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Aliases for DCAF6 Gene

Aliases for DCAF6 Gene

  • DDB1 And CUL4 Associated Factor 6 2 3 5
  • Androgen Receptor Complex-Associated Protein 3 4
  • IQ Motif And WD Repeat-Containing Protein 1 3 4
  • Nuclear Receptor Interaction Protein 3 4
  • IQ Motif And WD Repeats 1 2 3
  • IQWD1 3 4
  • ARCAP 3 4
  • NRIP 3 4
  • DDB1- And CUL4-Associated Factor 6 3
  • 1200006M05Rik 3
  • MSTP055 3
  • PC326 3

External Ids for DCAF6 Gene

Previous HGNC Symbols for DCAF6 Gene

  • IQWD1

Previous GeneCards Identifiers for DCAF6 Gene

  • GC01P166173
  • GC01P139151

Summaries for DCAF6 Gene

Entrez Gene Summary for DCAF6 Gene

  • The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]

GeneCards Summary for DCAF6 Gene

DCAF6 (DDB1 And CUL4 Associated Factor 6) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is WDTC1.

UniProtKB/Swiss-Prot for DCAF6 Gene

  • Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF6 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF6 Gene

Genomics for DCAF6 Gene

GeneHancer (GH) Regulatory Elements for DCAF6 Gene

Promoters and enhancers for DCAF6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J167933 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 760 5.8 CLOCK FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MPC2 DCAF6 ADCY10 MPZL1 POU2F1 DPT
GH01J167862 Promoter/Enhancer 1.4 EPDnew ENCODE 650.2 -72.3 -72289 2.3 ATF1 ARNT NCOA2 ZNF280A TCF12 ARID2 FOS ATF7 CAVIN1 NCOA1 DCAF6 MPZL1 GC01P167854 ADCY10
GH01J167904 Enhancer 1 Ensembl ENCODE 11.2 -30.8 -30839 1.4 HDAC1 TFAP4 PKNOX1 FOXA2 JUN YY1 FOSL1 CTBP1 ZNF316 ZBTB48 MPC2 DCAF6 ENSG00000232194 ENSG00000250762 ADCY10 GC01P167854
GH01J168621 Enhancer 1.3 Ensembl ENCODE dbSUPER 5.2 +686.9 686900 3.4 FEZF1 ZNF2 ATF7 FOS RXRA TSHZ1 ZNF518A ATF4 GLIS1 STAT3 ATP1B1 ENSG00000237707 DCAF6 LOC105371604 RPL7AP21
GH01J167924 Enhancer 0.7 dbSUPER 8 -11.1 -11050 1 ARNT NFRKB TEAD4 TAL1 CC2D1A TCF12 ZNF316 NCOR1 ADNP PRDM10 DCAF6 ADCY10 MPC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF6 Gene

Genomic Locations for DCAF6 Gene
chr1:167,935,783-168,075,843
(GRCh38/hg38)
Size:
140,061 bases
Orientation:
Plus strand
chr1:167,905,021-168,045,081
(GRCh37/hg19)
Size:
140,061 bases
Orientation:
Plus strand

Genomic View for DCAF6 Gene

Genes around DCAF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF6 Gene

Proteins for DCAF6 Gene

  • Protein details for DCAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58WW2-DCAF6_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 6
    Protein Accession:
    Q58WW2
    Secondary Accessions:
    • A2A295
    • B4DNB8
    • Q7L8I0
    • Q8IXH3
    • Q8TB19

    Protein attributes for DCAF6 Gene

    Size:
    860 amino acids
    Molecular mass:
    96292 Da
    Quaternary structure:
    • Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.

    Three dimensional structures from OCA and Proteopedia for DCAF6 Gene

    Alternative splice isoforms for DCAF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF6 Gene

Post-translational modifications for DCAF6 Gene

  • Ubiquitination at posLast=694694 and Lys575
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for DCAF6
  • Boster Bio Antibodies for DCAF6
  • Santa Cruz Biotechnology (SCBT) Antibodies for DCAF6

No data available for DME Specific Peptides for DCAF6 Gene

Domains & Families for DCAF6 Gene

Gene Families for DCAF6 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF6: view

No data available for UniProtKB/Swiss-Prot for DCAF6 Gene

Function for DCAF6 Gene

Molecular function for DCAF6 Gene

UniProtKB/Swiss-Prot Function:
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF6 Gene

Gene Ontology (GO) - Molecular Function for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 15784617
genes like me logo Genes that share ontologies with DCAF6: view
genes like me logo Genes that share phenotypes with DCAF6: view

Animal Model Products

miRNA for DCAF6 Gene

miRTarBase miRNAs that target DCAF6

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF6 Gene

Localization for DCAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF6 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15784617
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0005925 focal adhesion IDA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF6: view

Pathways & Interactions for DCAF6 Gene

SuperPathways for DCAF6 Gene

No Data Available

UniProtKB/Swiss-Prot Q58WW2-DCAF6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
GO:0045944 positive regulation of transcription by RNA polymerase II IGI 15784617
genes like me logo Genes that share ontologies with DCAF6: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF6 Gene

