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Aliases for DCAF12L2 Gene

Aliases for DCAF12L2 Gene

  • DDB1 And CUL4 Associated Factor 12 Like 2 2 3 5
  • WD Repeat-Containing Protein 40C 3 4
  • WDR40C 3 4
  • DDB1- And CUL4-Associated Factor 12-Like Protein 2 3
  • WD Repeat Domain 40C 2

External Ids for DCAF12L2 Gene

Previous HGNC Symbols for DCAF12L2 Gene

  • WDR40C

Previous GeneCards Identifiers for DCAF12L2 Gene

  • GC0XM125127
  • GC0XM125298
  • GC0XM114677

Summaries for DCAF12L2 Gene

Entrez Gene Summary for DCAF12L2 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

GeneCards Summary for DCAF12L2 Gene

DCAF12L2 (DDB1 And CUL4 Associated Factor 12 Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF12L1.

Additional gene information for DCAF12L2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12L2 Gene

Genomics for DCAF12L2 Gene

GeneHancer (GH) Regulatory Elements for DCAF12L2 Gene

Promoters and enhancers for DCAF12L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI126165 Promoter 1.1 EPDnew Ensembl 560.5 0.0 -3 1 EZH2 DCAF12L2 GC0XM126100
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF12L2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF12L2 Gene

Genomic Locations for DCAF12L2 Gene
2,599 bases
Minus strand

Genomic View for DCAF12L2 Gene

Genes around DCAF12L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF12L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF12L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF12L2 Gene

Proteins for DCAF12L2 Gene

  • Protein details for DCAF12L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 12-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RN42

    Protein attributes for DCAF12L2 Gene

    463 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF12L2 Gene

Post-translational modifications for DCAF12L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF12L2 Gene

Domains & Families for DCAF12L2 Gene

Gene Families for DCAF12L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF12L2 Gene

Suggested Antigen Peptide Sequences for DCAF12L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF12 family.
  • Belongs to the WD repeat DCAF12 family.
genes like me logo Genes that share domains with DCAF12L2: view

Function for DCAF12L2 Gene

Phenotypes for DCAF12L2 Gene

genes like me logo Genes that share phenotypes with DCAF12L2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF12L2 Gene

Localization for DCAF12L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF12L2 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCAF12L2 Gene

Pathways & Interactions for DCAF12L2 Gene

SuperPathways for DCAF12L2 Gene

No Data Available

Interacting Proteins for DCAF12L2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q5VW00-DC122_HUMAN ENSP00000353128 for DCAF12L2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for DCAF12L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF12L2 Gene

Drugs & Compounds for DCAF12L2 Gene

No Compound Related Data Available

Transcripts for DCAF12L2 Gene

mRNA/cDNA for DCAF12L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF12L2 Gene

DDB1 and CUL4 associated factor 12-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12L2 Gene

No ASD Table

Relevant External Links for DCAF12L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF12L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF12L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12L2 Gene

This gene is overexpressed in Testis (x6.8) and Brain - Hypothalamus (x5.3).

NURSA nuclear receptor signaling pathways regulating expression of DCAF12L2 Gene:


SOURCE GeneReport for Unigene cluster for DCAF12L2 Gene:

genes like me logo Genes that share expression patterns with DCAF12L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF12L2 Gene

Orthologs for DCAF12L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF12L2 34
  • 100 (a)
LOC100613674 33
  • 99.42 (n)
(Canis familiaris)
Mammalia LOC492114 33
  • 88.31 (n)
-- 34
  • 85 (a)
-- 34
  • 81 (a)
(Bos Taurus)
Mammalia LOC100847467 33
  • 81.19 (n)
(Mus musculus)
Mammalia Dcaf12l2 33 16 34
  • 80.06 (n)
Dcaf12l1 34
  • 71 (a)
(Rattus norvegicus)
Mammalia Dcaf12l2 33
  • 79.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 34
  • 38 (a)
Species where no ortholog for DCAF12L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF12L2 Gene

Gene Tree for DCAF12L2 (if available)
Gene Tree for DCAF12L2 (if available)

Paralogs for DCAF12L2 Gene

Paralogs for DCAF12L2 Gene

(2) SIMAP similar genes for DCAF12L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF12L2: view

Variants for DCAF12L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF12L2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002096068 -- 126,164,051(-) T/C 3_prime_UTR_variant
rs1002695991 -- 126,166,531(-) T/A upstream_transcript_variant
rs1003179191 -- 126,166,839(-) T/G upstream_transcript_variant
rs1003824887 -- 126,167,746(-) AAAAAAA/AAAAAA upstream_transcript_variant
rs1003960250 -- 126,166,499(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF12L2 Gene

Variant ID Type Subtype PubMed ID
nsv519795 CNV gain 19592680
nsv524503 CNV gain 19592680

Variation tolerance for DCAF12L2 Gene

Residual Variation Intolerance Score: 45.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF12L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12L2 Gene

Disorders for DCAF12L2 Gene

Additional Disease Information for DCAF12L2

No disorders were found for DCAF12L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF12L2 Gene

Publications for DCAF12L2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett EJ … Harper JW (Cell 2010) 3 58
  3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 58
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for DCAF12L2 Gene

Sources for DCAF12L2 Gene

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