Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3 5
  • Dephospho-CoA Kinase Domain-Containing Protein 3 4
  • EC 2.7.1.24 52

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include dephospho-CoA kinase activity. An important paralog of this gene is COASY.

Additional gene information for DCAKD Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

GeneHancer (GH) Regulatory Elements for DCAKD Gene

Promoters and enhancers for DCAKD Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAKD on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCAKD

Top Transcription factor binding sites by QIAGEN in the DCAKD gene promoter:
  • AP-1
  • AP-4
  • c-Fos
  • Cart-1
  • IRF-1
  • MAZR

Genomic Locations for DCAKD Gene

Genomic Locations for DCAKD Gene
chr17:45,023,338-45,061,141
(GRCh38/hg38)
Size:
37,804 bases
Orientation:
Minus strand
chr17:43,100,706-43,138,473
(GRCh37/hg19)
Size:
37,768 bases
Orientation:
Minus strand

Genomic View for DCAKD Gene

Genes around DCAKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVC6-DCAKD_HUMAN
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Q8WVC6
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    Size:
    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAKD Gene

Selected DME Specific Peptides for DCAKD Gene

Q8WVC6:
  • DIPLLFE
  • LTGGIASGK

Post-translational modifications for DCAKD Gene

  • Ubiquitination at Lys67, Lys168, and Lys186
  • Modification sites at PhosphoSitePlus

Domains & Families for DCAKD Gene

Gene Families for DCAKD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DCAKD Gene

Blocks:
  • Dephospho-CoA kinase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:
  • Dephospho-CoA kinase domain-containing protein (DCAKD_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WVC6

UniProtKB/Swiss-Prot:

DCAKD_HUMAN :
  • Belongs to the CoaE family.
Family:
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

Function for DCAKD Gene

Enzyme Numbers (IUBMB) for DCAKD Gene

Phenotypes From GWAS Catalog for DCAKD Gene

Gene Ontology (GO) - Molecular Function for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCAKD: view
genes like me logo Genes that share phenotypes with DCAKD: view

Animal Models for DCAKD Gene

MGI Knock Outs for DCAKD:
  • Dcakd Dcakd<tm1b(EUCOMM)Hmgu>

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for DCAKD

No data available for Molecular function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DCAKD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAKD Gene

Pathways & Interactions for DCAKD Gene

PathCards logo

SuperPathways for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IBA 21873635
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCAKD: view

No data available for SIGNOR curated interactions for DCAKD Gene

Drugs & Compounds for DCAKD Gene

No Compound Related Data Available

Transcripts for DCAKD Gene

mRNA/cDNA for DCAKD Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for DCAKD

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
DCAKD

Expression for DCAKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAKD Gene

Protein differential expression in normal tissues from HIPED for DCAKD Gene

This gene is overexpressed in Nasal epithelium (27.3) and Bone (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAKD Gene



Protein tissue co-expression partners for DCAKD Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCAKD

SOURCE GeneReport for Unigene cluster for DCAKD Gene:

Hs.463148

Evidence on tissue expression from TISSUES for DCAKD Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with DCAKD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAKD 31 30
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCAKD 31 30
  • 89.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCAKD 31 30
  • 87.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcakd 30
  • 87 (n)
mouse
(Mus musculus)
Mammalia Dcakd 17 31 30
  • 86.09 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAKD 31
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAKD 31 30
  • 67.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAKD 31
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 30
  • 60.55 (n)
Str.7183 30
zebrafish
(Danio rerio)
Actinopterygii dcakd 31 30
  • 61.42 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dpck 31 30
  • 55.19 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 30
  • 51.16 (n)
worm
(Caenorhabditis elegans)
Secernentea T05G5.5 31 30
  • 48.27 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 30
  • 53.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 30
  • 46.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 33 31 30
  • 46.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 30
  • 46.36 (n)
rice
(Oryza sativa)
Liliopsida Os01g0360600 30
  • 50.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 30
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 30
  • 48.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 41 (a)
OneToOne
Species where no ortholog for DCAKD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

ENSEMBL:
Gene Tree for DCAKD (if available)
TreeFam:
Gene Tree for DCAKD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAKD: view image

Paralogs for DCAKD Gene

Paralogs for DCAKD Gene

(1) SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

  • DCAKD_HUMAN
  • K7ESP4_HUMAN
genes like me logo Genes that share paralogs with DCAKD: view

Variants for DCAKD Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCAKD Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs17850104 - p.Asn84Ile

Additional dbSNP identifiers (rs#s) for DCAKD Gene

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
esv1217416 CNV deletion 17803354
esv2438788 CNV deletion 19546169
esv2674469 CNV deletion 23128226
esv3640657 CNV loss 21293372
nsv1072739 CNV deletion 25765185
nsv1144803 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953902 CNV deletion 24416366

Variation tolerance for DCAKD Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAKD Gene

Human Gene Mutation Database (HGMD)
DCAKD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAKD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Additional Disease Information for DCAKD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DCAKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAKD Gene

Publications for DCAKD Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  3. The shieldin complex mediates 53BP1-dependent DNA repair. (PMID: 30022168) Noordermeer SM … Durocher D (Nature 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for DCAKD Gene

Sources for DCAKD Gene