Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCAF4 Gene

Aliases for DCAF4 Gene

  • DDB1 And CUL4 Associated Factor 4 2 3 5
  • WD Repeat-Containing Protein 21A 3 4
  • WD Repeat Domain 21A 2 3
  • WDR21A 3 4
  • WDR21 3 4
  • DDB1- And CUL4-Associated Factor 4 3
  • WD Repeat Domain 21 2

External Ids for DCAF4 Gene

Previous HGNC Symbols for DCAF4 Gene

  • WDR21
  • WDR21A

Previous GeneCards Identifiers for DCAF4 Gene

  • GC14P072464
  • GC14P073393
  • GC14P053559

Summaries for DCAF4 Gene

Entrez Gene Summary for DCAF4 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF4 Gene

DCAF4 (DDB1 And CUL4 Associated Factor 4) is a Protein Coding gene. Diseases associated with DCAF4 include Telomere Length, Mean Leukocyte. An important paralog of this gene is DCAF4L1.

UniProtKB/Swiss-Prot for DCAF4 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF4 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4 Gene

Genomics for DCAF4 Gene

GeneHancer (GH) Regulatory Elements for DCAF4 Gene

Promoters and enhancers for DCAF4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J072924 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 686.3 -0.1 -89 3.6 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B DCAF4 LOC100420966 ZNF410 PSEN1 LOC101928123 RBM25 ELMSAN1 ZFYVE1 HEATR4 DPF3
GH14J073885 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.5 +961.1 961142 4.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ZNF410 PIR36223 ENSG00000273711 PTGR2 DCAF4 LOC100506476 LOC100420966 ELMSAN1 RBM25 ENSG00000223300
GH14J073456 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.9 +534.0 534006 7.9 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZBTB7B YY1 NUMB DPF3 ZNF410 LOC100420966 ELMSAN1 DCAF4 ENSG00000258891 ENSG00000258695 ENSG00000258944 RBM25
GH14J073782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.2 +860.8 860751 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC100506476 ELMSAN1 GC14P073786 ZNF410 RBM25 PTGR2 LOC100420966 DCAF4 YLPM1 ENSG00000258559
GH14J072903 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.4 -20.4 -20404 5 FOXA2 PKNOX1 ATF1 ARNT ZNF766 ARID2 ZNF143 FOS ATF7 DEK RBM25 ZNF410 DCAF4 ELMSAN1 PSEN1 NUMB LOC100420966 LOC101928123 DPF3 PAPLN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF4 Gene

Genomic Locations for DCAF4 Gene
35,767 bases
Plus strand
33,372 bases
Plus strand

Genomic View for DCAF4 Gene

Genes around DCAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4 Gene

Proteins for DCAF4 Gene

  • Protein details for DCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 4
    Protein Accession:
    Secondary Accessions:
    • B4DUT6
    • G3V522
    • Q86U31
    • Q8IV10
    • Q96K22
    • Q9Y4P5

    Protein attributes for DCAF4 Gene

    495 amino acids
    Molecular mass:
    55694 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

    Three dimensional structures from OCA and Proteopedia for DCAF4 Gene

    Alternative splice isoforms for DCAF4 Gene


neXtProt entry for DCAF4 Gene

Post-translational modifications for DCAF4 Gene

  • Ubiquitination at Lys460
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAF4 Gene

Domains & Families for DCAF4 Gene

Gene Families for DCAF4 Gene

Protein Domains for DCAF4 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF4: view

No data available for UniProtKB/Swiss-Prot for DCAF4 Gene

Function for DCAF4 Gene

Molecular function for DCAF4 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF4 Gene

Gene Ontology (GO) - Molecular Function for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with DCAF4: view
genes like me logo Genes that share phenotypes with DCAF4: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4 Gene

Localization for DCAF4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005682 U5 snRNP IBA --
GO:0071011 precatalytic spliceosome IBA --
GO:0071013 catalytic step 2 spliceosome IBA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF4 Gene

Pathways & Interactions for DCAF4 Gene

SuperPathways for DCAF4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WV16-DCAF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008380 RNA splicing IBA --
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF4 Gene

Drugs & Compounds for DCAF4 Gene

(1) Drugs for DCAF4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with DCAF4: view

Transcripts for DCAF4 Gene

Unigene Clusters for DCAF4 Gene

DDB1 and CUL4 associated factor 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -

Relevant External Links for DCAF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF4 Gene:


SOURCE GeneReport for Unigene cluster for DCAF4 Gene:


Evidence on tissue expression from TISSUES for DCAF4 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with DCAF4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF4 Gene

Orthologs for DCAF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF4 34 33
  • 99.53 (n)
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
DCAF4 33
  • 86.95 (n)
(Bos Taurus)
Mammalia DCAF4 33
  • 84.45 (n)
WDR21A 34
  • 81 (a)
(Mus musculus)
Mammalia Dcaf4 16 34 33
  • 83.44 (n)
(Rattus norvegicus)
Mammalia Dcaf4 33
  • 83.23 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
-- 34
  • 41 (a)
(Gallus gallus)
Aves DCAF4 33
  • 69.11 (n)
-- 34
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf4 33
  • 59.18 (n)
(Danio rerio)
Actinopterygii wdr21 34 33 33
  • 61.45 (n)
Species where no ortholog for DCAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4 Gene

Gene Tree for DCAF4 (if available)
Gene Tree for DCAF4 (if available)
Evolutionary constrained regions (ECRs) for DCAF4: view image

Paralogs for DCAF4 Gene

Paralogs for DCAF4 Gene

(2) SIMAP similar genes for DCAF4 Gene using alignment to 4 proteins:

  • G3V3D6_HUMAN
  • Q86SY2_HUMAN
genes like me logo Genes that share paralogs with DCAF4: view

Variants for DCAF4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4 Gene

An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin (PubMed:25624462).

Sequence variations from dbSNP and Humsavar for DCAF4 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs2535913 uncertain-significance, Telomere length, mean leukocyte 72,948,525(+) G/A intron_variant
rs1000087640 -- 72,928,368(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000176647 -- 72,945,525(+) T/C intron_variant
rs1000226251 -- 72,929,849(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000291259 -- 72,945,164(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF4 Gene

Variant ID Type Subtype PubMed ID
esv3353836 CNV insertion 20981092
esv3892560 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1048734 CNV gain 25217958
nsv1049819 CNV gain 25217958

Variation tolerance for DCAF4 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for DCAF4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCAF4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
telomere length, mean leukocyte
  • ltl
- elite association - COSMIC cancer census association via MalaCards
Search DCAF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DCAF4

genes like me logo Genes that share disorders with DCAF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCAF4 Gene

Publications for DCAF4 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 58
  2. DCAF4, a novel gene associated with leucocyte telomere length. (PMID: 25624462) Mangino M … Aviv A (Journal of medical genetics 2015) 3 4 58
  3. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S … Zheng N (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DCAF4 Gene

Sources for DCAF4 Gene

Loading form....