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Aliases for DCANP1 Gene

Aliases for DCANP1 Gene

  • Dendritic Cell Associated Nuclear Protein 2 3 5
  • Dendritic Cell Nuclear Protein 1 2 3
  • C5orf20 3 4
  • DCNP1 3 4
  • Dendritic Cell-Associated Nuclear Protein 4
  • Chromosome 5 Open Reading Frame 20 2
  • Dendritic Cell Nuclear Protein-1 4

External Ids for DCANP1 Gene

Previous HGNC Symbols for DCANP1 Gene

  • C5orf20

Summaries for DCANP1 Gene

Entrez Gene Summary for DCANP1 Gene

  • This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCANP1 Gene

DCANP1 (Dendritic Cell Associated Nuclear Protein) is a Protein Coding gene. Diseases associated with DCANP1 include Depression.

UniProtKB/Swiss-Prot for DCANP1 Gene

  • Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Additional gene information for DCANP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCANP1 Gene

Genomics for DCANP1 Gene

GeneHancer (GH) Regulatory Elements for DCANP1 Gene

Promoters and enhancers for DCANP1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J135353 Enhancer 0.8 ENCODE dbSUPER 11.8 +91.7 91747 4.3 RXRA REST NR2F2 SP1 NFIC JUND RCOR1 ZBTB17 ENSG00000270021 H2AFY DCANP1 PIR34891 GC05M135339 C5orf66
GH05J135357 Enhancer 0.6 dbSUPER 11.8 +87.2 87189 4.6 ZIC2 NR2F2 PRDM6 ZFHX2 ZNF585B PRDM1 ZBTB17 EGR2 ENSG00000270021 H2AFY DCANP1 TXNDC15 JADE2 PIR34891 GC05M135339 C5orf66
GH05J135132 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 2.4 +312.6 312567 3.8 HDGF PKNOX1 SMAD1 ARNT ARID4B DMAP1 YY1 ZNF766 CBX5 E2F8 DDX46 C5orf66 SEC24A JADE2 DCANP1 PITX1 LOC105379188 ENSG00000248753 C5orf66-AS2
GH05J135433 Enhancer 1.3 VISTA Ensembl ENCODE 0.4 +12.4 12423 3.1 BCOR ELF3 TFAP4 ARID4B ZMYM3 ZBTB40 POLR2A ADNP SMARCA5 CEBPB ENSG00000249639 H2AFY NEUROG1 ENSG00000270021 DCANP1
GH05J135436 Enhancer 1 Ensembl ENCODE 0.4 +8.9 8942 3.6 PKNOX1 NFIB SIN3A ZNF766 IKZF2 RUNX3 ZBTB11 ZNF592 ZNF148 NFIC TXNDC15 H2AFY ENSG00000249639 JADE2 DCANP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCANP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCANP1 Gene

Genomic Locations for DCANP1 Gene
3,135 bases
Minus strand
3,135 bases
Minus strand

Genomic View for DCANP1 Gene

Genes around DCANP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCANP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCANP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCANP1 Gene

Proteins for DCANP1 Gene

  • Protein details for DCANP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dendritic cell nuclear protein 1
    Protein Accession:

    Protein attributes for DCANP1 Gene

    244 amino acids
    Molecular mass:
    26704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCANP1 Gene

Post-translational modifications for DCANP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCANP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCANP1 Gene

Domains & Families for DCANP1 Gene

Gene Families for DCANP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCANP1 Gene


Suggested Antigen Peptide Sequences for DCANP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCANP1: view

No data available for UniProtKB/Swiss-Prot for DCANP1 Gene

Function for DCANP1 Gene

Molecular function for DCANP1 Gene

UniProtKB/Swiss-Prot Function:
Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Gene Ontology (GO) - Molecular Function for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCANP1: view

Phenotypes for DCANP1 Gene

genes like me logo Genes that share phenotypes with DCANP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCANP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCANP1 Gene

Localization for DCANP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCANP1 Gene

Nucleus. Cytoplasm. Note=Particularly on the periphery. Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. {ECO:0000269 PubMed:20693543}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCANP1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCANP1 Gene

Pathways & Interactions for DCANP1 Gene

SuperPathways for DCANP1 Gene

No Data Available

Interacting Proteins for DCANP1 Gene

Selected Interacting proteins: Q8TF63-DCNP1_HUMAN for DCANP1 Gene via UniProtKB IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007356 thorax and anterior abdomen determination IGI 23419067
GO:0021559 trigeminal nerve development IGI 23419067
GO:0021650 vestibulocochlear nerve formation IGI 23419067
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Pathways by source and SIGNOR curated interactions for DCANP1 Gene

Drugs & Compounds for DCANP1 Gene

No Compound Related Data Available

Transcripts for DCANP1 Gene

mRNA/cDNA for DCANP1 Gene

(1) REFSEQ mRNAs :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCANP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCANP1 Gene

No ASD Table

Relevant External Links for DCANP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCANP1 Gene

Protein differential expression in normal tissues from HIPED for DCANP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCANP1 Gene

Protein tissue co-expression partners for DCANP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCANP1 Gene:


mRNA Expression by UniProt/SwissProt for DCANP1 Gene:

Tissue specificity: Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells.

Evidence on tissue expression from TISSUES for DCANP1 Gene

  • Lung(4)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCANP1 Gene

Orthologs for DCANP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCANP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C5H5orf20 33
  • 98.36 (n)
Species where no ortholog for DCANP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCANP1 Gene

Gene Tree for DCANP1 (if available)
Gene Tree for DCANP1 (if available)
Evolutionary constrained regions (ECRs) for DCANP1: view image

Paralogs for DCANP1 Gene

No data available for Paralogs for DCANP1 Gene

Variants for DCANP1 Gene

Sequence variations from dbSNP and Humsavar for DCANP1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000476115 -- 135,447,971(-) C/G upstream_transcript_variant
rs1000516626 -- 135,446,158(-) C/ 3_prime_UTR_variant
rs1001559869 -- 135,445,565(-) C/T 3_prime_UTR_variant
rs1001893830 -- 135,444,594(-) C/G 3_prime_UTR_variant
rs1002367668 -- 135,449,199(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCANP1 Gene

Variant ID Type Subtype PubMed ID
esv2657420 CNV deletion 23128226

Variation tolerance for DCANP1 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCANP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCANP1 Gene

Disorders for DCANP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCANP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
  • major depressive disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCANP1

genes like me logo Genes that share disorders with DCANP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCANP1 Gene

Publications for DCANP1 Gene

  1. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. (PMID: 11798177) Masuda M … Nishimura Y (Biochemical and biophysical research communications 2002) 2 3 4 22 58
  2. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. (PMID: 20693543) Zhou T … Swaab DF (Brain : a journal of neurology 2010) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for DCANP1 Gene

Sources for DCANP1 Gene

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