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Aliases for DBP Gene

Aliases for DBP Gene

  • D-Box Binding PAR BZIP Transcription Factor 2 3 5
  • D Site Of Albumin Promoter (Albumin D-Box) Binding Protein 2 3
  • Tax-Responsive Enhancer Element-Binding Protein 302 3 4
  • Albumin D-Element-Binding Protein 3 4
  • Albumin D Box-Binding Protein 3 4
  • TaxREB302 3 4
  • D Site-Binding Protein 3
  • DABP 3

External Ids for DBP Gene

Previous GeneCards Identifiers for DBP Gene

  • GC19M049778
  • GC19M049501
  • GC19M053809
  • GC19M053825
  • GC19M049133
  • GC19M045513

Summaries for DBP Gene

Entrez Gene Summary for DBP Gene

  • The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for DBP Gene

DBP (D-Box Binding PAR BZIP Transcription Factor) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression and Circadian rythm related genes. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is HLF.

UniProtKB/Swiss-Prot for DBP Gene

  • This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Gene Wiki entry for DBP Gene

Additional gene information for DBP Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBP Gene

Genomics for DBP Gene

GeneHancer (GH) Regulatory Elements for DBP Gene

Promoters and enhancers for DBP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J048632 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.1 1073 7.8 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 SEC1P DBP PRR12 SNRNP70 PIH1D1 GRWD1 SNORD35A SNORD35B RPS11 NOP53-AS1
GH19J048736 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.1 -102.0 -102033 5.5 HDGF PKNOX1 FOXA2 ARNT SIN3A POLR2B ZNF766 ZNF143 KLF13 SP3 RASIP1 FUT2 IZUMO1 PRR12 CYTH2 ENSG00000268093 PRMT1 SNRNP70 LIG1 DBP
GH19J048672 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 12.3 -38.4 -38391 7 HDGF ARID4B SIN3A ZNF48 YY1 ZNF121 ZNF143 RUNX3 YY2 REST NTN5 LOC105372431 FUT2 RASIP1 MAMSTR DBP SEC1P IZUMO1 BCAT2 TULP2
GH19J048898 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 9.4 -262.7 -262692 3.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL SEC1P DBP IRF3 NUCB1-AS1
GH19J048768 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.5 -134.3 -134333 6.8 PKNOX1 FOXA2 MLX ARNT ARID4B YY1 TCF12 ZNF121 ATF7 RXRA SCAF1 FUT2 IZUMO1 RASIP1 BCAT2 DKKL1 MAMSTR DBP SEC1P TULP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DBP on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBP gene promoter:
  • deltaCREB
  • c-Jun
  • ATF-2
  • CREB
  • COUP
  • COUP-TF1

Genomic Locations for DBP Gene

Genomic Locations for DBP Gene
chr19:48,630,030-48,637,550
(GRCh38/hg38)
Size:
7,521 bases
Orientation:
Minus strand
chr19:49,133,287-49,140,695
(GRCh37/hg19)
Size:
7,409 bases
Orientation:
Minus strand

Genomic View for DBP Gene

Genes around DBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBP Gene

Proteins for DBP Gene

  • Protein details for DBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10586-DBP_HUMAN
    Recommended name:
    D site-binding protein
    Protein Accession:
    Q10586
    Secondary Accessions:
    • A2I2P4

    Protein attributes for DBP Gene

    Size:
    325 amino acids
    Molecular mass:
    34349 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

neXtProt entry for DBP Gene

Post-translational modifications for DBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBP Gene

No data available for DME Specific Peptides for DBP Gene

Domains & Families for DBP Gene

Gene Families for DBP Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for DBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q10586

UniProtKB/Swiss-Prot:

DBP_HUMAN :
  • Belongs to the bZIP family. PAR subfamily.
Family:
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with DBP: view

Function for DBP Gene

Molecular function for DBP Gene

UniProtKB/Swiss-Prot Function:
This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.
GENATLAS Biochemistry:
albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney

Phenotypes From GWAS Catalog for DBP Gene

Gene Ontology (GO) - Molecular Function for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 20093779
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA,IEA 20093779
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with DBP: view
genes like me logo Genes that share phenotypes with DBP: view

Animal Models for DBP Gene

MGI Knock Outs for DBP:
  • Dbp Dbp<tm1Schb>
  • Dbp Dbp<tm2Schb>

miRNA for DBP Gene

miRTarBase miRNAs that target DBP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBP Gene

