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Aliases for DCAF12L1 Gene

Aliases for DCAF12L1 Gene

  • DDB1 And CUL4 Associated Factor 12 Like 1 2 3 5
  • WD Repeat-Containing Protein 40B 3 4
  • WD Repeat Domain 40B 2 3
  • WDR40B 3 4
  • DDB1- And CUL4-Associated Factor 12-Like Protein 1 3
  • KIAA1892L 3

External Ids for DCAF12L1 Gene

Previous HGNC Symbols for DCAF12L1 Gene

  • WDR40B

Previous GeneCards Identifiers for DCAF12L1 Gene

  • GC0XM125512
  • GC0XM125683
  • GC0XM115062

Summaries for DCAF12L1 Gene

Entrez Gene Summary for DCAF12L1 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCAF12L1 Gene

DCAF12L1 (DDB1 And CUL4 Associated Factor 12 Like 1) is a Protein Coding gene. Diseases associated with DCAF12L1 include Spermatogenic Failure, X-Linked, 1. An important paralog of this gene is DCAF12L2.

Additional gene information for DCAF12L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12L1 Gene

Genomics for DCAF12L1 Gene

GeneHancer (GH) Regulatory Elements for DCAF12L1 Gene

Promoters and enhancers for DCAF12L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ126552 Promoter 0.6 EPDnew 650.7 +0.0 25 0.1 POLR2A DCAF12L1 OR4W1P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF12L1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF12L1 Gene

Genomic Locations for DCAF12L1 Gene
3,477 bases
Minus strand

Genomic View for DCAF12L1 Gene

Genes around DCAF12L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF12L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF12L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF12L1 Gene

Proteins for DCAF12L1 Gene

  • Protein details for DCAF12L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 12-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q8IYK3

    Protein attributes for DCAF12L1 Gene

    463 amino acids
    Molecular mass:
    51201 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF12L1 Gene

Post-translational modifications for DCAF12L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF12L1 Gene

Domains & Families for DCAF12L1 Gene

Gene Families for DCAF12L1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCAF12L1 Gene

Suggested Antigen Peptide Sequences for DCAF12L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF12 family.
  • Belongs to the WD repeat DCAF12 family.
genes like me logo Genes that share domains with DCAF12L1: view

Function for DCAF12L1 Gene

Gene Ontology (GO) - Molecular Function for DCAF12L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25814554
genes like me logo Genes that share ontologies with DCAF12L1: view
genes like me logo Genes that share phenotypes with DCAF12L1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCAF12L1 Gene

Localization for DCAF12L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF12L1 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF12L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with DCAF12L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for DCAF12L1 Gene

Pathways & Interactions for DCAF12L1 Gene

SuperPathways for DCAF12L1 Gene

No Data Available

Interacting Proteins for DCAF12L1 Gene

Gene Ontology (GO) - Biological Process for DCAF12L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DCAF12L1: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF12L1 Gene

Drugs & Compounds for DCAF12L1 Gene

No Compound Related Data Available

Transcripts for DCAF12L1 Gene

mRNA/cDNA for DCAF12L1 Gene

(11) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF12L1 Gene

DDB1 and CUL4 associated factor 12-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12L1 Gene

No ASD Table

Relevant External Links for DCAF12L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF12L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF12L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12L1 Gene

This gene is overexpressed in Testis (x25.1) and Fallopian Tube (x5.3).

Protein differential expression in normal tissues from HIPED for DCAF12L1 Gene

This gene is overexpressed in Testis (65.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF12L1 Gene

Protein tissue co-expression partners for DCAF12L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF12L1 Gene:


SOURCE GeneReport for Unigene cluster for DCAF12L1 Gene:

genes like me logo Genes that share expression patterns with DCAF12L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF12L1 Gene

Orthologs for DCAF12L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF12L1 34 33
  • 98.63 (n)
(Canis familiaris)
Mammalia -- 34
  • 77 (a)
-- 34
  • 74 (a)
(Mus musculus)
Mammalia Dcaf12l2 34
  • 72 (a)
Dcaf12l1 34
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 34
  • 38 (a)
Species where no ortholog for DCAF12L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF12L1 Gene

Gene Tree for DCAF12L1 (if available)
Gene Tree for DCAF12L1 (if available)
Evolutionary constrained regions (ECRs) for DCAF12L1: view image

Paralogs for DCAF12L1 Gene

Paralogs for DCAF12L1 Gene

(2) SIMAP similar genes for DCAF12L1 Gene using alignment to 1 proteins:

  • DC121_HUMAN
genes like me logo Genes that share paralogs with DCAF12L1: view

Variants for DCAF12L1 Gene

Sequence variations from dbSNP and Humsavar for DCAF12L1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000127603 -- 126,554,263(-) C/T upstream_transcript_variant
rs1002390113 -- 126,550,251(-) C/A/T 3_prime_UTR_variant
rs1003529531 -- 126,551,264(-) G/C coding_sequence_variant, missense_variant
rs1004393150 -- 126,554,138(-) T/C upstream_transcript_variant
rs1004432170 -- 126,552,422(-) A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF12L1 Gene

Variant ID Type Subtype PubMed ID
nsv483075 CNV gain 15286789
nsv7078 CNV insertion 18451855

Variation tolerance for DCAF12L1 Gene

Residual Variation Intolerance Score: 20.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.20; 4.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF12L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12L1 Gene

Disorders for DCAF12L1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCAF12L1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure, x-linked, 1
  • spgfx1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for DCAF12L1

genes like me logo Genes that share disorders with DCAF12L1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCAF12L1 Gene

Publications for DCAF12L1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 3 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 4 58

Products for DCAF12L1 Gene

Sources for DCAF12L1 Gene

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