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Aliases for DCAF4L1 Gene

Aliases for DCAF4L1 Gene

  • DDB1 And CUL4 Associated Factor 4 Like 1 2 3 5
  • WD Repeat-Containing Protein 21B 3 4
  • WD Repeat Domain 21B 2 3
  • WDR21B 3 4
  • DDB1- And CUL4-Associated Factor 4-Like Protein 1 3

External Ids for DCAF4L1 Gene

Previous HGNC Symbols for DCAF4L1 Gene

  • WDR21B

Previous GeneCards Identifiers for DCAF4L1 Gene

  • GC04P041679
  • GC04P041305

Summaries for DCAF4L1 Gene

GeneCards Summary for DCAF4L1 Gene

DCAF4L1 (DDB1 And CUL4 Associated Factor 4 Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF4.

Additional gene information for DCAF4L1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4L1 Gene

Genomics for DCAF4L1 Gene

GeneHancer (GH) Regulatory Elements for DCAF4L1 Gene

Promoters and enhancers for DCAF4L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I041981 Promoter 0.5 EPDnew 550.8 +0.1 60 0.1 DCAF4L1 ENSG00000272862
GH04I041938 Enhancer 0.7 ENCODE 11 -42.5 -42450 1.4 MEIS2 MAX CEBPG RAD21 IRF9 ZNF316 POLR2A SCRT2 ATF7 TRIM24 DCAF4L1 TMEM33 GC04P041959
GH04I041418 Enhancer 0.6 Ensembl ENCODE dbSUPER 4.8 -563.1 -563133 1.1 LIMCH1 APBB2 DCAF4L1 GC04P041427 GC04P041402
GH04I041419 Enhancer 0.3 dbSUPER 4.4 -561.3 -561333 2.1 ZNF366 LIMCH1 SHISA3 DCAF4L1 GC04P041427 GC04P041402
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF4L1 Gene

Genomic Locations for DCAF4L1 Gene
chr4:41,981,696-41,986,467
(GRCh38/hg38)
Size:
4,772 bases
Orientation:
Plus strand
chr4:41,983,713-41,988,484
(GRCh37/hg19)

Genomic View for DCAF4L1 Gene

Genes around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L1 Gene

Proteins for DCAF4L1 Gene

  • Protein details for DCAF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXM0-DC4L1_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 1
    Protein Accession:
    Q3SXM0
    Secondary Accessions:
    • B3KVI3
    • Q3ZCW8
    • Q499Y5
    • Q9UFI0

    Protein attributes for DCAF4L1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DCAF4L1 Gene

Post-translational modifications for DCAF4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L1 Gene

Domains & Families for DCAF4L1 Gene

Gene Families for DCAF4L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF4L1 Gene

Suggested Antigen Peptide Sequences for DCAF4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF4L1: view

No data available for UniProtKB/Swiss-Prot for DCAF4L1 Gene

Function for DCAF4L1 Gene

genes like me logo Genes that share phenotypes with DCAF4L1: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4L1 Gene

Localization for DCAF4L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF4L1 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF4L1 Gene

Pathways & Interactions for DCAF4L1 Gene

SuperPathways for DCAF4L1 Gene

No Data Available

Interacting Proteins for DCAF4L1 Gene

Gene Ontology (GO) - Biological Process for DCAF4L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCAF4L1 Gene

Drugs & Compounds for DCAF4L1 Gene

No Compound Related Data Available

Transcripts for DCAF4L1 Gene

mRNA/cDNA for DCAF4L1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF4L1 Gene

DDB1 and CUL4 associated factor 4-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L1 Gene

No ASD Table

Relevant External Links for DCAF4L1 Gene

GeneLoc Exon Structure for
DCAF4L1
ECgene alternative splicing isoforms for
DCAF4L1

Expression for DCAF4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L1 Gene

This gene is overexpressed in Testis (x28.2).

Protein differential expression in normal tissues from HIPED for DCAF4L1 Gene

This gene is overexpressed in Testis (40.5) and Ovary (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCAF4L1 Gene



Protein tissue co-expression partners for DCAF4L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF4L1 Gene:

DCAF4L1

SOURCE GeneReport for Unigene cluster for DCAF4L1 Gene:

Hs.213307
genes like me logo Genes that share expression patterns with DCAF4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF4L1 Gene

Orthologs for DCAF4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF4L1 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia WDR21A 34
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf4 34
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 34 (a)
ManyToMany
-- 34
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wdr21 34
  • 52 (a)
OneToMany
Species where no ortholog for DCAF4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L1 Gene

ENSEMBL:
Gene Tree for DCAF4L1 (if available)
TreeFam:
Gene Tree for DCAF4L1 (if available)

Paralogs for DCAF4L1 Gene

Paralogs for DCAF4L1 Gene

(2) SIMAP similar genes for DCAF4L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF4L1: view

Variants for DCAF4L1 Gene

Sequence variations from dbSNP and Humsavar for DCAF4L1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000410786 -- 41,981,634(+) T/C upstream_transcript_variant
rs1001674645 -- 41,981,027(+) C/T upstream_transcript_variant
rs1001957709 -- 41,981,351(+) A/C upstream_transcript_variant
rs1002522322 -- 41,986,077(+) C/G 3_prime_UTR_variant
rs1002677299 -- 41,979,759(+) G/A upstream_transcript_variant

Variation tolerance for DCAF4L1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCAF4L1 Gene

Disorders for DCAF4L1 Gene

Additional Disease Information for DCAF4L1

No disorders were found for DCAF4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4L1 Gene

Publications for DCAF4L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for DCAF4L1 Gene

Sources for DCAF4L1 Gene

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