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Aliases for DCAF8L2 Gene

Aliases for DCAF8L2 Gene

  • DDB1 And CUL4 Associated Factor 8 Like 2 2 3 5
  • WD Repeat-Containing Protein 42C 3 4
  • WD Repeat Domain 42C 2 3
  • WDR42C 3 4
  • DDB1- And CUL4-Associated Factor 8-Like Protein 2 3

External Ids for DCAF8L2 Gene

Previous HGNC Symbols for DCAF8L2 Gene

  • WDR42C

Previous GeneCards Identifiers for DCAF8L2 Gene

  • GC0XP027662
  • GC0XP027764
  • GC0XP025504

Summaries for DCAF8L2 Gene

GeneCards Summary for DCAF8L2 Gene

DCAF8L2 (DDB1 And CUL4 Associated Factor 8 Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF8L1.

Additional gene information for DCAF8L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8L2 Gene

Genomics for DCAF8L2 Gene

GeneHancer (GH) Regulatory Elements for DCAF8L2 Gene

Promoters and enhancers for DCAF8L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ027597 Enhancer 0.4 ENCODE 0.4 +8.1 8056 1 SOX5 SOX13 VEZF1 DCAF8L2 MAGEB10
GH0XJ027564 Enhancer 0.5 ENCODE 0.3 -24.2 -24232 2.8 SOX13 JUN ZKSCAN8 VEZF1 CBFA2T3 FOXA1 GC0XP027553 DCAF8L2
GH0XJ027600 Enhancer 0.3 ENCODE 0.4 +10.6 10557 0.2 JUN DCAF8L2 MAGEB10
GH0XJ027619 Enhancer 0.4 ENCODE 0.3 +29.3 29309 1 CTCF JUN RAD21 DCAF8L2 MAGEB10
GH0XJ027675 Enhancer 0.4 ENCODE 0.2 +85.3 85297 0.2 NFIB CEBPB DCAF8L2 MAGEB10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF8L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF8L2 Gene

Genomic Locations for DCAF8L2 Gene
158,440 bases
Plus strand

Genomic View for DCAF8L2 Gene

Genes around DCAF8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8L2 Gene

Proteins for DCAF8L2 Gene

  • Protein details for DCAF8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 8-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RXH9
    • J3KT06

    Protein attributes for DCAF8L2 Gene

    631 amino acids
    Molecular mass:
    71191 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF8L2 Gene

Post-translational modifications for DCAF8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCAF8L2 Gene

Domains & Families for DCAF8L2 Gene

Gene Families for DCAF8L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF8L2 Gene

Suggested Antigen Peptide Sequences for DCAF8L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF8 family.
  • Belongs to the WD repeat DCAF8 family.
genes like me logo Genes that share domains with DCAF8L2: view

Function for DCAF8L2 Gene

genes like me logo Genes that share phenotypes with DCAF8L2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCAF8L2 Gene

Localization for DCAF8L2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF8L2 Gene

Pathways & Interactions for DCAF8L2 Gene

SuperPathways for DCAF8L2 Gene

No Data Available

Interacting Proteins for DCAF8L2 Gene

Gene Ontology (GO) - Biological Process for DCAF8L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF8L2 Gene

Drugs & Compounds for DCAF8L2 Gene

No Compound Related Data Available

Transcripts for DCAF8L2 Gene

mRNA/cDNA for DCAF8L2 Gene

(3) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(11) REFSEQ mRNAs :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8L2 Gene

DDB1 and CUL4 associated factor 8-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8L2 Gene

No ASD Table

Relevant External Links for DCAF8L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF8L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF8L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF8L2 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for DCAF8L2 Gene

This gene is overexpressed in Ovary (49.9) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF8L2 Gene

Protein tissue co-expression partners for DCAF8L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF8L2 Gene:


SOURCE GeneReport for Unigene cluster for DCAF8L2 Gene:

genes like me logo Genes that share expression patterns with DCAF8L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF8L2 Gene

Orthologs for DCAF8L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF8L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF8L2 34 33
  • 98.31 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 70 (a)
(Canis familiaris)
Mammalia -- 34
  • 69 (a)
(Mus musculus)
Mammalia Pet2 34
  • 47 (a)
(Gallus gallus)
Aves -- 34
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 51 (a)
(Danio rerio)
Actinopterygii DCAF8 34
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8001 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35140 33
  • 49.25 (n)
(Oryza sativa)
Liliopsida Os10g0544500 33
  • 48.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 34
  • 49 (a)
Species where no ortholog for DCAF8L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8L2 Gene

Gene Tree for DCAF8L2 (if available)
Gene Tree for DCAF8L2 (if available)
Evolutionary constrained regions (ECRs) for DCAF8L2: view image

Paralogs for DCAF8L2 Gene

Paralogs for DCAF8L2 Gene

(2) SIMAP similar genes for DCAF8L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF8L2: view

Variants for DCAF8L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF8L2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003128073 -- 27,746,968(+) G/A coding_sequence_variant, missense_variant
rs1006746708 -- 27,747,482(+) G/A/T coding_sequence_variant, missense_variant
rs1007782634 -- 27,745,894(+) T/G upstream_transcript_variant
rs1007877454 -- 27,746,454(+) A/G upstream_transcript_variant
rs1011283785 -- 27,745,638(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF8L2 Gene

Variant ID Type Subtype PubMed ID
nsv508756 CNV insertion 20534489
nsv521729 CNV gain 19592680
nsv526948 CNV gain 19592680

Variation tolerance for DCAF8L2 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF8L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF8L2 Gene

Disorders for DCAF8L2 Gene

Additional Disease Information for DCAF8L2

No disorders were found for DCAF8L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF8L2 Gene

Publications for DCAF8L2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58

Products for DCAF8L2 Gene

Sources for DCAF8L2 Gene

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