Aliases for DBX2 Gene

Aliases for DBX2 Gene

  • Developing Brain Homeobox 2 2 3 5
  • Developing Brain Homeobox Protein 2 3 4
  • Homeobox Protein DBX2 3 4
  • FLJ16139 2
  • DBX2 5

External Ids for DBX2 Gene

Previous GeneCards Identifiers for DBX2 Gene

  • GC12M043697
  • GC12M045408
  • GC12M042436

Summaries for DBX2 Gene

GeneCards Summary for DBX2 Gene

DBX2 (Developing Brain Homeobox 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX1.

Gene Wiki entry for DBX2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DBX2 Gene

Genomics for DBX2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for DBX2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J045050 Promoter 0.9 Ensembl 295.4 +0.8 798 3.4 ZNF10 ZIC2 ZNF341 KLF9 SP2 KLF16 SCRT1 CBX2 ZNF362 GLIS1 DBX2 DBX2-AS1 NELL2 LOC105369742
GH12J044874 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 15 +175.6 175599 4.2 EZH2 ZNF654 ZNF600 ZNF10 ZIC2 ZBTB10 REST ZNF341 ZEB1 KLF7 NELL2 DBX2 ENSG00000201788 lnc-DBX2-5 lnc-DBX2-3
GH12J045089 Enhancer 0.6 UCNEbase Ensembl 35.8 -38.8 -38802 1.4 POLR2A DBX2 piR-37026-124 RF00001-074 RNA5SP361 DBX2-AS1 ANO6
GH12J044846 Promoter/Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 14.9 +203.2 203150 2.3 SP1 NR2C1 IRF4 CBFB BATF SCRT1 STAT5A NR2F1 TCF7 MTA3 NELL2 DBX2 lnc-DBX2-5 piR-39341-082 lnc-TMEM117-4
GH12J045076 Enhancer 0.7 Ensembl ENCODE 19.7 -26.2 -26202 3 ZNF341 ATF4 GLIS1 ZNF18 POU5F1 NANOG POLR2A DBX2 NELL2 piR-37026-124 SSBL3P DBX2-AS1 ANO6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBX2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DBX2

Top Transcription factor binding sites by QIAGEN in the DBX2 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for DBX2 Gene

Latest Assembly
chr12:45,014,672-45,051,099
(GRCh38/hg38)
Size:
36,428 bases
Orientation:
Minus strand

Previous Assembly
chr12:45,408,455-45,444,882
(GRCh37/hg19 by Entrez Gene)
Size:
36,428 bases
Orientation:
Minus strand

chr12:45,408,455-45,444,882
(GRCh37/hg19 by Ensembl)
Size:
36,428 bases
Orientation:
Minus strand

Genomic View for DBX2 Gene

Genes around DBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX2 Gene

Proteins for DBX2 Gene

  • Protein details for DBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG2-DBX2_HUMAN
    Recommended name:
    Homeobox protein DBX2
    Protein Accession:
    Q6ZNG2

    Protein attributes for DBX2 Gene

    Size:
    339 amino acids
    Molecular mass:
    36555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX2 Gene

Post-translational modifications for DBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX2 Gene

Domains & Families for DBX2 Gene

Gene Families for DBX2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DBX2 Gene

InterPro:
Blocks:
  • Lambda and other repressor helix-turn-helix signature

Suggested Antigen Peptide Sequences for DBX2 Gene

GenScript: Design optimal peptide antigens:
  • Developing brain homeobox protein 2 (DBX2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZNG2

UniProtKB/Swiss-Prot:

DBX2_HUMAN :
  • Belongs to the H2.0 homeobox family.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX2: view

Function for DBX2 Gene

Phenotypes From GWAS Catalog for DBX2 Gene

Gene Ontology (GO) - Molecular Function for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with DBX2: view
genes like me logo Genes that share phenotypes with DBX2: view

miRNA for DBX2 Gene

miRTarBase miRNAs that target DBX2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBX2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DBX2 Gene

Localization for DBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBX2 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBX2 Gene

Pathways & Interactions for DBX2 Gene

PathCards logo

SuperPathways for DBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with DBX2: view

No data available for Pathways by source and SIGNOR curated interactions for DBX2 Gene

Drugs & Compounds for DBX2 Gene

No Compound Related Data Available

Transcripts for DBX2 Gene

mRNA/cDNA for DBX2 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBX2

Alternative Splicing Database (ASD) splice patterns (SP) for DBX2 Gene

No ASD Table

Relevant External Links for DBX2 Gene

GeneLoc Exon Structure for
DBX2

Expression for DBX2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBX2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0), Brain - Substantia nigra (x5.1), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for DBX2 Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBX2 Gene



Protein tissue co-expression partners for DBX2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DBX2

SOURCE GeneReport for Unigene cluster for DBX2 Gene:

Hs.302764
genes like me logo Genes that share expression patterns with DBX2: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBX2 Gene

Orthologs for DBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DBX2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia DBX2 29 30
  • 98.82 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia DBX2 30
  • 91 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia DBX2 29 30
  • 86.88 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Dbx2 29
  • 79.51 (n)
Mouse
(Mus musculus)
Mammalia Dbx2 29 16 30
  • 79.19 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia DBX2 30
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves DBX2 29 30
  • 77.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia DBX2 30
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia dbx2 29
  • 63.73 (n)
Zebrafish
(Danio rerio)
Actinopterygii dbx2 30
  • 43 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Dbx 30
  • 13 (a)
OneToOne
Species where no ortholog for DBX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for DBX2 Gene

ENSEMBL:
Gene Tree for DBX2 (if available)
TreeFam:
Gene Tree for DBX2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBX2: view image
Alliance of Genome Resources:
Additional Orthologs for DBX2

Paralogs for DBX2 Gene

Paralogs for DBX2 Gene

(7) SIMAP similar genes for DBX2 Gene using alignment to 1 proteins:

  • DBX2_HUMAN
genes like me logo Genes that share paralogs with DBX2: view

Variants for DBX2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DBX2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs117073125 Benign: not provided 45,016,505(-) C/T
NM_001004329.3(DBX2):c.801G>A (p.Arg267=)
SYNONYMOUS
rs2731038 -- p.Met171Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for DBX2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for DBX2 Gene

Variant ID Type Subtype PubMed ID
esv1002864 CNV insertion 20482838
esv1534356 CNV insertion 17803354
esv2404363 CNV deletion 18987734
esv2745836 CNV deletion 23290073
esv2745837 CNV deletion 23290073
esv2745838 CNV deletion 23290073
esv2745839 CNV deletion 23290073
esv2745840 CNV deletion 23290073
esv3580254 CNV loss 25503493
nsv1051285 CNV loss 25217958
nsv1142807 CNV tandem duplication 24896259

Variation tolerance for DBX2 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBX2 Gene

Human Gene Mutation Database (HGMD)
DBX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBX2
Leiden Open Variation Database (LOVD)
DBX2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX2 Gene

Disorders for DBX2 Gene

Additional Disease Information for DBX2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for DBX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBX2 Gene

Publications for DBX2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A … Jessell TM (Neuron 2001) 2 3
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Dbx2 exhibits a tumor-promoting function in hepatocellular carcinoma cell lines via regulating Shh-Gli1 signaling. (PMID: 30833799) Hu YT … Zhu X (World journal of gastroenterology 2019) 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for DBX2 Gene

Sources for DBX2 Gene