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Aliases for DCAF12 Gene

Aliases for DCAF12 Gene

  • DDB1 And CUL4 Associated Factor 12 2 3 5
  • KIAA1892 2 3 4
  • Testis Cancer Centrosome-Related Protein 3 4
  • Centrosome-Related Protein TCC52 3 4
  • WD Repeat-Containing Protein 40A 3 4
  • Cancer/Testis Antigen 102 2 3
  • WD Repeat Domain 40A 2 3
  • WDR40A 3 4
  • TCC52 3 4
  • DDB1- And CUL4-Associated Factor 12 3
  • CT102 3

External Ids for DCAF12 Gene

Previous HGNC Symbols for DCAF12 Gene

  • KIAA1892
  • WDR40A

Summaries for DCAF12 Gene

Entrez Gene Summary for DCAF12 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF12 Gene

DCAF12 (DDB1 And CUL4 Associated Factor 12) is a Protein Coding gene. An important paralog of this gene is DCAF12L2.

UniProtKB/Swiss-Prot for DCAF12 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF12 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12 Gene

Genomics for DCAF12 Gene

GeneHancer (GH) Regulatory Elements for DCAF12 Gene

Promoters and enhancers for DCAF12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J034123 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656.9 +1.7 1706 4.3 HDGF PKNOX1 CLOCK SMAD1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 DCAF12 PIGO ENSG00000228352 FANCG NOL6 ENSG00000260947 KIF24 CCL19 PIRC37 GC09P034340
GH09J034157 Enhancer 1.2 Ensembl ENCODE 13.3 -31.3 -31328 1.6 PKNOX1 ATF1 FOXA2 ZNF2 ZNF48 ZNF121 ZNF766 ATF7 FOS SP3 IMPDH1P1 DCAF12 ENSG00000228352 UBAP1 GC09P034339 PIR62533 GC09P034340
GH09J034185 Enhancer 1.1 Ensembl ENCODE 12 -59.1 -59140 2.6 FOXA2 FEZF1 ZNF2 IRF4 BRCA1 ZNF121 ZNF213 ATF7 FOS RUNX3 LOC114224 NUDT2 UBAP1 IMPDH1P1 DCAF12 RPL35AP2
GH09J034071 Enhancer 1.1 Ensembl ENCODE 11.1 +54.3 54305 3 FOXA2 ARNT ARID4B SIN3A ETS1 YY1 ZNF121 ZNF143 FOS NFKBIZ UBAP2 RNU4ATAC11P DCAF12 IMPDH1P1 SNORD121A ENSG00000260947 UBE2R2 ENSG00000228352 RN7SKP114
GH09J034191 Enhancer 1 Ensembl ENCODE 12 -64.3 -64331 1.2 FOXA2 ARID4B FEZF1 RAD21 YY1 ZNF335 ZNF614 CREM THAP11 RXRA RPL35AP2 GC09P034315 IMPDH1P1 DCAF12 ENSG00000228352 KIF24 GC09M034194 UBAP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DCAF12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for DCAF12 Gene

Genomic Locations for DCAF12 Gene
chr9:34,086,383-34,127,399
(GRCh38/hg38)
Size:
41,017 bases
Orientation:
Minus strand
chr9:34,086,381-34,127,397
(GRCh37/hg19)

Genomic View for DCAF12 Gene

Genes around DCAF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF12 Gene

Proteins for DCAF12 Gene

  • Protein details for DCAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6F0-DCA12_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 12
    Protein Accession:
    Q5T6F0
    Secondary Accessions:
    • A8KA70
    • D3DRL6
    • Q5T6E9
    • Q5T6F1
    • Q6P3V0
    • Q7L4F8
    • Q96PZ5
    • Q9NXA9
    • Q9UFJ1

    Protein attributes for DCAF12 Gene

    Size:
    453 amino acids
    Molecular mass:
    50517 Da
    Quaternary structure:
    • Interacts with DDB1.
    SequenceCaution:
    • Sequence=BAA91106.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=BAB67785.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF12 Gene

neXtProt entry for DCAF12 Gene

Post-translational modifications for DCAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12 Gene

No data available for DME Specific Peptides for DCAF12 Gene

Domains & Families for DCAF12 Gene

Gene Families for DCAF12 Gene

Suggested Antigen Peptide Sequences for DCAF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T6F0

UniProtKB/Swiss-Prot:

