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Aliases for DCAF8L1 Gene

Aliases for DCAF8L1 Gene

  • DDB1 And CUL4 Associated Factor 8 Like 1 2 3 5
  • WD Repeat-Containing Protein 42B 3 4
  • WD Repeat Domain 42B 2 3
  • WDR42B 3 4
  • DDB1- And CUL4-Associated Factor 8-Like Protein 1 3

External Ids for DCAF8L1 Gene

Previous HGNC Symbols for DCAF8L1 Gene

  • WDR42B

Previous GeneCards Identifiers for DCAF8L1 Gene

  • GC0XM027907
  • GC0XM025736

Summaries for DCAF8L1 Gene

Entrez Gene Summary for DCAF8L1 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

GeneCards Summary for DCAF8L1 Gene

DCAF8L1 (DDB1 And CUL4 Associated Factor 8 Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF8L2.

Additional gene information for DCAF8L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8L1 Gene

Genomics for DCAF8L1 Gene

Genomic Locations for DCAF8L1 Gene

Genomic Locations for DCAF8L1 Gene
3,457 bases
Minus strand
3,457 bases
Minus strand

Genomic View for DCAF8L1 Gene

Genes around DCAF8L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF8L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8L1 Gene

No data available for GeneHancer (GH) Regulatory Elements for DCAF8L1 Gene

Proteins for DCAF8L1 Gene

  • Protein details for DCAF8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 8-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KXX1

    Protein attributes for DCAF8L1 Gene

    600 amino acids
    Molecular mass:
    67373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF8L1 Gene

Post-translational modifications for DCAF8L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF8L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF8L1 Gene

Domains & Families for DCAF8L1 Gene

Gene Families for DCAF8L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF8L1 Gene

Suggested Antigen Peptide Sequences for DCAF8L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF8 family.
  • Belongs to the WD repeat DCAF8 family.
genes like me logo Genes that share domains with DCAF8L1: view

Function for DCAF8L1 Gene

Phenotypes From GWAS Catalog for DCAF8L1 Gene

genes like me logo Genes that share phenotypes with DCAF8L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCAF8L1 Gene

Localization for DCAF8L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF8L1 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF8L1 Gene

Pathways & Interactions for DCAF8L1 Gene

SuperPathways for DCAF8L1 Gene

No Data Available

Interacting Proteins for DCAF8L1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A6NGE4-DC8L1_HUMAN ENSP00000405222 for DCAF8L1 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DCAF8L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF8L1 Gene

Drugs & Compounds for DCAF8L1 Gene

No Compound Related Data Available

Transcripts for DCAF8L1 Gene

mRNA/cDNA for DCAF8L1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8L1 Gene

DDB1 and CUL4 associated factor 8-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8L1 Gene

No ASD Table

Relevant External Links for DCAF8L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF8L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF8L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF8L1 Gene

This gene is overexpressed in Testis (x44.4) and Bladder (x4.9).

Protein differential expression in normal tissues from HIPED for DCAF8L1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCAF8L1 Gene

Protein tissue co-expression partners for DCAF8L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF8L1 Gene:


SOURCE GeneReport for Unigene cluster for DCAF8L1 Gene:

genes like me logo Genes that share expression patterns with DCAF8L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF8L1 Gene

Orthologs for DCAF8L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF8L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF8L1 34
  • 97 (a)
(Canis familiaris)
Mammalia -- 34
  • 66 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
(Mus musculus)
Mammalia Pet2 34
  • 43 (a)
(Gallus gallus)
Aves -- 34
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 48 (a)
(Danio rerio)
Actinopterygii DCAF8 34
  • 51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8001 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 34
  • 48 (a)
Species where no ortholog for DCAF8L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8L1 Gene

Gene Tree for DCAF8L1 (if available)
Gene Tree for DCAF8L1 (if available)
Evolutionary constrained regions (ECRs) for DCAF8L1: view image

Paralogs for DCAF8L1 Gene

Paralogs for DCAF8L1 Gene

(2) SIMAP similar genes for DCAF8L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF8L1: view

Variants for DCAF8L1 Gene

Sequence variations from dbSNP and Humsavar for DCAF8L1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1001188837 -- 27,982,921(-) G/T upstream_transcript_variant
rs1002178761 -- 27,978,464(-) A/G 3_prime_UTR_variant
rs1002634546 -- 27,977,755(-) A/G downstream_transcript_variant
rs1004451559 -- 27,978,266(-) T/G 3_prime_UTR_variant
rs1004506846 -- 27,977,707(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF8L1 Gene

Variant ID Type Subtype PubMed ID
nsv518944 CNV gain 19592680
nsv6839 CNV deletion 18451855

Variation tolerance for DCAF8L1 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF8L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF8L1 Gene

Disorders for DCAF8L1 Gene

Additional Disease Information for DCAF8L1

No disorders were found for DCAF8L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF8L1 Gene

Publications for DCAF8L1 Gene

  1. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns SL … Rosenstein BS (International journal of radiation oncology, biology, physics 2010) 3 44 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk JB … O'Connor GT (BMC medical genetics 2007) 44 58
  4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for DCAF8L1 Gene

Sources for DCAF8L1 Gene

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