Aliases for DBX1 Gene

Aliases for DBX1 Gene

  • Developing Brain Homeobox 1 2 3 5
  • Developing Brain Homeobox Protein 1 3 4
  • Homeobox Protein DBX1 3 4

External Ids for DBX1 Gene

Previous GeneCards Identifiers for DBX1 Gene

  • GC11M020135
  • GC11M019861

Summaries for DBX1 Gene

GeneCards Summary for DBX1 Gene

DBX1 (Developing Brain Homeobox 1) is a Protein Coding gene. Diseases associated with DBX1 include Central Hypoventilation Syndrome, Congenital. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX2.

UniProtKB/Swiss-Prot Summary for DBX1 Gene

  • Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Gene Wiki entry for DBX1 Gene

Additional gene information for DBX1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DBX1 Gene

Genomics for DBX1 Gene

GeneHancer (GH) Regulatory Elements for DBX1 Gene

Promoters and enhancers for DBX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J020158 Enhancer 0.6 ENCODE 500.7 +1.7 1675 0.2 REST AFF1 HDAC2 EZH2 MIER1 EHMT2 SIN3A ZNF792 RNF2 MIER2 DBX1 lnc-NAV2-3 ENSG00000279266
GH11J020161 Enhancer 0.5 ENCODE 500.7 -0.9 -915 0.2 EZH2 SUZ12 RCOR1 CHD2 EGR1 CTBP2 REST DBX1 LOC105376583
GH11J020109 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.5 +48.9 48892 4 CTCF TCF12 RBAK JUND FOS ZFX ZNF639 ZNF10 POLR2A CLOCK DBX1 piR-33390 NAV2-AS2 NAV2
GH11J019917 Enhancer 1 Ensembl ENCODE dbSUPER 9.9 +239.8 239774 5.8 EP300 JUND FOS RFX1 CTBP1 FOXA2 ESRRA FOSL2 MAFK STAT3 DBX1 HSALNG0083067 piR-36393-062 NAV2
GH11J020128 Enhancer 0.8 ENCODE dbSUPER 10.5 +32.0 32035 0.2 CTCF REST RAD21 TRIM22 SMC3 ZNF263 NR3C1 SKIL RB1 ZNF654 DBX1 HTATIP2 ENSG00000279266 lnc-NAV2-1 lnc-NAV2-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBX1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DBX1

Top Transcription factor binding sites by QIAGEN in the DBX1 gene promoter:
  • AREB6
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for DBX1 Gene

Genomic Locations for DBX1 Gene
chr11:20,156,155-20,160,475
(GRCh38/hg38)
Size:
4,321 bases
Orientation:
Minus strand
chr11:20,177,701-20,182,159
(GRCh37/hg19)
Size:
4,459 bases
Orientation:
Minus strand

Genomic View for DBX1 Gene

Genes around DBX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX1 Gene

Proteins for DBX1 Gene

  • Protein details for DBX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NMT0-DBX1_HUMAN
    Recommended name:
    Homeobox protein DBX1
    Protein Accession:
    A6NMT0

    Protein attributes for DBX1 Gene

    Size:
    343 amino acids
    Molecular mass:
    37283 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX1 Gene

Post-translational modifications for DBX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX1 Gene

Domains & Families for DBX1 Gene

Gene Families for DBX1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DBX1 Gene

Suggested Antigen Peptide Sequences for DBX1 Gene

GenScript: Design optimal peptide antigens:
  • Developing brain homeobox protein 1 (DBX1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NMT0

UniProtKB/Swiss-Prot:

DBX1_HUMAN :
  • Belongs to the H2.0 homeobox family.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX1: view

Function for DBX1 Gene

Molecular function for DBX1 Gene

UniProtKB/Swiss-Prot Function:
Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).

Phenotypes From GWAS Catalog for DBX1 Gene

Gene Ontology (GO) - Molecular Function for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX1: view
genes like me logo Genes that share phenotypes with DBX1: view

Animal Models for DBX1 Gene

MGI Knock Outs for DBX1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBX1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DBX1 Gene

Localization for DBX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBX1 gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBX1 Gene

Pathways & Interactions for DBX1 Gene

PathCards logo

SuperPathways for DBX1 Gene

No Data Available

Interacting Proteins for DBX1 Gene

;

Gene Ontology (GO) - Biological Process for DBX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA,IEA 21873635
GO:0007275 multicellular organism development IEA --
GO:0021515 cell differentiation in spinal cord IBA 21873635
GO:0021521 ventral spinal cord interneuron specification IEA --
genes like me logo Genes that share ontologies with DBX1: view

No data available for Pathways by source and SIGNOR curated interactions for DBX1 Gene

Drugs & Compounds for DBX1 Gene

No Compound Related Data Available

Transcripts for DBX1 Gene

mRNA/cDNA for DBX1 Gene

1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for DBX1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBX1 Gene

No ASD Table

Relevant External Links for DBX1 Gene

GeneLoc Exon Structure for
DBX1

Expression for DBX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DBX1 Gene

mRNA differential expression in normal tissues according to GTEx for DBX1 Gene

This gene is overexpressed in Testis (x26.0) and Pituitary (x7.9).

Protein differential expression in normal tissues from HIPED for DBX1 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBX1 Gene



Protein tissue co-expression partners for DBX1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DBX1

SOURCE GeneReport for Unigene cluster for DBX1 Gene:

Hs.558604

Evidence on tissue expression from TISSUES for DBX1 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with DBX1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBX1 Gene

Orthologs for DBX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBX1 31 30
  • 97.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DBX1 31 30
  • 90.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dbx1 17 31 30
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia Dbx1 30
  • 83.48 (n)
dog
(Canis familiaris)
Mammalia DBX1 31 30
  • 82.49 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBX1 31
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBX1 31 30
  • 76.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBX1 31
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495433 30
  • 72.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia dbx-A 30
zebrafish
(Danio rerio)
Actinopterygii dbx1b 31 30
  • 64.31 (n)
OneToMany
dbx1a 31
  • 63 (a)
OneToMany
-- 30
Species where no ortholog for DBX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX1 Gene

ENSEMBL:
Gene Tree for DBX1 (if available)
TreeFam:
Gene Tree for DBX1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBX1: view image

Paralogs for DBX1 Gene

Paralogs for DBX1 Gene

genes like me logo Genes that share paralogs with DBX1: view

Variants for DBX1 Gene

Additional dbSNP identifiers (rs#s) for DBX1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DBX1 Gene

Variant ID Type Subtype PubMed ID
nsv467720 CNV gain 19166990
nsv469939 CNV gain 18288195
nsv553678 CNV gain 21841781

Variation tolerance for DBX1 Gene

Gene Damage Index Score: 5.71; 73.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBX1 Gene

Human Gene Mutation Database (HGMD)
DBX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DBX1 Gene

Disorders for DBX1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DBX1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • cchs
- elite association - COSMIC cancer census association via MalaCards
Search DBX1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DBX1

genes like me logo Genes that share disorders with DBX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBX1 Gene

Publications for DBX1 Gene

  1. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A … Jessell TM (Neuron 2001) 2 3 54
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  3. Developmental origin of preBötzinger complex respiratory neurons. (PMID: 21048147) Gray PA … Del Negro CA (The Journal of neuroscience : the official journal of the Society for Neuroscience 2010) 3 54
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 54
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 54

Products for DBX1 Gene

Sources for DBX1 Gene