DCA12_HUMAN :
  • Belongs to the WD repeat DCAF12 family.
Family:
  • Belongs to the WD repeat DCAF12 family.
genes like me logo Genes that share domains with DCAF12: view

Function for DCAF12 Gene

Molecular function for DCAF12 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF12 Gene

Gene Ontology (GO) - Molecular Function for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16949367
genes like me logo Genes that share ontologies with DCAF12: view
genes like me logo Genes that share phenotypes with DCAF12: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF12 Gene

Localization for DCAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF12 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF12 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 18957058
GO:0005813 centrosome IDA 18957058
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IMP 16949367
genes like me logo Genes that share ontologies with DCAF12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCAF12 Gene

Pathways & Interactions for DCAF12 Gene

SuperPathways for DCAF12 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T6F0-DCA12_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF12: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF12 Gene

Drugs & Compounds for DCAF12 Gene

No Compound Related Data Available

Transcripts for DCAF12 Gene

mRNA/cDNA for DCAF12 Gene

Unigene Clusters for DCAF12 Gene

DDB1 and CUL4 associated factor 12:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12 Gene

No ASD Table

Relevant External Links for DCAF12 Gene

GeneLoc Exon Structure for
DCAF12
ECgene alternative splicing isoforms for
DCAF12

Expression for DCAF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF12 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for DCAF12 Gene

This gene is overexpressed in Synovial fluid (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF12 Gene



Protein tissue co-expression partners for DCAF12 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF12 Gene:

DCAF12

SOURCE GeneReport for Unigene cluster for DCAF12 Gene:

Hs.493750

mRNA Expression by UniProt/SwissProt for DCAF12 Gene:

Q5T6F0-DCA12_HUMAN
Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Evidence on tissue expression from TISSUES for DCAF12 Gene

  • Nervous system(4.9)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DCAF12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF12 Gene

Orthologs for DCAF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF12 34 33
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF12 34 33
  • 94.19 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF12 34 33
  • 93.89 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf12 16 34 33
  • 91.61 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF12 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682812 33
  • 83.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF12 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF12 34 33
  • 80.5 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF12 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf12 33
  • 73.69 (n)
MGC76023 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3728 33
zebrafish
(Danio rerio)
Actinopterygii dcaf12 34 33
  • 68.83 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002260 33
  • 51.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 34 33
  • 51.2 (n)
OneToMany
Species where no ortholog for DCAF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF12 Gene

ENSEMBL:
Gene Tree for DCAF12 (if available)
TreeFam:
Gene Tree for DCAF12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAF12: view image

Paralogs for DCAF12 Gene

Paralogs for DCAF12 Gene

(2) SIMAP similar genes for DCAF12 Gene using alignment to 1 proteins:

  • DCA12_HUMAN
genes like me logo Genes that share paralogs with DCAF12: view

Variants for DCAF12 Gene

Sequence variations from dbSNP and Humsavar for DCAF12 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000004023 -- 34,099,265(-) C/A intron_variant
rs1000056595 -- 34,099,522(-) G/A intron_variant
rs1000108798 -- 34,103,231(-) G/T intron_variant
rs1000132983 -- 34,109,921(-) T/C intron_variant
rs1000308158 -- 34,111,535(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF12 Gene

Variant ID Type Subtype PubMed ID
dgv1336e199 CNV deletion 23128226
esv1229280 CNV insertion 17803354
esv2676427 CNV deletion 23128226
esv3573225 CNV loss 25503493
esv3573226 CNV loss 25503493
esv3620335 CNV gain 21293372
esv3620345 CNV gain 21293372
esv3620346 CNV loss 21293372
nsv1023129 CNV gain 25217958
nsv1030732 CNV gain 25217958
nsv1110012 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv509300 CNV insertion 20534489
nsv520467 CNV gain 19592680
nsv614154 CNV loss 21841781
nsv6525 CNV deletion 18451855
nsv819806 CNV gain 19587683

Variation tolerance for DCAF12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12 Gene

Disorders for DCAF12 Gene

Additional Disease Information for DCAF12

No disorders were found for DCAF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF12 Gene

Publications for DCAF12 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  3. Novel centrosome protein, TCC52, is a cancer-testis antigen. (PMID: 18957058) Li S … He D (Cancer science 2008) 3 4 58
  4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S … Zheng N (Nature 2006) 3 4 58
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 58

Products for DCAF12 Gene

Sources for DCAF12 Gene

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