The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014] See more...

Aliases for DBP Gene

Aliases for DBP Gene

  • D-Box Binding PAR BZIP Transcription Factor 2 3 5
  • D Site Of Albumin Promoter (Albumin D-Box) Binding Protein 2 3
  • Tax-Responsive Enhancer Element-Binding Protein 302 3 4
  • Albumin D-Element-Binding Protein 3 4
  • Albumin D Box-Binding Protein 3 4
  • D Site-Binding Protein 3 4
  • TaxREB302 3 4
  • DABP 3

External Ids for DBP Gene

Previous GeneCards Identifiers for DBP Gene

  • GC19M049778
  • GC19M049501
  • GC19M053809
  • GC19M053825
  • GC19M049133
  • GC19M045513

Summaries for DBP Gene

Entrez Gene Summary for DBP Gene

  • The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for DBP Gene

DBP (D-Box Binding PAR BZIP Transcription Factor) is a Protein Coding gene. Diseases associated with DBP include Hemophilia B and Advanced Sleep Phase Syndrome. Among its related pathways are Circadian rythm related genes and BMAL1-CLOCK,NPAS2 activates circadian gene expression. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is HLF.

UniProtKB/Swiss-Prot Summary for DBP Gene

  • This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Gene Wiki entry for DBP Gene

Additional gene information for DBP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for DBP Gene

Genomics for DBP Gene

GeneHancer (GH) Regulatory Elements for DBP Gene

Promoters and enhancers for DBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048632 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.1 1073 7.8 EP300 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 MYC SEC1P DBP NONHSAG026179.2 PRR12 SNRNP70 GRWD1 EHD2 NOP53-AS1 FAM83E CA11
GH19J048736 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.1 -102.0 -102033 5.5 EP300 CTCF NRF1 USF1 POLR2G PHF8 ZBTB11 TCF7 ZBTB26 TARDBP RASIP1 lnc-IZUMO1-1 lnc-IZUMO1-2 FUT2 IZUMO1 SNRNP70 IRF3 PRR12 CYTH2 SNORD35B
GH19J048898 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 9.4 -262.7 -262692 3.8 ZBTB40 ZNF217 CTCF TCF12 NRF1 POLR2G SP1 GTF2E2 SIX5 PHB2 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL DBP SEC1P IRF3 NONHSAG026197.2
GH19J048724 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.5 -88.3 -88251 3.5 ZBTB40 ZNF217 SIX5 POLR2A ZBTB10 ZBTB11 TARDBP TRIM25 ATF2 ZEB1 FUT2 IZUMO1 PRR12 FUT1 FGF21 DBP SEC1P BCAT2 RUVBL2 PRMT1
GH19J048977 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -341.4 -341358 3.4 CTCF TCF12 SP1 JUND FOS ZNF639 ZBTB10 HES1 MEF2C TSC22D4 BAX NUCB1-AS1 NUCB1 TULP2 CGB7 NTF4 KCNA7 DBP SEC1P C19orf73
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for DBP

Top Transcription factor binding sites by QIAGEN in the DBP gene promoter:
  • ATF-2
  • c-Jun
  • COUP
  • COUP-TF1
  • CREB
  • deltaCREB

Genomic Locations for DBP Gene

Genomic Locations for DBP Gene
chr19:48,630,030-48,637,550
(GRCh38/hg38)
Size:
7,521 bases
Orientation:
Minus strand
chr19:49,133,287-49,140,695
(GRCh37/hg19)
Size:
7,409 bases
Orientation:
Minus strand

Genomic View for DBP Gene

Genes around DBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBP Gene

Proteins for DBP Gene

  • Protein details for DBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10586-DBP_HUMAN
    Recommended name:
    D site-binding protein
    Protein Accession:
    Q10586
    Secondary Accessions:
    • A2I2P4

    Protein attributes for DBP Gene

    Size:
    325 amino acids
    Molecular mass:
    34349 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

neXtProt entry for DBP Gene

Post-translational modifications for DBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBP Gene

No data available for DME Specific Peptides for DBP Gene

Domains & Families for DBP Gene

Gene Families for DBP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBP Gene

GenScript: Design optimal peptide antigens:
  • Tax-responsive enhancer element-binding protein 302 (DBP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q10586

UniProtKB/Swiss-Prot:

DBP_HUMAN :
  • Belongs to the bZIP family. PAR subfamily.
Family:
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with DBP: view

Function for DBP Gene

Molecular function for DBP Gene

UniProtKB/Swiss-Prot Function:
This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
GENATLAS Biochemistry:
albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney

