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Aliases for DCAF15 Gene

Aliases for DCAF15 Gene

  • DDB1 And CUL4 Associated Factor 15 2 3 5
  • DDB1- And CUL4-Associated Factor 15 3 4
  • C19orf72 3 4
  • Chromosome 19 Open Reading Frame 72 2

External Ids for DCAF15 Gene

Previous HGNC Symbols for DCAF15 Gene

  • C19orf72

Previous GeneCards Identifiers for DCAF15 Gene

  • GC19P014063
  • GC19P013634

Summaries for DCAF15 Gene

GeneCards Summary for DCAF15 Gene

DCAF15 (DDB1 And CUL4 Associated Factor 15) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF15 Gene

  • May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.

Additional gene information for DCAF15 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF15 Gene

Genomics for DCAF15 Gene

GeneHancer (GH) Regulatory Elements for DCAF15 Gene

Promoters and enhancers for DCAF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J013951 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 612.5 +0.4 409 2.6 SP1 ZNF148 NKRF POLR2A GTF2F1 CSDE1 FOS TFE3 ZBTB7A YY1 DCAF15 PODNL1 ENSG00000267519 DDX39A CCDC130 MRI1 RFX1 SAMD1
GH19J013148 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 58.5 -799.1 -799100 10.8 MTA3 ZNF652 SP1 ZFX CC2D1A ELF3 MNT SIX5 ZNF148 NKRF STX10 IER2 ENSG00000267598 CCDC130 ZNF136 TRMT1 ZNF44 ZNF564 WDR83OS RFX1
GH19J014000 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 34.7 +51.6 51608 7 MTA3 ZNF652 SP1 ELF3 CC2D1A ZFX MNT SIX5 CBFA2T2 ZNF148 RFX1 CCDC130 TRMT1 DDX39A DCAF15 MRI1 ZNF333 ENSG00000267519 ZSWIM4 TECR
GH19J013833 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 25.8 -107.9 -107920 23.1 HDGF MTA3 SP1 ZFX CC2D1A ZNF652 ELF3 ZKSCAN8 MNT CBFA2T2 ENSG00000267519 GC19M013965 CCDC130 ZNF333 MRI1 TRMT1 DCAF15 RFX1 DDX39A RPS6P25
GH19J014782 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 29.1 +832.4 832368 4 CC2D1A CTCF CBFA2T2 ZNF148 MLLT1 ZNF121 GTF2F1 MCM2 NCOA6 TRIM24 DCAF15 DDX39A RFX1 ADGRE2 AKAP8 BRD4 OR7C1 ZNF333 ADGRE3 OR7A5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF15 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF15 Gene

Genomic Locations for DCAF15 Gene
chr19:13,952,492-13,961,449
(GRCh38/hg38)
Size:
8,958 bases
Orientation:
Plus strand
chr19:14,063,304-14,072,256
(GRCh37/hg19)
Size:
8,953 bases
Orientation:
Plus strand

Genomic View for DCAF15 Gene

Genes around DCAF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF15 Gene

Proteins for DCAF15 Gene

  • Protein details for DCAF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K64-DCA15_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 15
    Protein Accession:
    Q66K64
    Secondary Accessions:
    • B3KS86
    • Q96DW0
    • Q9BU31

    Protein attributes for DCAF15 Gene

    Size:
    600 amino acids
    Molecular mass:
    66463 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAH13280.2; Type=Frameshift; Positions=89; Evidence={ECO:0000305};

neXtProt entry for DCAF15 Gene

Post-translational modifications for DCAF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF15 Gene

No data available for DME Specific Peptides for DCAF15 Gene

Domains & Families for DCAF15 Gene

Gene Families for DCAF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF15 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCAF15 Gene

GenScript: Design optimal peptide antigens:
  • DDB1- and CUL4-associated factor 15 (DCA15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF15: view

No data available for UniProtKB/Swiss-Prot for DCAF15 Gene

Function for DCAF15 Gene

Molecular function for DCAF15 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase.