Drugs & Compounds for DCAF6 Gene

No Compound Related Data Available

Transcripts for DCAF6 Gene

Unigene Clusters for DCAF6 Gene

DDB1 and CUL4 associated factor 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - -
SP5: - -
SP6: - -
SP7: - -
SP8: -
SP9:
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14: - - - - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c
SP1: - - - - - - -
SP2:
SP3: - - -
SP4:
SP5: - - - - - -
SP6: -
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for DCAF6 Gene

GeneLoc Exon Structure for
DCAF6
ECgene alternative splicing isoforms for
DCAF6

Expression for DCAF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF6 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF6 Gene

This gene is overexpressed in Muscle - Skeletal (x11.6).

Protein differential expression in normal tissues from HIPED for DCAF6 Gene

This gene is overexpressed in Testis (38.9), Ovary (11.5), and Heart (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF6 Gene



Protein tissue co-expression partners for DCAF6 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF6 Gene:

DCAF6

SOURCE GeneReport for Unigene cluster for DCAF6 Gene:

Hs.435741

mRNA Expression by UniProt/SwissProt for DCAF6 Gene:

Q58WW2-DCAF6_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.

Evidence on tissue expression from TISSUES for DCAF6 Gene

  • Heart(4.5)
  • Nervous system(4.5)
  • Liver(4.4)
  • Muscle(2.6)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with DCAF6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF6 Gene

Orthologs for DCAF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF6 34 33
  • 99.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IQWD1 34
  • 94 (a)
OneToOne
DCAF6 33
  • 91.33 (n)
dog
(Canis familiaris)
Mammalia DCAF6 34 33
  • 91.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf6 16 34 33
  • 88.59 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf6 33
  • 88.48 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF6 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF6 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF6 34 33
  • 77.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF6 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf6 33
  • 71.95 (n)
Str.11007 33
zebrafish
(Danio rerio)
Actinopterygii dcaf6 34 33
  • 63.18 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000981 33
  • 50.39 (n)
Species where no ortholog for DCAF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF6 Gene

ENSEMBL:
Gene Tree for DCAF6 (if available)
TreeFam:
Gene Tree for DCAF6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAF6: view image

Paralogs for DCAF6 Gene

Paralogs for DCAF6 Gene

(1) SIMAP similar genes for DCAF6 Gene using alignment to 2 proteins:

  • DCAF6_HUMAN
  • F2Z305_HUMAN

Pseudogenes.org Pseudogenes for DCAF6 Gene

genes like me logo Genes that share paralogs with DCAF6: view

Variants for DCAF6 Gene

Sequence variations from dbSNP and Humsavar for DCAF6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs145189179 likely-pathogenic, Cerebral visual impairment and intellectual disability 168,045,209(+) G/A coding_sequence_variant, missense_variant
rs1000000072 -- 168,062,674(+) A/ intron_variant
rs1000018411 -- 168,000,113(+) C/T intron_variant
rs1000027657 -- 168,026,832(+) T/C intron_variant
rs1000056004 -- 167,952,501(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF6 Gene

Variant ID Type Subtype PubMed ID
dgv111e212 CNV loss 25503493
dgv219n106 CNV deletion 24896259
esv1732326 CNV deletion 17803354
esv2312150 CNV deletion 18987734
esv2497978 CNV deletion 19546169
esv2672177 CNV deletion 23128226
esv2719228 CNV deletion 23290073
esv2849013 CNV deletion 24192839
esv32660 CNV loss 17666407
esv3542222 CNV deletion 23714750
esv3578242 CNV loss 25503493
esv8761 CNV loss 19470904
esv996972 CNV deletion 20482838
nsv1012959 CNV loss 25217958
nsv1078878 OTHER inversion 25765185
nsv1078892 CNV deletion 25765185
nsv478534 CNV novel sequence insertion 20440878
nsv930468 CNV deletion 23359205
nsv946487 CNV duplication 23825009
nsv955720 CNV deletion 24416366

Variation tolerance for DCAF6 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.97; 79.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF6 Gene

Human Gene Mutation Database (HGMD)
DCAF6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF6 Gene

Disorders for DCAF6 Gene

Additional Disease Information for DCAF6

No disorders were found for DCAF6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF6 Gene

Publications for DCAF6 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 58
  2. NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors. (PMID: 15784617) Tsai TC … Chen SL (The Journal of biological chemistry 2005) 3 4 22 58
  3. Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization. (PMID: 18673574) Han CP … Kok LF (Journal of experimental & clinical cancer research : CR 2008) 3 22 58
  4. Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. (PMID: 17984071) Chen PH … Chen SL (Nucleic acids research 2008) 3 22 58
  5. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S … Zheng N (Nature 2006) 3 4 58

Products for DCAF6 Gene

Sources for DCAF6 Gene

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