Aliases for DCD Gene
External Ids for DCD Gene
Previous GeneCards Identifiers for DCD Gene
This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
GeneCards Summary for DCD Gene
DCD (Dermcidin) is a Protein Coding gene. Diseases associated with DCD include Root Caries and Netherton Syndrome. Among its related pathways are Defensins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptidase activity. An important paralog of this gene is LACRT.
UniProtKB/Swiss-Prot Summary for DCD Gene
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443).
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.