gene Ontology (GO) - Cellular Components for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
GO:0030496 midbody IDA 22159412
GO:0072686 mitotic spindle IDA 22159412
GO:0090543 Flemming body IDA 22159412
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for DCDC1 Gene

Pathways & Interactions for DCDC1 Gene

SuperPathways for DCDC1 Gene

No Data Available

Interacting Proteins for DCDC1 Gene

Gene Ontology (GO) - Biological Process for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
GO:1902412 regulation of mitotic cytokinesis IMP 22159412
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC1 Gene

Drugs & Compounds for DCDC1 Gene

No Compound Related Data Available

Transcripts for DCDC1 Gene

mRNA/cDNA for DCDC1 Gene

Unigene Clusters for DCDC1 Gene

Doublecortin domain containing 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -

Relevant External Links for DCDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DCDC1 Gene

This gene is overexpressed in Pituitary (x8.3), Testis (x6.8), Brain - Hippocampus (x5.4), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for DCDC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC1 Gene

Protein tissue co-expression partners for DCDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCDC1 Gene:


SOURCE GeneReport for Unigene cluster for DCDC1 Gene:


mRNA Expression by UniProt/SwissProt for DCDC1 Gene:

Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.
genes like me logo Genes that share expression patterns with DCDC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC1 Gene

Orthologs for DCDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCDC1 34 33
  • 99.06 (n)
(Canis familiaris)
Mammalia DCDC1 34 33
  • 90.75 (n)
(Bos Taurus)
Mammalia DCDC1 34 33
  • 88.56 (n)
(Ornithorhynchus anatinus)
Mammalia DCDC1 34
  • 62 (a)
(Anolis carolinensis)
Reptilia DCDC1 34
  • 58 (a)
Species where no ortholog for DCDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC1 Gene

Gene Tree for DCDC1 (if available)
Gene Tree for DCDC1 (if available)
Evolutionary constrained regions (ECRs) for DCDC1: view image

Paralogs for DCDC1 Gene

(2) SIMAP similar genes for DCDC1 Gene using alignment to 6 proteins:

  • H0Y2Q8_HUMAN
  • H7C298_HUMAN
  • M0R2J8_HUMAN
genes like me logo Genes that share paralogs with DCDC1: view

No data available for Paralogs for DCDC1 Gene

Variants for DCDC1 Gene

Sequence variations from dbSNP and Humsavar for DCDC1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000021246 -- 31,288,984(-) C/T intron_variant
rs1000031855 -- 31,335,578(-) T/A intron_variant
rs1000042477 -- 31,307,608(-) G/A intron_variant
rs1000118575 -- 31,267,896(-) C/T intron_variant
rs1000120345 -- 31,364,985(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC1 Gene

Variant ID Type Subtype PubMed ID
dgv1734n54 CNV loss 21841781
esv2658686 CNV deletion 23128226
esv2751022 CNV loss 17911159
esv3579461 CNV loss 25503493
esv3625826 CNV loss 21293372
nsv1040432 CNV loss 25217958
nsv1042013 CNV loss 25217958
nsv1046329 CNV loss 25217958
nsv1139547 CNV duplication 24896259
nsv467784 CNV loss 19166990
nsv478430 CNV novel sequence insertion 20440878
nsv508621 CNV deletion 20534489
nsv529004 CNV loss 19592680
nsv553949 CNV loss 21841781
nsv553950 CNV loss 21841781
nsv7725 CNV deletion 18451855
nsv832106 CNV gain 17160897
nsv975898 CNV duplication 23825009

Variation tolerance for DCDC1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC1 Gene

Disorders for DCDC1 Gene

Additional Disease Information for DCDC1

No disorders were found for DCDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC1 Gene

Publications for DCDC1 Gene

  1. Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PMID: 12820024) Zeng L … Mao Y (Journal of human genetics 2003) 2 3 4 22 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner BL … Wichterle H (PloS one 2015) 3 58
  5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K … Rivadeneira F (Nature genetics 2012) 3 58

Products for DCDC1 Gene

Sources for DCDC1 Gene

Loading form....