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Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3 5
  • Dephospho-CoA Kinase Domain-Containing Protein 3

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include dephospho-CoA kinase activity.

Additional gene information for DCAKD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

GeneHancer (GH) Regulatory Elements for DCAKD Gene

Promoters and enhancers for DCAKD Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J045059 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 674.6 -0.6 -605 4.9 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 DCAKD PIR53442 NMT1 ENSG00000262372 ASB16-AS1 TMUB2 UBTF ENSG00000224505 EFTUD2 MAP3K14-AS1
GH17J045049 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 681 +9.8 9787 3 HDGF SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 DCAKD NMT1 ENSG00000262372 UBTF ASB16-AS1 SLC25A39 GC17M045043
GH17J045089 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 34.9 -31.1 -31065 4.6 FOXA2 ZSCAN4 ARID4B SIN3A RAD21 RARA YY1 ZNF121 FOS ZNF362 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 HIGD1B ADAM11 ENSG00000200888 MIR6784
GH17J045143 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 21.9 -86.8 -86806 9.6 CLOCK MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 HEXIM1 ENSG00000276728 GC17M045149 ENSG00000262372 ASB16-AS1 UBTF TMUB2 ENSG00000224505 LINC02210 EFTUD2
GH17J045020 Enhancer 1.4 Ensembl ENCODE dbSUPER 27.4 +39.7 39717 2.5 ATF1 ZFP64 ARID4B DMAP1 ZNF48 ZNF207 ZNF143 ZFP91 ATF7 NFKBIZ DCAKD ASB16-AS1 UBTF TMUB2 NMT1 C1QL1 GFAP CCDC103 EFTUD2 FAM187A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAKD on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DCAKD gene promoter:

Genomic Locations for DCAKD Gene

Genomic Locations for DCAKD Gene
chr17:45,023,338-45,061,141
(GRCh38/hg38)
Size:
37,804 bases
Orientation:
Minus strand
chr17:43,100,706-43,138,473
(GRCh37/hg19)

Genomic View for DCAKD Gene

Genes around DCAKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVC6-DCAKD_HUMAN
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Q8WVC6
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    Size:
    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAKD Gene

Post-translational modifications for DCAKD Gene

  • Ubiquitination at posLast=186186, posLast=168168, and posLast=6767
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAKD Gene

Domains & Families for DCAKD Gene

Gene Families for DCAKD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DCAKD Gene

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVC6

UniProtKB/Swiss-Prot:

DCAKD_HUMAN :
  • Belongs to the CoaE family.
Family:
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

Function for DCAKD Gene

Phenotypes From GWAS Catalog for DCAKD Gene

Gene Ontology (GO) - Molecular Function for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCAKD: view
genes like me logo Genes that share phenotypes with DCAKD: view

Animal Model Products

Clone Products

  • Addgene plasmids for DCAKD

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
mitochondrion 3
cytosol 3
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with DCAKD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAKD Gene

Pathways & Interactions for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCAKD: view

No data available for SIGNOR curated interactions for DCAKD Gene

Drugs & Compounds for DCAKD Gene

No Compound Related Data Available

Transcripts for DCAKD Gene

Unigene Clusters for DCAKD Gene

Dephospho-CoA kinase domain containing:
Representative Sequences:

Clone Products

  • Addgene plasmids for DCAKD

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
DCAKD
ECgene alternative splicing isoforms for
DCAKD

Expression for DCAKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAKD Gene

Protein differential expression in normal tissues from HIPED for DCAKD Gene

This gene is overexpressed in Nasal epithelium (27.3) and Bone (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAKD Gene



Protein tissue co-expression partners for DCAKD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAKD Gene:

DCAKD

SOURCE GeneReport for Unigene cluster for DCAKD Gene:

Hs.463148

Evidence on tissue expression from TISSUES for DCAKD Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with DCAKD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAKD 34 33
  • 99.13 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCAKD 34 33
  • 89.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCAKD 34 33
  • 87.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcakd 33
  • 87 (n)
mouse
(Mus musculus)
Mammalia Dcakd 16 34 33
  • 86.09 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAKD 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAKD 34 33
  • 67.13 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAKD 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 33
  • 60.55 (n)
Str.7183 33
zebrafish
(Danio rerio)
Actinopterygii dcakd 34 33
  • 61.42 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dpck 34 33
  • 55.19 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 33
  • 51.16 (n)
worm
(Caenorhabditis elegans)
Secernentea T05G5.5 34 33
  • 48.27 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 33
  • 53.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 33
  • 46.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 36 34 33
  • 46.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 33
  • 46.36 (n)
rice
(Oryza sativa)
Liliopsida Os01g0360600 33
  • 50.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 33
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 33
  • 48.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for DCAKD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

ENSEMBL:
Gene Tree for DCAKD (if available)
TreeFam:
Gene Tree for DCAKD (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAKD: view image

Paralogs for DCAKD Gene

(1) SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

  • DCAKD_HUMAN
  • K7ESP4_HUMAN
genes like me logo Genes that share paralogs with DCAKD: view

No data available for Paralogs for DCAKD Gene

Variants for DCAKD Gene

Sequence variations from dbSNP and Humsavar for DCAKD Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000027557 -- 45,054,204(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000177332 -- 45,057,795(-) GAGG/G genic_upstream_transcript_variant, intron_variant
rs1000195666 -- 45,049,187(-) C/G genic_upstream_transcript_variant, intron_variant
rs1000242322 -- 45,056,525(-) G/T genic_upstream_transcript_variant, intron_variant
rs1000281128 -- 45,037,004(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
esv1217416 CNV deletion 17803354
esv2438788 CNV deletion 19546169
esv2674469 CNV deletion 23128226
esv3640657 CNV loss 21293372
nsv1072739 CNV deletion 25765185
nsv1144803 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953902 CNV deletion 24416366

Variation tolerance for DCAKD Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAKD Gene

Human Gene Mutation Database (HGMD)
DCAKD
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAKD

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Additional Disease Information for DCAKD

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DCAKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAKD Gene

Publications for DCAKD Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for DCAKD Gene

  • Addgene plasmids for DCAKD

Sources for DCAKD Gene

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