Aliases for DCAF4L1 Gene

Aliases for DCAF4L1 Gene

  • DDB1 And CUL4 Associated Factor 4 Like 1 2 3 5
  • DDB1- And CUL4-Associated Factor 4-Like Protein 1 3 4
  • WD Repeat-Containing Protein 21B 3 4
  • WD Repeat Domain 21B 2 3
  • WDR21B 3 4

External Ids for DCAF4L1 Gene

Previous HGNC Symbols for DCAF4L1 Gene

  • WDR21B

Previous GeneCards Identifiers for DCAF4L1 Gene

  • GC04P041679
  • GC04P041305

Summaries for DCAF4L1 Gene

GeneCards Summary for DCAF4L1 Gene

DCAF4L1 (DDB1 And CUL4 Associated Factor 4 Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF4.

Additional gene information for DCAF4L1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCAF4L1 Gene

Genomics for DCAF4L1 Gene

GeneHancer (GH) Regulatory Elements for DCAF4L1 Gene

Promoters and enhancers for DCAF4L1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J041938 Enhancer 0.7 ENCODE 11 -42.5 -42450 1.4 CEBPB ZNF316 MAFF TRIM24 CEBPG MAFK ZBTB33 SPI1 JUND STAT3 DCAF4L1 NONHSAG037834.2 TMEM33 lnc-DCAF4L1-2
GH04J042136 Enhancer 0.4 Ensembl 10.1 +155.0 155005 0.6 TEAD4 SIN3A CHD7 SP1 DCAF4L1 piR-38351-332 ENSG00000285454 BEND4
GH04J041418 Enhancer 0.7 Ensembl ENCODE dbSUPER 4.8 -562.9 -562896 1.6 ZNF366 ETV6 LIMCH1 APBB2 DCAF4L1 SHISA3 RF00017-4296 RPL12P20 lnc-UCHL1-1
GH04J041954 Enhancer 0.3 Ensembl 11.7 -26.8 -26795 1 HNRNPK SLC30A9 DCAF4L1 BEND4 lnc-DCAF4L1-2 NONHSAG037834.2 TMEM33
GH04J041922 Enhancer 0.3 Ensembl 10.1 -58.2 -58195 0.2 SPI1 ENSG00000249887 lnc-TMEM33-1 ENSG00000249216 LIMCH1 DCAF4L1 HSALNG0034077 ENSG00000249771 LOC105374426
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCAF4L1

Genomic Locations for DCAF4L1 Gene

Genomic Locations for DCAF4L1 Gene
chr4:41,981,696-41,986,467
(GRCh38/hg38)
Size:
4,772 bases
Orientation:
Plus strand
chr4:41,983,713-41,988,484
(GRCh37/hg19)
Size:
4,772 bases
Orientation:
Plus strand

Genomic View for DCAF4L1 Gene

Genes around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L1 Gene

Proteins for DCAF4L1 Gene

  • Protein details for DCAF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXM0-DC4L1_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 1
    Protein Accession:
    Q3SXM0
    Secondary Accessions:
    • B3KVI3
    • Q3ZCW8
    • Q499Y5
    • Q9UFI0

    Protein attributes for DCAF4L1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DCAF4L1 Gene

Post-translational modifications for DCAF4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L1 Gene

Domains & Families for DCAF4L1 Gene

Gene Families for DCAF4L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF4L1 Gene

Suggested Antigen Peptide Sequences for DCAF4L1 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 21B (DC4L1_HUMAN)
genes like me logo Genes that share domains with DCAF4L1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for DCAF4L1 Gene

Function for DCAF4L1 Gene

Phenotypes From GWAS Catalog for DCAF4L1 Gene

genes like me logo Genes that share phenotypes with DCAF4L1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4L1 Gene

Localization for DCAF4L1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF4L1 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF4L1 Gene

Pathways & Interactions for DCAF4L1 Gene

PathCards logo

SuperPathways for DCAF4L1 Gene

No Data Available

Interacting Proteins for DCAF4L1 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000327796 Q3SXM0-DC4L1_HUMAN for DCAF4L1 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for DCAF4L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCAF4L1 Gene

Drugs & Compounds for DCAF4L1 Gene

No Compound Related Data Available

Transcripts for DCAF4L1 Gene

mRNA/cDNA for DCAF4L1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L1 Gene

No ASD Table

Relevant External Links for DCAF4L1 Gene

GeneLoc Exon Structure for
DCAF4L1

Expression for DCAF4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAF4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L1 Gene

This gene is overexpressed in Testis (x28.2).

Protein differential expression in normal tissues from HIPED for DCAF4L1 Gene

This gene is overexpressed in Testis (40.5) and Ovary (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCAF4L1 Gene



Protein tissue co-expression partners for DCAF4L1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCAF4L1

SOURCE GeneReport for Unigene cluster for DCAF4L1 Gene:

Hs.213307
genes like me logo Genes that share expression patterns with DCAF4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF4L1 Gene

Orthologs for DCAF4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF4L1 31 30
  • 99.41 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 31
  • 62 (a)
OneToMany
cow
(Bos Taurus)
Mammalia WDR21A 31
  • 61 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf4 31
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wdr21 31
  • 52 (a)
OneToMany
Species where no ortholog for DCAF4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L1 Gene

ENSEMBL:
Gene Tree for DCAF4L1 (if available)
TreeFam:
Gene Tree for DCAF4L1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAF4L1: view image

Paralogs for DCAF4L1 Gene

(2) SIMAP similar genes for DCAF4L1 Gene using alignment to 2 proteins:

  • DC4L1_HUMAN
  • L8E8J2_HUMAN
genes like me logo Genes that share paralogs with DCAF4L1: view

Variants for DCAF4L1 Gene

Additional dbSNP identifiers (rs#s) for DCAF4L1 Gene

Variation tolerance for DCAF4L1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for DCAF4L1 Gene

Disorders for DCAF4L1 Gene

Additional Disease Information for DCAF4L1

No disorders were found for DCAF4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4L1 Gene

Publications for DCAF4L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. (PMID: 28786561) Poirson J … Masson M (The FEBS journal 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 54

Products for DCAF4L1 Gene

Sources for DCAF4L1 Gene