Aliases for DCC Gene
External Ids for DCC Gene
Previous GeneCards Identifiers for DCC Gene
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
GeneCards Summary for DCC Gene
DCC (DCC Netrin 1 Receptor) is a Protein Coding gene. Diseases associated with DCC include Mirror Movements 1 and Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development. Among its related pathways are Activation of cAMP-Dependent PKA and Netrin-1 signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is NEO1.
UniProtKB/Swiss-Prot Summary for DCC Gene
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.