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Aliases for DCAF16 Gene

Aliases for DCAF16 Gene

  • DDB1 And CUL4 Associated Factor 16 2 3 5
  • C4orf30 3 4
  • DDB1- And CUL4-Associated Factor 16 3
  • Chromosome 4 Open Reading Frame 30 2

External Ids for DCAF16 Gene

Previous HGNC Symbols for DCAF16 Gene

  • C4orf30

Previous GeneCards Identifiers for DCAF16 Gene

  • GC04M017412
  • GC04M017157

Summaries for DCAF16 Gene

GeneCards Summary for DCAF16 Gene

DCAF16 (DDB1 And CUL4 Associated Factor 16) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF16 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF16 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF16 Gene

Genomics for DCAF16 Gene

GeneHancer (GH) Regulatory Elements for DCAF16 Gene

Promoters and enhancers for DCAF16 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J017807 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 678 -0.4 -380 7.6 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 DCAF16 NCAPG MED28 LCORL GC04M017884
GH04J018019 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37.6 -210.7 -210727 3.4 HDGF PKNOX1 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 LCORL DCAF16 MED28 KRT18P63
GH04J017613 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 +196.2 196168 2.4 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 POLR2B MED28 ENSG00000249502 LAP3 DCAF16 QDPR
GH04J017575 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 11.5 +232.1 232139 5.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 YY1 LAP3 MED28 ENSG00000249502 DCAF16 NCAPG QDPR LCORL GC04M017599
GH04J017543 Enhancer 1.3 FANTOM5 Ensembl ENCODE 19.9 +266.2 266194 1.3 ATF1 PKNOX1 FOXA2 MLX ARID4B ETS1 ATF7 NFKBIZ SP5 ZHX2 DCAF16 MED28 CLRN2 QDPR NCAPG GC04M017552
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF16 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF16 Gene

Genomic Locations for DCAF16 Gene
10,115 bases
Minus strand
10,104 bases
Minus strand

Genomic View for DCAF16 Gene

Genes around DCAF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF16 Gene

Proteins for DCAF16 Gene

  • Protein details for DCAF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 16
    Protein Accession:
    Secondary Accessions:
    • B3KPB7

    Protein attributes for DCAF16 Gene

    216 amino acids
    Molecular mass:
    24193 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

neXtProt entry for DCAF16 Gene

Post-translational modifications for DCAF16 Gene

  • Ubiquitination at posLast=150150 and Lys79
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF16 Gene

No data available for DME Specific Peptides for DCAF16 Gene

Domains & Families for DCAF16 Gene

Gene Families for DCAF16 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF16 Gene


Suggested Antigen Peptide Sequences for DCAF16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF16: view

No data available for UniProtKB/Swiss-Prot for DCAF16 Gene

Function for DCAF16 Gene

Molecular function for DCAF16 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF16 Gene

Gene Ontology (GO) - Molecular Function for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
genes like me logo Genes that share ontologies with DCAF16: view
genes like me logo Genes that share phenotypes with DCAF16: view

Animal Model Products

miRNA for DCAF16 Gene

miRTarBase miRNAs that target DCAF16

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF16 Gene

Localization for DCAF16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF16 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF16 Gene

Pathways & Interactions for DCAF16 Gene

SuperPathways for DCAF16 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NXF7-DCA16_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF16: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF16 Gene

Drugs & Compounds for DCAF16 Gene

No Compound Related Data Available

Transcripts for DCAF16 Gene

Unigene Clusters for DCAF16 Gene

DDB1 and CUL4 associated factor 16:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -

Relevant External Links for DCAF16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF16 Gene

Protein differential expression in normal tissues from HIPED for DCAF16 Gene

This gene is overexpressed in Ovary (39.8), Testis (10.4), NK cells (8.2), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF16 Gene

Protein tissue co-expression partners for DCAF16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF16 Gene:


SOURCE GeneReport for Unigene cluster for DCAF16 Gene:


Evidence on tissue expression from TISSUES for DCAF16 Gene

  • Kidney(4.3)
  • Heart(4.2)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with DCAF16: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF16 Gene

Orthologs for DCAF16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DCAF16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF16 34
  • 100 (a)
(Bos Taurus)
Mammalia DCAF16 34
  • 95 (a)
(Canis familiaris)
Mammalia DCAF16 33
  • 92.28 (n)
Species where no ortholog for DCAF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF16 Gene

Gene Tree for DCAF16 (if available)
Gene Tree for DCAF16 (if available)
Evolutionary constrained regions (ECRs) for DCAF16: view image

Paralogs for DCAF16 Gene

No data available for Paralogs for DCAF16 Gene

Variants for DCAF16 Gene

Sequence variations from dbSNP and Humsavar for DCAF16 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000219646 -- 17,802,534(-) A/G 3_prime_UTR_variant
rs10002231 -- 17,808,840(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000272017 -- 17,802,278(-) G/A 3_prime_UTR_variant
rs1000308888 -- 17,811,378(-) A/G upstream_transcript_variant
rs1000791467 -- 17,798,290(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF16 Gene

Variant ID Type Subtype PubMed ID
esv2645526 CNV deletion 19546169
esv3893889 CNV loss 25118596

Variation tolerance for DCAF16 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF16 Gene

Disorders for DCAF16 Gene

Additional Disease Information for DCAF16

No disorders were found for DCAF16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF16 Gene

Publications for DCAF16 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M … Qi L (Human molecular genetics 2015) 3 58

Products for DCAF16 Gene

Sources for DCAF16 Gene

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