Aliases for DCAF10 Gene

Aliases for DCAF10 Gene

  • DDB1 And CUL4 Associated Factor 10 2 3 5
  • DDB1- And CUL4-Associated Factor 10 3 4
  • WD Repeat-Containing Protein 32 3 4
  • WD Repeat Domain 32 2 3
  • WDR32 3 4

External Ids for DCAF10 Gene

Previous HGNC Symbols for DCAF10 Gene

  • WDR32

Previous GeneCards Identifiers for DCAF10 Gene

  • GC09P037793
  • GC09P037753

Summaries for DCAF10 Gene

GeneCards Summary for DCAF10 Gene

DCAF10 (DDB1 And CUL4 Associated Factor 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for DCAF10 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Additional gene information for DCAF10 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DCAF10 Gene

Genomics for DCAF10 Gene

GeneHancer (GH) Regulatory Elements for DCAF10 Gene

Promoters and enhancers for DCAF10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DCAF10 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DCAF10

Genomic Locations for DCAF10 Gene

Genomic Locations for DCAF10 Gene
chr9:37,800,554-37,867,669
(GRCh38/hg38)
Size:
67,116 bases
Orientation:
Plus strand
chr9:37,800,499-37,867,666
(GRCh37/hg19)
Size:
67,168 bases
Orientation:
Plus strand

Genomic View for DCAF10 Gene

Genes around DCAF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF10 Gene

Proteins for DCAF10 Gene

  • Protein details for DCAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QP82-DCA10_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 10
    Protein Accession:
    Q5QP82
    Secondary Accessions:
    • A4VCJ5
    • Q32NE2
    • Q8N2Q5
    • Q96ET5
    • Q9BTQ5
    • Q9H5P6

    Protein attributes for DCAF10 Gene

    Size:
    559 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    • Interacts with DDB1.
    SequenceCaution:
    • Sequence=AAI08687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15574.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11043.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF10 Gene

Post-translational modifications for DCAF10 Gene

  • Ubiquitination at Lys128, Lys204, Lys421, Lys476, and Lys502
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF10 Gene

No data available for DME Specific Peptides for DCAF10 Gene

Domains & Families for DCAF10 Gene

Gene Families for DCAF10 Gene

Suggested Antigen Peptide Sequences for DCAF10 Gene

GenScript: Design optimal peptide antigens:
  • WD repeat-containing protein 32 (DCA10_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5QP82

UniProtKB/Swiss-Prot:

DCA10_HUMAN :
  • Belongs to the WD repeat DCAF10 family.
Family:
  • Belongs to the WD repeat DCAF10 family.
genes like me logo Genes that share domains with DCAF10: view

Function for DCAF10 Gene

Molecular function for DCAF10 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes From GWAS Catalog for DCAF10 Gene

genes like me logo Genes that share phenotypes with DCAF10: view

Animal Models for DCAF10 Gene

MGI Knock Outs for DCAF10:
  • Dcaf10 Dcaf10<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCAF10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCAF10 Gene

Localization for DCAF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF10 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF10 Gene

Pathways & Interactions for DCAF10 Gene

PathCards logo

SuperPathways for DCAF10 Gene

No Data Available

UniProtKB/Swiss-Prot Q5QP82-DCA10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF10: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF10 Gene

Drugs & Compounds for DCAF10 Gene

No Compound Related Data Available

Transcripts for DCAF10 Gene

mRNA/cDNA for DCAF10 Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DCAF10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - - - -
SP7: - - -
SP8:

Relevant External Links for DCAF10 Gene

GeneLoc Exon Structure for
DCAF10

Expression for DCAF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAF10 Gene

Protein differential expression in normal tissues from HIPED for DCAF10 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF10 Gene



Protein tissue co-expression partners for DCAF10 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DCAF10

SOURCE GeneReport for Unigene cluster for DCAF10 Gene:

Hs.118394

Evidence on tissue expression from TISSUES for DCAF10 Gene

  • Intestine(4.2)
  • Liver(4.2)
  • Skin(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with DCAF10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF10 Gene

Orthologs for DCAF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF10 31 30
  • 99.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF10 31 30
  • 91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF10 31 30
  • 89.56 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf10 30
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Dcaf10 17 31 30
  • 88.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF10 31
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF10 31
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF10 31 30
  • 83.1 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF10 31
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf10 30
  • 77.55 (n)
Str.16568 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53557 30
zebrafish
(Danio rerio)
Actinopterygii wdr32 31 30
  • 70.2 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000200 30
  • 50.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1523 31
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
OneToOne
Species where no ortholog for DCAF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF10 Gene

ENSEMBL:
Gene Tree for DCAF10 (if available)
TreeFam:
Gene Tree for DCAF10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DCAF10: view image

Paralogs for DCAF10 Gene

No data available for Paralogs for DCAF10 Gene

Variants for DCAF10 Gene

Additional dbSNP identifiers (rs#s) for DCAF10 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCAF10 Gene

Variant ID Type Subtype PubMed ID
esv1381799 CNV insertion 17803354
nsv1125318 OTHER inversion 24896259
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for DCAF10 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DCAF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DCAF10 Gene

Disorders for DCAF10 Gene

Additional Disease Information for DCAF10

No disorders were found for DCAF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF10 Gene

Publications for DCAF10 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J … Walter JC (Molecular cell 2006) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. (PMID: 30166453) Chen SH … Krogan NJ (The EMBO journal 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 54

Products for DCAF10 Gene

Sources for DCAF10 Gene