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Aliases for DCAF4L2 Gene

Aliases for DCAF4L2 Gene

  • DDB1 And CUL4 Associated Factor 4 Like 2 2 3 5
  • WD Repeat-Containing Protein 21C 3 4
  • WD Repeat Domain 21C 2 3
  • WDR21C 3 4
  • DDB1- And CUL4-Associated Factor 4-Like Protein 2 3

External Ids for DCAF4L2 Gene

Previous HGNC Symbols for DCAF4L2 Gene

  • WDR21C

Previous GeneCards Identifiers for DCAF4L2 Gene

  • GC08M088954
  • GC08M084093
  • GC08M088882

Summaries for DCAF4L2 Gene

GeneCards Summary for DCAF4L2 Gene

DCAF4L2 (DDB1 And CUL4 Associated Factor 4 Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF4.

Additional gene information for DCAF4L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4L2 Gene

Genomics for DCAF4L2 Gene

GeneHancer (GH) Regulatory Elements for DCAF4L2 Gene

Promoters and enhancers for DCAF4L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I087874 Promoter 1 EPDnew 550.8 +0.0 33 0.1 ZBTB40 DIDO1 ZNF316 CBX5 POLR2A TRIM24 CREM ZNF639 ZBTB11 NRF1 PIR59491 DCAF4L2
GH08I087917 Enhancer 0.5 Ensembl ENCODE 11.1 -44.1 -44146 1.9 NR2F1 GC08M087918 DCAF4L2 ENSG00000253171
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF4L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF4L2 Gene

Genomic Locations for DCAF4L2 Gene
3,326 bases
Minus strand

Genomic View for DCAF4L2 Gene

Genes around DCAF4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L2 Gene

Proteins for DCAF4L2 Gene

  • Protein details for DCAF4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 2
    Protein Accession:

    Protein attributes for DCAF4L2 Gene

    395 amino acids
    Molecular mass:
    43747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF4L2 Gene

Post-translational modifications for DCAF4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L2 Gene

Domains & Families for DCAF4L2 Gene

Gene Families for DCAF4L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF4L2 Gene

Suggested Antigen Peptide Sequences for DCAF4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF4L2: view

No data available for UniProtKB/Swiss-Prot for DCAF4L2 Gene

Function for DCAF4L2 Gene

Phenotypes From GWAS Catalog for DCAF4L2 Gene

Phenotypes for DCAF4L2 Gene

GenomeRNAi human phenotypes for DCAF4L2:
genes like me logo Genes that share phenotypes with DCAF4L2: view

miRNA for DCAF4L2 Gene

miRTarBase miRNAs that target DCAF4L2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4L2 Gene

Localization for DCAF4L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF4L2 gene
Compartment Confidence
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF4L2 Gene

Pathways & Interactions for DCAF4L2 Gene

SuperPathways for DCAF4L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCAF4L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF4L2 Gene

Drugs & Compounds for DCAF4L2 Gene

No Compound Related Data Available

Transcripts for DCAF4L2 Gene

mRNA/cDNA for DCAF4L2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF4L2 Gene

DDB1 and CUL4 associated factor 4-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L2 Gene

No ASD Table

Relevant External Links for DCAF4L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF4L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF4L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L2 Gene

This gene is overexpressed in Testis (x50.8).

Protein differential expression in normal tissues from HIPED for DCAF4L2 Gene

This gene is overexpressed in Pancreatic juice (50.6) and Testis (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCAF4L2 Gene

Protein tissue co-expression partners for DCAF4L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF4L2 Gene:


SOURCE GeneReport for Unigene cluster for DCAF4L2 Gene:

genes like me logo Genes that share expression patterns with DCAF4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF4L2 Gene

Orthologs for DCAF4L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF4L2 33
  • 98.99 (n)
(Canis familiaris)
Mammalia -- 34
  • 60 (a)
(Bos Taurus)
Mammalia WDR21A 34
  • 57 (a)
(Mus musculus)
Mammalia Dcaf4 34
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
-- 34
  • 33 (a)
(Gallus gallus)
Aves -- 34
  • 49 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
(Danio rerio)
Actinopterygii wdr21 34
  • 51 (a)
Species where no ortholog for DCAF4L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L2 Gene

Gene Tree for DCAF4L2 (if available)
Gene Tree for DCAF4L2 (if available)

Paralogs for DCAF4L2 Gene

Paralogs for DCAF4L2 Gene

(2) SIMAP similar genes for DCAF4L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF4L2: view

Variants for DCAF4L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF4L2 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000220604 -- 87,872,142(-) C/G 3_prime_UTR_variant
rs1000821195 -- 87,870,915(-) A/G 3_prime_UTR_variant
rs1000947558 -- 87,871,655(-) A/T 3_prime_UTR_variant
rs1001237121 -- 87,871,289(-) A/G 3_prime_UTR_variant
rs1001504252 -- 87,874,274(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF4L2 Gene

Variant ID Type Subtype PubMed ID
nsv465734 CNV gain 19166990
nsv611709 CNV gain 21841781
nsv831384 CNV gain 17160897
nsv831385 CNV loss 17160897

Variation tolerance for DCAF4L2 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF4L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4L2 Gene

Disorders for DCAF4L2 Gene

Additional Disease Information for DCAF4L2

No disorders were found for DCAF4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4L2 Gene

Publications for DCAF4L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PMID: 23512105) Beaty TH … Ruczinski I (Human genetics 2013) 3 58

Products for DCAF4L2 Gene

Sources for DCAF4L2 Gene

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