Localization for DBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBP gene
Compartment Confidence
nucleus 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with DBP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DBP Gene

Pathways & Interactions for DBP Gene

genes like me logo Genes that share pathways with DBP: view

Pathways by source for DBP Gene

1 BioSystems pathway for DBP Gene

Gene Ontology (GO) - Biological Process for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IEA 8786133
GO:0006366 transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with DBP: view

No data available for SIGNOR curated interactions for DBP Gene

Drugs & Compounds for DBP Gene

(23) Drugs for DBP Gene - From: ClinicalTrials and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Angiotensin II Approved, Investigational Pharma Full agonist, Agonist Potent vasopressor and a powerful stimulus for production and release of aldosterone from the adrenal cortex. 1217
Doxazosin Approved Pharma 64
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 306
Ergocalciferol Approved Nutra 1362
Vitamin D Approved, Vet_approved Nutra 1796
genes like me logo Genes that share compounds with DBP: view

Transcripts for DBP Gene

mRNA/cDNA for DBP Gene

Unigene Clusters for DBP Gene

D site of albumin promoter (albumin D-box) binding protein:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - - - -

Relevant External Links for DBP Gene

GeneLoc Exon Structure for
DBP
ECgene alternative splicing isoforms for
DBP

Expression for DBP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBP Gene



Protein tissue co-expression partners for DBP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DBP Gene:

DBP

SOURCE GeneReport for Unigene cluster for DBP Gene:

Hs.414480

mRNA Expression by UniProt/SwissProt for DBP Gene:

Q10586-DBP_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Evidence on tissue expression from TISSUES for DBP Gene

  • Nervous system(4.8)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with DBP: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBP Gene

Orthologs for DBP Gene

This gene was present in the common ancestor of animals.

Orthologs for DBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA11 34
  • 100 (a)
OneToOne
DBP 33
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia DBP 34 33
  • 90.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DBP 34 33
  • 89.95 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbp 33
  • 85.85 (n)
mouse
(Mus musculus)
Mammalia Dbp 16 34 33
  • 85.74 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DBP 34
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBP 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbp 33
  • 65.03 (n)
zebrafish
(Danio rerio)
Actinopterygii dbpa 34
  • 38 (a)
OneToMany
dbpb 34
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7786 34
  • 27 (a)
OneToMany
gt 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ces-2 34
  • 22 (a)
OneToMany
atf-8 34
  • 16 (a)
OneToMany
Species where no ortholog for DBP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBP Gene

ENSEMBL:
Gene Tree for DBP (if available)
TreeFam:
Gene Tree for DBP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DBP: view image

Paralogs for DBP Gene

Paralogs for DBP Gene

(2) SIMAP similar genes for DBP Gene using alignment to 3 proteins:

  • DBP_HUMAN
  • M0QXP1_HUMAN
  • M0QXW3_HUMAN
genes like me logo Genes that share paralogs with DBP: view

Variants for DBP Gene

Sequence variations from dbSNP and Humsavar for DBP Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000184091 -- 48,635,832(-) A/G coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000188827 -- 48,636,088(-) G/T intron_variant
rs1000393717 -- 48,630,499(-) G/T downstream_transcript_variant
rs1000474293 -- 48,634,608(-) C/A intron_variant
rs1000524671 -- 48,634,747(-) G/A intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for DBP Gene

Variant ID Type Subtype PubMed ID
dgv3617n100 CNV gain 25217958
nsv9739 CNV gain+loss 18304495

Variation tolerance for DBP Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBP Gene

Disorders for DBP Gene

Additional Disease Information for DBP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for DBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBP Gene

Publications for DBP Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib ZA … Look AT (Genomics 1994) 2 3 4 22 58
  2. Genomic structure of the human D-site binding protein (DBP) gene. (PMID: 8786133) Shutler G … Mueller CR (Genomics 1996) 3 4 22 58
  3. PER2 variantion is associated with depression vulnerability. (PMID: 19693801) Lavebratt C … Forsell Y (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  4. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PMID: 20072116) Soria V … Urretavizcaya M (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2010) 3 44 58
  5. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PMID: 20174623) Utge SJ … Paunio T (PloS one 2010) 3 44 58

Products for DBP Gene

Sources for DBP Gene

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