Phenotypes From GWAS Catalog for DBP Gene

Gene Ontology (GO) - Molecular Function for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA,IEA 20093779
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA,IDA 20093779
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with DBP: view
genes like me logo Genes that share phenotypes with DBP: view

Animal Models for DBP Gene

MGI Knock Outs for DBP:
  • Dbp Dbp<tm1Schb>
  • Dbp Dbp<tm2Schb>

Animal Model Products

CRISPR Products

miRNA for DBP Gene

miRTarBase miRNAs that target DBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBP Gene

Localization for DBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBP gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
genes like me logo Genes that share ontologies with DBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBP Gene

Pathways & Interactions for DBP Gene

genes like me logo Genes that share pathways with DBP: view

Pathways by source for DBP Gene

1 BioSystems pathway for DBP Gene

SIGNOR curated interactions for DBP Gene

Activates:

Gene Ontology (GO) - Biological Process for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IEA 8786133
GO:0007623 circadian rhythm IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA,IEA 20093779
genes like me logo Genes that share ontologies with DBP: view

Drugs & Compounds for DBP Gene

(27) Drugs for DBP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1383
Doxazosin Approved Pharma 66
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 359
Calcifediol Approved Nutra Major circulating form of vitamin D3 148
Calcium Approved Nutra 7884
genes like me logo Genes that share compounds with DBP: view

Transcripts for DBP Gene

mRNA/cDNA for DBP Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - - - -

Relevant External Links for DBP Gene

GeneLoc Exon Structure for
DBP

Expression for DBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBP Gene



Protein tissue co-expression partners for DBP Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for DBP

SOURCE GeneReport for Unigene cluster for DBP Gene:

Hs.414480

mRNA Expression by UniProt/SwissProt for DBP Gene:

Q10586-DBP_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Evidence on tissue expression from TISSUES for DBP Gene

  • Nervous system(4.8)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with DBP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBP Gene

Orthologs for DBP Gene

This gene was present in the common ancestor of animals.

Orthologs for DBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA11 31
  • 100 (a)
OneToOne
DBP 30
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia DBP 31 30
  • 90.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DBP 31 30
  • 89.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbp 30
  • 85.85 (n)
mouse
(Mus musculus)
Mammalia Dbp 17 31 30
  • 85.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DBP 31
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBP 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbp 30
  • 65.03 (n)
zebrafish
(Danio rerio)
Actinopterygii dbpa 31
  • 38 (a)
OneToMany
dbpb 31
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7786 31
  • 27 (a)
OneToMany
gt 31
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ces-2 31
  • 22 (a)
OneToMany
atf-8 31
  • 16 (a)
OneToMany
Species where no ortholog for DBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBP Gene

ENSEMBL:
Gene Tree for DBP (if available)
TreeFam:
Gene Tree for DBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBP: view image

Paralogs for DBP Gene

Paralogs for DBP Gene

(2) SIMAP similar genes for DBP Gene using alignment to 3 proteins:

  • DBP_HUMAN
  • M0QXP1_HUMAN
  • M0QXW3_HUMAN
genes like me logo Genes that share paralogs with DBP: view

Variants for DBP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for DBP Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712816 Likely Benign: not provided 48,636,925(-) C/T MISSENSE_VARIANT
754053 Likely Benign: not provided 48,633,456(-) C/T SYNONYMOUS_VARIANT
755604 Likely Benign: not provided 48,635,662(-) C/T SYNONYMOUS_VARIANT
774960 Benign: not provided 48,630,903(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for DBP Gene

Structural Variations from Database of Genomic Variants (DGV) for DBP Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for DBP Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBP Gene

Disorders for DBP Gene

MalaCards: The human disease database

(2) MalaCards diseases for DBP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hemophilia b
  • hemb
advanced sleep phase syndrome
  • familial advanced sleep-phase syndrome
- elite association - COSMIC cancer census association via MalaCards
Search DBP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DBP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with DBP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBP Gene

Publications for DBP Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib ZA … Look AT (Genomics 1994) 2 3 4 23 54
  2. Genomic structure of the human D-site binding protein (DBP) gene. (PMID: 8786133) Shutler G … Mueller CR (Genomics 1996) 3 4 23 54
  3. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 41 54
  4. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PMID: 20174623) Utge SJ … Paunio T (PloS one 2010) 3 41 54
  5. PER2 variantion is associated with depression vulnerability. (PMID: 19693801) Lavebratt C … Forsell Y (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 41 54

Products for DBP Gene

Sources for DBP Gene