Phenotypes From GWAS Catalog for DCAF15 Gene

Gene Ontology (GO) - Molecular Function for DCAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
genes like me logo Genes that share ontologies with DCAF15: view
genes like me logo Genes that share phenotypes with DCAF15: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCAF15

Clone Products

  • Applied Biological Materials (abm): Clones for DCAF15 - Now 50% OFF >
  • * DCAF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCAF15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF15 Gene

Localization for DCAF15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF15 gene
Compartment Confidence
nucleus 3
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032991 protein-containing complex IMP 28437394
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF15 Gene

Pathways & Interactions for DCAF15 Gene

PathCards logo

SuperPathways for DCAF15 Gene

No Data Available

UniProtKB/Swiss-Prot Q66K64-DCA15_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA,IMP 28437394
genes like me logo Genes that share ontologies with DCAF15: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF15 Gene

Drugs & Compounds for DCAF15 Gene

No Compound Related Data Available

Transcripts for DCAF15 Gene

mRNA/cDNA for DCAF15 Gene

Unigene Clusters for DCAF15 Gene

DDB1 and CUL4 associated factor 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCAF15

Clone Products

  • Applied Biological Materials (abm): Clones for DCAF15 - Now 50% OFF >
  • * DCAF15 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * DCAF15 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - - - -
SP2: - -
SP3:
SP4:
SP5: - -
SP6: -
SP7:

Relevant External Links for DCAF15 Gene

GeneLoc Exon Structure for
DCAF15
ECgene alternative splicing isoforms for
DCAF15

Expression for DCAF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF15 Gene

Protein differential expression in normal tissues from HIPED for DCAF15 Gene

This gene is overexpressed in Bone (61.4) and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF15 Gene



Protein tissue co-expression partners for DCAF15 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF15 Gene:

DCAF15

SOURCE GeneReport for Unigene cluster for DCAF15 Gene:

Hs.443636

Evidence on tissue expression from TISSUES for DCAF15 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with DCAF15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF15 Gene

Orthologs for DCAF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF15 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia DCAF15 34 35
  • 90.06 (n)
dog
(Canis familiaris)
Mammalia DCAF15 35 34
  • 89.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf15 17 34 35
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf15 34
  • 85.98 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF15 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF15 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf15 34
  • 67.63 (n)
Str.2483 34
zebrafish
(Danio rerio)
Actinopterygii dcaf15 35 34
  • 62.82 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6325 35
  • 12 (a)
OneToOne
Species where no ortholog for DCAF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF15 Gene

ENSEMBL:
Gene Tree for DCAF15 (if available)
TreeFam:
Gene Tree for DCAF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAF15: view image

Paralogs for DCAF15 Gene

No data available for Paralogs for DCAF15 Gene

Variants for DCAF15 Gene

Sequence variations from dbSNP and Humsavar for DCAF15 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000111425 -- 13,954,049(+) G/A intron_variant
rs1000145724 -- 13,958,172(+) C/T intron_variant
rs1000262291 -- 13,958,358(+) A/T intron_variant
rs1000401859 -- 13,958,675(+) A/G intron_variant
rs1001041808 -- 13,954,541(+) C/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF15 Gene

Variant ID Type Subtype PubMed ID
nsv820186 CNV loss 19587683
nsv828451 CNV loss 20364138
nsv953979 CNV deletion 24416366

Variation tolerance for DCAF15 Gene

Residual Variation Intolerance Score: 10.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.50; 71.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF15 Gene

Disorders for DCAF15 Gene

Additional Disease Information for DCAF15

No disorders were found for DCAF15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF15 Gene

Publications for DCAF15 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. (PMID: 28302793) Han T … Nijhawan D (Science (New York, N.Y.) 2017) 3 58
  4. Selective degradation of splicing factor CAPERα by anticancer sulfonamides. (PMID: 28437394) Uehara T … Owa T (Nature chemical biology 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for DCAF15 Gene

Sources for DCAF15 Gene

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