This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with a... See more...

Aliases for DCANP1 Gene

Aliases for DCANP1 Gene

  • Dendritic Cell Associated Nuclear Protein 2 3 5
  • Dendritic Cell Nuclear Protein 1 2 3 4
  • C5orf20 3 4
  • DCNP1 3 4
  • Dendritic Cell-Associated Nuclear Protein 4
  • Chromosome 5 Open Reading Frame 20 2
  • Dendritic Cell Nuclear Protein-1 4

External Ids for DCANP1 Gene

Previous HGNC Symbols for DCANP1 Gene

  • C5orf20

Summaries for DCANP1 Gene

Entrez Gene Summary for DCANP1 Gene

  • This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCANP1 Gene

DCANP1 (Dendritic Cell Associated Nuclear Protein) is a Protein Coding gene. Diseases associated with DCANP1 include Depression and Moebius Syndrome.

UniProtKB/Swiss-Prot Summary for DCANP1 Gene

  • Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Additional gene information for DCANP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCANP1 Gene

Genomics for DCANP1 Gene

GeneHancer (GH) Regulatory Elements for DCANP1 Gene

Promoters and enhancers for DCANP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCANP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCANP1

Genomic Locations for DCANP1 Gene

Genomic Locations for DCANP1 Gene
chr5:135,444,214-135,447,348
(GRCh38/hg38)
Size:
3,135 bases
Orientation:
Minus strand
chr5:134,779,904-134,783,038
(GRCh37/hg19)
Size:
3,135 bases
Orientation:
Minus strand

Genomic View for DCANP1 Gene

Genes around DCANP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCANP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCANP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCANP1 Gene

Proteins for DCANP1 Gene

  • Protein details for DCANP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF63-DCNP1_HUMAN
    Recommended name:
    Dendritic cell nuclear protein 1
    Protein Accession:
    Q8TF63

    Protein attributes for DCANP1 Gene

    Size:
    244 amino acids
    Molecular mass:
    26704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCANP1 Gene

Post-translational modifications for DCANP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCANP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCANP1 Gene

Domains & Families for DCANP1 Gene

Gene Families for DCANP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCANP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DCANP1 Gene

GenScript: Design optimal peptide antigens:
  • Dendritic cell nuclear protein 1 (DCNP1_HUMAN)
genes like me logo Genes that share domains with DCANP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DCANP1 Gene

Function for DCANP1 Gene

Molecular function for DCANP1 Gene

UniProtKB/Swiss-Prot Function:
Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Phenotypes From GWAS Catalog for DCANP1 Gene

Gene Ontology (GO) - Molecular Function for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCANP1: view

Phenotypes for DCANP1 Gene

genes like me logo Genes that share phenotypes with DCANP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCANP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCANP1 Gene

Localization for DCANP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCANP1 Gene

Nucleus. Cytoplasm. Note=Particularly on the periphery. Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. {ECO:0000269 PubMed:20693543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCANP1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCANP1 Gene

Pathways & Interactions for DCANP1 Gene

PathCards logo

SuperPathways for DCANP1 Gene

No Data Available

Interacting Proteins for DCANP1 Gene

Selected Interacting proteins: Q8TF63-DCNP1_HUMAN for DCANP1 Gene via UniProtKB IID

Symbol External ID(s) Details
MDFI
;

Gene Ontology (GO) - Biological Process for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007356 thorax and anterior abdomen determination IGI 23419067
GO:0021559 trigeminal nerve development IGI 23419067
GO:0021650 vestibulocochlear nerve formation IGI 23419067
GO:0030432 peristalsis IGI 23419067
GO:0031223 auditory behavior IGI 23419067
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Pathways by source and SIGNOR curated interactions for DCANP1 Gene

Drugs & Compounds for DCANP1 Gene

No Compound Related Data Available

Transcripts for DCANP1 Gene

mRNA/cDNA for DCANP1 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCANP1

Alternative Splicing Database (ASD) splice patterns (SP) for DCANP1 Gene

No ASD Table

Relevant External Links for DCANP1 Gene

GeneLoc Exon Structure for
DCANP1

Expression for DCANP1 Gene

Protein differential expression in normal tissues from HIPED for DCANP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCANP1 Gene



Protein tissue co-expression partners for DCANP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCANP1

mRNA Expression by UniProt/SwissProt for DCANP1 Gene:

Q8TF63-DCNP1_HUMAN
Tissue specificity: Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells.

Evidence on tissue expression from TISSUES for DCANP1 Gene

  • Lung(4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCANP1 Gene

Orthologs for DCANP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCANP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf20 30
  • 98.36 (n)
Species where no ortholog for DCANP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCANP1 Gene

ENSEMBL:
Gene Tree for DCANP1 (if available)
TreeFam:
Gene Tree for DCANP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCANP1: view image

Paralogs for DCANP1 Gene

No data available for Paralogs for DCANP1 Gene

Variants for DCANP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCANP1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs1031844 - p.Thr75Pro
rs12520809 - p.Asn97Asp

Additional dbSNP identifiers (rs#s) for DCANP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCANP1 Gene

Variant ID Type Subtype PubMed ID
esv2657420 CNV deletion 23128226

Variation tolerance for DCANP1 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCANP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCANP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCANP1 Gene

Disorders for DCANP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCANP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
depression
  • major depressive disorder
moebius syndrome
  • mbs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCANP1

genes like me logo Genes that share disorders with DCANP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCANP1 Gene

Publications for DCANP1 Gene

  1. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. (PMID: 11798177) Masuda M … Nishimura Y (Biochemical and biophysical research communications 2002) 2 3 4 23 54
  2. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. (PMID: 20693543) Zhou T … Swaab DF (Brain : a journal of neurology 2010) 2 3 4 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 54
  5. Dendritic cell nuclear protein-1 regulates melatonin biosynthesis by binding to BMAL1 and inhibiting the transcription of N-acetyltransferase in C6 cells. (PMID: 29219947) Chen D … Wang GH (Acta pharmacologica Sinica 2018) 3 54

Products for DCANP1 Gene

Sources for DCANP1 Gene