Aliases for DCAF7 Gene
External Ids for DCAF7 Gene
Previous HGNC Symbols for DCAF7 Gene
Previous GeneCards Identifiers for DCAF7 Gene
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for DCAF7 Gene
DCAF7 (DDB1 And CUL4 Associated Factor 7) is a Protein Coding gene. Diseases associated with DCAF7 include Mental Retardation, Autosomal Dominant 7 and Abdominal Obesity-Metabolic Syndrome 3. Among its related pathways are Chaperonin-mediated protein folding and Metabolism of proteins.
UniProtKB/Swiss-Prot Summary for DCAF7 Gene
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.