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Aliases for DCAF5 Gene

Aliases for DCAF5 Gene

  • DDB1 And CUL4 Associated Factor 5 2 3 5
  • WD Repeat-Containing Protein 22 3 4
  • WDR22 3 4
  • BCRG2 3 4
  • BCRP2 3 4
  • Breakpoint Cluster Region Protein, Uterine Leiomyoma, 2 3
  • Breakpoint Cluster Region Protein 2 4
  • DDB1- And CUL4-Associated Factor 5 3
  • WD Repeat Domain 22 2
  • D14S1461E 3
  • KIAA1824 4

External Ids for DCAF5 Gene

Previous HGNC Symbols for DCAF5 Gene

  • WDR22

Previous GeneCards Identifiers for DCAF5 Gene

  • GC14M068588
  • GC14M069517
  • GC14M049688

Summaries for DCAF5 Gene

GeneCards Summary for DCAF5 Gene

DCAF5 (DDB1 And CUL4 Associated Factor 5) is a Protein Coding gene. Diseases associated with DCAF5 include Leiomyoma.

UniProtKB/Swiss-Prot for DCAF5 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF5 Gene

Genomics for DCAF5 Gene

GeneHancer (GH) Regulatory Elements for DCAF5 Gene

Promoters and enhancers for DCAF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I069149 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 550.8 +1.0 1038 5.8 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF213 DCAF5 ENSG00000276063 GC14M069144 ENSG00000206768
GH14I068778 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.1 +365.2 365172 20.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZFP36L1 DCAF5 ZFYVE26 SRSF5 SUSD6 DDX18P1 RNU6-921P GC14M068736 GC14M068442
GH14I068973 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 31.7 +174.9 174886 9.8 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 FOS SP3 ACTN1-AS1 ACTN1 DCAF5 SUSD6 DDX18P1 SRSF5 GC14P068937
GH14I069190 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.5 -38.3 -38345 1.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF766 E2F8 EXD2 SRSF5 DCAF5 ERH DDX18P1 ENSG00000258957 LOC105370550
GH14I069396 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 -245.5 -245538 4.5 PKNOX1 CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ERH SLC39A9 SRSF5 DDX18P1 DCAF5 RPL7AP6 GALNT16 PLEKHD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF5 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF5 Gene

Genomic Locations for DCAF5 Gene
chr14:69,050,881-69,153,393
(GRCh38/hg38)
Size:
102,513 bases
Orientation:
Minus strand
chr14:69,517,598-69,619,914
(GRCh37/hg19)

Genomic View for DCAF5 Gene

Genes around DCAF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF5 Gene

Proteins for DCAF5 Gene

  • Protein details for DCAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JK2-DCAF5_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 5
    Protein Accession:
    Q96JK2
    Secondary Accessions:
    • B2RN31
    • G3V4J7
    • O60559
    • Q8N3V3
    • Q8N3V5

    Protein attributes for DCAF5 Gene

    Size:
    942 amino acids
    Molecular mass:
    103963 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAC08965.1; Type=Frameshift; Positions=772, 809, 812, 817, 836, 844, 858; Evidence={ECO:0000305}; Sequence=BAB47453.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF5 Gene

    Alternative splice isoforms for DCAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF5 Gene

Post-translational modifications for DCAF5 Gene

  • Ubiquitination at posLast=209209 and Lys678

No data available for DME Specific Peptides for DCAF5 Gene

Domains & Families for DCAF5 Gene

Gene Families for DCAF5 Gene

Suggested Antigen Peptide Sequences for DCAF5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF5: view

No data available for UniProtKB/Swiss-Prot for DCAF5 Gene

Function for DCAF5 Gene

Molecular function for DCAF5 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF5 Gene

Gene Ontology (GO) - Molecular Function for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
genes like me logo Genes that share ontologies with DCAF5: view
genes like me logo Genes that share phenotypes with DCAF5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF5 Gene

Localization for DCAF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF5 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF5 Gene

Pathways & Interactions for DCAF5 Gene

SuperPathways for DCAF5 Gene

No Data Available

UniProtKB/Swiss-Prot Q96JK2-DCAF5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF5: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF5 Gene

Drugs & Compounds for DCAF5 Gene

No Compound Related Data Available

Transcripts for DCAF5 Gene

Unigene Clusters for DCAF5 Gene

DDB1 and CUL4 associated factor 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for DCAF5 Gene

GeneLoc Exon Structure for
DCAF5
ECgene alternative splicing isoforms for
DCAF5

Expression for DCAF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF5 Gene

Protein differential expression in normal tissues from HIPED for DCAF5 Gene

This gene is overexpressed in Adrenal (26.6) and Lung (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAF5 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCAF5 Gene:

DCAF5

SOURCE GeneReport for Unigene cluster for DCAF5 Gene:

Hs.509780

mRNA Expression by UniProt/SwissProt for DCAF5 Gene:

Q96JK2-DCAF5_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for DCAF5 Gene

  • Nervous system(4.5)
  • Muscle(4.4)
  • Liver(4.3)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with DCAF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF5 Gene

Orthologs for DCAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF5 33 34
  • 99.65 (n)
dog
(Canis familiaris)
Mammalia DCAF5 33 34
  • 91.96 (n)
cow
(Bos Taurus)
Mammalia DCAF5 33 34
  • 90.14 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf5 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Dcaf5 33 16 34
  • 89.04 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF5 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF5 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF5 33 34
  • 72.45 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 94 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf5 33
  • 65.52 (n)
zebrafish
(Danio rerio)
Actinopterygii dcaf5 33 34
  • 64.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG42233 34
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11D1.1 34
  • 25 (a)
OneToOne
Species where no ortholog for DCAF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF5 Gene

ENSEMBL:
Gene Tree for DCAF5 (if available)
TreeFam:
Gene Tree for DCAF5 (if available)

Paralogs for DCAF5 Gene

(2) SIMAP similar genes for DCAF5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF5: view

No data available for Paralogs for DCAF5 Gene

Variants for DCAF5 Gene

Sequence variations from dbSNP and Humsavar for DCAF5 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000002061 -- 69,081,289(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000139992 -- 69,130,814(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000156921 -- 69,075,887(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000177036 -- 69,111,458(-) C/T intron_variant
rs1000209340 -- 69,132,749(-) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF5 Gene

Variant ID Type Subtype PubMed ID
nsv983839 CNV duplication 23825009
nsv952860 CNV deletion 24416366
nsv832823 CNV loss 17160897
nsv1331 CNV insertion 18451855
nsv1070640 CNV deletion 25765185
esv3634832 CNV loss 21293372
esv2663736 CNV deletion 23128226

Variation tolerance for DCAF5 Gene

Residual Variation Intolerance Score: 4.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF5 Gene

Disorders for DCAF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCAF5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leiomyoma
  • leiomyomatous neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search DCAF5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCAF5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DCAF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCAF5 Gene

Publications for DCAF5 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 58
  2. Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (PMID: 9740667) Lynch RA … Menon AG (Genomics 1998) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S … Zheng N (Nature 2006) 3 4 58

Products for DCAF5 Gene

Sources for DCAF5 Gene

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